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  1. Article ; Online: A comparative study on the use of fractional CO

    Bakr, Radwa M / Abdel-Gaber, Reham M / Tawfik, Yasmin M

    Dermatologic therapy

    2020  Volume 34, Issue 1, Page(s) e14604

    Abstract: Conventional methods of treatment for vitiligo are often unsatisfactory to the patients and time consuming, new treatment modalities are needed. This study was conducted to evaluate the efficacy and safety of fractional carbon dioxide ( ... ...

    Abstract Conventional methods of treatment for vitiligo are often unsatisfactory to the patients and time consuming, new treatment modalities are needed. This study was conducted to evaluate the efficacy and safety of fractional carbon dioxide (CO
    MeSH term(s) Calcitriol/analogs & derivatives ; Carbon Dioxide ; Combined Modality Therapy ; Humans ; Tacrolimus/therapeutic use ; Treatment Outcome ; Ultraviolet Therapy ; Vitiligo/diagnosis ; Vitiligo/therapy
    Chemical Substances Carbon Dioxide (142M471B3J) ; calcipotriene (143NQ3779B) ; Calcitriol (FXC9231JVH) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Efficacy of topical calcipotriol betamethasone dipropionate as a new adjuvant therapy to follicular unit extraction technique in treatment of stable vitiligo: clinical, dermoscopic and immunohistological study.

    Abd Elazim, Nagwa E / Kamal, Ahmed / Abdel Gaber, Reham M / Fathy, Eman / El-Deek, Heba E M

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 9, Page(s) 2894–2905

    Abstract: Background: Follicular unit extraction (FUE) grafting is a surgical procedure which provides the vitiliginous patches with undifferentiated stem cells of the hair follicles. It has been postulated that adjuvant therapy enhances the results. This is the ... ...

    Abstract Background: Follicular unit extraction (FUE) grafting is a surgical procedure which provides the vitiliginous patches with undifferentiated stem cells of the hair follicles. It has been postulated that adjuvant therapy enhances the results. This is the first study to assess two different adjuvant therapies vs FUE alone.
    Aims: To study the efficiency of FUE alone or combined with either topical calcipotriol betamethasone dipropionate (CBD) or NB-UVB phototherapy in cases of nonsegmental stable vitiligo. To assess the role of dermoscopy in monitoring the pattern and degree of repigmentation.
    Patients/ methods: 53 patients with 94 lesions with stable nonsegmental vitiligo were divided into three groups. Group 1 (n = 16) with 30 lesions received FUE alone. Group 2 (n = 18) with 32 lesions received FUE plus topical CBD. Group 3 (n = 19) with 32 lesions received FUE plus NB-UVB phototherapy. Assessment was done by grades of repigmentation, color match, percent of size reduction, and immunohistochemical evaluation of perilesional CD8+T lymphocytes.
    Results: The fastest onset of repigmentation was observed in both groups 2 and 3 in the second week (16.7%, 10.5%, respectively).Group 2 achieved the best response by all methods of assessment. Perifollicular diffuse repigmentation was the commonest dermoscopic pattern in 60 lesions (63.8%). There was a statistically significant decrease in perilesional CD8+T lymphocytes after 4 months.
    Conclusion: FUE is an effective method of surgical treatment of stable vitiligo, and topical CBD as a new adjuvant therapy is successful in targeting the immunological background of vitiligo. Dermoscopy has an essential role in monitoring the repigmentation response.
    MeSH term(s) Betamethasone/analogs & derivatives ; Betamethasone/therapeutic use ; Calcitriol/analogs & derivatives ; Calcitriol/therapeutic use ; Combined Modality Therapy ; Humans ; Treatment Outcome ; Ultraviolet Therapy ; Vitiligo/drug therapy
    Chemical Substances calcipotriene (143NQ3779B) ; betamethasone-17,21-dipropionate (826Y60901U) ; Betamethasone (9842X06Q6M) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2021-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Efficacy of narrow band UVB with or without OMP in stabilization of vitiligo activity in skin photo-types (III-V): A double-blind, randomized, placebo-controlled, prospective, multicenter study.

    Esmat, Samia M / El-Mofty, Medhat / Rasheed, H / Mostafa, Wedad Z / Anbar, Tag S / Abdallah, Marwa / Bassiouny, Dalia / Abdel-Halim, Dalia / Hegazy, Rehab / Eid, Amira Abulfotooh / Nassar, Ahmed / Abdel-Aziz, Rasha Ta / Fawzy, Marwa M / Gawdat, Heba I / El Hawary, Marwa / Sany, Iman / Shalaby, Suzan / Ragab, Nanis / Abdel-Gaber, Reham M /
    Tawfik, Yasmin M / El-Bassiouny, Mahy / El-Husseiny, Rania / Attia, Miriam Samir / Farid, Carmen / Genedy, Rasha Mahmoud / Mogawer, Rania M

    Photodermatology, photoimmunology & photomedicine

    2021  Volume 38, Issue 3, Page(s) 277–287

    Abstract: Background: NB-UVB has long been the vitiligo management pillar with capability of achieving the main treatment outcomes; repigmentation and stabilization. Its stabilizing effect in dark skin has been debatable. However, randomized controlled trials ... ...

    Abstract Background: NB-UVB has long been the vitiligo management pillar with capability of achieving the main treatment outcomes; repigmentation and stabilization. Its stabilizing effect in dark skin has been debatable. However, randomized controlled trials regarding NB-UVB ability to control disease activity are lacking.
    Purpose: To assess stabilizing effect of NB-UVB in comparison to systemic corticosteroids, the mainstay in vitiligo stabilization, in skin photo-types (III-V).
    Methods: This is a multicenter, placebo-controlled, randomized, prospective study. Eighty patients with active nonsegmental vitiligo (NSV) (Vitiligo disease activity (VIDA) ≥2) were randomized to either NB-UVB and placebo (NB-placebo) or NB-UVB and dexamethasone oral mini-pulse (OMP) therapy (NB-OMP) for 6 months. Sixty four patients completed the study, 34 in the NB-OMP group and 30 in the NB-placebo group. Patients were evaluated fortnightly according to presence or absence of symptoms/signs of activity.
    Results: In spite of earlier control of disease activity observed in the NB-OMP group, it was comparable in both groups by the end of the study period. Disease activity prior to therapy, but not extent, was found to influence control of activity in both groups. Thus, NB-UVB is a safe sole therapeutic tool in vitiligo management. Not only does it efficiently achieve repigmentation, but also it is a comparable stabilizing tool for systemic corticosteroids in spite of slightly delayed control.
    Conclusion: NB-UVB is the only well-established vitiligo therapy that can be used solely whenever corticosteroids are contraindicated or immune-suppression is unjustified. Nonetheless, its combination with corticosteroids expedites response and improves compliance.
    MeSH term(s) Combined Modality Therapy ; Humans ; Prospective Studies ; Skin Pigmentation ; Treatment Outcome ; Ultraviolet Therapy ; Vitiligo/drug therapy ; Vitiligo/radiotherapy
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1951: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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