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  1. AU="Abdela, Abdurezak Ahmed"
  2. AU="Sanda, Miloslav"
  3. AU="Srinivas Ramishetti"
  4. AU="Chen, Yaoqing"
  5. AU="Cotton, Anitria"
  6. AU="Bayer, Adrian E."
  7. AU="Boerke, A"
  8. AU="Brown, Guy C."
  9. AU=Ford Caleb A.
  10. AU="Hussain, Muhammad Afaq"
  11. AU="Werner Henkel"
  12. AU=Zellweger M J
  13. AU="Marasco, Michelangelo"
  14. AU="Landa-Moreno, Cinthia"
  15. AU="Kuntner, Matjaz"
  16. AU="Lemes, Robertha Mariana Rodrigues"
  17. AU="Riccioni, M E"
  18. AU="Traer, Colin J"
  19. AU="Cao, Xuejie"
  20. AU="Chen, Zishuo"
  21. AU="Kalachikov, Sergey"
  22. AU="Das, Tilak"
  23. AU="Bessat, Cécile"
  24. AU="Galina Velikova"
  25. AU="Greene, Sharrell"
  26. AU="Chen, Kallie J"
  27. AU="Schwab, Jörg O."
  28. AU="Ke Chen"
  29. AU="Hewei Liang"
  30. AU="Abreu, Cristina"
  31. AU="Mamani Ortiz, Yercin"
  32. AU="Castro, Lucíola de Fátima Albuquerque Almeida Peixoto"
  33. AU="Šimůnek, Tomáš"
  34. AU="Ong, Lizhen"
  35. AU="Chai, Chaoqing"
  36. AU="Maheswaran Kesavan"
  37. AU="Mehta, Mrunal"
  38. AU=Paredes Sergio D
  39. AU=Ghosh Nilanjan AU=Ghosh Nilanjan
  40. AU="Hofmann, Alexander"
  41. AU="Radici, Marco"
  42. AU="Noro, Fabrizia"
  43. AU="Wang, Jianzhao"
  44. AU="Divya Jeyam"
  45. AU="Wolf, Lisette"
  46. AU="Marjanovic, Nemanja Despot"
  47. AU="Jitxin, Lim"

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  1. Artikel ; Online: Prevalence and risk factors of metabolic syndrome in Ethiopia: describing an emerging outbreak in HIV clinics of the sub-Saharan Africa - a cross-sectional study.

    Abdela, Abdurezak Ahmed / Yifter, Helen / Reja, Ahmed / Shewaamare, Aster / Ofotokun, Ighovwerha / Degu, Wondwossen Amogne

    BMJ open

    2023  Band 13, Heft 12, Seite(n) e069637

    Abstract: Objectives: HIV-induced chronic inflammation, immune activation and combination antiretroviral therapy (cART) are linked with adverse metabolic changes known to cause cardiovascular adversities. This study evaluates the prevalence of lipodystrophy, and ... ...

    Abstract Objectives: HIV-induced chronic inflammation, immune activation and combination antiretroviral therapy (cART) are linked with adverse metabolic changes known to cause cardiovascular adversities. This study evaluates the prevalence of lipodystrophy, and metabolic syndrome (MetS), and analyses risk factors in HIV-infected Ethiopians taking cART.
    Methods: A multicentre cross-sectional study was conducted at tertiary-level hospitals. Eligible participants attending the HIV clinics were enrolled. Sociodemographic, anthropometric, clinical, HIV treatment variables, lipid profile, fasting blood glucose level, risk factors and components of MetS, also lipodystrophy, were studied. Data were analysed by SPSS statistical package V.25 with descriptive and analytical statistics. For multivariable analysis of risk factors, a logistic regression model was used. Results were presented in frequency and percentages, mean±SD, or median+IQR. Statistical significance was taken as p<0.05.
    Results: Among 518 studied participants, two-thirds were females, and the mean age of the study population was 45 years (SD=11). The mean duration of cART was 10 years (SD=4). Median CD4 count was 460 cells/mm
    Conclusion: Our study revealed 38% of the participants had MetS indicating considerable cardiovascular disease (CVD) risks. Independent risk factors for MetS were BMI≥25 kg/m
    Mesh-Begriff(e) Adult ; Humans ; Female ; Middle Aged ; Male ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/complications ; Lopinavir/therapeutic use ; Ritonavir/adverse effects ; Cross-Sectional Studies ; Prevalence ; Ethiopia/epidemiology ; Risk Factors ; Lipodystrophy/complications ; Lipodystrophy/drug therapy ; Lipodystrophy/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications
    Chemische Substanzen efavirenz (JE6H2O27P8) ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Sprache Englisch
    Erscheinungsdatum 2023-12-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069637
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Bacterial isolates from diabetic foot ulcers and their antimicrobial resistance profile from selected hospitals in Addis Ababa, Ethiopia.

