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Article ; Online: Neurophysiological correlates of motor deficits in patients in Benign Epilepsy with Centro-Temporal Spikes.

Abe, Mitsunari

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2016 Volume 127, Issue 2, Page(s) 991–992

MeSH term(s)	Brain Waves/physiology ; Cortical Synchronization/physiology ; Epilepsy, Rolandic/diagnosis ; Epilepsy, Rolandic/physiopathology ; Female ; Humans ; Magnetoencephalography/methods ; Male ; Motor Cortex/physiopathology
Language	English
Publishing date	2016-02
Publishing country	Netherlands
Document type	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2015.10.002
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Article ; Online: A computational model based on corticospinal functional MRI revealed asymmetrically organized motor corticospinal networks in humans.

Takasawa, Eiji / Abe, Mitsunari / Chikuda, Hirotaka / Hanakawa, Takashi

Communications biology

2022 Volume 5, Issue 1, Page(s) 664

Abstract: Evolution of the direct, monosynaptic connection from the primary motor cortex to the spinal cord parallels acquisition of hand dexterity and lateralization of hand preference. In non-human mammals, the indirect, multi-synaptic connections between the ... ...

Abstract	Evolution of the direct, monosynaptic connection from the primary motor cortex to the spinal cord parallels acquisition of hand dexterity and lateralization of hand preference. In non-human mammals, the indirect, multi-synaptic connections between the bilateral primary motor cortices and the spinal cord also participates in controlling dexterous hand movement. However, it remains unknown how the direct and indirect corticospinal pathways work in concert to control unilateral hand movement with lateralized preference in humans. Here we demonstrated the asymmetric functional organization of the two corticospinal networks, by combining network modelling and simultaneous functional magnetic resonance imaging techniques of the brain and the spinal cord. Moreover, we also found that the degree of the involvement of the two corticospinal networks paralleled lateralization of hand preference. The present results pointed to the functionally lateralized motor nervous system that underlies the behavioral asymmetry of handedness in humans.
MeSH term(s)	Animals ; Brain ; Functional Laterality ; Hand ; Humans ; Magnetic Resonance Imaging ; Mammals ; Spinal Cord
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03615-2
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Article: Harmonizing multisite data with the ComBat method for enhanced Parkinson's disease diagnosis via DAT-SPECT.

Wakasugi, Noritaka / Takano, Harumasa / Abe, Mitsunari / Sawamoto, Nobukatsu / Murai, Toshiya / Mizuno, Toshiki / Matsuoka, Teruyuki / Yamakuni, Ryo / Yabe, Hirooki / Matsuda, Hiroshi / Hanakawa, Takashi

Frontiers in neurology

2024 Volume 15, Page(s) 1306546

Abstract: Background: Dopamine transporter single-photon emission computed tomography (DAT-SPECT) is a crucial tool for evaluating patients with Parkinson's disease (PD). However, its implication is limited by inter-site variability in large multisite clinical ... ...

Abstract	Background: Dopamine transporter single-photon emission computed tomography (DAT-SPECT) is a crucial tool for evaluating patients with Parkinson's disease (PD). However, its implication is limited by inter-site variability in large multisite clinical trials. To overcome the limitation, a conventional prospective correction method employs linear regression with phantom scanning, which is effective yet available only in a prospective manner. An alternative, although relatively underexplored, involves retrospective modeling using a statistical method known as "combatting batch effects when combining batches of gene expression microarray data" (ComBat). Methods: We analyzed DAT-SPECT-specific binding ratios (SBRs) derived from 72 healthy older adults and 81 patients with PD registered in four clinical sites. We applied both the prospective correction and the retrospective ComBat correction to the original SBRs. Next, we compared the performance of the original and two corrected SBRs to differentiate the PD patients from the healthy controls. Diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AUC-ROC). Results: The original SBRs were 6.13 ± 1.54 (mean ± standard deviation) and 2.03 ± 1.41 in the control and PD groups, respectively. After the prospective correction, the mean SBRs were 6.52 ± 1.06 and 2.40 ± 0.99 in the control and PD groups, respectively. After the retrospective ComBat correction, the SBRs were 5.25 ± 0.89 and 2.01 ± 0.73 in the control and PD groups, respectively, resulting in substantial changes in mean values with fewer variances. The original SBRs demonstrated fair performance in differentiating PD from controls (Hedges's Conclusion: Although we confirmed that SBRs fairly discriminated PD from healthy older adults without any correction, the correction methods improved their discrimination performance in a multisite setting. Our results support the utility of harmonization methods with ComBat for consolidating SBR-based diagnosis or stratification of PD in multisite studies. Nonetheless, given the substantial changes in the mean values of ComBat-corrected SBRs, caution is advised when interpreting them.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1306546
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Article ; Online: Abnormal motor cortical plasticity as a useful neurophysiological biomarker for Alzheimer's disease pathology.

