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  1. Article ; Online: Efficacy of intratracheal dexmedetomidine on recovery from general anaesthesia in paediatric patients undergoing lower abdominal surgeries: A randomised controlled trial.

    Abdel Rady, Marwa Mahmoud / Ali, Wesam Nashat / Mansour, Fatma Batity / Abdullah Othman, Ekram / Abo Elfadl, Ghada Mohammad

    Journal of perioperative practice

    2024  , Page(s) 17504589241231197

    Abstract: Background: This study investigated the effectiveness of intratracheal dexmedetomidine in reducing untoward laryngeal responses in paediatrics undergoing lower abdominal surgeries.: Methods: This trial included 60 patients divided into two groups ... ...

    Abstract Background: This study investigated the effectiveness of intratracheal dexmedetomidine in reducing untoward laryngeal responses in paediatrics undergoing lower abdominal surgeries.
    Methods: This trial included 60 patients divided into two groups scheduled for lower abdominal surgeries. Group D were given intratracheal dexmedetomidine at a dosage of 0.5mg/kg, while Group C received intratracheal saline (0.9%). The cough severity score, the Paediatric Objective Pain Scale for pain assessment, awareness, extubation, emergence agitation score, Ramsay sedation score and adverse effects were recorded.
    Results: There was a significant difference in the incidence of coughing severity between Groups D and C both at extubation and after five minutes of extubation (p < 0.001). The median scores of the Paediatric Objective Pain Scales and the median agitation scales of Group D were significantly lower over the first four hours (p < 0.050). The mean time to first request rescue analgesia was significantly longer in the D group than in the control group (p < 0.001). The mean total consumption of rescue analgesia in the first 24 hours postoperatively was significantly lower in the dexmedetomidine group (p < 0.050). Awareness and extubation times were comparable in both groups, and none of the subjects reported any adverse effects.
    Conclusion: In the current study, lower abdominal surgery patients who received intratracheal dexmedetomidine at a dose of 0.5mg/kg 30 minutes before the completion of the procedure experienced smooth extubation and balanced anaesthetic recovery.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2226186-2
    ISSN 2515-7949 ; 1750-4589
    ISSN (online) 2515-7949
    ISSN 1750-4589
    DOI 10.1177/17504589241231197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 83: Show issues

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  2. Article ; Online: Add dexmedetomidine to levobupivacaine for transversus abdominis plane block in elderly patients undergoing inguinal hernia repair: Could it make a difference? A randomised trial.

    Abo Elfadl, Ghada Mohammad / Ali, Wesam Nashat / Ahmed, Fatma Nabil / Abd El-Rady, Nessren M / Ali, Ahmed Mohammed / Abdel Rady, Marwa Mahmoud

    Journal of perioperative practice

    2023  , Page(s) 17504589231196653

    Abstract: Background: Transversus abdominis plane block is becoming more common as part of multimodal analgesia for post-abdominal operation pain relief. This study compared the analgesic effects of adding dexmedetomidine to levobupivacaine (transversus abdominis ...

    Abstract Background: Transversus abdominis plane block is becoming more common as part of multimodal analgesia for post-abdominal operation pain relief. This study compared the analgesic effects of adding dexmedetomidine to levobupivacaine (transversus abdominis plane) block in elderly patients undergoing inguinal hernia surgery to adding fentanyl.
    Methods: Overall, 90 elderly patients with a simple inguinal hernia repair were randomly assigned to one of three groups. After spinal anaesthesia, an ultrasound-guided transversus abdominis plane block was performed. Transversus abdominis plane block was accomplished with 0.25% levobupivacaine + 0.9% normal saline in Group L (n = 30) (20mL). Transversus abdominis plane block was accomplished with 0.25% levobupivacaine + 1 µg/kg dexmedetomidine in Group D (n = 30) (20mL). Transversus abdominis plane block was obtained with 0.25% levobupivacaine + 1 µg/kg fentanyl in Group F (n = 30) (20mL). The primary outcome was the first analgesic request, and the secondary outcomes were the visual analog scale, postoperative analgesic requirements, sedation, hemodynamic stability, and related complications 24 hours postoperatively. 1gm paracetamol intravenously was provided as rescue analgesia.
    Results: The time to first analgesic request in the dexmedetomidine group was substantially more prolonged than in the fentanyl and control groups (516.5±27.8, 451.2±11.1, and 403.9±10.5min, respectively; p < 0.05). Postoperative analgesic requirements were significantly decreased in dexmedetomidine 1(1-2) than control 2(1-3) and fentanyl 1.5(1-2) respectively (P<0.01). VAS was significantly lower in Group D and Group F than in Group L postoperatively. No significant difference in side effects was noted between the groups.
    Conclusion: The transversus abdominis plane block is the best multimodal analgesia choice for inguinal hernia repair in older patients. Combining dexmedetomidine with levobupivacaine in the transversus abdominis plane block can improve the quality of postoperative analgesia while avoiding significant side effects.
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2226186-2
    ISSN 2515-7949 ; 1750-4589
    ISSN (online) 2515-7949
    ISSN 1750-4589
    DOI 10.1177/17504589231196653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 83: Show issues

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  3. Article ; Online: Efficacy of Levobupivacaine Versus Levobupivacaine Plus Dexmedetomidine Infiltration for Post-Tonsillectomy Analgesia: A Randomized Controlled Trial.

