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Article: Evaluation of cardiac energetics by non-invasive

Abdurrachim, Desiree / Prompers, Jeanine J

Biochimica et biophysica acta. Molecular basis of disease

2017 Volume 1864, Issue 5 Pt B, Page(s) 1939–1948

Abstract: Alterations in myocardial energy metabolism have been implicated in the pathophysiology of cardiac diseases such as heart failure and diabetic cardiomyopathy. ...

Abstract	Alterations in myocardial energy metabolism have been implicated in the pathophysiology of cardiac diseases such as heart failure and diabetic cardiomyopathy.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Biomarkers/metabolism ; Creatine Kinase/metabolism ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/physiopathology ; Energy Metabolism ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Magnetic Resonance Spectroscopy/methods ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/physiopathology ; Myocardium/metabolism ; Phosphocreatine/metabolism ; Phosphorus Isotopes
Chemical Substances	Biomarkers ; Phosphorus Isotopes ; Phosphocreatine (020IUV4N33) ; Adenosine Triphosphate (8L70Q75FXE) ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2017-11-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0925-4439 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0925-4439 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 1874-9399
DOI	10.1016/j.bbadis.2017.11.013
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Article ; Online: Leukotriene B4 receptor 1 (BLT1) does not mediate disease progression in a mouse model of liver fibrosis.

Coyne, Erin / Nie, Yilin / Abdurrachim, Desiree / Ong, Charlene Lin Zhi / Zhou, Yongqi / Ali, Asad Abu Bakar / Meyers, Stacey / Grein, Jeff / Blumenschein, Wendy / Gongol, Brendan / Liu, Yang / Hugelshofer, Cedric Lorenz / Carballo-Jane, Ester / Talukdar, Saswata

The Biochemical journal

2023

Abstract: MASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) is a potent pro-inflammatory chemoattractant that drives ... ...

Abstract	MASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) is a potent pro-inflammatory chemoattractant that drives macrophage and neutrophil chemotaxis, and genetic loss or inhibition of its high affinity receptor, leukotriene B4 receptor 1 (BLT1), results in improved insulin sensitivity and decreased hepatic steatosis. To validate the therapeutic efficacy of BLT1 inhibition in an inflammatory and pro-fibrotic mouse model of MASH and fibrosis, mice were challenged with a choline-deficient, L-amino acid defined high fat diet and treated with a BLT1 antagonist at 30 or 90 mg/kg for 8 weeks. Liver function, histology, and gene expression were evaluated at the end of the study. Treatment with the BLT1 antagonist significantly reduced plasma lipids and liver steatosis but had no impact on liver injury biomarkers or histological endpoints such as inflammation, ballooning, or fibrosis compared to control. Artificial intelligence-powered digital pathology analysis revealed a significant reduction in steatosis co-localized fibrosis in livers treated with the BLT1 antagonist. Liver RNA-seq and pathway analyses revealed significant changes in fatty acid, arachidonic acid, and eicosanoid metabolic pathways with BLT1 antagonist treatment, however, these changes were not sufficient to impact inflammation and fibrosis endpoints. Targeting this LTB4-BLT1 axis with a small molecule inhibitor in animal models of chronic liver disease should be considered with caution, and additional studies are warranted to understand the mechanistic nuances of BLT1 inhibition in the context of MASH and liver fibrosis.
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2969-5
ISSN	1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
ISSN (online)	1470-8728
ISSN	0006-2936 ; 0306-3275 ; 0264-6021
DOI	10.1042/BCJ20230422
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Article ; Online: Single dose of empagliflozin increases in vivo cardiac energy status in diabetic db/db mice.