    Atlaw, Asegdew / Kebede, Habtamu Biazin / Abdela, Abdurezak Ahmed / Woldeamanuel, Yimtubezinash

    Frontiers in endocrinology

    2022  Band 13, Seite(n) 987487

    Abstract: Introduction: Infected diabetic foot ulcer (IDFU) is a worldwide problem associated with diabetes mellitus. It could lead from soft tissue infection to bone infection and is a leading cause of lower limb amputation. Gram-negative and Gram-positive ... ...

    Abstract Introduction: Infected diabetic foot ulcer (IDFU) is a worldwide problem associated with diabetes mellitus. It could lead from soft tissue infection to bone infection and is a leading cause of lower limb amputation. Gram-negative and Gram-positive bacteria, including anaerobic bacteria and fungi, are considered potential causes of infection. The early diagnosis of DFU infection and appropriate treatment based on the identification of the pathogens and their antimicrobial susceptibility pattern is important for good prognosis. Therefore, the purpose of this study was to isolate the bacteria that infect foot ulcers in selected Hospitals and determine their antimicrobial resistance profile.
    Method: An institutional-based multicenter, cross-sectional study was conducted in selected Hospitals in Addis Ababa, Ethiopia, from November 2020 to May 2021. A sterile swab was used to collect samples from the foot ulcer and a sterile needle to collect pus. Isolates were identified by culture, Gram-staining, and a series of biochemical tests. For each bacterial species identified, the antibiotic profiling was determined by the Kirby-Bauer disk diffusion method.
    Results: one hundred and twenty-seven pathogenic bacteria were isolated from samples taken from 130 patients with a diabetic foot ulcer. Sixty-eight percent had growth of multiple microorganisms. Two-thirds (66.7%) of the isolates were gram-negative bacteria. The predominant bacterial species were
    Conclusion: The majority of bacteria isolated from patients presenting with Diabetic foot ulcer infections were found to be multi-drug resistant in the study sites of the current study. The results demonstrate the importance of timely identification of infection of diabetic foot ulcers, proper sample collection for identification of the pathogens and for determining their antibiotic susceptibility pattern before initiating antimicrobial treatment.
    Mesh-Begriff(e) Amikacin/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Aztreonam/therapeutic use ; Bacteria ; Chloramphenicol/therapeutic use ; Clindamycin/therapeutic use ; Cross-Sectional Studies ; Diabetes Mellitus/drug therapy ; Diabetic Foot/drug therapy ; Diabetic Foot/epidemiology ; Drug Resistance, Bacterial ; Ethiopia/epidemiology ; Hospitals ; Humans ; Microbial Sensitivity Tests ; Staphylococcus aureus
    Chemische Substanzen Anti-Bacterial Agents ; Clindamycin (3U02EL437C) ; Chloramphenicol (66974FR9Q1) ; Amikacin (84319SGC3C) ; Aztreonam (G2B4VE5GH8)
    Sprache Englisch
    Erscheinungsdatum 2022-08-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.987487
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Prevalence of Extended-Spectrum β-Lactamase and Carbapenemase Producers of Gram-Negative Bacteria, and Methicillin-Resistant

    Woldeteklie, Asegdew Atlaw / Kebede, Habtamu Biazin / Abdela, Abdurezak Ahmed / Woldeamanuel, Yimtubezinash

    Infection and drug resistance

    2022  Band 15, Seite(n) 4435–4441

    Abstract: Background: Infectious diabetic foot ulcers (IDFU) are a widespread health issue that affects people all over the world. IDFU, like other medical disorders, can have negative implications if drug resistance develops. Clinicians will be able to choose ... ...

    Abstract Background: Infectious diabetic foot ulcers (IDFU) are a widespread health issue that affects people all over the world. IDFU, like other medical disorders, can have negative implications if drug resistance develops. Clinicians will be able to choose the optimal antibiotics to treat impacted patients based on the antibiotic susceptibility pattern of bacterial strains. In this project, we attempted to evaluate the levels of extended-spectrum beta-lactamase (ESBL), carbapenemase, and MRSA in patients with diabetic foot ulcers.
    Methods: A sterile swab was used to collect a sample from the leg ulcer, while a sterile needle was used to collect the aspirated pus. Bacteria identification and antibiotic susceptibility tests are carried out based on conventional bacterial culture. The double-disc inactivation method and modified carbapenem (meropenem) were used to screen the production of ESBL and carbapenemase.
    Results: Of the 76 isolates tested, 53.9% (41/76) were phenotypically ESBL producers.
    Conclusion: The result draws attention to the management of diabetic foot ulcer infections based on the results of microbiological analysis and drug susceptibility testing.
    Sprache Englisch
    Erscheinungsdatum 2022-08-11
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S371431
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Euthymia in Diabetes: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

