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Article ; Online: Organic chemistry and medicinal applications.

Abdel-Jalil, Raid / Stoll, Raphael

Zeitschrift fur Naturforschung. C, Journal of biosciences

2023 Volume 78, Issue 3-4, Page(s) 91–92

MeSH term(s)	Chemistry, Organic ; Chemistry, Pharmaceutical
Language	English
Publishing date	2023-02-24
Publishing country	Germany
Document type	Editorial
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2023-0013
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Article ; Online: Bioactive Peptides and Proteins in Medicinal Chemistry.

Abdel-Jalil, Raid / Stoll, Raphael

Current medicinal chemistry

2022 Volume 29, Issue 42, Page(s) 6335

MeSH term(s)	Humans ; Chemistry, Pharmaceutical ; Peptides ; Amino Acid Sequence
Chemical Substances	Peptides
Language	English
Publishing date	2022-11-08
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/092986732942221012104710
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Zs.A 4432: Show issues

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Article ; Online: An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint.

Moghadam, Ebrahim Saeedian / Mireskandari, Katayoon / Abdel-Jalil, Raid / Amini, Mohsen

Mini reviews in medicinal chemistry

2022 Volume 22, Issue 19, Page(s) 2486–2561

Abstract: Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to the importance of pyrrole structure in drug design and development, herein, we tried to conduct an extensive review of the bioactive pyrrole-based compounds ... ...

Abstract	Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to the importance of pyrrole structure in drug design and development, herein, we tried to conduct an extensive review of the bioactive pyrrole-based compounds reported recently. The bioactivity of pyrrole derivatives varies, so in the review, we categorized them based on their direct pharmacologic targets. Therefore, readers are able to find the variety of biological targets for pyrrole-containing compounds easily. This review explains around seventy different biologic targets for pyrrole-based derivatives, so it is helpful for medicinal chemists in the design and development of novel bioactive compounds for different diseases. This review presents an extensive, meaningful structure-activity relationship for each reported structure as much as possible. The review focuses on papers published between 2018 and 2020.
MeSH term(s)	Biological Products ; Chemistry, Pharmaceutical ; Drug Design ; Pyrroles/chemistry ; Pyrroles/pharmacology ; Structure-Activity Relationship
Chemical Substances	Biological Products ; Pyrroles
Language	English
Publishing date	2022-04-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557522666220325150531
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Zs.A 5891: Show issues

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Article ; Online: Importance of Fluorine in Benzazole Compounds.

Al-Harthy, Thuraya / Zoghaib, Wajdi / Abdel-Jalil, Raid

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 20

Abstract: Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to ...

Abstract	Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.
MeSH term(s)	Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Benzimidazoles/chemistry ; Benzimidazoles/pharmacology ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacology ; Chemistry, Pharmaceutical/methods ; Drug Design ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Fluorine/chemistry ; Heterocyclic Compounds, 2-Ring/chemistry ; Heterocyclic Compounds, 2-Ring/pharmacology ; Humans ; Structure-Activity Relationship
Chemical Substances	Benzimidazoles ; Benzothiazoles ; Enzyme Inhibitors ; Heterocyclic Compounds, 2-Ring ; Fluorine (284SYP0193) ; benzimidazole (E24GX49LD8) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; BTK protein, human (EC 2.7.10.2) ; benzothiazole (G5BW2593EP)
Language	English
Publishing date	2020-10-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25204677
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Article ; Online: Chest wall and diaphragm reconstruction; a technique not well established in literature - case report.

Abdel Jalil, Riad / Abou Chaar, Mohamad K / Al-Qudah, Obada / Kakish, Hanna / Elfar, Salam

Journal of cardiothoracic surgery

2021 Volume 16, Issue 1, Page(s) 196

Abstract: Introduction: Regardless of its rarity, and indolent clinical course, chest wall tumor places high morbidity and burden on patients especially when invasion to a neighboring structure is found. Once detected, surgery is the cornerstone for treatment of ... ...