Abdurrachim, Desiree / Manders, Emmy / Nicolay, Klaas / Mayoux, Eric / Prompers, Jeanine J

Cardiovascular research

2018 Volume 114, Issue 14, Page(s) 1843–1844

MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Benzhydryl Compounds/administration & dosage ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus/diagnostic imaging ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Disease Models, Animal ; Energy Metabolism/drug effects ; Glucosides/administration & dosage ; Ketones/blood ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Phosphocreatine/analogs & derivatives ; Phosphocreatine/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/administration & dosage ; Ventricular Function/drug effects
Chemical Substances	Benzhydryl Compounds ; Blood Glucose ; Glucosides ; Ketones ; Sodium-Glucose Transporter 2 Inhibitors ; Phosphocreatine (020IUV4N33) ; phosphocreatinine (5786-71-0) ; Adenosine Triphosphate (8L70Q75FXE) ; empagliflozin (HDC1R2M35U)
Language	English
Publishing date	2018-10-08
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvy246
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Article ; Online: A new hyperpolarized

Abdurrachim, Desiree / Woo, Chern Chiuh / Teo, Xing Qi / Chan, Wei Xin / Radda, George K / Lee, Philip Teck Hock

Scientific reports

2019 Volume 9, Issue 1, Page(s) 5532

Abstract: Emerging studies have recently shown the potential importance of ketone bodies in cardio-metabolic health. However, techniques to determine myocardial ketone body utilization in vivo are lacking. In this work, we developed a novel method to assess ... ...

Abstract	Emerging studies have recently shown the potential importance of ketone bodies in cardio-metabolic health. However, techniques to determine myocardial ketone body utilization in vivo are lacking. In this work, we developed a novel method to assess myocardial ketone body utilization in vivo using hyperpolarized [3-
MeSH term(s)	Acetoacetates/analysis ; Animals ; Carbon-13 Magnetic Resonance Spectroscopy ; Cardiomegaly/diagnostic imaging ; Cardiomegaly/metabolism ; Diabetes Mellitus, Experimental/diagnostic imaging ; Diabetes Mellitus, Experimental/physiopathology ; Ketones/chemistry ; Magnetic Resonance Imaging, Cine ; Male ; Myocardium/chemistry ; Oxidation-Reduction ; Rats ; Stroke Volume
Chemical Substances	Acetoacetates ; Ketones ; acetoacetic acid (4ZI204Y1MC)
Language	English
Publishing date	2019-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-39378-w
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Article ; Online: Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized

Abdurrachim, Desiree / Teo, Xing Qi / Woo, Chern Chiuh / Ong, Sing Yee / Salleh, Nurul Farhana / Lalic, Janise / Tan, Ru-San / Lee, Philip Teck Hock

Diabetes, obesity & metabolism

2019 Volume 21, Issue 4, Page(s) 949–960

Abstract: Aim: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats.: Materials and methods: Diabetic GK rats were fed with KD ...

Abstract	Aim: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats. Materials and methods: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and Results: KD lowered blood glucose, triglyceride and insulin levels while increasing blood ketone body levels. In KD-fed diabetic rats, myocardial ketone body and glucose oxidation were lower than in chow-fed diabetic rats, while myocardial glycolysis and short-chain fatty acid oxidation were unaltered. Dobutamine stress revealed an increased cardiac preload and reduced cardiac compliance in KD-fed diabetic rats. Dobutamine-induced stimulation of myocardial glycolysis was more enhanced in KD-fed diabetic rats than in chow-fed diabetic rats, which was potentially facilitated via an upregulation in basal expression of proteins involved in glucose transport and glycolysis in the hearts of KD-fed rats. The metabolic profile induced by KD was accompanied by cardiac hypertrophy, a trend for increased myocardial lipid and collagen content, and an increased marker of oxidative stress. Conclusion: KD seems to exacerbate diabetic cardiomyopathy in GK rats, which may be associated with maladaptive cardiac metabolic modulation and lipotoxicity.
MeSH term(s)	Acetoacetates ; Animals ; Blood Glucose/metabolism ; Butyrates ; Carbon-13 Magnetic Resonance Spectroscopy ; Cardiotonic Agents ; Diabetes Mellitus/metabolism ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Diet, Carbohydrate-Restricted ; Diet, Ketogenic ; Diet, Protein-Restricted ; Dobutamine ; Fatty Acids, Volatile/metabolism ; Glucose/metabolism ; Glycolysis ; Insulin/metabolism ; Ketone Bodies/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Pyruvic Acid ; Rats ; Triglycerides/metabolism
Chemical Substances	Acetoacetates ; Blood Glucose ; Butyrates ; Cardiotonic Agents ; Fatty Acids, Volatile ; Insulin ; Ketone Bodies ; Triglycerides ; Dobutamine (3S12J47372) ; acetoacetic acid (4ZI204Y1MC) ; Pyruvic Acid (8558G7RUTR) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2019-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.13608
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Article ; Online: Empagliflozin reduces myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized

