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Book: Helicases

Abdelhaleem, Mohamed M.

methods and protocols

(Methods in molecular biology ; 587 ; Springer protocols)

2010

Author's details	ed. by Mohamed M. Abdelhaleem
Series title	Methods in molecular biology ; 587 Springer protocols
Collection
Keywords	Helicasen ; Untersuchungsmethode
Subject	Helikase ; Helikasen ; Helicase ; EC 3.6.4 ; DNA-Helicasen ; RNA-Helicasen
Language	English
Size	XI, 404 S. : Ill., graph. Darst.
Publisher	Humana Press
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT016022877
ISBN	978-1-61779-667-8 ; 1-61779-667-0 ; 978-1-60327-354-1 ; 9781603273558 ; 1-60327-354-9 ; 1603273557
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Helicases: an overview.

Abdelhaleem, Mohamed

Methods in molecular biology (Clifton, N.J.)

2010 Volume 587, Page(s) 1–12

Abstract: Helicases are essential enzymes involved in all aspects of nucleic acid metabolism including DNA replication, repair, recombination, transcription, ribosome biogenesis and RNA processing, translation, and decay. They occur in vivo as part of molecular ... ...

Abstract	Helicases are essential enzymes involved in all aspects of nucleic acid metabolism including DNA replication, repair, recombination, transcription, ribosome biogenesis and RNA processing, translation, and decay. They occur in vivo as part of molecular complexes that include the components required for each specific step of nucleic acid metabolism. The role of the helicases is to utilize the energy derived from nucleoside triphosphate hydrolysis to translocate along nucleic acid strands, unwind/separate the helical structure of double-stranded nucleic acid, and, in some cases, disrupt protein-nucleic acid interactions. Because of their essential function, helicases are ubiquitous and evolutionary conserved proteins. This chapter briefly highlights helicase structure and activities and provides examples of the helicases involved in nucleic acid metabolism.
MeSH term(s)	DNA/metabolism ; DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA Repair ; DNA, Mitochondrial/metabolism ; Protein Biosynthesis ; RNA/metabolism ; RNA Helicases/chemistry ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA Splicing ; Recombination, Genetic ; Transcription, Genetic
Chemical Substances	DNA, Mitochondrial ; RNA (63231-63-0) ; DNA (9007-49-2) ; DNA Helicases (EC 3.6.4.-) ; RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2010
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-60327-355-8_1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Will helicases contribute to the fight against malaria?

Abdelhaleem, Mohamed

Cell cycle (Georgetown, Tex.)

2010 Volume 9, Issue 4, Page(s) 642

MeSH term(s)	Animals ; DEAD-box RNA Helicases/antagonists & inhibitors ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/genetics ; Humans ; Malaria/drug therapy ; Plasmodium falciparum/enzymology ; Plasmodium falciparum/genetics ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/chemistry ; Protozoan Proteins/genetics
Chemical Substances	Protozoan Proteins ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2010-02-15
Publishing country	United States
Document type	Comment ; News
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.9.4.10823
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Article: The expression of cytoplasmic CD79a correlates with surface CD3 expression in childhood T-ALL lymphoblasts.

Abdelhaleem, Mohamed

Leukemia research

2008 Volume 32, Issue 3, Page(s) 511–512

MeSH term(s)	Adolescent ; Antigens, Surface/metabolism ; CD3 Complex/metabolism ; CD79 Antigens/metabolism ; Child ; Cytoplasm/immunology ; Humans ; Leukemia-Lymphoma, Adult T-Cell/immunology
Chemical Substances	Antigens, Surface ; CD3 Complex ; CD79 Antigens
Language	English
Publishing date	2008-03
Publishing country	England
Document type	Letter
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2007.05.004
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Article ; Online: Continuous reference curves for common hematology markers in the CALIPER cohort of healthy children and adolescents on the Sysmex XN-3000 system.

Wilson, Siobhan / Bohn, Mary Kathryn / Hall, Alexandra / Higgins, Victoria / Abdelhaleem, Mohamed / Adeli, Khosrow

International journal of laboratory hematology

2021 Volume 43, Issue 6, Page(s) 1394–1402

Abstract: Introduction: Clinicians and healthcare professionals rely heavily on health-associated standards, such as reference intervals (RIs), for appropriate laboratory test result interpretation. RIs are commonly partitioned into discrete age/sex bins based on ...

