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Article ; Online: The Impact of Microelectrode Pattern on the Sensitivity of Tracing Environmental CO

Bourbour, Faegheh / Abadijoo, Hamed / Nazari, Fatemeh / Ehtesabi, Hamideh / Abdolahad, Mohammad

2023 Volume 13, Issue 8

Abstract: Here, two different electrode patterns are described as cyclic voltammetry (CV) biosensors to detect the effect of a hypo ... ...

Abstract	Here, two different electrode patterns are described as cyclic voltammetry (CV) biosensors to detect the effect of a hypo CO
MeSH term(s)	Microelectrodes ; Carbon Dioxide ; Apoptosis ; Biological Transport ; Cell Culture Techniques
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13080762
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Article ; Online: Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis.

Tavassoli, Noureddin / Ghahremani, Alireza / Namakin, Kosar / Naserghandi, Alvand / Miri, Seyed Rouhollah / Abdolahad, Mohammad

Therapeutic hypothermia and temperature management

2023

Abstract: Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. ...

Abstract	Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. The study examines how mild intraoperative cooling affects cancer cells and their gene expression. It aims to discover strategies for reducing tumor growth after surgery. Nine cases of solid tumor were included in the study, nine samples were cooled with the Peltier-Seebeck device down to12°C, and cooled and noncooled regions of tumors were analyzed using reverse transcription-polymerase chain reaction. Key transcriptomes, including neural-cadherin, cadherins (
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609342-X
ISSN	2153-7933 ; 2153-7658
ISSN (online)	2153-7933
ISSN	2153-7658
DOI	10.1089/ther.2023.0060
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Article ; Online: Electrochemical therapy (EChT) of cancer tumor with an external anode, a way to achieve pathological complete response.

Miripour, Zohreh Sadat / Ghahremani, Alireza / Karimi, Koosha / Jahanbakhsh, Fahimeh / Abbasvandi, Fereshteh / Hoseinpour, Parisa / Parniani, Mohammad / Abdolahad, Mohammad

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 4, Page(s) 117

Abstract: There is a critical need for re-evaluation of electrochemical therapy (EChT) approaches of solid tumors to address the challenges of the currently used method: incomplete pathological response. The coexistence of anode and cathode in the tumor region ... ...

Abstract	There is a critical need for re-evaluation of electrochemical therapy (EChT) approaches of solid tumors to address the challenges of the currently used method: incomplete pathological response. The coexistence of anode and cathode in the tumor region resulted in acid-alkaline mixation (buffered pH) when the electrodes are so near each other (d < 1 cm), and in the non-affected lesions when the electrodes are far from each other (d > 1 cm), both have resulted in intact tumoral lesions in EChT field. Here, we presented a designation model study of EChT with an external anode out of the tumor and filled the tumor with dense distribution of cathode electrodes to completely destroy the tumoral lesions without any remaining vital tumoral residues. Anode was located in a biological ionic gel chamber (located on top of the skin) which mediates the ionic interface between the external anode and intratumoral cathode. Our newly reported method can solve the lack of a comprehensive therapeutic guideline for any solid tumors. A remarkable increase in the efficiency of EChT without any over-treating was achieved by alkaline therapy of the tumor (without any limitation in locating cathodic needles all over the tumor) and an external acidic region on top of the skin in a cylindrical gel chamber. We found that the destructive volumes and treating ability of mice tumors by this newly represented method were more significant than the conventional EChT method in fewer therapy sessions and no damage to the skin (both anode and cathode electrodes inside the tumor) (P < 0.05). Results of this study applied to mouse model tumors shed new light on returning attraction to EChT as a valuable complementary method for treating different types of solid breast tumors.
MeSH term(s)	Mice ; Animals ; Electrochemistry/methods ; Electric Stimulation Therapy/methods ; Electrodes ; Disease Models, Animal ; Mammary Neoplasms, Animal
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-01979-x
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Article ; Online: Bioelectrical impedimetric sensor for single cell analysis based on nanoroughened quartz substrate; suitable for cancer therapeutic purposes.