Abdurrachim, Desiree / Teo, Xing Qi / Woo, Chern Chiuh / Chan, Wei Xin / Lalic, Janise / Lam, Carolyn S P / Lee, Philip Teck Hock

Diabetes, obesity & metabolism

2018 Volume 21, Issue 2, Page(s) 357–365

Abstract: Aim: To investigate the effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on myocardial ketone body utilization in diabetic, obese rats with spontaneously hypertensive heart failure (SHHF), after 6 months of treatment.: Materials ... ...

Abstract	Aim: To investigate the effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on myocardial ketone body utilization in diabetic, obese rats with spontaneously hypertensive heart failure (SHHF), after 6 months of treatment. Materials and methods: Myocardial ketone body utilization was measured in vivo real time using a novel ketone probe (hyperpolarized [3- Results: At baseline, myocardial ketone and glucose utilization were both higher in SHHF compared with control rats. Six months of empagliflozin treatment in SHHF rats was associated with less obesity, lower blood pressure, reduced blood glucose and insulin levels, and increased fasting blood β-hydroxybutyrate levels, as expected. Contrary to the hypothesis, myocardial ketone body utilization was lower in empagliflozin-treated SHHF rats, while glucose utilization and cardiac function were unaltered and hepatic congestion was reduced, compared with vehicle-treated SHHF rats. Conclusions: In diabetic hypertensive heart disease, empagliflozin reduces afterload without altering myocardial function and glucose utilization in the face of falling blood glucose levels, but does not enhance myocardial ketone utilization despite increased circulating levels.
MeSH term(s)	Animals ; Benzhydryl Compounds/therapeutic use ; Blood Pressure/drug effects ; Carbon-13 Magnetic Resonance Spectroscopy/methods ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/diagnosis ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/pathology ; Diabetic Angiopathies/prevention & control ; Glucose/metabolism ; Glucosides/therapeutic use ; Heart/diagnostic imaging ; Ketones/metabolism ; Male ; Myocardium/chemistry ; Myocardium/metabolism ; Obesity/complications ; Obesity/diagnosis ; Obesity/metabolism ; Obesity/pathology ; Rats ; Rats, Inbred SHR ; Rats, Sprague-Dawley ; Weight Gain/drug effects
Chemical Substances	Benzhydryl Compounds ; Glucosides ; Ketones ; empagliflozin (HDC1R2M35U) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.13536
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Article ; Online: Dexamethasone inhibits regeneration and causes ventricular aneurysm in the neonatal porcine heart after myocardial infarction.

Tao, Zhonghao / Loo, Szejie / Su, Liping / Abdurrachim, Desiree / Lalic, Janise / Lee, Teck Hock / Chen, Xin / Tan, Ru-San / Zhang, Jianyi / Ye, Lei

Journal of molecular and cellular cardiology

2020 Volume 144, Page(s) 15–23

Abstract: Aims: Recently, we demonstrated that the hearts of neonatal pigs (2-day old) have regenerative capacity, likely driven by cardiac myocyte division, but this potential is lost immediately after postnatal day 3. However, it is unknown if corticosteroid, a ...