Murakami, Takenobu / Abe, Mitsunari / Tiksnadi, Amanda / Nemoto, Ayaka / Futamura, Miyako / Yamakuni, Ryo / Kubo, Hitoshi / Kobayashi, Naoto / Ito, Hiroshi / Hanajima, Ritsuko / Hashimoto, Yasuhiro / Ugawa, Yoshikazu

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2024 Volume 158, Page(s) 170–179

Abstract: Objective: Amyloid-beta (Aβ) and tau accumulations impair long-term potentiation (LTP) induction in animal hippocampi. We investigated relationships between motor-cortical plasticity and biomarkers for Alzheimer's disease (AD) diagnosis in subjects with ...

Abstract	Objective: Amyloid-beta (Aβ) and tau accumulations impair long-term potentiation (LTP) induction in animal hippocampi. We investigated relationships between motor-cortical plasticity and biomarkers for Alzheimer's disease (AD) diagnosis in subjects with cognitive decline. Methods: Twenty-six consecutive subjects who complained of memory problems participated in this study. We applied transcranial quadripuse stimulation with an interstimulus interval of 5 ms (QPS5) to induce LTP-like plasticity. Motor-evoked potentials were recorded from the right first-dorsal interosseous muscle before and after QPS5. Cognitive functions, Aβ42 and tau levels in the cerebrospinal fluid (CSF) were measured. Amyloid positron-emission tomography (PET) with Results: QPS5-induced LTP-like plasticity positively correlated with cognitive scores. The degree of LTP-like plasticity negatively correlated with levels of CSF-tau, and the amount of amyloid-PET accumulation at the precuneus, and correlated with the CSF-Aβ42 level positively. In the amyloid-PET positive subjects, non-responder rate of QPS5 was higher than the CSF-tau positive rate. Conclusions: Findings suggest that QPS5-induced LTP-like plasticity is a functional biomarker of AD. QPS5 could detect abnormality at earlier stages than CSF-tau in the amyloid-PET positive subjects. Significance: Assessing motor-cortical plasticity could be a useful neurophysiological biomarker for AD pathology.
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Long-Term Potentiation/physiology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/cerebrospinal fluid ; Positron-Emission Tomography ; Biomarkers
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Biomarkers
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2023.12.131
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Article ; Online: Analysis of the Relationship Between Muscle Tones and Abnormal Postures in a Computational Model.

Omura, Yuichiro / Togo, Hiroki / Kaminishi, Kohei / Hasegawa, Tetsuya / Chiba, Ryosuke / Yozu, Arito / Takakusaki, Kaoru / Abe, Mitsunari / Takahashi, Yuji / Hanakawa, Takashi / Ota, Jun

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–4

Abstract: Patients with Parkinson's disease (PD), a neurodegenerative disorder, exhibit a characteristic posture known as a forward flexed posture. Increased muscle tone is suggested as a possible cause of this abnormal posture. For further analysis, it is ... ...

Abstract	Patients with Parkinson's disease (PD), a neurodegenerative disorder, exhibit a characteristic posture known as a forward flexed posture. Increased muscle tone is suggested as a possible cause of this abnormal posture. For further analysis, it is necessary to measure muscle tone, but the experimental measurement of muscle tone during standing is challenging. The aim of this study was to examine the hypothesis that "In patients with PD, abnormal postures are those with a small sway at increased muscle tones" using a computational model. The muscle tones of various magnitudes were estimated using the computational model and standing data of patients with PD. The postures with small sway at the estimated muscle tones were then calculated through an optimization method. The postures and sway calculated using the computational model were compared to those of patients with PD. The results showed that the differences in posture and sway between the simulation and experimental results were small at higher muscle tones compared to those considered plausible in healthy subjects by the simulations. This simulation result indicates that the reproduced sway at high muscle tones is similar to that of actual patients with PD and that the reproduced postures with small sway locally at high muscle tones in the simulations are similar to those of patients with PD. The result is consistent with the hypothesis, reinforcing the hypothesis.Clinical relevance- This study implies that improving the increased muscle tone in patients with PD may lead to an improved abnormal posture.
MeSH term(s)	Humans ; Muscle Tonus ; Parkinson Disease ; Posture/physiology
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10341129
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Article: Correction: Hoshi et al. High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease.