Gharooni, Milad / Abdolahad, Mohammad

Journal of pharmaceutical and biomedical analysis

2017 Volume 142, Page(s) 315–323

Abstract: Single cells analysis has been interested in recent decade. Apart from scientific benefits to achieve new biological phenomena in cell study, many diagnostic and therapeutic protocols in non-communicable diseases were introduced by single cell analysis. ... ...

Abstract	Single cells analysis has been interested in recent decade. Apart from scientific benefits to achieve new biological phenomena in cell study, many diagnostic and therapeutic protocols in non-communicable diseases were introduced by single cell analysis. Moreover, non-invasive methods to maintain the investigated cell for time dependent monitoring has been widely studied because of its importance in some crucial cases such as drug resistance in cancer. Bioelectrical monitoring is one of such methods Although the procedures reported based on electrical probing might not induce cell disruption, indirect connection between recording electrodes and cell membrane (mostly in microfluidic approaches) reduced the quality of response and limited the precision of the results. Here, a bioelectronic sensor for monitoring the effect of anticancer drugs on single breast cancer cells was fabricated based on nano-roughened gold electrodes on a quartz substrate applied direct contacts to cell membrane. Whole of the surface except a microcircle surrounded the sensing region was passivated by overbaked photoresist layer. Cells were dropped on the sensor without the assistance of any micropipette or microfluidic systems and just individual regions for attachment of one cell has been opened on the sensing region arrays. MCF-7 cancer cells were time tracked under the effect of Paclitaxel and Mebendazole anti-tubulin drugs in low and high doses. Inducing non regulated depolymerization and polymerization in tubulin structures of the single cancer cells were monitored by the electrical signals recorded before and after drug treatment. Electrical responses of single cells to their incubation with drugs completely reflected their vitality and biological states which were confirmed by confocal imaging. This is one of the first investigation on bioelectrical monitoring of single cell's resistance to anticancer drugs.
Language	English
Publishing date	2017-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2017.05.024
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Article ; Online: Monitoring the effect of sonoporation on the cells using electrochemical approach.

Khayamian, Mohammad Ali / Baniassadi, Majid / Abdolahad, Mohammad

Ultrasonics sonochemistry

2018 Volume 41, Page(s) 619–625

Abstract: Sonoporation is applied to enhance the permeability of the cell to bioactive materials by employing the acoustic cavitation of microbubbles. This phenomena would be helpful in molecular biology, delivery of large molecules into the cells and gene therapy. ...

Abstract	Sonoporation is applied to enhance the permeability of the cell to bioactive materials by employing the acoustic cavitation of microbubbles. This phenomena would be helpful in molecular biology, delivery of large molecules into the cells and gene therapy. Many methods have been applied to monitor the biological effects and trace of sonoporation on the cells such as scanning/transmission electron microscopy, confocal imaging and flow cytometry. Here, we monitored the effect of sonoporation on the cells using electrochemical method with an integrated three electrode system. Electrochemical responses of stimulated cells, compared to flow cytometry and electron microscopy results, presented different patterns of sonoporation in the cells detectable by cyclic voltammetry. In addition, confocal microscopy from actin stress fibers and young's modulus measured by AFM revealed the correlation of cell mechanics and amount of induced sonopores in the cells. This method could be applied as a new trend in cellular mechanochemical studies.
MeSH term(s)	Biomechanical Phenomena ; Electrochemistry ; Humans ; MCF-7 Cells ; Sonication
Language	English
Publishing date	2018-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2017.10.030
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Zs.A 4441: Show issues

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Article ; Online: Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells.

Miripour, Zohreh S / Aghaee, Parisa / Abbasvandi, Fereshteh / Hoseinpour, Parisa / Parniani, Mohammad / Abdolahad, Mohammad

Bioscience reports

2020 Volume 40, Issue 6

Abstract: Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH ... ...

Abstract	Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Hydrogen-Ion Concentration ; Lipogenesis ; Lymphatic Metastasis ; Predictive Value of Tests ; Sentinel Lymph Node/metabolism ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2020-05-21
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20200970
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Article: Intraoperative use of electrical impedance spectroscopy for adenoid cystic carcinoma of the lacrimal gland: A case report.