Abstract	Aims: Recently, we demonstrated that the hearts of neonatal pigs (2-day old) have regenerative capacity, likely driven by cardiac myocyte division, but this potential is lost immediately after postnatal day 3. However, it is unknown if corticosteroid, a broad anti-inflammatory agent, will abrogate the regenerative capacity in the hearts of neonatal pigs. The aim of the current study is to evaluate the effect Dexamethasone (Dex), a broad anti-inflammatory agent, on heart regeneration, structure, and function of the neonatal pigs' post-myocardial infarction (MI). Methods and results: Dex (0.2 mg/kg/day) was injected intramuscularly into the neonatal pig (age: 2 days postnatal) during the first week post-MI. Myocardial scar and left ventricular function were determined by cardiac magnetic resonance (CMR) imaging. Bromodeoxyuridine (BrdU) pulse-chase labeling, histology, immunohistochemistry, and flow cytometry were performed to determine inflammatory cell infiltration, CM cytokinesis, and myocardial fibrosis. Dex injection during the first-week suppressed acute inflammation post-MI in the pig hearts. It inhibited BrdU incorporation to pig CMs and CM cytokinesis via inhibiting aurora-B protein expression which was associated with mature scar formation and thinned walls at the infarct site. CMR imaging showed Dex caused left ventricular aneurysm and poor ejection fraction. Conclusions: Dex inhibited CM cytokinesis and functional recovery and caused ventricular aneurysm in the hearts of 2-day old pigs post-MI.
MeSH term(s)	Animals ; Animals, Newborn ; Biomarkers ; Dexamethasone/adverse effects ; Dexamethasone/pharmacology ; Disease Management ; Disease Models, Animal ; Disease Susceptibility ; Echocardiography ; Fluorescent Antibody Technique ; Heart Aneurysm/diagnostic imaging ; Heart Aneurysm/etiology ; Heart Aneurysm/metabolism ; Heart Aneurysm/pathology ; Immunohistochemistry ; Magnetic Resonance Imaging ; Myocardial Infarction/complications ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Swine ; Ventricular Remodeling/drug effects ; Wound Healing/drug effects
Chemical Substances	Biomarkers ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2020.04.033
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Article ; Online: In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T.

Bakermans, Adrianus J / Abdurrachim, Desiree / Geraedts, Tom R / Houten, Sander M / Nicolay, Klaas / Prompers, Jeanine J

Magnetic resonance in medicine

2015 Volume 73, Issue 6, Page(s) 2069–2074

Abstract: Purpose: Proton magnetic resonance spectroscopy ((1) H-MRS) for quantitative in vivo assessment of mouse myocardial metabolism requires accurate acquisition timing to minimize motion artifacts and corrections for T1 -dependent partial saturation effects. ...

Abstract	Purpose: Proton magnetic resonance spectroscopy ((1) H-MRS) for quantitative in vivo assessment of mouse myocardial metabolism requires accurate acquisition timing to minimize motion artifacts and corrections for T1 -dependent partial saturation effects. In this study, mouse myocardial water and metabolite T1 relaxation time constants were quantified. Methods: Cardiac-triggered and respiratory-gated PRESS-localized (1) H-MRS was employed at 9.4 T to acquire signal from a 4-µL voxel in the septum of healthy mice (n = 10) while maintaining a steady state of magnetization using dummy scans during respiratory gates. Signal stability was assessed via standard deviations (SD) of zero-order phases and amplitudes of water spectra. Saturation-recovery experiments were performed to determine T1 values. Results: Phase SD did not vary for different repetition times (TR), and was 13.1° ± 4.5°. Maximal amplitude SD was 14.2% ± 5.1% at TR = 500 ms. Myocardial T1 values (mean ± SD) were quantified for water (1.71 ± 0.25 s), taurine (2.18 ± 0.62 s), trimethylamine from choline-containing compounds and carnitine (1.67 ± 0.25 s), creatine-methyl (1.34 ± 0.19 s), triglyceride-methylene (0.60 ± 0.15 s), and triglyceride-methyl (0.90 ± 0.17 s) protons. Conclusion: This work provides in vivo quantifications of proton T1 values for mouse myocardial water and metabolites at 9.4 T.
MeSH term(s)	Animals ; Cardiac-Gated Imaging Techniques ; Electrocardiography ; Mice ; Mice, Inbred C57BL ; Myocardium/metabolism ; Proton Magnetic Resonance Spectroscopy/methods ; Respiratory-Gated Imaging Techniques
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.25340
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Article ; Online: Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.

