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Article ; Online: Natural History of Lung Hernias.

Madani, Mohammad H / Abdelhafez, Yasser G / Nardo, Lorenzo

Respiration; international review of thoracic diseases

2023 Volume 102, Issue 9, Page(s) 843–851

Abstract: Background: Lung herniation has been described in case reports or series. There are scare data in the form of original research studies to systematically evaluate this condition.: Objective: Our aim was to evaluate lung hernias with a focus on their ... ...

Abstract	Background: Lung herniation has been described in case reports or series. There are scare data in the form of original research studies to systematically evaluate this condition. Objective: Our aim was to evaluate lung hernias with a focus on their natural history. Methods: This is a retrospective study at our institution of patients who were found to have lung herniation on imaging between September 2010 and November 2022. Electronic medical record review was performed to extract clinical information regarding patients. Computed tomographic imaging was used to evaluate hernia size and size progression over time with a median follow-up time of 3.8 years. Results: Thirty-eight patients were eligible for analysis. Majority of patients were overweight or obese (31/38), smokers (31/38), had prior thoracic surgery (30/38), and were asymptomatic (33/38). Twenty of 38 patients had stability in hernia size, 12 of 38 patients had hernia size progression, and 6 of 38 patients showed hernia size regression. Younger age was found to be predictive of hernia size progression with age of 60 years being the cut-off for its prediction. Conclusion: Lung hernias typically either remain stable in size or show size progression. Younger age (60 years cut-off) was found to be predictive of size progression. This is the largest systematic investigation at a medical institution to the best of our knowledge of lung hernias which used computed tomographic imaging to follow up lung hernias. Further information could be given to patients with this condition and to clinicians for potential management guidance.
MeSH term(s)	Humans ; Middle Aged ; Retrospective Studies ; Electronic Health Records ; Obesity ; Overweight ; Thorax
Language	English
Publishing date	2023-09-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000533196
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Article ; Online: EXPLORing Arthritis with Total-body Positron Emission Tomography.

Chaudhari, Abhijit J / Abdelhafez, Yasser G / Nardo, Lorenzo / Raychaudhuri, Siba P

Seminars in musculoskeletal radiology

2023 Volume 27, Issue 6, Page(s) 632–640

Abstract: Arthritis has significant adverse consequences on musculoskeletal tissues and often other organs of the body. Current methods for clinical evaluation of arthritis are suboptimal, and biomarkers that are objective and measurable indicators for monitoring ... ...

Abstract	Arthritis has significant adverse consequences on musculoskeletal tissues and often other organs of the body. Current methods for clinical evaluation of arthritis are suboptimal, and biomarkers that are objective and measurable indicators for monitoring of arthritis disease activity are in critical demand. Recently, total-body positron emission tomography (PET) has been developed that can collect imaging signals synchronously from the entire body at ultra-low doses and reduced scan times. These scanners have increased signal collection efficiency that overcomes several limitations of standard PET scanners in the evaluation of arthritis, and they may potentially provide biomarkers to assess local and systemic impact of the arthritis disease process. This article reviews current results from using total-body PET in the assessment of common arthritic conditions, and it outlines future opportunities and challenges.
MeSH term(s)	Humans ; Positron-Emission Tomography/methods ; Arthritis/diagnostic imaging ; Forecasting ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1360919-1
ISSN	1098-898X ; 1089-7860
ISSN (online)	1098-898X
ISSN	1089-7860
DOI	10.1055/s-0043-1775746
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Article ; Online: Pericardial computed tomography imaging findings in the setting of coccidioidomycosis.

Madani, Mohammad H / Ghasemiesfe, Ahmadreza / Abdelhafez, Yasser G / Nardo, Lorenzo

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 623

Abstract: Background: Pericardial disease can be a manifestation of infection and imaging can have a role in its diagnosis. coccidioidomycosis endemic fungal infection has been more frequently reported over the past few decades. Other than case reports or series, ...