Fattahi, Mohammad Reza / Zarafshani, Mohammadkian / Abdolahad, Mohammad / Jalaeefar, Amirmohsen / Mahdavi, Reihane / Yousefpour, Narges / Saffar, Hana / Mousavi-Kiasary, Seyed Mohamad Sadegh / Pakdel, Farzad

Clinical case reports

2023 Volume 11, Issue 10, Page(s) e7995

Abstract: Key clinical message: Electrical Impedimetric Tumor Detection System is a novel and promising tool for fast intraoperative tumor delineation and accurate safe margin detection in orbital tumors.: Abstract: Adenoid cystic carcinoma (ACC) is a rare ... ...

Abstract	Key clinical message: Electrical Impedimetric Tumor Detection System is a novel and promising tool for fast intraoperative tumor delineation and accurate safe margin detection in orbital tumors. Abstract: Adenoid cystic carcinoma (ACC) is a rare malignant tumor of epithelial origin, typically arising from the salivary and lacrimal glands. ACC is notorious for recurrence and a high rate of morbidity and mortality despite therapy. We presented a 48-year-old male patient with lacrimal gland ACC of the right orbit who underwent radical tumor resection and adjuvant radiotherapy. We applied a new diagnostic method, the Electrical Impedimetric Tumor Detection System, during surgery and tested its performance to enhance the precision of tumor resection. Two months after surgery, he underwent external radiation of 58 Gy in 29 fractions. He showed no tumor recurrence or metastasis in the 1-year follow-up visits. ITDS showed a precision of tumor and margin detection consistent with histopathology results. This novel ITDS may be a reliable system for fast intraoperative tumor delineation and accurate, safe margin detection in orbital tumors.
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7995
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Article ; Online: Targeted Delivery of Anticancer Drug Loaded Charged PLGA Polymeric Nanoparticles Using Electrostatic Field.

Miraghaie, Seyyed Hossein / Zandi, Ashkan / Davari, Zahra / Mousavi-Kiasary, Mohamad Sadegh / Saghafi, Zohre / Gilani, Ali / Kordehlachin, Yasin / Shojaeian, Fatemeh / Mamdouh, Amir / Heydari, Zahra / Dorkoosh, Farid Abedin / Kaffashi, Babak / Abdolahad, Mohammad

Macromolecular bioscience

2023 Volume 23, Issue 9, Page(s) e2300181

Abstract: Pure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with ... ...

Abstract	Pure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with negatively charged poly(lactide-co-glycolide) (PLGA) and Poly(vinyl-alcohol) PVA into the tumor site of mouse models. The charged patch is installed on top of the skin in the mouse models' tumor region, and the controlled selective release of the drug is assayed by biochemical, radiological, and histological experiments on both tumorized models and normal rats' livers. It is found that DLNs synthesized by PLGA show great attraction to PPECs due to their stable negative charges, which would not degrade immediately in blood. The burst and drug release after less than 48h of this synthesized DLNs are 10% and 50%, respectively. These compounds can deliver the loaded-drug into the tumor site with the assistance of PPECs, and the targeted-retarded release will take place. Hence, local therapy can be achieved with much lower drug concentration (conventional chemotherapy [2 mg kg
MeSH term(s)	Mice ; Rats ; Animals ; Drug Delivery Systems ; Polylactic Acid-Polyglycolic Acid Copolymer/metabolism ; Static Electricity ; Antineoplastic Agents/chemistry ; Polymers/therapeutic use ; Neoplasms/drug therapy ; Nanoparticles/chemistry ; Drug Carriers/chemistry ; Drug Liberation
Chemical Substances	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Antineoplastic Agents ; Polymers ; Drug Carriers
Language	English
Publishing date	2023-07-20
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202300181
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Article ; Online: Hydroelectric actuator for 3-dimensional analysis of electrophoretic and dielectrophoretic behavior of cancer cells; suitable in diagnosis and invasion studies.