Hoshi, Kyoka / Kanno, Mayumi / Abe, Mitsunari / Murakami, Takenobu / Ugawa, Yoshikazu / Goto, Aya / Honda, Takashi / Saito, Takashi / Saido, Takaomi C / Yamaguchi, Yoshiki / Miyajima, Masakazu / Furukawa, Katsutoshi / Arai, Hiroyuki / Hashimoto, Yasuhiro

Metabolites

2023 Volume 13, Issue 6

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060685
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Article ; Online: Quadripulse transcranial magnetic stimulation inducing long-term depression in healthy subjects may increase seizure risk in some patients with intractable epilepsy.

Nakatani-Enomoto, Setsu / Hanajima, Ritstuko / Hamada, Masashi / Matsumoto, Hideyuki / Terao, Yasuo / Jun Groiss, Stefan / Murakami, Takenobu / Abe, Mitsunari / Enomoto, Hiroyuki / Kawai, Kensuke / Kan, Rumiko / Niwa, Shin-Ichi / Yabe, Hirooki / Ugawa, Yoshikazu

Clinical neurophysiology practice

2023 Volume 8, Page(s) 137–142

Abstract: Objective: This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy.: Methods: Four patients were included in the study. QPS-50, which induces long-term ... ...

Abstract	Objective: This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy. Methods: Four patients were included in the study. QPS-50, which induces long-term depression in healthy subjects, was administered for 30 min on a weekly basis for 12 weeks. Patients' clinical symptoms and physiological parameters were evaluated before, during, and after the repeated QPS-50 period. We performed two control experiments: the effect in MEP (Motor evoked potential) size after a single QPS-50 session with a round coil in nine healthy volunteers, and a follow-up study of physiological parameters by repeated QPS-50 sessions in four other healthy participants. Results: Motor threshold (MT) decreased during the repeated QPS-50 sessions in all patients. Epileptic symptoms worsened in two patients, whereas no clinical worsening was observed in the other two patients. In contrast, MT remained unaffected for 12 weeks in all healthy volunteers. Conclusions: QPS-50 may not be effective as a treatment for intractable epilepsy. Significance: In intractable epilepsy patients, administering repeated QPS-50 may paradoxically render the motor cortex more excitable, probably because of abnormal inhibitory control within the epileptic cortex. The possibility of clinical aggravation should be seriously considered when treating intractable epilepsy patients with non-invasive stimulation methods.
Language	English
Publishing date	2023-07-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2467-981X
ISSN (online)	2467-981X
DOI	10.1016/j.cnp.2023.07.001
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Article: Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones.

Omura, Yuichiro / Togo, Hiroki / Kaminishi, Kohei / Hasegawa, Tetsuya / Chiba, Ryosuke / Yozu, Arito / Takakusaki, Kaoru / Abe, Mitsunari / Takahashi, Yuji / Hanakawa, Takashi / Ota, Jun

Frontiers in computational neuroscience

2023 Volume 17, Page(s) 1218707

Abstract: Patients with Parkinson's disease (PD) exhibit distinct abnormal postures, including neck-down, stooped postures, and Pisa syndrome, collectively termed "abnormal posture" henceforth. In the previous study, when assuming an upright stance, patients with ... ...

