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  1. Article ; Online: Impact of COVID-19 Pandemic on Vascular Surgery Training in the United States.

    Kwesiga, Daphine M / Abdou, Hossam / Nagarsheth, Khanjan

    The American surgeon

    2021  Volume 89, Issue 6, Page(s) 2847–2849

    MeSH term(s) Humans ; United States/epidemiology ; COVID-19/epidemiology ; Pandemics ; Specialties, Surgical ; SARS-CoV-2 ; Vascular Surgical Procedures
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348211060462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Raising Systemic Blood Pressure to Delay Irreversible Intestinal Ischemia in a Swine Model of Proximal Superior Mesenteric ArteryOcclusion.

    Stonko, David P / Edwards, Joseph / Abdou, Hossam / Treffalls, Rebecca / Walker, Patrick / Morrison, Jonathan J

    The Journal of surgical research

    2023  Volume 295, Page(s) 70–80

    Abstract: Introduction: Acute proximal superior mesenteric artery (SMA) occlusion is highly lethal, and adjuncts are needed to mitigate ischemic injury until definitive therapy. We hypothesized that raising mean arterial pressure (MAP) >90 mmHg with ... ...

    Abstract Introduction: Acute proximal superior mesenteric artery (SMA) occlusion is highly lethal, and adjuncts are needed to mitigate ischemic injury until definitive therapy. We hypothesized that raising mean arterial pressure (MAP) >90 mmHg with norepinephrine may delay irreversible bowel ischemia by increasing gastroduodenal artery (GDA) flow despite possible pressor-induced vasospasm.
    Methods: 12 anesthetized swine underwent laparotomy, GDA flow probe placement, and proximal SMA exposure and clamping. Animals were randomized between conventional therapy (CT) versus targeted MAP >90 mmHg (MAP push; MP) where norepinephrine was titrated after 45 min of SMA occlusion. Animals were followed until bowel death or 4 h. Kaplan-Meier bowel survival, mean normalized GDA flow, and histology were compared.
    Results: 12 swine (mean 57.8 ± 7.6 kgs) were included, six per group. Baseline weight, HR, MAP and GDA flows were not different. Within 5 min following SMA clamping, all 12 animals had an increase in MAP without other intervention from 81.7 to 105.5 mmHg (29.1%, P < 0.01) with a concomitant 74.9% increase in GDA flow as compared to baseline (P < 0.01). Beyond 45 min postclamp, MAP was greater in the MP group as intended, as were GDA flows. Median time to irreversibly ischemic bowel was 31% longer for MAP push animals (CT: 178 versus MP: 233 min, P = 0.006), Hazard Ratio of CT 8.85 (95% CI: 1.86-42.06); 3/6 MP animals versus 0/6 CT animals with bowel survived to predetermined end point.
    Conclusions: In this swine model of acute complete proximal SMA occlusion, increasing MAP >90 mmHg with norepinephrine was associated with an increase in macrovascular blood flow through the GDA and bowel survival. Norepinephrine was not associated with worse bowel survival and a MAP push may increase the time window where ischemic bowel can be salvaged.
    MeSH term(s) Animals ; Arterial Pressure ; Blood Pressure ; Ischemia/pathology ; Mesenteric Artery, Superior/surgery ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/surgery ; Norepinephrine ; Swine
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial, Veterinary
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.09.076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endovascular stenting techniques for blunt carotid injury.

    Abdou, Hossam / Treffalls, Rebecca N / Stonko, David P / Kundi, Rishi / Morrison, Jonathan J

    Vascular

    2023  , Page(s) 17085381231193062

    Abstract: Objectives: While methods of endovascular carotid artery stenting have improved over time, concerns surrounding the safety and efficacy of stenting for blunt carotid injury (BCI) remain. This study aims to present our approach to carotid artery stenting ...

