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  1. Article ; Online: Adjunct of Immunotherapy with the Use of Tocilizumab in Critically Ill COVID-19 Improves Prognosis?

    Abdul Rahim, Komal

    SSRN Electronic Journal ; ISSN 1556-5068

    A Case Study

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3624731
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Liver Disease Increases the Severity of COVID-19

    Abdul Rahim, Komal

    SSRN Electronic Journal ; ISSN 1556-5068

    A Case Study

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3617473
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Adjunct of Immunotherapy with the Use of Tocilizumab in Critically Ill COVID-19 Improves Prognosis?

    Abdul Rahim, Komal

    SSRN Electronic Journal ; ISSN 1556-5068

    A Case Study

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3622280
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mental health outcomes beyond the post-partum period among adolescent mothers: a systematic review and meta-analysis.

    Abdul Rahim, Komal / Egglestone, Natasha J / Tsagareli, Irakli G / Usmani, Wania / Meherali, Salima / Lassi, Zohra S

    Health psychology and behavioral medicine

    2024  Volume 12, Issue 1, Page(s) 2305741

    Abstract: Background: Adolescence is the most crucial part of life. The vulnerability of adolescent mothers is even more pronounced and can affect various health aspects. While they suffer from social and emotional stresses shortly after giving birth, the long- ... ...

    Abstract Background: Adolescence is the most crucial part of life. The vulnerability of adolescent mothers is even more pronounced and can affect various health aspects. While they suffer from social and emotional stresses shortly after giving birth, the long-term effect after the post-partum period of adolescent pregnancy on the mental outcomes holds prime importance. Thus, this systematic review aims to ascertain the association between adolescent pregnancy on mental health outcomes.
    Methods: The search strategy was run in June 2023 on databases including PubMed, CINAHL, Scopus, Psych Info, and Embase . Quality assessment of the studies was done using the National Institute of Health (NIH)'s National Heart, Lung and Blood Institute (NHLBI) tool for observational studies. For studies that measured similar outcomes, a meta-analysis was conducted.
    Findings: The search strategy yielded 21 results from all databases and cross-referencing. Of these, all except for one (case-control) were cross-sectional and cohort studies. The pooled analysis found a significant association between adolescent pregnancy and depression (RR 1.34; 95% CI 1.05, 1.72, 6 studies, heterogeneity: Chi
    Implication: These findings suggest that the mental health needs of adolescent mothers must be addressed and innovative and effective interventions that support and address the mental health needs of adolescent mothers are needed to improve their mental health.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2720684-1
    ISSN 2164-2850 ; 2164-2850
    ISSN (online) 2164-2850
    ISSN 2164-2850
    DOI 10.1080/21642850.2024.2305741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Undergraduate Medical Education Curriculum Reforms in Pakistan: A Mixed Methods Study of Academic Leadership Perspectives.

    Bakhshi, Saqib Kamran / Afzal, Noreen / Merchant, Asma Altaf Hussain / Abdul Rahim, Komal / Shaikh, Namra Qadeer / Noorali, Ali Aahil / Lakhdir, Maryam Pyar Ali / Tariq, Muhammad / Haider, Adil H

    Academic medicine : journal of the Association of American Medical Colleges

    2024  

    Abstract: Purpose: Periodic revision of undergraduate medical education (UGME) curricula is an essential part of evidence-based educational practices. Pakistan's national UGME curriculum, last updated in 2005, was reviewed, and recommended updates were made in ... ...

    Abstract Purpose: Periodic revision of undergraduate medical education (UGME) curricula is an essential part of evidence-based educational practices. Pakistan's national UGME curriculum, last updated in 2005, was reviewed, and recommended updates were made in 2022. The authors explore academic medical school leaders' perspectives about the proposed reforms, gaps within the existing curriculum, and how to ensure the reform implementation is effective, collaborative, and feedback-driven.
    Method: Using a mixed methods approach, data were collected from April-July 2022. Academic leadership (principals, who could designate vice principals or medical educators) at all medical schools across Pakistan (n = 117) were invited. Agreement with each of 20 proposed reforms was measured via a survey employing a Likert scale. A semi-structured interview guide expanded on the survey questions with probes.
    Results: Eighty-eight survey responses, from private (59; 67.0%) and public (29; 33.0%) institutions, were obtained (75.2% response rate). Participants recommended most of the proposed reforms. The 3 reforms that received the highest agreement were teaching professionalism as an integral part of the curriculum (83; 94.3%), mandating bedside procedural skills training (80; 90.9%), and including patient safety in the UGME curriculum (79; 89.8%). Including multidisciplinary tumor boards and surgical oncology had the lowest agreement (26; 29.5%). Fifteen interviews were conducted, which revealed 3 major themes: perceptions about changes to the curricular content; limitation of human and financial resources as barriers to reform implementation; and recommendations for effective implementation of an updated curriculum.
    Conclusions: The findings reflect an overall positive attitude of academic medical school leadership toward the 20 proposed UGME curriculum reforms, which could aid with on-the-ground implementation. However, major limitations, such as a lack of trained faculty and financial resources, must be addressed. The authors propose future research on the resources required for implementing UGME reforms and the reforms' impact after national implementation.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000005683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: No healthcare coverage, big problem: lack of insurance for older population associated with worse emergency general surgery outcomes.