Tan, Shi Hua / Loo, Sze Jie / Gao, Yu / Tao, Zhong Hao / Su, Li Ping / Wang, Chen Xu / Zhang, Sophia L / Mu, Yong Hui / Cui, Ying Hua / Abdurrachim, Desiree / Wang, Wei Hsin / Lalic, Janise / Lim, Kheng Choon / Bu, Jun / Tan, Ru San / Lee, Teck Hock / Zhang, Jianyi / Ye, Lei

Theranostics

2021 Volume 11, Issue 16, Page(s) 7879–7895

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; China ; Disease Models, Animal ; Endothelial Cells/pathology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/therapy ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Regeneration ; Stem Cell Transplantation/methods ; Swine ; Thymosin/metabolism ; Thymosin/pharmacology ; Thymosin/physiology
Chemical Substances	thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8)
Language	English
Publishing date	2021-06-26
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.56757
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Article ; Online: High frame rate retrospectively triggered Cine MRI for assessment of murine diastolic function.

Coolen, Bram F / Abdurrachim, Desiree / Motaal, Abdallah G / Nicolay, Klaas / Prompers, Jeanine J / Strijkers, Gustav J

Magnetic resonance in medicine

2013 Volume 69, Issue 3, Page(s) 648–656

Abstract: To assess left ventricular (LV) diastolic function in mice with Cine MRI, a high frame rate (>60 frames per cardiac cycle) is required. For conventional electrocardiography-triggered Cine MRI, the frame rate is inversely proportional to the pulse ... ...

Abstract	To assess left ventricular (LV) diastolic function in mice with Cine MRI, a high frame rate (>60 frames per cardiac cycle) is required. For conventional electrocardiography-triggered Cine MRI, the frame rate is inversely proportional to the pulse repetition time (TR). However, TR cannot be lowered at will to increase the frame rate because of gradient hardware, spatial resolution, and signal-to-noise limitations. To overcome these limitations associated with electrocardiography-triggered Cine MRI, in this paper, we introduce a retrospectively triggered Cine MRI protocol capable of producing high-resolution high frame rate Cine MRI of the mouse heart for addressing left ventricular diastolic function. Simulations were performed to investigate the influence of MRI sequence parameters and the k-space filling trajectory in relation to the desired number of frames per cardiac cycle. An optimized protocol was applied in vivo and compared with electrocardiography-triggered Cine for which a high-frame rate could only be achieved by several interleaved acquisitions. Retrospective high frame rate Cine MRI proved superior to the interleaved electrocardiography-triggered protocols. High spatial-resolution Cine movies with frames rates up to 80 frames per cardiac cycle were obtained in 25 min. Analysis of left ventricular filling rate curves allowed accurate determination of early and late filling rates and revealed subtle impairments in left ventricular diastolic function of diabetic mice in comparison with nondiabetic mice.
MeSH term(s)	Algorithms ; Animals ; Cardiac-Gated Imaging Techniques/methods ; Diabetic Cardiomyopathies/complications ; Diabetic Cardiomyopathies/diagnosis ; Diabetic Cardiomyopathies/physiopathology ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging, Cine/methods ; Mice ; Mice, Inbred C57BL ; Reproducibility of Results ; Sensitivity and Specificity ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology
Language	English
Publishing date	2013-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.24287
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