Abstract	Introduction: Regardless of its rarity, and indolent clinical course, chest wall tumor places high morbidity and burden on patients especially when invasion to a neighboring structure is found. Once detected, surgery is the cornerstone for treatment of such etiology combined with chemo-radiotherapy. In order to maintain intact respiratory function, chest wall reconstruction must be performed whenever resection is done. Herein, we present a case of chest wall tumor that necessitated three ribs and part of hemidiaphragm resection and reconstruction with optimal post-operative results. Case presentation: A 27-year-old male patient who had chest wall and diaphragm reconstruction for a chest wall Ewing sarcoma, using a single patch of expanded polytetrafluoroethylene (ePTFE) mesh with diaphragm implanted into the middle of the mesh. There were no immediate nor post-operative complications. The patient received post-operative radiotherapy with good functional and cosmetic results. Conclusion: We present a novel and safe technique for combined chest wall and diaphragmatic resection following excision of an invading tumor while ensuring cosmesis and functionality of the ribcage as well as the diaphragm.
MeSH term(s)	Adult ; Diaphragm/surgery ; Humans ; Male ; Polytetrafluoroethylene ; Radiotherapy, Adjuvant ; Plastic Surgery Procedures/methods ; Ribs/surgery ; Sarcoma, Ewing/radiotherapy ; Sarcoma, Ewing/surgery ; Surgical Mesh ; Thoracic Neoplasms/radiotherapy ; Thoracic Neoplasms/surgery ; Thoracic Wall/surgery
Chemical Substances	Polytetrafluoroethylene (9002-84-0)
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-021-01577-w
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Article ; Online: Novel benzimidazole derivatives; synthesis, bioactivity and molecular docking study as potent urease inhibitors.

Saeedian Moghadam, Ebrahim / Al-Sadi, Abdullah Mohammed / Talebi, Meysam / Amanlou, Massoud / Amini, Mohsen / Abdel-Jalil, Raid

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

2022 Volume 30, Issue 1, Page(s) 29–37

Abstract: Background: Benzimidazole derivatives are widely used to design and synthesize novel bioactive compounds. There are several approved benzimidazole-based drugs on the market.: Objectives: In this study, we aimed to design and synthesize a series of ... ...

Abstract	Background: Benzimidazole derivatives are widely used to design and synthesize novel bioactive compounds. There are several approved benzimidazole-based drugs on the market. Objectives: In this study, we aimed to design and synthesize a series of novel benzimidazole derivatives 8a-n that are urease inhibitors. Methods: All 8a-n were synthesized in a multistep. To determine the urease inhibitory effect of 8a-n, the urease inhibition kit was used. The cytotoxicity assay of 8a-n was determined using MTT method. Molecular modelling was determined using autodock software. Results: All 8a-n were synthesized in high yield, and their structures were determined using Conclusion: The synthesized benzimidazole derivatives exhibit high activity, suggesting that further research on this family of compounds would be beneficial to finding a potent urease inhibitor.
MeSH term(s)	Benzimidazoles/chemistry ; Benzimidazoles/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Urease/metabolism
Chemical Substances	Benzimidazoles ; Enzyme Inhibitors ; Urease (EC 3.5.1.5)
Language	English
Publishing date	2022-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2129183-4
ISSN	2008-2231 ; 1560-8115
ISSN (online)	2008-2231
ISSN	1560-8115
DOI	10.1007/s40199-021-00427-3
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Article ; Online: Design, synthesis, and molecular docking study of novel cinnoline derivatives as potential inhibitors of tubulin polymerization.

Mahmoud, Eman Mohammad / Shongwe, Musa / Moghadam, Ebrahim Saeedian / Moghimi-Rad, Parsa / Stoll, Raphael / Abdel-Jalil, Raid

Zeitschrift fur Naturforschung. C, Journal of biosciences

2022 Volume 78, Issue 3-4, Page(s) 123–131

Abstract: The preparation of a novel 4-methylbenzo[ ...

Abstract	The preparation of a novel 4-methylbenzo[
MeSH term(s)	Tubulin/metabolism ; Molecular Docking Simulation ; Polymerization ; Heterocyclic Compounds, 2-Ring/chemistry ; Heterocyclic Compounds, 2-Ring/pharmacology ; Molecular Structure ; Antineoplastic Agents/pharmacology ; Cell Proliferation
Chemical Substances	cinnoline (N5KD6I506O) ; Tubulin ; Heterocyclic Compounds, 2-Ring ; Antineoplastic Agents
Language	English
Publishing date	2022-08-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2022-0087
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Zs.A 962: Show issues

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Article ; Online: Maintaining quality of life after major lung resection for carcinoid tumor.