    Abdul Rahim, Komal / Shaikh, Namra Qadeer / Lakhdir, Maryam Pyar Ali / Afzal, Noreen / Merchant, Asma Altaf Hussain / Mahmood, Saad Bin Zafar / Bakhshi, Saqib Kamran / Ali, Mushyada / Samad, Zainab / Haider, Adil H

    Trauma surgery & acute care open

    2024  Volume 9, Issue 1, Page(s) e001165

    Abstract: Introduction: Older populations, being a unique subset of patients, have poor outcomes for emergency general surgery (EGS). In regions lacking specialized medical coverage for older patients, disparities in healthcare provision lead to poor clinical ... ...

    Abstract Introduction: Older populations, being a unique subset of patients, have poor outcomes for emergency general surgery (EGS). In regions lacking specialized medical coverage for older patients, disparities in healthcare provision lead to poor clinical outcomes. We aimed to identify factors predicting index admission inpatient mortality from EGS among sexagenarians, septuagenarians, and octogenarians.
    Methods: Data of patients aged >60 years with EGS conditions defined by the American Association for the Surgery of Trauma at primary index admission from 2010 to 2019 operated and non-operated at a large South Asian tertiary care hospital were analyzed. The primary outcome was primary index admission inpatient 30-day mortality. Parametric survival regression using Weibull distribution was performed. Factors such as patients' insurance status and surgical intervention were assessed using adjusted HR and 95% CI with a p-value of <0.05 considered statistically significant.
    Results: We included 9551 primary index admissions of patients diagnosed with the nine most common primary EGS conditions. The mean patient age was 69.55±7.59 years. Overall mortality and complication rates were 3.94% and 42.29%, respectively. Primary index admission inpatient mortality was associated with complications including cardiac arrest and septic shock. Multivariable survival analysis showed that insurance status was not associated with mortality (HR 1.13; 95% CI 0.79, 1.61) after adjusting for other variables. The odds of developing complications among self-paid individuals were higher (adjusted OR 1.17; 95% CI 1.02, 1.35).
    Conclusion: Lack of healthcare coverage for older adults can result in delayed presentation, leading to increased morbidity. Close attention should be paid to such patients for timely provision of treatment. There is a need to expand primary care access and proper management of comorbidities for overall patient well-being. Government initiatives for expanding insurance coverage for older population can further enhance their healthcare access, mitigating the risk of essential treatments being withheld due to financial limitations.
    Level of evidence: III.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ISSN 2397-5776
    ISSN (online) 2397-5776
    DOI 10.1136/tsaco-2023-001165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review).

    Gutiérrez-Vargas, Johanna Andrea / Castro-Álvarez, John Fredy / Zapata-Berruecos, Jose Fernando / Abdul-Rahim, Komal / Arteaga-Noriega, Anibal

    Biomedical reports

    2022  Volume 16, Issue 4, Page(s) 27

    Abstract: The cytoskeleton is the main intracellular structure that determines the morphology of neurons and maintains their integrity. Therefore, disruption of its structure and function may underlie several neurodegenerative diseases. This review summarizes the ... ...

    Abstract The cytoskeleton is the main intracellular structure that determines the morphology of neurons and maintains their integrity. Therefore, disruption of its structure and function may underlie several neurodegenerative diseases. This review summarizes the current literature on the tau protein, microtubule-associated protein 2 (MAP2) and neurofilaments as common denominators in pathological conditions such as Alzheimer's disease (AD), cerebral ischemia, and multiple sclerosis (MS). Insights obtained from experimental models using biochemical and immunocytochemical techniques highlight that changes in these proteins may be potentially used as protein targets in clinical settings, which provides novel opportunities for the detection, monitoring and treatment of patients with these neurodegenerative diseases.
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2022.1510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Barriers to research productivity amongst postgraduate trainees: results from a survey of 333 medical and surgical residents.

    Bakhshi, Saqib K / Abdul Rahim, Komal / Merchant, Asma A H / Afzal, Noreen / Qadeer Shaikh, Namra / Noorali, Ali A / Lakhdir, Maryam P A / Mahmood, Saad B Z / Tariq, Muhammad / Haider, Adil H

    Postgraduate medical journal

    2023  Volume 99, Issue 1177, Page(s) 1182–1188

    Abstract: Purpose: We aimed to determine the perceptions of, barriers to, and predictors of research engagement amongst residents at a national level in Pakistan.: Methods: This cross-sectional study used REDCap for online survey dissemination to residents ... ...