Moharamipour, Shima / Aminifar, Mina / Foroughi-Gilvaee, Mohammad Reza / Faranoush, Pooya / Mahdavi, Reihane / Abadijoo, Hamed / Parniani, Mohammad / Abbasvandi, Fereshteh / Mansouri, Sepideh / Abdolahad, Mohammad

Biomaterials advances

2023 Volume 151, Page(s) 213476

Abstract: Cancer is a cellular-based disease, so cytological diagnosis is one of the main challenges for its early detection. An extensive number of diagnostic methods have been developed to separate cancerous cells from normal ones, in electrical methods attract ... ...

Abstract	Cancer is a cellular-based disease, so cytological diagnosis is one of the main challenges for its early detection. An extensive number of diagnostic methods have been developed to separate cancerous cells from normal ones, in electrical methods attract progressive attention. Identifying and specifying different cells requires understanding their dielectric and electric properties. This study evaluated MDA-MB-231, HUVEC, and MCF-10A cell lines, WBCs isolated from blood, and patient-derived cell samples with a cylindrical body with two transparent FTO (fluorine-doped tin oxide) plate electrodes. Cell mobility rates were recorded in response to these stimuli. It was observed that cancer cells demonstrate drastic changes in their motility in the presence and absence of an electric field (DC/AC). Also, solution viscosity's effect on cancer cells' capturing efficacy was evaluated. This research's main distinguished specification uses a non-microfluidic platform to detect and pathologically evaluate cytological samples with a simple, cheap, and repeatable platform. The capturing procedure was carried out on a cytological slide without any complicated electrode patterning with the ability of cytological staining. Moreover, this platform successfully designed and experimented with the invasion assay (the ability of captured cancer cells to invade normal cells).
MeSH term(s)	Electrophoresis/instrumentation ; Electrophoresis/methods ; Neoplasms/diagnosis ; Neoplasms/pathology ; Neoplasm Invasiveness ; Electrodes ; Humans ; Cell Line, Tumor ; Printing, Three-Dimensional ; Cell Separation ; Cell Hypoxia ; Cell Migration Assays
Language	English
Publishing date	2023-05-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2023.213476
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Article ; Online: Tracing the pH dependent activation of autophagy in cancer cells by silicon nanowire-based impedance biosensor.

Alikhani, Alireza / Gharooni, Milad / Abiri, Hamed / Farokhmanesh, Fatemeh / Abdolahad, Mohammad

Journal of pharmaceutical and biomedical analysis

2018 Volume 154, Page(s) 158–165

Abstract: Monitoring the pH dependent behavior of normal and cancer cells by impedimetric biosensor based on Silicon Nanowires (SiNWs) was introduced to diagnose the invasive cancer cells. Autophagy as a biologically activated process in invasive cancer cells ... ...

Abstract	Monitoring the pH dependent behavior of normal and cancer cells by impedimetric biosensor based on Silicon Nanowires (SiNWs) was introduced to diagnose the invasive cancer cells. Autophagy as a biologically activated process in invasive cancer cells during acidosis, protect them from apoptosis in lower pH which presented in our work. As the autophagy is the only activated pathways which can maintain cellular proliferation in acidic media, responses of SiNW-ECIS in acidified cells could be correlated to the probability of autophagy activation in normal or cancer cells. In contrast, cell survival pathway wasn't activated in low-grade cancer cells which resulted in their acidosis. The measured electrical resistance of MCF10, MCF7, and MDA-MB468 cell lines, by SiNW sensor, in normal and acidic media were matched by the biological analyses of their vital functions. Invasive cancer cells exhibited increased electrical resistance in pH 6.5 meanwhile the two other types of the breast cells exhibited sharp (MCF10) and moderate (MCF7) decrease in their resistance. This procedure would be a new trend in microenvironment based cancer investigation.
MeSH term(s)	Apoptosis/physiology ; Autophagy/physiology ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Cell Proliferation/physiology ; Cell Survival/physiology ; Electric Impedance ; Humans ; Hydrogen-Ion Concentration ; MCF-7 Cells ; Nanowires/chemistry ; Neoplasms/pathology ; Silicon/chemistry
Chemical Substances	Silicon (Z4152N8IUI)
Language	English
Publishing date	2018-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2018.02.040
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