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  1. AU="Abdesselem, Mouna"
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  1. Article ; Online: Consequences of the constitutive NOX2 activity in living cells: Cytosol acidification, apoptosis, and localized lipid peroxidation.

    Valenta, Hana / Dupré-Crochet, Sophie / Abdesselem, Mouna / Bizouarn, Tania / Baciou, Laura / Nüsse, Oliver / Deniset-Besseau, Ariane / Erard, Marie

    Biochimica et biophysica acta. Molecular cell research

    2022  Volume 1869, Issue 9, Page(s) 119276

    Abstract: The phagocyte NADPH oxidase (NOX2) is a key enzyme of the innate immune system generating superoxide anions ( ... ...

    Abstract The phagocyte NADPH oxidase (NOX2) is a key enzyme of the innate immune system generating superoxide anions (O
    MeSH term(s) Apoptosis ; Cytosol/metabolism ; Hydrogen-Ion Concentration ; Lipid Peroxidation ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism
    Chemical Substances NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2022-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2022.119276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Myofibroblast modulation of cardiac myocyte structure and function.

    Nagaraju, Chandan K / Dries, Eef / Gilbert, Guillaume / Abdesselem, Mouna / Wang, Nan / Amoni, Matthew / Driesen, Ronald B / Sipido, Karin R

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 8879

    Abstract: After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and the interstitial fibrosis seen in the adjacent myocardium. Fb and MyoFb have the potential to interact with cardiac ... ...

    Abstract After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and the interstitial fibrosis seen in the adjacent myocardium. Fb and MyoFb have the potential to interact with cardiac myocytes (CMs) but insight into the phenotype-specific role and mode of interaction is still incomplete. Our objectives are to further define the modulation of CMs by MyoFbs compared to Fbs, as well as the role of direct contact through gap junctions vs. soluble mediators, using Fbs and CMs from pig left ventricle. Fbs were treated to maintain an undifferentiated state (SD-208) or to attain full differentiation to MyoFb (TGF-β1). Fbs and MyoFbs were co-cultured with CMs, with the possibility of direct contact or separated by a Thincert membrane. Only in direct co-culture, both Fbs and MyoFbs were able to decrease CM viability after 2 days. Only MyoFbs induced significant distal spreading of CMs in both direct and indirect co-culture. MyoFbs, but not Fbs, readily made connections with CMs in direct co-culture and connexin 43 expression in MyoFb was higher than in Fb. When coupled to CMs, MyoFbs reduced the CM action potential duration and hyperpolarized the CM resting membrane potential. Uncoupling reversed these effects. In conclusion, MyoFbs, but not Fbs, alter the CM structural phenotype. MyoFbs, but not Fbs, are likely to electrically connect to CMs and thereby modulate the CM membrane potential. These data provide further support for an active role of MyoFbs in the arrhythmogenic substrate after cardiac remodelling.
    MeSH term(s) Animals ; Cell Differentiation ; Coculture Techniques ; Membranes, Artificial ; Myocytes, Cardiac/cytology ; Myofibroblasts/cytology ; Swine ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Membranes, Artificial ; Transforming Growth Factor beta1
    Language English
    Publishing date 2019-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-45078-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability.

    Dries, Eef / Amoni, Matthew / Vandenberk, Bert / Johnson, Daniel M / Gilbert, Guillaume / Nagaraju, Chandan K / Puertas, Rosa Doñate / Abdesselem, Mouna / Santiago, Demetrio J / Roderick, H Llewelyn / Claus, Piet / Willems, Rik / Sipido, Karin R

    The Journal of physiology

    2020  Volume 598, Issue 14, Page(s) 2875–2895

    Abstract: Key points: Ventricular arrhythmias are a major complication after myocardial infarction (MI), associated with sympathetic activation. The structurally heterogeneous peri-infarct zone is a known substrate, but the functional role of the myocytes is less ...