    Kalra, Sanjay / Das, A K / Baruah, M P / Unnikrishnan, A G / Dasgupta, Arundhati / Shah, Parag / Sahay, Rakesh / Shukla, Rishi / Das, Sambit / Tiwaskar, Mangesh / Vijayakumar, G / Chawla, Manoj / Eliana, Fatimah / Suastika, Ketut / Orabi, Abbas / Rahim, Aly Ahmed Abdul / Uloko, Andrew / Lamptey, Roberta / Ngugi, Nancy /
    Bahendeka, Silver / Abdela, Abdurezak Ahmed / Mohammed, Fariduddin / Pathan, Mohammed Faruque / Rahman, Muhammed Hafizur / Afsana, Faria / Selim, Shajada / Moosa, Muaz / Murad, Moosa / Shreshtha, Pradeep Krishna / Shreshtha, Dina / Giri, Mimi / Hussain, Wiam / Al-Ani, Ahmed / Ramaiya, Kaushik / Singh, Surender / Raza, Syed Abbas / Aye, Than Than / Garusinghe, Chaminda / Muthukuda, Dimuthu / Weerakkody, Muditha / Kahandawa, Shyaminda / Bavuma, Charlotte / Ruder, Sundeep / Vanny, Koy / Khanolkar, Manish / Czupryniak, Leszek

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2019  Band 10, Heft 3, Seite(n) 791–804

    Abstract: Aim: To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.: Background: Diabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial ...

    Abstract Aim: To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.
    Background: Diabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial features. Emotional health disturbances may lead to psychological and psychiatric dysfunction and may negatively influence glycemic control. Patients with DM may experience diabetes distress (DD) associated with burden of self-care, interpersonal issues, and emotional worries regarding the ability to cope with the illness. Euthymia or a state of positive mental health and psychological well-being should be considered a key outcome of diabetes care. Therefore, to achieve optimal outcomes, the consideration and measurement of psychological and psychiatric aspects along with glycemic levels are very important. A group of multidisciplinary clinical experts came together in an international meeting held in India to develop a workable concept for euthymia in diabetes care. A multidisciplinary approach was suggested to enhance the clinical outcomes and facilitate patient-centered care. During the meeting emphasis was given to the concept of a euthymia model in diabetes care. This model focuses on enhancement of self-care skills in diabetic patients and preventative health awareness among diabetes care providers. Euthymia also encompasses patient-provider communication to aid enhancement of coping skills.
    Results: After due discussions and extensive deliberations, the expert group provided several recommendations on implementing the concept of euthymia in DM care.
    Conclusions: Introduction of the concept of euthymia in routine clinical practice is important to improve the quality of life and coping skills in patients with DM. A timely clinical assessment of psychological and psychiatric aspects along with patient-reported outcomes of diabetes contributes to overall health and well-being of affected individuals.
    Funding: Sanofi India.
    Sprache Englisch
    Erscheinungsdatum 2019-04-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-019-0614-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: BE-SMART (Basal Early Strategies to Maximize HbA1c Reduction with Oral Therapy): Expert Opinion.

    Bajaj, Sarita / Das, A K / Kalra, Sanjay / Sahay, Rakesh / Saboo, Banshi / Das, Sambit / Shunmugavelu, M / Jacob, Jubbin / Priya, Gagan / Khandelwal, Deepak / Dutta, Deep / Chawla, Manoj / Surana, Vineet / Tiwaskar, Mangesh / Joshi, Ameya / Shrestha, Pradip Krishna / Bhattarai, Jyoti / Bhowmik, Bishwajit / Latt, Tint Swe /
    Aye, Than Than / Vijayakumar, G / Baruah, Manash / Jawad, Fatema / Unnikrishnan, A G / Chowdhury, Subhankar / Pathan, Md Faruqe / Somasundaram, Noel / Sumanathilaka, Manilka / Raza, Abbas / Bahendeka, Silver K / Coetzee, Ankia / Ruder, Sundeep / Ramaiya, Kaushik / Lamptey, Roberta / Bavuma, Charlotte / Shaikh, Khalid / Uloko, Andrew / Chaudhary, Sandeep / Abdela, Abdurezak Ahmed / Akanov, Zhanay / Rodrìguez-Saldaña, Joel / Faradji, Raquel / Tiago, Armindo / Reja, Ahmed / Czupryniak, Leszek

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2019  Band 10, Heft 4, Seite(n) 1189–1204

    Abstract: The past three decades have seen a quadruple rise in the number of people affected by diabetes mellitus worldwide, with the disease being the ninth major cause of mortality. Type 2 diabetes mellitus (T2DM) often remains undiagnosed for several years due ... ...