    Abstract Objectives: While methods of endovascular carotid artery stenting have improved over time, concerns surrounding the safety and efficacy of stenting for blunt carotid injury (BCI) remain. This study aims to present our approach to carotid artery stenting (CAS) by incorporating new technologies such as flow-diverting stents and circuits.
    Methods: There is no robust evidence to support routine carotid artery stenting; however, there are several therapeutic options and approaches for treating BCI that currently require an individualized approach. Endovascular stenting and specific stent selection are largely dictated by the disease process the surgeon intends to treat. We will discuss patient selection, medical management, and the most common revascularization techniques, including transfemoral stenting, trans-carotid arterial revascularization using flow reversal, and stent-assisting coiling.
    Results: It must be stressed that endovascular intervention is not an alternative to or preclusive of antithrombotic or anticoagulant therapy. In the setting of BCI, transfemoral CAS is most appropriate in patients who are symptomatic, have a rapidly progressing or large lesion, and do not have a soft thrombus present due to risk of embolism. Unlike transfemoral CAS, TCAR offers an elegant solution for embolic protection when patients have a soft thrombus present. In the case of a large pseudoaneurysm, we perform stent-assisted coiling.
    Conclusions: We practice selective endovascular intervention, stenting lesions that are flow-limiting or have large or rapidly expanding pseudoaneurysms, and only in patients for whom anticoagulation and antiplatelet agents are not contraindicated. As technology and investigation progress, the concerns regarding the safety and the role of endovascular intervention in the treatment of BCI will be more clearly defined.
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381231193062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lower Extremity Staged Revascularization (LESR) as a new innovative concept for lower extremity salvage in acute popliteal artery injuries: a hypothesis.

    Edwards, Joseph / Treffalls, Rebecca N / Abdou, Hossam / Stonko, David P / Walker, Patrick F / Morrison, Jonathan J

    Patient safety in surgery

    2022  Volume 16, Issue 1, Page(s) 39

    Abstract: Popliteal artery injury following knee dislocation is associated with significant morbidity and high amputation rates. The complex and multi-disciplinary input required to manage this injury effectively can take time to arrange, prolonging the time to ... ...

    Abstract Popliteal artery injury following knee dislocation is associated with significant morbidity and high amputation rates. The complex and multi-disciplinary input required to manage this injury effectively can take time to arrange, prolonging the time to revascularization. Furthermore, open surgical bypass or interposition graft can be technically challenging in the acute setting, further prolonging ischemic time.Temporary intravascular shunts can be used to temporarily restore flow but require surgical exposure which takes time. Endovascular techniques can decrease the time to revascularization; however, endovascular popliteal stent-grafting is controversial because the biomechanical forces relating to flexion and extension of the knee may increase the risk of stent thrombosis. An ideal operation would result in rapid revascularization, eventually leading to a definitive and durable surgical solution.We hypothesize that a staged approach combing extracorporeal shunting, temporary endovascular covered stent placement, external fixation of bony injury, and definitive open repair provides for a superior approach to popliteal artery injury than current standard of care. We term this approach lower extremity staged revascularization (LESR) and the aim is to minimize the known factors contributing to poor outcomes after traumatic popliteal artery injury.
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409244-7
    ISSN 1754-9493
    ISSN 1754-9493
    DOI 10.1186/s13037-022-00349-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Open Proximal Endarterectomy with Retrograde Access and Stenting: A Novel Technique for Lower Extremity Revascularization.

    Blitzer, David N / Rolle, Nicholas P / Abdou, Hossam / Berg, Lars / Nagarsheth, Khanjan H

    Vascular and endovascular surgery

    2022  Volume 57, Issue 1, Page(s) 5–10

    Abstract: Background: Treatment of chronic limb threatening ischemia (CLTI) poses a significant clinical challenge despite recent medical advancements. Chronic total occlusion (CTO) lesions make endovascular approaches to CLTI particularly challenging. Open ... ...