    Abstract Key points: Ventricular arrhythmias are a major complication after myocardial infarction (MI), associated with sympathetic activation. The structurally heterogeneous peri-infarct zone is a known substrate, but the functional role of the myocytes is less well known. Recordings of monophasic action potentials in vivo reveal that the peri-infarct zone is a source of delayed afterdepolarizations (DADs) and has a high beat-to-beat variability of repolarization (BVR) during adrenergic stimulation (isoproterenol, ISO). Myocytes isolated from the peri-infarct region have more DADs and spontaneous action potentials, with spontaneous Ca
    Abstract: Ventricular arrhythmias are a major early complication after myocardial infarction (MI). The heterogeneous peri-infarct zone forms a substrate for re-entry while arrhythmia initiation is often associated with sympathetic activation. We studied the mechanisms triggering these post-MI arrhythmias in vivo and their relation to regional myocyte remodelling. In pigs with chronic MI (6 weeks), in vivo monophasic action potentials were simultaneously recorded in the peri-infarct and remote regions during adrenergic stimulation with isoproterenol (isoprenaline; ISO). Sham animals served as controls. During infusion of ISO in vivo, the incidence of delayed afterdepolarizations (DADs) and beat-to-beat variability of repolarization (BVR) was higher in the peri-infarct than in the remote region. Myocytes isolated from the peri-infarct region, in comparison to myocytes from the remote region, had more DADs, associated with spontaneous Ca
    MeSH term(s) Action Potentials ; Adrenergic Agents ; Animals ; Arrhythmias, Cardiac/etiology ; Myocardial Infarction ; Myocytes, Cardiac ; Swine
    Chemical Substances Adrenergic Agents
    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP278839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  4. Article ; Online: Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure.

    Nagaraju, Chandan K / Robinson, Emma L / Abdesselem, Mouna / Trenson, Sander / Dries, Eef / Gilbert, Guillaume / Janssens, Stefan / Van Cleemput, Johan / Rega, Filip / Meyns, Bart / Roderick, H Llewelyn / Driesen, Ronald B / Sipido, Karin R

    Journal of the American College of Cardiology

    2019  Volume 73, Issue 18, Page(s) 2267–2282

    Abstract: Background: Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb). Recent clinical evidence suggests that in ...

    Abstract Background: Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb). Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible.
    Objectives: The study aims to examine the degree of differentiation of cardiac MyoFb in end-stage HF and the potential for their phenotypic reversibility.
    Methods: Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts. Fibroblasts were maintained in culture without passaging for 4 or 8 days (treatment studies). Phenotyping included functional testing, immunostaining, and expression studies for markers of differentiation. These data were complemented with immunohistology and expression studies in tissue samples.
    Results: Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs. Tissue levels of transforming growth factor (TGF)-β1, lysyl oxidase, periostin, and osteopontin are elevated. Fibroblastic cells isolated from HF hearts are predominantly MyoFb, proliferative or nonproliferative, with mature α-smooth muscle actin stress fibers. HF MyoFb express high levels of profibrotic cytokines and the TGF-β1 pathway is activated. Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.
    Conclusion: MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyoFb.
    MeSH term(s) Cell Adhesion Molecules/analysis ; Cell Differentiation ; Cells, Cultured ; Disease Progression ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Heart Failure/metabolism ; Heart Failure/pathology ; Humans ; Immunohistochemistry ; Myocardium/metabolism ; Myocardium/pathology ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Osteopontin/analysis ; Protein-Lysine 6-Oxidase/analysis ; Signal Transduction ; Transforming Growth Factor beta1/analysis ; Ventricular Dysfunction/etiology ; Ventricular Dysfunction/metabolism ; Ventricular Dysfunction/pathology
    Chemical Substances Cell Adhesion Molecules ; POSTN protein, human ; Transforming Growth Factor beta1 ; Osteopontin (106441-73-0) ; Protein-Lysine 6-Oxidase (EC 1.4.3.13)
    Language English
    Publishing date 2019-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.02.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  5. Article ; Online: Ultra-wide range field-dependent measurements of the relaxivity of Gd

    Chou, Ching-Yu / Abdesselem, Mouna / Bouzigues, Cedric / Chu, Minglee / Guiga, Angelo / Huang, Tai-Huang / Ferrage, Fabien / Gacoin, Thierry / Alexandrou, Antigoni / Sakellariou, Dimitris

    Scientific reports

    2017  Volume 7, Page(s) 44770

    Abstract: The current trend for Magnetic Resonance Imaging points towards higher magnetic fields. Even though sensitivity and resolution are increased in stronger fields, T1 contrast is often reduced, and this represents a challenge for contrast agent design. ... ...

