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  1. Article ; Online: Chitinase-3-like 1-protein in CSF: a novel biomarker for progression in patients with multiple sclerosis.

    Talaat, Foraysa / Abdelatty, Sahar / Ragaie, Christine / Dahshan, Ahmed

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 9, Page(s) 3243–3252

    Abstract: Background: Chitinase -3-like 1-protein (CHI3L1) is a glycoside secreted by monocytes, microglia, and activated astrocytes. Its distribution in inflammatory lesions denotes its role in astrocytic response to modulate CNS inflammation. In multiple ... ...

    Abstract Background: Chitinase -3-like 1-protein (CHI3L1) is a glycoside secreted by monocytes, microglia, and activated astrocytes. Its distribution in inflammatory lesions denotes its role in astrocytic response to modulate CNS inflammation. In multiple sclerosis (MS), CHI3L1 levels have been found to be influenced by disease severity, activity, and progression. We aimed to measure CSF level of CHI3L1 in patients with MS and correlate its level with disability measures for a possible role as a biomarker for disease progression.
    Methods: Fifty-two MS patients (30 relapsing-remitting MS and 22 progressive MS) and thirty-five age and sex-matched healthy controls were included. They all underwent full clinical assessment (including disability and cognitive scales), radiological assessment, and CSF level of CHI3L1.
    Results: Patients with MS had higher CSF level of CHI3L1 than controls. Patients with progressive forms had higher levels than relapsing forms. There were positive correlations between disease duration, number of attacks, total EDSS, and CSF level of CHI3L1. Patients who had higher level of CSF CHI3L1 showed worse performance in MMSE and BICAMS and more lesions in T2 MRI brain. A cut off value of 154 ng/mL was found between patients with RRMS and PMS patients.
    Conclusion: CHI3L1 can be considered as a biomarker of disease progression. CHI3L1 level increases in progressive MS more than RRMS. Also, high CSF level of CHI3L1 was associated with more disability including motor, cognitive, and radiological aspects.
    MeSH term(s) Humans ; Multiple Sclerosis ; Chitinases ; Biomarkers ; Multiple Sclerosis, Chronic Progressive/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting ; Disease Progression
    Chemical Substances Chitinases (EC 3.2.1.14) ; Biomarkers
    Language English
    Publishing date 2023-03-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06764-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Copy Number Variations in Genetic Diagnosis of Congenital Adrenal Hyperplasia Children.

    Tolba, Aisha / Mandour, Iman / Musa, Noha / Elmougy, Fatma / Hafez, Mona / Abdelatty, Sahar / Ibrahim, Amany / Soliman, Hend / Labib, Bahaaeldin / Elshiwy, Yasmine / Ramzy, Tarek / Elsharkawy, Marwa

    Frontiers in genetics

    2022  Volume 13, Page(s) 785570

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.785570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel protocol for postpartum magnesium sulphate in severe pre-eclampsia: a randomized controlled pilot trial.

    El-Khayat, Waleed / Atef, Adel / Abdelatty, Sahar / El-Semary, Ali

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2016  Volume 29, Issue 1, Page(s) 154–158

    Abstract: Objective: Magnesium sulphate is the preferred anticonvulsant used to prevent the development of fits in severe pre-eclampsia; we aim to compare between three different protocols of postpartum magnesium sulphate in the effectiveness of preventing the ... ...

    Abstract Objective: Magnesium sulphate is the preferred anticonvulsant used to prevent the development of fits in severe pre-eclampsia; we aim to compare between three different protocols of postpartum magnesium sulphate in the effectiveness of preventing the development of fits in severe pre-eclampsia.
    Methods: Double-blind randomized controlled pilot trial, done in Cairo university hospital, Cairo, Egypt during 2013-2014, on 240 women with severe pre-eclampsia. Magnesium sulphate intravenous infusion was given in the postpartum period to all the patients, women were randomly allocated to group I (Single loading dose only), group II (12 h abbreviated protocol) or group III (24 h standard protocol) (n = 80 in each group).
    Results: There were no significant difference between the three groups as regards the incidence of eclampsia, elevated liver enzymes and low platelets syndrome, maternal ICU admission and; however The incidence of flushing was significantly higher in group III than group II and I (24 [30%] versus 12 [15%] versus 4 [5%]; p < 0.001) respectively.
    Conclusion: The pilot study demonstrates that the single-loading dose of postpartum magnesium sulphate is a promising alternative to the standard and the abbreviated protocol in preventing eclampsia; however, a large clinical trial is necessary to prove this.
    MeSH term(s) Adult ; Anticonvulsants/administration & dosage ; Clinical Protocols ; Eclampsia/prevention & control ; Female ; Humans ; Magnesium Sulfate/administration & dosage ; Pilot Projects ; Postpartum Period ; Pre-Eclampsia/drug therapy ; Pregnancy ; Young Adult
    Chemical Substances Anticonvulsants ; Magnesium Sulfate (7487-88-9)
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.3109/14767058.2014.991915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3510: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes.

    Abdelghaffar, Shereen / Shora, Hassan / Abdelatty, Sahar / Elmougy, Fatma / El Sayed, Reham / Abdelrahman, Heba / Soliman, Hend / Algebaly, HebatAllah / Ahmed, Sakinatalfouad / Alfy, Peter / Elshiwy, Yasmine

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2020  Volume 13, Page(s) 2485–2494

    Abstract: Purpose: Currently available markers for early detection of diabetic nephropathy (DN), the leading cause of end stage renal disease, have some limitations. There is insufficient evidence from previous studies about the role of several circulating ... ...

