Article ; Online: Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects.
2023 Volume 2023, Page(s) 8822205
Abstract: Background: Sex and gender have a large impact in human health and disease prediction. According to genomic/genetics, men differ from women by a limited number of genes in Y chromosome, while the phenotypes of the 2 sexes differ markedly.: Methods: ... ...
| Abstract | Background: Sex and gender have a large impact in human health and disease prediction. According to genomic/genetics, men differ from women by a limited number of genes in Y chromosome, while the phenotypes of the 2 sexes differ markedly. Methods: In this study, serum samples from six healthy Bahraini men and women were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Bioinformatics databases and tools were used for protein/peptide (PPs) identification and gene localization. The PPs that differed significantly ( Results: Revealed 20 PPs, 11 were upregulated in women with very high FC (up to 8 folds), and 9 were upregulated in men but with much lower FC. The PPs are encoded by genes located in autosomal chromosomes, indicative of sex-biased gene expression. The only PP related to sex, the sex hormone-binding globulin, was upregulated in women. The remaining PPs were involved in immunity, lipid metabolism, gene expression, connective tissue, and others, with some overlap in function. Conclusions: The upregulated PPs in men or women are mostly reflecting the functon or risk/protection provided by the PPs to the specific sex, e.g., Apo-B100 of LDLC. Finally, the basis of sex-biased gene expression and sex phenotypic differences needs further investigation. |
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| MeSH term(s) | Male ; Humans ; Female ; Chromatography, Liquid ; Healthy Volunteers ; Tandem Mass Spectrometry ; Y Chromosome ; Genome | |||||
| Language | English | |||||
| Publishing date | 2023-03-11 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2412681-0 | |||||
| ISSN | 1469-5073 ; 0016-6723 | |||||
| ISSN (online) | 1469-5073 | |||||
| ISSN | 0016-6723 | |||||
| DOI | 10.1155/2023/8822205 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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