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  1. Article: Clinicopathological Value Of Epidermal Growth Factor Receptor (EGFR) And Ki-67 Expression In Colorectal Adenoma And Adenocarcinoma.

    Ahmed Nor, Eman Mohamed / Saied, Eman Mohamed / Mina, Samir Nemr / Shareef, Mohamed Mostafa / Abdelaziz, Dareen Mohamed

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73Suppl 4, Issue 4, Page(s) S124–S130

    Abstract: Objectives: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma and carcinoma cases, and to relate their expression with the available clinicopathological data.: Method: The retrospective study ... ...

    Abstract Objectives: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma and carcinoma cases, and to relate their expression with the available clinicopathological data.
    Method: The retrospective study was conducted at the Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 to October 2020, and comprised formalin-fixed and paraffin-embedded specimens related to cases of colorectal adenoma and those of colorectal carcinoma, who had no previous radiation or chemotherapeutic treatment. Immunohistochemical staining of all thecases was done using anti-epidermal growth factor receptor and anti-Ki-67 antibodies. Data was analysed using SPSS 20.
    Results: Of the 70 cases, 20(28.5%) were of colorectal adenoma; mean age 52.95±13.47 years, and male-to-female ratio 1:1. The remaining 50(71.5%) cases had colorectal carcinoma; mean age 51.08±13.49 years, and male-to-female ratio 1.17:1. Epidermal growth factor receptor and Ki-67 overexpression related significantly to villous histopathological type and high-grade dysplasia in colorectal adenoma cases(p<0.05). In colorectal carcinoma cases, epidermal growth factor receptor overexpression related significantly to tumour grade (p<0.05). Ki-67 overexpression related significantly to increased pathological stage (p<0.05).
    Conclusions: Overexpression of epidermal growth factor receptor and Ki-67 was found to be an ominous sign of colorectal adenoma aggressiveness, and the risk of progression to colorectal carcinoma.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Adenocarcinoma/pathology ; Adenoma/pathology ; Colorectal Neoplasms/pathology ; ErbB Receptors ; Immunohistochemistry ; Retrospective Studies
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; MKI67 protein, human
    Language English
    Publishing date 2023-07-24
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.EGY-S4-26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pulsed dye laser versus ablative fractional CO

    Elgarhy, Lamia Hamouda / El-Tatawy, Rania Ahmed / Abdelaziz, Dareen / Dogheim, Noha Nabil

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2021  Volume 29, Issue 3, Page(s) 417–424

    Abstract: There is a continuous need to find out the best treatment for old hypertrophic scars (OHSs). Thirty patients with OHSs were included. Each scar was divided into right half treated with PDL (handpiece with a 7-mm spot, pulse duration of 1.5 ms and fluence ...

    Abstract There is a continuous need to find out the best treatment for old hypertrophic scars (OHSs). Thirty patients with OHSs were included. Each scar was divided into right half treated with PDL (handpiece with a 7-mm spot, pulse duration of 1.5 ms and fluence of 6 J/cm
    MeSH term(s) Carbon Dioxide ; Cicatrix, Hypertrophic/pathology ; Cicatrix, Hypertrophic/surgery ; Humans ; Lasers, Dye/therapeutic use ; Lasers, Gas/therapeutic use ; Treatment Outcome ; Wound Healing
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1111/wrr.12904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3890: Show issues Location:
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  3. Article ; Online: Localized experimental bone metastasis drives osteolysis and sensory hypersensitivity at distant non-tumor-bearing sites.

    Abdelaziz, Dareen M / Stone, Laura S / Komarova, Svetlana V

    Breast cancer research and treatment

    2015  Volume 153, Issue 1, Page(s) 9–20

    Abstract: Patients with breast cancer metastasis to bone suffer from inadequate pain relief. Animal models provide increased understanding of cancer-induced bone and sensory alterations. The objective of this study was to investigate the measures of pain at ... ...

    Abstract Patients with breast cancer metastasis to bone suffer from inadequate pain relief. Animal models provide increased understanding of cancer-induced bone and sensory alterations. The objective of this study was to investigate the measures of pain at distant non-tumor-bearing sites in animals with localized bone metastasis. Immunocompetent BALB/c mice are injected intra-tibially with murine mammary carcinoma cells (4T1) or saline, and the sensitivity to mechanical and thermal stimuli in the contralateral paw was examined. In addition to previously demonstrated development of osteolysis and hypersensitivity to mechanical and thermal stimuli in the cancer-injected tibia, these animals exhibited an increase in sensory hypersensitivity in the contralateral limb. No bone lesions were evident on radiographs of the contralateral limbs. Histomorphometry detected decreased bone volume per tissue volume and increased osteoclast number in the contralateral tibia and vertebral bones of cancer-bearing animals. Neuroplasticity was examined by immunofluorescence for calcitonin gene-related peptide (CGRP) in sensory neurons and glial fibrillary acidic protein (GFAP) in lumbar spinal cords. CGRP-immunoreactivity and GFAP-immunoreactivity were significantly elevated both ipsilateral and contralateral in tumor-bearing animals. The anti-inflammatory and osteolysis-targeting drug rapamycin reduced hypersensitivity to mechanical and cold stimuli, attenuated GFAP over-expression, and lowered osteoclast number. The osteoclast-targeting drug pamidronate reduced sensitivity to cold and protected against bone loss. Localized bone cancer drives hypersensitivity, bone remodeling, and sensory neuron plasticity at sites distant from the primary tumor area. Drugs targeting these mechanisms may be useful in the treatment of pain distant from the primary tumor site.
    MeSH term(s) Animals ; Behavior, Animal ; Biomarkers ; Bone Neoplasms/pathology ; Bone Neoplasms/physiopathology ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Gliosis/metabolism ; Gliosis/pathology ; Mice ; Osteoclasts/pathology ; Osteolysis/diagnostic imaging ; Osteolysis/pathology ; Pain ; Radiography ; Sensory Receptor Cells/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-015-3517-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1655: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin.