    Abstract Background: Treatment of chronic limb threatening ischemia (CLTI) poses a significant clinical challenge despite recent medical advancements. Chronic total occlusion (CTO) lesions make endovascular approaches to CLTI particularly challenging. Open proximal exposure with retrograde access and stenting (OPERAS) aims to solve this challenge through retrograde subintimal crossing of a CTO with direct visualization of proximal re-entry into the true lumen. We describe this novel technique and present its efficacy in eight patients.
    Methods: We conducted a retrospective case series at a single tertiary academic center. Data for patients who received OPERAS intervention included demographics, peri-operative details, and follow-up information. Statistical analysis was performed on length of stay, major post-operative complications, further intervention, clinical progression at 1 year, and amputation-free survival at 1 year. Immediate technical failure (ITF) and limb-based patency (LBP) at 1 year were calculated.
    Results: Nine limbs underwent OPERAS between January 2019 and March 2020. Inflow was achieved with common femoral artery endarterectomy. All limbs underwent balloon angioplasty and stenting of the SFA, and seven underwent the same procedure in the popliteal artery. ITF was 0% for all nine cases. There were no major post-operative complications, and ankle-brachial index significantly improved pre-and post-operatively (
    Conclusion: Our study presents a hybrid revascularization option to address severe, anatomically complex limbs (GLASS III) that lack a single autogenous conduit for open surgical revascularization. OPERAS addresses a main point of technical failure of subintimal techniques by directly visualizing the wire in the true lumen. Our data suggest that OPERAS can be effective to: (1) improve technical success of luminal re-entry following a subintimal approach; (2) address inflow concurrently with severe femoropopliteal disease; and (3) can be utilized when distal tissue loss is involved.
    MeSH term(s) Humans ; Retrospective Studies ; Treatment Outcome ; Endarterectomy/adverse effects ; Lower Extremity ; Popliteal Artery ; Postoperative Complications ; Vascular Diseases ; Chronic Limb-Threatening Ischemia
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/15385744221120203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Keep it SIMPL: Improved Feedback After Implementation of an App-Based Feedback Tool.

    Abdou, Hossam / Kidd-Romero, Sarah / Brown, Rebecca F / Kavic, Stephen M / Kubicki, Natalia S

    The American surgeon

    2022  Volume 88, Issue 7, Page(s) 1475–1478

    Abstract: Background: Data defining the utility of the system for improving and measuring procedural learning (SIMPL) in surgical education is limited. The aim of this pilot study is to describe the impact of SIMPL on resident and faculty perspectives regarding ... ...

    Abstract Background: Data defining the utility of the system for improving and measuring procedural learning (SIMPL) in surgical education is limited. The aim of this pilot study is to describe the impact of SIMPL on resident and faculty perspectives regarding operative feedback.
    Methods: Residents and faculty were surveyed prior to and 6 months after SIMPL implementation. Associations were analyzed using
    Results: The proportion of residents receiving intraoperative feedback at least once/day increased significantly (35% to 73%,
    Discussion: Despite a modest increase in frequency of postoperative feedback, perceived quality of feedback improved substantially after implementation of SIMPL. Introduction of SIMPL also increased the amount of feedback provided by faculty intraoperatively. SIMPL, via direct and indirect effects, has a positive impact on the resident operative learning environment. Further work is necessary to examine the influence this may have on resident operative skill and patient outcomes.
    MeSH term(s) Clinical Competence ; Feedback ; General Surgery/education ; Humans ; Internship and Residency ; Mobile Applications ; Pilot Projects
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348221082279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring Intra-arterial Contrast Administration for Intraoperative Imaging Using a Swine Model.

    Treffalls, Rebecca N / Poe, Kelly / Abdou, Hossam / Stonko, David P / Edwards, Joseph / DeMartino, Randall R / Ptak, Thomas / Morrison, Jonathan J

    Angiology

    2023  , Page(s) 33197231155225

    Abstract: Intraoperative computed tomography (CT) imaging with endovascular delivery of intra-arterial (IA) contrast could potentially provide higher attenuation with lower contrast volumes than intravenous (IV) administration. We aimed to compare IA and IV ... ...

    Abstract Intraoperative computed tomography (CT) imaging with endovascular delivery of intra-arterial (IA) contrast could potentially provide higher attenuation with lower contrast volumes than intravenous (IV) administration. We aimed to compare IA and IV contrast use for organ-specific CT abdominal imaging. Five anesthetized swine had external jugular and brachial artery access with ascending aortic pigtail placement. An IV protocol was 100 mL at 5 mL/sec over 20 sec
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231155225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A cautionary tale of an emergency cerebrovascular procedure in the COVID-19 era.

    Abdou, Hossam / Tolaymat, Besher / Jinwala, Felecia / Nagarsheth, Khanjan H

    Journal of vascular surgery cases and innovative techniques

    2020  Volume 6, Issue 4, Page(s) 603–605

    Abstract: The coronavirus disease 2019 pandemic has had an impact on system processes, with airway management being significantly affected. A 37-year-old woman diagnosed with stroke was found to have a filling defect at the origin of the right internal carotid ... ...

