Article ; Online: In vitro Sensitivity of Different Brands of Antiamoebic Drugs (Metronidazole Tablets) Against Clinical Isolates of Entamoeba histolytica in Bangladesh
Journal of Biological Sciences, Vol 8, Iss 5, Pp 925-
2008 Volume 929
Abstract: The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and ... ...
| Abstract | The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and small pharmaceuticals according to their business. The parasite count was adjusted to 3x10 6 parasites mL -1 in a medium. In vitro drug sensitivity assay of the samples was carried out by using microtiter plates after treatment with different concentrations of metronidazoles. The viable parasites were counted by haemocytometer. No statistical significance was observed in terms of viable parasites with the metronidazole tablets from three big pharmaceuticals at the concentration of 2.3, 3.5 and 4.6 μM when compared with the standard metronidazole. We conclude that brands from some big pharmaceuticals showed in vitro sensitivity against E. histolytica . |
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| Keywords | Amoebiasis ; metronidazole ; Entamoeba histolytica ; drug resistance ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences |
| Language | English |
| Publishing date | 2008-01-01T00:00:00Z |
| Publisher | Asian Network for Scientific Information |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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