Abstract	Background: Pericardial disease can be a manifestation of infection and imaging can have a role in its diagnosis. coccidioidomycosis endemic fungal infection has been more frequently reported over the past few decades. Other than case reports or series, there has been no systemic study evaluating pericardial imaging findings in patients with coccidioidomycosis to the best of our knowledge. The purpose of this study was to evaluate intrathoracic computed tomographic (CT) imaging abnormalities in patients with coccidioidal infection with specific emphasis on the pericardium. Methods: Retrospective review of radiology reports and clinical chart review was performed to identify patients with coccidioidomycosis between January 2000 and September 2021 at our medical center. Diagnosis of infection was confirmed predominately with serology. Patients were excluded if a CT was not performed within 3 months of confirmed diagnosis date and if there was concomitant additional granulomatous or fungal infection. Chest CT was reviewed for pericardial and additional intrathoracic findings. Results: The final retrospective cohort consisted of 37 patients. Imaging findings included lung nodules (N = 33/37), consolidation (N = 25/37), mediastinal or hilar lymphadenopathy (N = 20/37) and pleural effusions (N = 13/37). Eleven of 37 patients (30%) had either trace pericardial fluid (N = 3/37) or small pericardial effusions (N = 8/37). One patient had pericardial enhancement/thickening and history of pericardial tamponade. No other patient had clinical pericarditis or pericardial tamponade. Pericardial calcifications were not seen in any patient. Pericardial effusion was statistically associated with presence of pleural effusion as 9/13 patients with pleural effusion had pericardial effusion versus 2/26 patients without pleural effusion had pericardial effusion (p < 0.001). Otherwise patients with and without pericardial imaging findings were similar in terms of demographics, comorbidities and other imaging findings. Conclusion: Pulmonary parenchymal pathology is a common manifestation of coccidioidal infection. Most patients with coccidioidomycosis do not have pericardial imaging abnormalities on CT.
MeSH term(s)	Cardiac Tamponade ; Coccidioidomycosis/diagnostic imaging ; Coccidioidomycosis/microbiology ; Humans ; Pericardial Effusion/diagnostic imaging ; Pleural Effusion/microbiology ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2022-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07601-1
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Article ; Online: Numerical investigation reveals challenges in measuring the contrast recovery coefficients in PET.

Bayerlein, Reimund / Spencer, Benjamin A / Abdelhafez, Yasser G / Cherry, Simon R / Badawi, Ramsey D / Omidvari, Negar

Physics in medicine and biology

2023 Volume 68, Issue 21

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Reproducibility of Results ; Tomography, X-Ray Computed/methods ; Positron-Emission Tomography/methods ; Reference Standards ; Phantoms, Imaging ; Image Processing, Computer-Assisted
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad00fa
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Article: EXPLORing Arthritis with Total-body Positron Emission Tomography

Chaudhari, Abhijit J. / Abdelhafez, Yasser G. / Nardo, Lorenzo / Raychaudhuri, Siba P.

Seminars in Musculoskeletal Radiology

(Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation and Arthritis)

2023 Volume 27, Issue 06, Page(s) 632–640

Series title	Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation and Arthritis
Abstract	Arthritis has significant adverse consequences on musculoskeletal tissues and often other organs of the body. Current methods for clinical evaluation of arthritis are suboptimal, and biomarkers that are objective and measurable indicators for monitoring of arthritis disease activity are in critical demand. Recently, total-body positron emission tomography (PET) has been developed that can collect imaging signals synchronously from the entire body at ultra-low doses and reduced scan times. These scanners have increased signal collection efficiency that overcomes several limitations of standard PET scanners in the evaluation of arthritis, and they may potentially provide biomarkers to assess local and systemic impact of the arthritis disease process. This article reviews current results from using total-body PET in the assessment of common arthritic conditions, and it outlines future opportunities and challenges.
Keywords	total-body positron emission tomography ; rheumatoid arthritis ; psoriatic arthritis ; osteoarthritis ; molecular imaging
Language	English
Publishing date	2023-11-07
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1360919-1
ISSN	1098-898X ; 1089-7860
ISSN (online)	1098-898X
ISSN	1089-7860
DOI	10.1055/s-0043-1775746
Database	Thieme publisher's database

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Article ; Online: Pretherapy 18F-fluorodeoxyglucose positron emission tomography/computed tomography robust radiomic features predict overall survival in non-small cell lung cancer.

Mostafa, Rehab / Abdelsamie Kandeel, Ahmed / Abd Elkareem, Maha / Nardo, Lorenzo / Abdelhafez, Yasser G

Nuclear medicine communications

2022 Volume 43, Issue 5, Page(s) 540–548

Abstract: Objective: To extract robust radiomic features from staging positron emission tomography/computed tomography (18F- fluroodeoxyglucose PET/CT) in patients with non-small cell lung cancer from different segmentation methods and to assess their association ...