    Abo Elfadl, Ghada Mohammad / AbdelRady, Marwa Mahmoud / Osman, Hany M / Gad, Mohamed Omar / Abd El-Rady, Nessren M / Ali, Wesam Nashat

    Pain research & management

    2022  Volume 2022, Page(s) 9958668

    Abstract: Background: The study evaluated the analgesic effects of levobupivacaine infiltration in the tonsil bed, and a combination of levobupivacaine and dexmedetomidine in patients undergoing tonsillectomy.: Methods: Ninety children (ages 3 to 7 years) who ... ...

    Abstract Background: The study evaluated the analgesic effects of levobupivacaine infiltration in the tonsil bed, and a combination of levobupivacaine and dexmedetomidine in patients undergoing tonsillectomy.
    Methods: Ninety children (ages 3 to 7 years) who were scheduled for a tonsillectomy were allocated randomly into two groups. (L Group
    Results: The first rescue analgesia time in the LD group was longer (644.31 ± 112.89 min) than in the
    Conclusions: The Children's peritonsillar infiltration of levobupivacaine and dexmedetomidine improved postoperative pain after adenotonsillectomy. The topically applied levobupivacaine and dexmedetomidine were concomitant with no systemic effects, greater total oral intake on the first day postoperative, and higher family satisfaction.
    MeSH term(s) Acetaminophen/therapeutic use ; Analgesia ; Analgesics/therapeutic use ; Anesthetics, Local/therapeutic use ; Bupivacaine/therapeutic use ; Child ; Child, Preschool ; Dexmedetomidine/therapeutic use ; Double-Blind Method ; Humans ; Levobupivacaine/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Tonsillectomy/adverse effects
    Chemical Substances Analgesics ; Anesthetics, Local ; Acetaminophen (362O9ITL9D) ; Dexmedetomidine (67VB76HONO) ; Levobupivacaine (A5H73K9U3W) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2041085-2
    ISSN 1918-1523 ; 1203-6765
    ISSN (online) 1918-1523
    ISSN 1203-6765
    DOI 10.1155/2022/9958668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5498: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Glucagon-like peptide-1 analog improves neuronal and behavioral impairment and promotes neuroprotection in a rat model of aluminum-induced dementia.

    Abd El-Rady, Nessren M / Ahmed, Amel / Abdel-Rady, Marwa Mahmoud / Ismail, Omnia I

    Physiological reports

    2020  Volume 8, Issue 24, Page(s) e14651

    Abstract: Background: Alzheimer's disease (AD) is a worldwide severe medical and social burden. Liraglutide (LIR) has neuroprotective effects in preclinical animal models.: Aim: To explore the probable neuroprotective impact of Glucagon-like peptide-1 (GLP-1) ... ...

    Abstract Background: Alzheimer's disease (AD) is a worldwide severe medical and social burden. Liraglutide (LIR) has neuroprotective effects in preclinical animal models.
    Aim: To explore the probable neuroprotective impact of Glucagon-like peptide-1 (GLP-1) on rats' behavior and to elucidate its underlying mechanisms.
    Methods: A total of 24 male albino rats were assigned to control, LIR (300 µg/kg subcutaneously (s.c.)), AD only (100 mg/kg aluminum chloride (AlCl
    Results: LIR prevents the impairment of learning and improves both working memory and reference memory through significant reduction of serum tumor necrosis factor (TNF-α), interleukin 6 (IL-6) and interferon-γ (INF-γ) and malondialdehyde (MDA) and through the increase of superoxide dismutase (SOD), dopamine, adrenaline, and noradrenaline. LIR also improves hippocampal histological features of ALCL
    Conclusion: LIR normalizes ALCL
    MeSH term(s) Aluminum/toxicity ; Animals ; Blood Glucose/metabolism ; Cytokines/metabolism ; Dementia/drug therapy ; Dementia/etiology ; Glucagon-Like Peptide 1/analogs & derivatives ; Hippocampus/metabolism ; Incretins/administration & dosage ; Incretins/therapeutic use ; Liraglutide/administration & dosage ; Liraglutide/therapeutic use ; Male ; Maze Learning ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/therapeutic use ; Neurotransmitter Agents/metabolism ; Oxidative Stress ; Rats ; Rats, Wistar
    Chemical Substances Blood Glucose ; Cytokines ; Incretins ; Neuroprotective Agents ; Neurotransmitter Agents ; Liraglutide (839I73S42A) ; Glucagon-Like Peptide 1 (89750-14-1) ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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