Abdel Jalil, Riad / Abdallah, Farah A / Obeid, Zeinab / Abou Chaar, Mohamad K / Harb, Ahmad Khaled / Shannies, Tariq Bassam / El-Edwan, Ahed / Haddad, Hussam / Ghraibeh, Azza / Abu-Shanab, Ahmad

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 330

Abstract: Background: Pulmonary carcinoid is a rare diagnosis with surgery remaining the standard treatment of choice. However, resection may impact patients' daily activities due to decreased lung volume reserve and postoperative pain. Our study aims to compare ... ...

Abstract	Background: Pulmonary carcinoid is a rare diagnosis with surgery remaining the standard treatment of choice. However, resection may impact patients' daily activities due to decreased lung volume reserve and postoperative pain. Our study aims to compare the impact of different types of surgical resection on the post-operative quality of life with the application of a strict peri-operative pulmonary care program. Methods: Patients who underwent surgery for bronchopulmonary carcinoid tumors in a tertiary cancer center between August, 2017 and March, 2020 were identified and demographic data was collected. Patients were contacted via phone for the qualitative and quantitative assessment of pain and quality of life, utilizing the Arabic version of Short-form McGill Pain Questionnaire and Activity of Daily Living (ADL) instrument respectively. Lung reserve was assessed before and after surgery. Statistical analysis used Chi-Square for categorical variables and ANOVA for continuous variables. Results: A total of 16 patients underwent different type of resection. The majority were male (n = 10; 63%) with a mean age of 44 years (19-81). Most common clinical stage was stage I (n = 12, 75%) with typical carcinoid features recorded in more than half of the cases (n = 11, 69%). Almost all patients underwent surgical excision (n = 15, 94%) with negative resection margin and no major post-operative complications. Bilobectomy was the most frequent procedure (n = 6, 40%) and video-assisted thoracoscopic surgery (VATS) was utilized in 8 patients (50%). Expected changes were recorded in pre- and postoperative pulmonary function test with an average drop of 10 in FEV1 and 14 mL/min/mmHg in DLCO. The majority of patients (n = 15, 94%) were totally independent doing daily activities. Mild intermittent pain was found in 7 patients (44%) who scored an average intensity of 1.6 out of 10. Conclusions: Excellent long-term outcomes can be achieved following surgical resection of pulmonary carcinoid tumors with little to no effect on patients' lung function and quality of life in regard to performance status and post-operative pain when a good peri-operative pulmonary, physical rehabilitation, and pain management programs are adopted and strictly implemented.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Quality of Life ; Lung Neoplasms/pathology ; Lung/pathology ; Carcinoid Tumor/surgery ; Carcinoid Tumor/complications ; Pneumonectomy/methods ; Pain, Postoperative/etiology ; Thoracic Surgery, Video-Assisted/methods
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02435-7
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Article ; Online: Locally advanced thymoma; does neoadjuvant chemotherapy make a difference?

Abdel Jalil, Riad / Abdallah, Farah A / Obeid, Zeinab / Harb, Ahmad Khaled / Abou Chaar, Mohamad K / Shannies, Tariq Bassem / El-Edwan, Ahed / Haddad, Hussam / Ghraibeh, Azza / Abu-Shanab, Ahmad

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 245

Abstract: Background: Regardless of its rare occurrence, Thymoma remains the most frequently encountered primary tumor of the anterior mediastinum comprising about 50% of all masses in the region. Surgical resection, via thymectomy, remains the mainstay treatment ...