Abstract	Objective: To extract robust radiomic features from staging positron emission tomography/computed tomography (18F- fluroodeoxyglucose PET/CT) in patients with non-small cell lung cancer from different segmentation methods and to assess their association with 2-year overall survival. Methods: Eighty-one patients with stage I-IV non-small cell lung cancer were included. All patients underwent a pretherapy 18F-FDG PET/CT. Primary tumors were delineated using four different segmentation methods: method 1, manual; method 2: manual with peripheral 1 mm erosion; method 3: absolute threshold at standardized uptake value (SUV) 2.5; and method 4: relative threshold at 40% SUVmax. Radiomic features from each method were extracted using Image Biomarker Standardization Initiative-compliant process. The study cohort was divided into two groups (exploratory and testing) in a ratio of 1:2 (n = 25 and n = 56, respectively). Exploratory cohort was used to identify robust radiomic features, defined as having a minimum concordance correlation coefficient ≥0.75 among all the 4-segmentation methods. The resulting texture features were evaluated for association with 2-year overall survival in the testing cohort (n = 56). All patients in the testing cohort had a follow-up for 2 years from the date of staging 18F-FDG PET/CT scan or till death. Cox proportional hazard models were used to evaluate the independent prognostic factors. Results: Exploratory and validation cohorts were equivalent regarding their basic characteristics (age, sex, and tumor stage). Ten radiomic features were deemed robust to the described four segmentation methods: SUV SD, SUVmax, SUVQ3, SUVpeak in 0.5 ml, total lesion glycolysis, histogram entropy log 2, histogram entropy log 10, histogram energy uniformity, gray level run length matrix-gray level non-uniformity, and gray level zone length matrix-gray level non-uniformity. At the end of 2-year follow-up, 41 patients were dead and 15 were still alive (overall survival = 26.8%; median survival = 14.7 months, 95% confidence interval: 10.2-19.2 months). Three texture features, regardless the segmentation method, were associated with 2-year overall survival: total lesion glycolysis, gray level run length matrix_gray level non-uniformity, and gray level zone length matrix_run-length non-uniformity. In the final Cox-regression model: total lesion glycolysis, and gray level zone length matrix_gray level non-uniformity were independent prognostic factors. The quartiles from the two features were combined with clinical staging in a prognostic model that allowed better risk stratification of patients for overall survival. Conclusion: Ten radiomic features were robust to segmentation methods and two of them (total lesion glycolysis and gray level zone length matrix_gray level non-uniformity) were independently associated with 2-year overall survival. Together with the clinical staging, these features could be utilized towards improved risk stratification of lung cancer patients.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/therapy ; Fluorodeoxyglucose F18/metabolism ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/therapy ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001541
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Article ; Online: Posttherapy technetium-99m pentavalent dimercaptosuccinic acid brain single-photon emission computed tomography/computed tomography: diagnostic and prognostic values in patients with glioma.

Mohamadien, Nsreen R A / Diab, Waleed A / Abd El-Ghani, Wael M A / Abdelhafez, Yasser G

Nuclear medicine communications

2022 Volume 43, Issue 12, Page(s) 1195–1203

Abstract: Purpose: To assess the value of posttherapy 99mTc-pentavalent dimercaptosuccinic acid (DMSA-V) brain SPECT/CT in patients with brain glioma.: Methods: Patients with pathologically or radiologically proven glioma were prospectively enrolled in this ... ...