Abstract	Introduction: Clinicians and healthcare professionals rely heavily on health-associated standards, such as reference intervals (RIs), for appropriate laboratory test result interpretation. RIs are commonly partitioned into discrete age/sex bins based on statistical and/or clinical significance. In pediatric hematology, such partitioning does not adequately represent complex variation in analyte concentrations throughout maturation. The objective of this study was to establish continuous RIs for common hematological parameters in the healthy pediatric Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort. Methods: Data from healthy CALIPER children and adolescents (6 months-<19 years) were used to generate continuous RIs (ie, 2.5th and 97.5th quantiles) for 19 hematological parameters. Continuous curves were statistically established with nonparametric quantile regressions. Flagging rate analysis was completed for the established continuous upper and lower reference limits and subsequently compared to previously published discrete CALIPER reference intervals for all parameters. Results: Continuous RIs were established for 19 hematology parameters, where seven required sex-specific reference curves. Based on flagging rate assessment, continuous RIs appear to more accurately estimate hematological reference limits over the pediatric age range, especially for analytes with complex age- and sex-specific reference value patterns. Conclusions: This is the first study to generate continuous RIs for a breadth of hematological markers in a healthy pediatric Canadian population. The increased power of continuous reference intervals to accurately estimate the complex relationship between hematological analyte concentration and age during a time of extensive growth and development is expected to improve laboratory test result interpretation and, subsequently, pediatric clinical decision-making.
MeSH term(s)	Adolescent ; Canada ; Child ; Child, Preschool ; Cohort Studies ; Databases, Factual ; Female ; Hematologic Tests ; Humans ; Infant ; Male ; Reference Values
Language	English
Publishing date	2021-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.13670
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Article: Frequent but nonrandom expression of myeloid markers on de novo childhood acute lymphoblastic leukemia.

Abdelhaleem, Mohamed

Experimental and molecular pathology

2007 Volume 83, Issue 1, Page(s) 138–141

Abstract: The expression of the myeloid markers CD13, CD33, and CD15 in two hundred and eighty-three cases of de novo childhood acute lymphoblastic leukemia (ALL) is examined. The expression of at least one marker is a frequent event which is noted in 64% and 74% ... ...

Abstract	The expression of the myeloid markers CD13, CD33, and CD15 in two hundred and eighty-three cases of de novo childhood acute lymphoblastic leukemia (ALL) is examined. The expression of at least one marker is a frequent event which is noted in 64% and 74% of B- and T-lineage ALL cases, respectively. Certain patterns of myeloid antigen expression can be recognized including: no expression of CD13, CD33, and CD15 in mature B-ALL, significantly higher levels of CD13 and CD33 and significantly lower levels of CD15 in TEL-AML1-positive B cell precursor ALL, no expression of CD13 and CD33 in E2A-PBX1-positive B cell precursor ALL cases and common T-ALL (double positive for CD4 and CD8), and no expression of CD13 in MLL-AF4-positive B cell precursor ALL cases. Although the numbers in some ALL subtypes are small, these patterns are consistent with nonrandom expression of myeloid markers in de novo childhood ALL.
MeSH term(s)	Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Biomarkers, Tumor/metabolism ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; CD13 Antigens/metabolism ; Cell Differentiation ; Child ; Core Binding Factor Alpha 2 Subunit/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Lewis X Antigen/metabolism ; Myeloid Cells/metabolism ; Oncogene Proteins, Fusion/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Sialic Acid Binding Ig-like Lectin 3
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Biomarkers, Tumor ; CD33 protein, human ; Core Binding Factor Alpha 2 Subunit ; Homeodomain Proteins ; Lewis X Antigen ; Oncogene Proteins, Fusion ; Sialic Acid Binding Ig-like Lectin 3 ; TEL-AML1 fusion protein ; E2A-Pbx1 fusion protein (146150-85-8) ; CD13 Antigens (EC 3.4.11.2)
Language	English
Publishing date	2007-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2007.02.004
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Article: Cytotoxic granule disruption is a late event in chemotherapy-induced apoptosis in natural killer YT cells.

Abdelhaleem, Mohamed

Experimental and molecular pathology

2007 Volume 83, Issue 1, Page(s) 112–114

Abstract: Cytotoxic lymphocytes such as Natural Killer (NK) cells can result in leukemias and lymphomas with aggressive clinical course. The cytoplasmic granules of NK cells contain molecules that cause apoptosis of their target cells. In this study, we examined ... ...

Abstract	Cytotoxic lymphocytes such as Natural Killer (NK) cells can result in leukemias and lymphomas with aggressive clinical course. The cytoplasmic granules of NK cells contain molecules that cause apoptosis of their target cells. In this study, we examined changes of the cytotoxic granules of the Natural Killer cell line YT during Etoposide-induced apoptosis. Etoposide treatment resulted in an early upregulation of Fas and cytoplasmic release of mitochondrial cytochrome c. The cytotoxic granules remain intact in the early stages of apoptosis induction with no significant cytoplasmic release of granzyme B, which is one of the components of the cytotoxic granules. These results suggest that disruption of the cytotoxic granules is not involved in the induction stage of Etoposide-induced apoptosis in the NK cell line YT.
MeSH term(s)	Apoptosis/drug effects ; Cell Line ; Cytoplasmic Granules/drug effects ; Cytoplasmic Granules/enzymology ; Etoposide/pharmacology ; Granzymes/metabolism ; Killer Cells, Natural/cytology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/enzymology ; Time Factors
Chemical Substances	Etoposide (6PLQ3CP4P3) ; Granzymes (EC 3.4.21.-)
Language	English
Publishing date	2007-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2006.10.005
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Article: Frequent but nonrandom expression of lymphoid markers on de novo childhood acute myeloid leukemia.