    Abstract Purpose: We aimed to determine the perceptions of, barriers to, and predictors of research engagement amongst residents at a national level in Pakistan.
    Methods: This cross-sectional study used REDCap for online survey dissemination to residents from 12 institutes accredited by the national accreditation body (College of Physicians and Surgeons Pakistan) for core medical and surgical specialties. Logistic regression was used to estimate associations between likelihood of publications and participant characteristics.
    Results: The response rate was 79% (333/423), with 171 (51%) medical and 162 (49%) surgical residents. The mean ± standard deviation age was 28.8 ± 2.7 years; 137 (41%) were males and 195 (59%) females. More than half the residents, 202 (61%), had received research training, but 189 (57%) scored <33% on basic research knowledge. While most residents agreed on the positive impact of research on their careers (P = .012) and realized that they should be involved in it (P = .33), they also strongly believed that it was difficult to engage in research during training (P < .01). Only 60 (18%) trainees had published a paper in local and 37 (11%) in international journals, respectively. The most significant barriers to conducting research included time limitation due to clinical work, lack of financial support, and unavailability of data (P < .01).
    Conclusion: Residents have a positive attitude towards research. However, research engagement among residents is low. Improving research mentorship and creating systems that enable protected time and institutional access to data are needed to increase research output of postgraduate trainees. Key messages What is already known on this topic Postgraduate trainees benefit academically from research conducted during residency training. However, in low- and middle-income countries like Pakistan, research output among residents has remained low over the years. The nation has consistently produced very little research. What this study adds The current study helped shed light on the reasons for low research productivity amongst medical and surgical residents in Pakistan. How this study might affect research, practice, or policy The potential predictors for low research involvement highlighted in this study necessitate modification of the existing national residency curriculum to increase research engagement and productivity among residents. Not only can the potential factors be improved, but the study also helps in bringing stakeholders' attention to increasing research opportunities in Pakistan.
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1093/postmj/qgad062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mental Health of Children and Adolescents Amidst COVID-19 and Past Pandemics: A Rapid Systematic Review.

    Meherali, Salima / Punjani, Neelam / Louie-Poon, Samantha / Abdul Rahim, Komal / Das, Jai K / Salam, Rehana A / Lassi, Zohra S

    International journal of environmental research and public health

    2021  Volume 18, Issue 7

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Anxiety ; COVID-19 ; Child ; Child, Preschool ; Humans ; Mental Health ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18073432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disparities in patient-resident physician communication and counseling: A multi-perspective exploratory qualitative study.

    Merchant, Asma Altaf Hussain / Shaikh, Namra Qadeer / Afzal, Noreen / Noorali, Ali Aahil / Abdul Rahim, Komal / Ahmad, Rida / Ahmer, Areesha / Khan, Adnan Ali / Bakhshi, Saqib Kamran / Mahmood, Saad Bin Zafar / Lakhdir, Maryam Pyar Ali / Khan, Muhammad Rizwan / Tariq, Muhammad / Haider, Adil H

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0288549

    Abstract: Effective communication between physicians and patients plays an integral role in clinical care. Gaps in a physician's ability to ensure effective communication, especially with patients from diverse backgrounds, are known causes of medical errors. This ... ...

    Abstract Effective communication between physicians and patients plays an integral role in clinical care. Gaps in a physician's ability to ensure effective communication, especially with patients from diverse backgrounds, are known causes of medical errors. This study explores the potential biases and disparities in patient-resident communication, which may influence a patient's quality of care. This exploratory qualitative study was conducted at the largest academic medical center in Pakistan. Purposive sampling was used to approach participants from surgery, medicine, obstetrics and gynecology, pediatrics and family medicine. Faculty, fellows and residents working in these departments and medical students in their fourth and fifth years of undergraduate education with prior experience of at least one month in these specialties during their clinical rotations were included. Focus group discussions (FGDs) lasting 45-60 minutes were conducted with each cohort of healthcare professionals separately, using a semi-structured interview guide. Sixty participants (19 males and 41 females, mean age: 32.9, SD: 10.9) took part in the study. Thematic analysis revealed five major themes. Four themes focused on residents' biases and patient disparities hindering patient-resident communication: (1) patient-resident gender discordance (2) ethnicity and language barriers, (3) differing social class of the patient, and (4) challenging patient-resident interactions (patients resistant to treatment, exceedingly inquisitive and those with multiple attendants, etc.). The fifth theme identified the need for a communication skills curriculum in postgraduate medical education. Opposite gender and discordant socioeconomic/cultural backgrounds of patients pose a challenge to effective patient-physician communication. Self-identification and awareness of residents' biases when interacting with patients can ensure their active elimination and improve their communication skills. Integrating these components in a standardized curriculum within postgraduate programs can enable resident-physicians to provide the same level of care and communicate more efficiently with patients of all backgrounds.
    MeSH term(s) Male ; Female ; Humans ; Child ; Adult ; Internship and Residency ; Physician-Patient Relations ; Curriculum ; Counseling ; Physicians ; Communication
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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