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  1. Article ; Online: Development of green micellar HPLC-DAD method for simultaneous determination of some sulbactam combinations used in COVID-19 regimen.

    Ragab, Gamal H / Saleh, Hanaa M / Abdulla, Nermeen M / Bahgat, Eman A

    BMC chemistry

    2023  Volume 17, Issue 1, Page(s) 94

    Abstract: In a new attempt to separate some sulbactam combinations by green chemical method we came up with this research in which an ecofriendly, green, sustainable and selective method was established for separation of four antibiotics, namely, cefoperazone (CFP) ...

    Abstract In a new attempt to separate some sulbactam combinations by green chemical method we came up with this research in which an ecofriendly, green, sustainable and selective method was established for separation of four antibiotics, namely, cefoperazone (CFP), cefixime (CFX), ampicillin (AMP) and sulbactam (SLB). No organic solvents were used in the composition of the mobile phase as it was replaced by mixing two surfactants together, sodium dodecyl sulfate (SDS) and polyoxyethylene-23-lauryl ether (Brij-35). Effect of varying the concentrations of the two surfactants on chromatographic separation was studied. Optimum separation was maintained using a mobile phase consisting of 0.01 mol/L SDS, 0.03 mol/L Brij-35, 0.4% Tri-ethylamine (TEA) and pH of 2.8 adjusted by using 1 M ortho-phosphoric acid on reversed phase Isère C
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-023-01006-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Green Spectrophotometric Determination of Two Cephalosporin Drugs Used in COVID-19 Regimen Through Silver Nanoparticle Synthesis.

    Saleh, Hanaa M / Ragab, Gamal H / Abdulla, Nermeen M / Bahgat, Eman A

    Journal of AOAC International

    2023  Volume 106, Issue 3, Page(s) 613–623

    Abstract: Background: Cefixime trihydrate (CFX) and cefuroxime axetil (CFU) are antibacterial drugs. They are widely used in the treatment of bacterial infection and recently in COVID-19 treatment.: Objective: In this article, the two antibacterial drugs, CFX ... ...

    Abstract Background: Cefixime trihydrate (CFX) and cefuroxime axetil (CFU) are antibacterial drugs. They are widely used in the treatment of bacterial infection and recently in COVID-19 treatment.
    Objective: In this article, the two antibacterial drugs, CFX and CFU, were determined by a new simple, sensitive, effective, and green spectrophotometric method via reaction with silver nitrate (AgNO3).
    Methods: The reaction was based on reduction of AgNO3 by the cited drugs to silver nanoparticles (Ag-NPs) in the presence of polyvinylpyrrolidine (PVP) as stabilizing agent. Very intense surface plasmon resonance peaks were obtained at 435 nm for CFX and CFU that allow quantitative determination of the drugs.
    Results: The calibration curves were linear with concentration ranges of 0.2-1.4 μg/mL and 0.3-2.1 μg/mL for CFX and CFU, respectively. Validation of the proposed method has been done according to ICH (International Conference of Harmonization) guidelines; the method was verified on the Green Analytical Procedure Index and Analytical Greenness metric approach (AGREE) in regard to its greenness and was found to be an excellent green alternative method.
    Conclusion: A very sensitive and green spectrophotometric method was developed for determination of CFX and CFU in pure and dosage form.
    Highlight: The developed method not previously reported for simultaneous determination of CFX and CFU.
    MeSH term(s) Humans ; Cephalosporins ; Metal Nanoparticles ; COVID-19 Drug Treatment ; COVID-19 ; Silver ; Anti-Bacterial Agents ; Monobactams
    Chemical Substances Cephalosporins ; Silver (3M4G523W1G) ; Anti-Bacterial Agents ; Monobactams
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    DOI 10.1093/jaoacint/qsad014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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