    Abstract The past three decades have seen a quadruple rise in the number of people affected by diabetes mellitus worldwide, with the disease being the ninth major cause of mortality. Type 2 diabetes mellitus (T2DM) often remains undiagnosed for several years due to its asymptomatic nature during the initial stages. In India, 70% of diagnosed diabetes cases remain uncontrolled. Current guidelines endorse the initiation of insulin early in the course of the disease, specifically in patients with HbA1c > 10%, as the use of oral agents alone is unlikely to achieve glycemic targets. Early insulin initiation and optimization of glycemic control using insulin titration algorithms and patient empowerment can facilitate the effective management of uncontrolled diabetes. Early glucose control has sustained benefits in people with diabetes. However, insulin initiation, dose adjustment, and the need to repeatedly assess blood glucose levels are often perplexing for both physicians and patients, and there are misconceptions and concerns regarding its use. Hence, an early transition to insulin and ideal intensification of treatment may aid in delaying the onset of diabetes complications. This opinion statement was formulated by an expert panel on the basis of existing guidelines, clinical experience, and economic and cultural contexts. The statement stresses the timely and appropriate use of basal insulin in T2DM. It focuses on the seven vital Ts-treatment initiation, timing of administration, transportation and storage, technique of administration, targets for titration, tablets, and tools for monitoring.Funding: Sanofi.
    Sprache Englisch
    Erscheinungsdatum 2019-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-019-0629-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

    Kalra, Sanjay / Das, A K / Baruah, M P / Unnikrishnan, A G / Dasgupta, Arundhati / Shah, Parag / Sahay, Rakesh / Shukla, Rishi / Das, Sambit / Tiwaskar, Mangesh / Vijayakumar, G / Chawla, Manoj / Eliana, Fatimah / Suastika, Ketut / Orabi, Abbas / Rahim, Aly Ahmed Abdul / Uloko, Andrew / Bahendeka, Silver / Abdela, Abdurezak Ahmed /
    Mohammed, Fariduddin / Pathan, Faruque / Rahman, Muhammed Hafizur / Afsana, Faria / Selim, Shajada / Moosa, Muaz / Murad, Moosa / Shreshtha, Pradeep Krishna / Shreshtha, Dina / Giri, Mimi / Hussain, Wiam / Al-Ani, Ahmed / Ramaiya, Kaushik / Singh, Surender / Raza, Syed Abbas / Aye, Than Than / Garusinghe, Chaminda / Muthukuda, Dimuthu / Weerakkody, Muditha / Kahandawa, Shyaminda / Bavuma, Charlotte / Ruder, Sundeep / Vanny, Koy / Khanolkar, Manish / Czupryniak, Leszek

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2019  Band 10, Heft 5, Seite(n) 1577–1593

    Abstract: Aim: The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus ( ... ...

    Abstract Aim: The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus (DM).
    Background: Modern SUs may be considered a panacea in DM care with their beneficial extra-pancreatic, pleiotropic, and cardiovascular effects. Safe glycemic control with SUs could be achieved with appropriate patient selection, drug and dosage selection, and patient empowerment. Additionally, sulfonylureas also exhibit certain endocrine and metabolic effects, which could be considered beneficial in the management of DM. In this regard, a group of international clinical experts discussed the less known beneficial aspects of SUs and safe and smart prescription of modern SUs in DM care.
    Results: The concept of glucocrinology or the relationship of glycemia with the endocrine system was emphasized during the meetings. Clinical experts arrived at a consensus for the usage of modern SUs in the presence of other endocrine dysfunction and the impact of these drugs on endocrine health. The beneficial pleiotropic and cardiovascular effects of modern SUs were also discussed. The key discussion points were considered to develop clinical expert opinions for the use of modern SUs in persons with DM. Clinical expert opinions were developed for indications, pleiotropic benefits, cardiovascular outcomes, adherence, and safe use of modern SUs.
    Conclusions: Appropriate clinical judgement coupled with a patient-centered approach is crucial to achieve the best outcome in persons with DM. Owing to their safety, efficacy, extra-pancreatic benefits including effects on endocrine and metabolic aspects, and low cost of therapy, modern SUs could be considered as drugs/agents of choice for the treatment of diabetes.
    Funding: Sanofi India.
    Sprache Englisch
    Erscheinungsdatum 2019-07-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-019-0651-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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