    Abstract The coronavirus disease 2019 pandemic has had an impact on system processes, with airway management being significantly affected. A 37-year-old woman diagnosed with stroke was found to have a filling defect at the origin of the right internal carotid artery. She was taken to the operating room urgently for carotid endarterectomy. The procedure was uneventful; however, anaphylaxis developed on extubation, subsequently attributed to sugammadex. Institutional policies and limited resources resulted in delayed reintubation. Fortunately, she did not have lasting deficits, but this highlights the potential of current policies to lead to complications and the need to improve policies to minimize harm.
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2020.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: USMLE Step 1 Is Pass/Fail - Should the ABSITE Follow Suit?

    Abdou, Hossam / Kidd-Romero, Sarah / Kubicki, Natalia S / Kavic, Stephen M

    Journal of surgical education

    2020  Volume 78, Issue 3, Page(s) 711–713

    Abstract: The United States Medical Licensing Examination (USMLE) Step 1 was recently made pass/fail. This decision was controversial largely because of the reliance on USMLE Step 1 scores in resident selection. However, these scores do not correlate with resident ...

    Abstract The United States Medical Licensing Examination (USMLE) Step 1 was recently made pass/fail. This decision was controversial largely because of the reliance on USMLE Step 1 scores in resident selection. However, these scores do not correlate with resident ability. In this manuscript, we consider if the American Board of Surgery In-Training Examination (ABSITE) should be pass/fail as well. The ABSITE has been used for "high-stakes" purposes, such as preliminary resident advancement and prospective fellow evaluation, for which it was not intended. Moreover, similar to the USMLE Step 1 exam, ABSITE scores have demonstrated no correlation with clinical ability. A pass/fail ABSITE would return the exam to its original purpose and minimize an over-reliance on scores. Moving forward, new objective measures will need to be developed to assess surgical trainees in a more holistic manner.
    MeSH term(s) Clinical Competence ; Educational Measurement ; Internship and Residency ; Prospective Studies ; United States
    Language English
    Publishing date 2020-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2020.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: State-of-the-Art Review: Sex Hormone Therapy in Trauma-Hemorrhage.

    Lang, Eric / Abdou, Hossam / Edwards, Joseph / Patel, Neerav / Morrison, Jonathan J

    Shock (Augusta, Ga.)

    2021  Volume 57, Issue 3, Page(s) 317–326

    Abstract: Abstract: Trauma-hemorrhage is the leading cause of prehospital and early in-hospital deaths, while also significantly contributing to the later development of multisystem organ dysfunction/failure and sepsis. Common and advanced resuscitative methods ... ...

    Abstract Abstract: Trauma-hemorrhage is the leading cause of prehospital and early in-hospital deaths, while also significantly contributing to the later development of multisystem organ dysfunction/failure and sepsis. Common and advanced resuscitative methods would potentially demonstrate benefits in the prehospital setting; however, they face a variety of barriers to application and implementation. Thus, a dialogue around a novel adjunct has arisen, sex hormone therapy. Proposed candidates include estradiol and its derivatives, metoclopramide hydrochloride/prolactin, dehydroepiandrosterone, and flutamide; with each having demonstrated a range of salutary effects in several animal model studies. Several retrospective analyses have observed a gender-based dimorphism in mortality following trauma-hemorrhage, thus suggesting that estrogens contribute to this pattern. Trauma-hemorrhage animal models have shown estrogens offer protective effects to the cardiovascular, pulmonary, hepatic, gastrointestinal, and immune systems. Additionally, a series of survival studies utilizing 17α-ethinylestradiol-3-sulfate, a potent, water-soluble synthetic estrogen, have demonstrated a significant survival benefit and beneficial effects on cardiovascular function. This review presents the findings of retrospective clinical studies, preclinical animal studies, and discusses how and why 17α-ethinylestradiol-3-sulfate should be considered for investigation within a prospective clinical trial.
    MeSH term(s) Animals ; Disease Models, Animal ; Female ; Gonadal Steroid Hormones/therapeutic use ; Humans ; Male ; Sex Factors ; Shock, Hemorrhagic/drug therapy ; Shock, Hemorrhagic/etiology ; Wounds and Injuries/complications ; Wounds and Injuries/therapy
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2021-10-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001871
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