    Abdelaziz, Dareen M / Stone, Laura S / Komarova, Svetlana V

    Breast cancer research and treatment

    2014  Volume 143, Issue 2, Page(s) 227–237

    Abstract: In advanced breast cancer, bone metastases occur in 70 % of patients. Managing the devastating pain associated with the disease is difficult. Rapamycin is an immunomodulatory drug that targets the mammalian target of rapamycin pathway. Rapamycin has been ...

    Abstract In advanced breast cancer, bone metastases occur in 70 % of patients. Managing the devastating pain associated with the disease is difficult. Rapamycin is an immunomodulatory drug that targets the mammalian target of rapamycin pathway. Rapamycin has been shown to decrease osteolysis associated with metastatic breast cancer in pre-clinical models and to reduce pain in inflammatory and neuropathic models. The aim of this study was to evaluate the effectiveness of rapamycin in reducing pain associated with experimental osteolytic metastases. Bone cancer was induced by intra-tibial injections of murine mammary carcinoma cells (4T1) in immunocompetent BALB/c mice and treated intraperitoneally for up to 5 weeks with vehicle, rapamycin or pamidronate (a bisphosphonate currently used to reduce bone loss in bone cancer patients). The control group received intra-tibial injection with saline (sham) and was treated with vehicle intraperitoneally. Cancer-induced osteolysis was observed histologically and radiographically 2-3 weeks following cancer inoculation and gradually increased with time. Measures of evoked nociceptive behaviors including sensitivity to mechanical, thermal, and cold stimuli and spontaneous nociceptive behaviors (limping, guarding) were evaluated. Significant hypersensitivity to sensory stimuli developed in cancer-bearing mice compared to sham 3 weeks following inoculation. Rapamycin decreased or delayed the development of cancer-induced mechanical, heat, and cold hypersensitivity, while pamidronate reduced heat and cold hypersensitivity. Both rapamycin and pamidronate had a partial protective effect on the spontaneous nociceptive behaviors, limping and guarding. Our data suggest that rapamycin may have efficacy in the management of pain associated with metastatic breast cancer.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/therapeutic use ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Cell Line, Tumor ; Diphosphonates/therapeutic use ; Disease Models, Animal ; Female ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Osteolysis/drug therapy ; Pain/drug therapy ; Pain Measurement ; Sirolimus/therapeutic use ; TOR Serine-Threonine Kinases/antagonists & inhibitors
    Chemical Substances Antibiotics, Antineoplastic ; Bone Density Conservation Agents ; Diphosphonates ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, mouse (EC 2.7.1.1) ; pamidronate (OYY3447OMC) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2014-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-013-2799-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1655: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta.

    Abdelaziz, Dareen M / Abdullah, Sami / Magnussen, Claire / Ribeiro-da-Silva, Alfredo / Komarova, Svetlana V / Rauch, Frank / Stone, Laura S

    Bone

    2015  Volume 81, Page(s) 400–406

    Abstract: Osteogenesis imperfecta (OI) is a congenital disorder caused most often by dominant mutations in the COL1A1 or COL1A2 genes that encode the alpha chains of type I collagen. Severe forms of OI are associated with skeletal deformities and frequent ... ...

    Abstract Osteogenesis imperfecta (OI) is a congenital disorder caused most often by dominant mutations in the COL1A1 or COL1A2 genes that encode the alpha chains of type I collagen. Severe forms of OI are associated with skeletal deformities and frequent fractures. Skeletal pain can occur acutely after fracture, but also arises chronically without preceding fractures. In this study we assessed OI-associated pain in the Col1a1Jrt/+ mouse, a recently developed model of severe dominant OI. Similar to severe OI in humans, this mouse has significant skeletal abnormalities and develops spontaneous fractures, joint dislocations and vertebral deformities. In this model, we investigated behavioral measures of pain and functional impairment. Significant hypersensitivity to mechanical, heat and cold stimuli, assessed by von Frey filaments, radiant heat paw withdrawal and the acetone tests, respectively, were observed in OI compared to control wildtype littermates. OI mice also displayed reduced motor activity in the running wheel and open field assays. Immunocytochemical analysis revealed no changes between OI and WT mice in innervation of the glabrous skin of the hindpaw or in expression of the pain-related neuropeptide calcitonin gene-related protein in sensory neurons. In contrast, increased sensitivity to mechanical and cold stimulation strongly correlated with the extent of skeletal deformities in OI mice. Thus, we demonstrated that the Col1a1Jrt/+ mouse model of severe OI has hypersensitivity to mechanical and thermal stimuli, consistent with a state of chronic pain.
    MeSH term(s) Analgesics/therapeutic use ; Animals ; Behavior, Animal ; Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Chronic Pain/physiopathology ; Chronic Pain/therapy ; Cold Temperature ; Collagen Type I/genetics ; Collagen Type I/physiology ; Ganglia, Spinal/pathology ; Hot Temperature ; Immunohistochemistry ; Male ; Maze Learning ; Mice ; Mutation ; Neuropeptides/chemistry ; Osteogenesis Imperfecta/drug therapy ; Pain ; Pain Management ; Skin/pathology ; Stress, Mechanical ; X-Ray Microtomography
    Chemical Substances Analgesics ; Collagen Type I ; Neuropeptides ; collagen type I, alpha 1 chain
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2015.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1571: Show issues Location:
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    Zs.MO 332: Show issues

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