Abdelhaleem, Mohamed

Experimental and molecular pathology

2007 Volume 83, Issue 2, Page(s) 259–263

Abstract: Lymphoid marker expression in 59 cases of de novo childhood acute myeloid leukemia (AML) was as follows: CD2 (15.5%), CD4 (73.8%), CD7 (25.8%), CD19 (22%) and CD56 (28.9%). Individual marker expression, as well as co-expression with other lymphoid ... ...

Abstract	Lymphoid marker expression in 59 cases of de novo childhood acute myeloid leukemia (AML) was as follows: CD2 (15.5%), CD4 (73.8%), CD7 (25.8%), CD19 (22%) and CD56 (28.9%). Individual marker expression, as well as co-expression with other lymphoid markers, could be correlated with the FAB subtype of leukemia and the presence and type of certain leukemia fusion gene transcripts. The data showed that the expression of lymphoid markers in childhood de novo AML was common but nonrandom and was likely a reflection of the biological differences between various types of leukemia.
MeSH term(s)	Antigens, CD/genetics ; Antigens, CD19/genetics ; Antigens, CD7/genetics ; CD2 Antigens/genetics ; CD4 Antigens/genetics ; CD56 Antigen/genetics ; Child ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia, Myeloid/genetics ; Leukemia, Myeloid/immunology ; Leukemia, Myeloid/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
Chemical Substances	Antigens, CD ; Antigens, CD19 ; Antigens, CD7 ; CD2 Antigens ; CD4 Antigens ; CD56 Antigen
Language	English
Publishing date	2007-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2007.05.007
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Book: Helicases

Abdelhaleem, Mohamed M

methods and protocols

(Springer protocols ; Methods in molecular biology, ; 587)

2010

Author's details	edited by Mohamed M. Abdelhaleem
Series title	Springer protocols Methods in molecular biology, ; 587
MeSH term(s)	DNA Helicases ; RNA Helicases
Language	English
Size	xi, 404 p. :, ill. ;, 27 cm.
Publisher	Humana Press
Publishing place	New York, N.Y
Document type	Book
ISBN	9781603273541 ; 1603273549 ; 9781603273558 ; 1603273557
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: RNA helicases: regulators of differentiation.

Abdelhaleem, Mohamed

Clinical biochemistry

2005 Volume 38, Issue 6, Page(s) 499–503

Abstract: RNA helicases are highly conserved enzymes that utilize the energy derived from NTP hydrolysis to modulate the structure of RNA. RNA helicases participate in all biological processes that involve RNA, including transcription, splicing and translation. ... ...

Abstract	RNA helicases are highly conserved enzymes that utilize the energy derived from NTP hydrolysis to modulate the structure of RNA. RNA helicases participate in all biological processes that involve RNA, including transcription, splicing and translation. Based on the sequence of the helicase domain, they are classified into families, such as DDX and DHX families of human RNA helicases. The specificity of RNA helicases to their targets is likely due to several factors, such as the sequence, interacting molecules, subcellular localization and the expression pattern of the helicases. There are several examples of the involvement of RNA helicases in differentiation. Human DDX3 has two closely related genes designated DDX3Y and DDX3X, which are localized to the Y and X chromosomes, respectively. DDX3Y protein is specifically expressed in germ cells and is essential for spermatogenesis. DDX25 is another RNA helicase which has been shown to be required for spermatogenesis. DDX4 shows specific expression in germ cells. The Drosophila ortholog of DDX4, known as vasa, is required for the formation of germ cells and oogenesis by a mechanism that involves regulating the translation of mRNAs essential for differentiation. Abstrakt is the Drosphila ortholog of DDX41, which has been shown to be involved in visual and CNS system development. DDX5 (p68) and its related DDX17 (p72) have also been implicated in organ/tissue differentiation. The ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation.
MeSH term(s)	Animals ; Cell Differentiation ; Gene Expression Regulation ; Humans ; RNA Helicases/classification ; RNA Helicases/genetics ; RNA Helicases/physiology ; RNA Processing, Post-Transcriptional
Chemical Substances	RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2005-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	390372-2
ISSN	0009-9120
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2005.01.010
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