Abstract	Background: Regardless of its rare occurrence, Thymoma remains the most frequently encountered primary tumor of the anterior mediastinum comprising about 50% of all masses in the region. Surgical resection, via thymectomy, remains the mainstay treatment modality. In locally advanced and borderline resectable tumors, neoadjuvant chemotherapy (NACT) may be utilized to increase the chance of R0 resection, raising the question of its efficacy and safety. Methods: Demographic and clinical data from patients who presented to a tertiary cancer center between January 2015-October 2021 with a diagnosis of thymoma and underwent curative surgical resection was collected. Computed tomography scan was used to delineate clinical staging, tumor size and to detect post-therapeutic variations in tumor burden. The response evaluation criteria in solid tumors (RECIST) was used to classify the effect of NACT on tumor burden. The pathological response was determined by measuring the percentage of necrotic tissue. Results: A total of 23 patients were diagnosed with thymoma. Most patients were male with a mean age 46 (± 15) years at diagnosis. The most common clinical stage was stage II with 5 patients (22%). A total of 12 patients had NACT as compared to 11 patients who had upfront surgery. The mean change in tumor volume was 165 cm Conclusions: The exact role of induction chemotherapy in locally advanced thymoma patients remains controversial. NACT effect after utilizing radiological and pathological assessment tools was not found to significantly improve oncological outcomes compared to upfront surgery in locally advanced disease, with minimal radiologic and pathologic effect. To further demonstrate the impact of induction chemotherapy, we recommend multicentric collaborative studies.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Thymoma/drug therapy ; Thymoma/surgery ; Neoadjuvant Therapy ; Thymus Neoplasms/drug therapy ; Thymus Neoplasms/surgery ; Mediastinum ; Necrosis
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02357-4
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Article ; Online: Early surgical and oncological outcomes during adoption of a single port VATS lung resection in a tertiary cancer center: a retrospective analysis.

Abdel Jalil, Riad / Abou Chaar, Mohamad K / Al-Qudah, Obada / Al-Edwan, Ahed / Almajali, Omar / Ababneh, Hazim / U'wais, Ahmad / Al-Ghazawi, Munir / Al-Najjar, Hani / Abu-Shanab, Ahmad

Journal of cardiothoracic surgery

2022 Volume 17, Issue 1, Page(s) 26

Abstract: Background: Video-assisted thoracoscopic surgery (VATS) is a safe and effective surgical approach for pulmonary resection. VATS can be accomplished with only a single incision, resulting in less postoperative pain and paresthesia, better cosmetic ... ...

Abstract	Background: Video-assisted thoracoscopic surgery (VATS) is a safe and effective surgical approach for pulmonary resection. VATS can be accomplished with only a single incision, resulting in less postoperative pain and paresthesia, better cosmetic results, and greater patient satisfaction. Single-port VATS (spVATS) has become increasingly common for lung resection. We assess the early surgical and oncological outcomes after adopting this new technique at our tertiary cancer center as the first institution to do so in the country. Method: Medical records for 257 patients in a tertiary cancer center, with a diagnosis of non-small cell lung cancer, pulmonary metastasis, or other chest-confined pathology, were accessed to obtain perioperative outcomes, pathologic results, post-operative follow-up data, and early surgical and oncological outcomes. All patients underwent spVATS for limited or major lung resection. Simple descriptive analysis was utilized. Results: spVATS was either performed with curative intent (79.8%, N = 205), or as a diagnostic procedure (20.2%, N = 52). Resection types were subcategorized for curative intent group as limited (73.6%, N = 151), lobectomy (16.6%, N = 34), and complex (9.7%, N = 20). Resection with a negative margin (R0) rate was 100% for the primary lung cancer (PLC) patients and 97% for the pulmonary metastasectomy (PM) group. The complication rate was 5%. Three-year disease-free survival was 87% and 68.5% for PLC and PM group, respectively. The 3-year overall-survival was 91.3% for the PLC and 82.8% for PM. Operation duration showed a downtrend over the study period in each curative subcategory with a borderline difference in the limited resection (P value = 0.05). Conclusion: All the spVATS procedures were successfully performed without perioperative severe complications or mortality, regardless of complexity. R0 resection was excellent. Middle- and long-term efficacies of spVATS for lung cancer require further follow-up. With proper training, appropriate indication and meticulous application, adopting spVATS is safe and feasible technique that does not compromise surgical and oncological outcomes.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Humans ; Lung/pathology ; Lung Neoplasms/pathology ; Pneumonectomy/methods ; Retrospective Studies ; Thoracic Surgery, Video-Assisted/methods
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01777-y
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