    Abstract Purpose: Currently available markers for early detection of diabetic nephropathy (DN), the leading cause of end stage renal disease, have some limitations. There is insufficient evidence from previous studies about the role of several circulating microRNAs (miRNAs) in the early development of DN. This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury.
    Patients and methods: Seventy type 1 diabetic patients, with 5 years' duration of diabetes or more, were recruited from Children's Hospital, Faculty of Medicine, Cairo University. Quantitative real-time reverse-transcription PCR (qRT-PCR) was used to measure the expression of the above mentioned miRNAs in serum and to assess its association with DN, and the studied risk factors.
    Results: There was a significantly higher percentage of up-regulation of miRNA-377 and miRNA-93 (
    Conclusion: miRNA-377, miRNA-93, miRNA-216a, and miRNA-21 may be implicated in the pathogenesis of DN, while miRNA-25 may have a reno-protective role. More studies are needed to document the value of these miRNAs as diagnostic biomarkers as well as therapeutic targets in DN.
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S247062
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  5. Article: MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes

    Abdelghaffar, Shereen / Shora, Hassan / Abdelatty, Sahar / Elmougy, Fatma / El Sayed, Reham / Abdelrahman, Heba / Soliman, Hend / Algebaly, HebatAllah / Ahmed, Sakinatalfouad / Alfy, Peter / Elshiwy, Yasmine

    Diabetes Metab Syndr Obes

    Abstract: Purpose: Currently available markers for early detection of diabetic nephropathy (DN), the leading cause of end stage renal disease, have some limitations. There is insufficient evidence from previous studies about the role of several circulating ... ...

    Abstract Purpose: Currently available markers for early detection of diabetic nephropathy (DN), the leading cause of end stage renal disease, have some limitations. There is insufficient evidence from previous studies about the role of several circulating microRNAs (miRNAs) in the early development of DN. This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury. Patients and Methods: Seventy type 1 diabetic patients, with 5 years' duration of diabetes or more, were recruited from Children's Hospital, Faculty of Medicine, Cairo University. Quantitative real-time reverse-transcription PCR (qRT-PCR) was used to measure the expression of the above mentioned miRNAs in serum and to assess its association with DN, and the studied risk factors. Results: There was a significantly higher percentage of up-regulation of miRNA-377 and miRNA-93 (P=0.03, 0.02, respectively) in addition to significant down-regulation of miRNA-25 (P=0.01) in patients with DN than in patients without DN. In patients with DN, expression of miR-216a was significantly negatively correlated with creatinine (r=-0.4, P=0.04) and positively correlated with eGFR using creatinine (r=0.5, P=0.03). In the same group, expression of miR-21 was positively correlated with urinary cystatin C (r=0.6, P=0.01) and was negatively correlated with e-GFR using cystatin c (r=-0.6, P=0.01). miRNA-93 was associated with increased risk (odds ratio=15, 95% CI=12.03-24.63, P=0.01), while miRNA-25 was associated with decreased risk for albuminuria (odds ratio=0.15, 95% CI=0.08-0.55, P=0.03). Conclusion: miRNA-377, miRNA-93, miRNA-216a, and miRNA-21 may be implicated in the pathogenesis of DN, while miRNA-25 may have a reno-protective role. More studies are needed to document the value of these miRNAs as diagnostic biomarkers as well as therapeutic targets in DN.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32765027
    Database COVID19

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  6. Article ; Online: IP-10 Serum Level in Chronic Hepatitis C Virus Patients: Relation to Fibrosis and Response to Combined Interferon/Ribavirin Therapy.

    El Raziky, Maissa / Elsharkawy, Aisha / Said, Salma E / Abdelatty, Sahar / El Akel, Wafaa / Tantawy, Omnia / Gamal Eldeen, Hadeel / Mabrouk, Mahasen

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2015  Volume 35, Issue 8, Page(s) 649–653

    Abstract: Despite the appearance of the direct acting antiviral drugs, pegylated interferon/ribavirin (PEG-IFN/RBV) still has a place in the standard of care (SOC) therapy for chronic HCV4. Studies were conducted to find an accurate prediction in response to SOC ... ...

    Abstract Despite the appearance of the direct acting antiviral drugs, pegylated interferon/ribavirin (PEG-IFN/RBV) still has a place in the standard of care (SOC) therapy for chronic HCV4. Studies were conducted to find an accurate prediction in response to SOC therapy. Pretreatment serum interferon-γ-inducible protein-10 (IP-10) is an independent predictive factor of sustained virological response (SVR) in HCV1-infected patients. To assess whether the pretreatment serum level of IP-10 influences hepatic fibrosis and PEG-IFN/RBV therapy response, a study was conducted on 88 chronic Hepatitis C virus (HCV) patients who received PEG-IFN/RBV. Patients were subjected to a pretreatment routine laboratory evaluation, liver biopsy, and serum IP-10 assessment. They were followed up for 6 months after cessation of therapy (week 72). Patients were classified into 3 groups according to their response; nonresponders, relapsers, or sustained virological responders. The relation of pretreatment IP-10 with fibrosis and response was assessed. The studied groups were matched regarding their demographic data. There was no statistically significant association between the pretreatment IP-10 level and fibrosis (P=0.86) and no relation to response was found at week 12, 24, 48, and 72 (P=0.58, 0.8, 0.47, and 0.43, respectively). Pretreatment IP-10 could not predict either fibrosis or response to PEG-IFN/RIB therapy in chronic HCV Egyptian patients.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antiviral Agents/therapeutic use ; Chemokine CXCL10/blood ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/virology ; Humans ; Interferon-alpha/therapeutic use ; Liver Cirrhosis/etiology ; Liver Function Tests ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; Ribavirin/therapeutic use ; Treatment Outcome ; Viral Load ; Young Adult
    Chemical Substances Antiviral Agents ; Chemokine CXCL10 ; Interferon-alpha ; Ribavirin (49717AWG6K)
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2014.0193
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
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