Abstract	Purpose: To assess the value of posttherapy 99mTc-pentavalent dimercaptosuccinic acid (DMSA-V) brain SPECT/CT in patients with brain glioma. Methods: Patients with pathologically or radiologically proven glioma were prospectively enrolled in this study. 99mTc-DMSA-V brain SPECT/CT images were acquired at 120-180 min after i.v. injection of 555-740 MBq of 99mTc-DMSA-V. Three nuclear medicine physicians blindly interpreted the scans visually as positive or negative for residual/recurrent disease. Agreement between two or more readers was considered a consensus. The composite reference standard was considered based on subsequent clinical/neuroimaging follow-up or histopathology whenever available. Overall survival (OS) was calculated from the date of initial diagnosis till the death or the date of last follow-up. Results: Thirty-four patients (18 males and 16 females; mean age 37.7 ± 16 years) were enrolled in this study. Interreader agreement between the readers ranged from 0.71 to 0.82. Based on the composite reference standard, residual/recurrent disease was confirmed in 16 patients, whereas 18 patients were negative for disease. Consensus reading of 99mTc-DMSA-V SPECT/CT accurately diagnosed 13 true positive (sensitivity 81%) and 17 true negative scans (specificity 94%). After a median follow-up of 22.9 months, 7/14 patients with positive 99mTc-DMSA-V SPECT/CT brain readings died compared to 4/20 with negative readings. The median survival was 24.1 months for the positive group and was not reached for the negative group. Conclusion: Posttherapy brain SPECT/CT scanning with 99mTc-DMSA-V is a noninvasive, reliable, and specific tool for evaluation of patients with brain glioma after definitive therapy. Scan positivity was associated with poor OS.
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Adult ; Middle Aged ; Technetium Tc 99m Dimercaptosuccinic Acid ; Technetium ; Prognosis ; Glioma/diagnostic imaging ; Glioma/therapy ; Tomography, Emission-Computed, Single-Photon/methods ; Brain ; Radiopharmaceuticals ; Sensitivity and Specificity
Chemical Substances	Technetium Tc 99m Dimercaptosuccinic Acid (494JNQ8L28) ; Technetium (7440-26-8) ; Radiopharmaceuticals
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001623
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Article: Total-body Dynamic Imaging and Kinetic Modeling of

Omidvari, Negar / Levi, Jelena / Abdelhafez, Yasser G / Wang, Yiran / Nardo, Lorenzo / Daly, Megan E / Wang, Guobao / Cherry, Simon R

medRxiv : the preprint server for health sciences

2023

Abstract: Immunotherapies, especially the checkpoint inhibitors such as anti-PD-1 antibodies, have transformed cancer treatment by enhancing immune system's capability to target and kill cancer cells. However, predicting immunotherapy response remains challenging. ...

Abstract	Immunotherapies, especially the checkpoint inhibitors such as anti-PD-1 antibodies, have transformed cancer treatment by enhancing immune system's capability to target and kill cancer cells. However, predicting immunotherapy response remains challenging. Methods: The study consisted of 90-min total-body dynamic scans of four healthy subjects and one non-small cell lung cancer (NSCLC) patient, scanned before and after anti-PD-1 immunotherapy. Compartmental modeling with Akaike information criterion model selection were employed to analyze tracer kinetics in various organs. Additionally, seven sub-regions of the primary lung tumor and four mediastinal lymph nodes were analyzed. Practical identifiability analysis was performed to assess reliability of kinetic parameter estimation. Correlations of SUVmean, SUVR (tissue-to-blood ratio), and Logan plot slope Results: Strong correlations were observed between Conclusion: Our findings highlight the promise of
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.22.23295860
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Article ; Online: Facial Anonymization and Privacy Concerns in Total-Body PET/CT.

Selfridge, Aaron R / Spencer, Benjamin A / Abdelhafez, Yasser G / Nakagawa, Keisuke / Tupin, John D / Badawi, Ramsey D

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 8, Page(s) 1304–1309

Abstract: Total-body PET/CT images can be rendered to produce images of a subject's face and body. In response to privacy and identifiability concerns when sharing data, we have developed and validated a workflow that obscures (defaces) a subject's face in 3- ... ...

Abstract	Total-body PET/CT images can be rendered to produce images of a subject's face and body. In response to privacy and identifiability concerns when sharing data, we have developed and validated a workflow that obscures (defaces) a subject's face in 3-dimensional volumetric data.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Privacy ; Tomography, X-Ray Computed/methods ; Positron-Emission Tomography/methods ; Image Processing, Computer-Assisted/methods ; Fluorodeoxyglucose F18
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.265280
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Article ; Online: Development of a Monte Carlo-based scatter correction method for total-body PET using the uEXPLORER PET/CT scanner.

Bayerlein, Reimund / Spencer, Benjamin A / Leung, Edwin K / Omidvari, Negar / Abdelhafez, Yasser G / Wang, Qian / Nardo, Lorenzo / Cherry, Simon R / Badawi, Ramsey D

Physics in medicine and biology

2024 Volume 69, Issue 4

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Reproducibility of Results ; Scattering, Radiation ; Positron-Emission Tomography/methods ; Algorithms ; Monte Carlo Method ; Phantoms, Imaging ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad2230
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