Abstract	Patients with Parkinson's disease (PD) exhibit distinct abnormal postures, including neck-down, stooped postures, and Pisa syndrome, collectively termed "abnormal posture" henceforth. In the previous study, when assuming an upright stance, patients with PD exhibit heightened instability in contrast to healthy individuals with disturbance, implying that abnormal postures serve as compensatory mechanisms to mitigate sway during static standing. However, limited studies have explored the relationship between abnormal posture and sway in the context of static standing. Increased muscle tone (i.e., constant muscle activity against the gravity) has been proposed as an underlying reason for abnormal postures. Therefore, this study aimed to investigate the following hypothesis: abnormal posture with increased muscle tone leads to a smaller sway compared with that in other postures, including normal upright standing, under the sway minimization criterion. To investigate the hypothesis, we assessed the sway in multiple postures, which is determined by joint angles, including cases with bended hip joints. Our approach involved conducting forward dynamics simulations using a computational model comprising a musculoskeletal model and a neural controller model. The neural controller model proposed integrates two types of control mechanisms: feedforward control (representing muscle tone as a vector) and feedback control using proprioceptive and vestibular sensory information. An optimization was performed to determine the posture of the musculoskeletal model and the accompanied parameters of the neural controller model for each of the given muscle tone vector to minimize sway. The optimized postures to minimize sway for the optimal muscle tone vector of patients with PD were compared to the actual postures observed in these patients. The results revealed that on average, the joint-angle differences between these postures was <4°, which was less than one-tenth of the typical joint range of motion. These results suggest that patients with PD exhibit less sway in the abnormal posture than in other postures. Thus, adopting an abnormal posture with increased muscle tone can potentially serve as a valid strategy for minimizing sway in patients with PD.
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452964-3
ISSN	1662-5188
ISSN	1662-5188
DOI	10.3389/fncom.2023.1218707
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Article ; Online: Contribution of amyloid and putative Lewy body pathologies in neuropsychiatric symptoms.

Matsuoka, Teruyuki / Narumoto, Jin / Morii-Kitani, Fukiko / Niwa, Fumitoshi / Mizuno, Toshiki / Abe, Mitsunari / Takano, Harumasa / Wakasugi, Noritaka / Shima, Atsushi / Sawamoto, Nobukatsu / Ito, Hiroshi / Toda, Wataru / Hanakawa, Takashi

International journal of geriatric psychiatry

2023 Volume 38, Issue 9, Page(s) e5993

Abstract: Objectives: Neuropsychiatric symptom could be useful for detecting patients with prodromal dementia. Similarities and differences in the NPSs between preclinical/prodromal Alzheimer's disease (AD) and prodromal Parkinson's disease dementia (PDD)/ ... ...

Abstract	Objectives: Neuropsychiatric symptom could be useful for detecting patients with prodromal dementia. Similarities and differences in the NPSs between preclinical/prodromal Alzheimer's disease (AD) and prodromal Parkinson's disease dementia (PDD)/Dementia with Lewy bodies (DLB) may exist. This study aimed to compare the NPSs between preclinical/prodromal AD and prodromal PDD/DLB. Methods: One hundred and three participants without dementia aged ≥50 years were included in this study. The mild behavioral impairment (MBI) total score and the MBI scores for each domain were calculated using the neuropsychiatric inventory questionnaire score. Participants were divided into five groups based on the clinical diagnosis by neurologists or psychiatrists in each institution based on the results of the amyloid positron emission tomography and dopamine transporter single photon emission computed tomography (DAT-SPECT): Group 1: amyloid-positive and abnormal DAT-SPECT, Group 2: amyloid-negative and abnormal DAT-SPECT, Group 3: amyloid-positive and normal DAT-SPECT, Group 4: mild cognitive impairment unlikely due to AD with normal DAT-SPECT, and Group 5: cognitively normal with amyloid-negative and normal DAT-SPECT. Results: The MBI abnormal perception or thought content scores were significantly higher in Group 1 than Group 5 (Bonferroni-corrected p = 0.012). The MBI total score (Bonferroni-corrected p = 0.011) and MBI impulse dyscontrol score (Bonferroni-corrected p = 0.033) in Group 4 were significantly higher than those in Group 5. Conclusion: The presence of both amyloid and putative Lewy body pathologies may be associated with psychotic symptoms.
MeSH term(s)	Humans ; Lewy Bodies ; Dementia ; Parkinson Disease ; Alzheimer Disease/diagnostic imaging ; Cognitive Dysfunction
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5993
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Article ; Online: Reduced pineal volume may be associated with amyloid pathology and not with putative Lewy body pathology.

Matsuoka, Teruyuki / Oya, Nozomu / Narumoto, Jin / Kitani-Morii, Fukiko / Niwa, Fumitoshi / Mizuno, Toshiki / Akazawa, Kentaro / Yamada, Kei / Abe, Mitsunari / Takano, Harumasa / Wakasugi, Noritaka / Shima, Atsushi / Sawamoto, Nobukatsu / Ito, Hiroshi / Toda, Wataru / Hanakawa, Takashi

Journal of neurology, neurosurgery, and psychiatry

2023

Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Letter
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2023-332252
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