    Abstract The current trend for Magnetic Resonance Imaging points towards higher magnetic fields. Even though sensitivity and resolution are increased in stronger fields, T1 contrast is often reduced, and this represents a challenge for contrast agent design. Field-dependent measurements of relaxivity are thus important to characterize contrast agents. At present, the field-dependent curves of relaxivity are usually carried out in the field range of 0 T to 2 T, using fast field cycling relaxometers. Here, we employ a high-speed sample shuttling device to switch the magnetic fields experienced by the nuclei between virtually zero field, and the center of any commercial spectrometer. We apply this approach on rare-earth (mixed Gadolinium-Europium) vanadate nanoparticles, and obtain the dispersion curves from very low magnetic field up to 11.7 T. In contrast to the relaxivity profiles of Gd chelates, commonly used for clinical applications, which display a plateau and then a decrease for increasing magnetic fields, these nanoparticles provide maximum contrast enhancement for magnetic fields around 1-1.5 T. These field-dependent curves are fitted using the so-called Magnetic Particle (MP) model and the extracted parameters discussed as a function of particle size and composition. We finally comment on the new possibilities offered by this approach.
    Language English
    Publishing date 2017-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep44770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to multifunctional rare-earth vanadate nanoparticles: luminescent labels, oxidant sensors, and MRI contrast agents.

    Abdesselem, Mouna / Schoeffel, Markus / Maurin, Isabelle / Ramodiharilafy, Rivo / Autret, Gwennhael / Clément, Olivier / Tharaux, Pierre-Louis / Boilot, Jean-Pierre / Gacoin, Thierry / Bouzigues, Cedric / Alexandrou, Antigoni

    ACS nano

    2015  Volume 9, Issue 4, Page(s) 4660

    Language English
    Publishing date 2015-04-28
    Publishing country United States
    Document type Published Erratum
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.5b01924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multifunctional rare-Earth vanadate nanoparticles: luminescent labels, oxidant sensors, and MRI contrast agents.

    Abdesselem, Mouna / Schoeffel, Markus / Maurin, Isabelle / Ramodiharilafy, Rivo / Autret, Gwennhael / Clément, Olivier / Tharaux, Pierre-Louis / Boilot, Jean-Pierre / Gacoin, Thierry / Bouzigues, Cedric / Alexandrou, Antigoni

    ACS nano

    2014  Volume 8, Issue 11, Page(s) 11126–11137

    Abstract: Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which are luminescent probes, ... ...

    Abstract Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which are luminescent probes, oxidant sensors, and contrast agents in magnetic resonance imaging (MRI). Eu(3+) ions in an yttrium vanadate matrix have been demonstrated to emit strong, nonblinking, and stable luminescence. Time- and space-resolved optical oxidant detection is feasible after reversible photoreduction of Eu(3+) to Eu(2+) and reoxidation by oxidants, such as H2O2, leading to a modulation of the luminescence emission. The incorporation of paramagnetic Gd(3+) confers in addition proton relaxation enhancing properties to the system. We synthesized and characterized nanoparticles of either 5 or 30 nm diameter with compositions of GdVO4 and Gd0.6Eu0.4VO4. These particles retain the luminescence and oxidant detection properties of YVO4:Eu. Moreover, the proton relaxivity of GdVO4 and Gd0.6Eu0.4VO4 nanoparticles of 5 nm diameter is higher than that of the commercial Gd(3+) chelate compound Dotarem at 20 MHz. Nuclear magnetic resonance dispersion spectroscopy showed a relaxivity increase above 10 MHz. Complexometric titration indicated that rare-earth leaching is negligible. The 5 nm nanoparticles injected in mice were observed with MRI to concentrate in the liver and the bladder after 30 min. Thus, these multifunctional rare-earth vanadate nanoparticles pave the way for simultaneous optical and magnetic resonance detection, in particular, for in vivo localization evolution and reactive oxygen species detection in a broad range of physiological and pathophysiological conditions.
    MeSH term(s) Animals ; Contrast Media/chemistry ; Luminescence ; Magnetic Resonance Imaging ; Metals, Rare Earth/chemistry ; Mice ; Microscopy, Electron, Transmission ; Nanoparticles/chemistry ; Oxidants/chemistry ; Spectroscopy, Fourier Transform Infrared ; Vanadium/chemistry
    Chemical Substances Contrast Media ; Metals, Rare Earth ; Oxidants ; Vanadium (00J9J9XKDE)
    Language English
    Publishing date 2014-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/nn504170x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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