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Article: [Redo Mitral Valve Replacement for Prosthetic Valve Endocarditis in a Patient with End Stage Colon Cancer:Report of a Case].

Kondo, Taichi / Hirai, Yuuki / Abe, Takayuki / Orii, Kouan

Kyobu geka. The Japanese journal of thoracic surgery

2024 Volume 77, Issue 5, Page(s) 361–363

Abstract: Prosthetic valve endocarditis (PVE) is rare but devastating. A 69-year old man admitted for active endocarditis caused by Streptococcus pasteurianus. Antibiotic therapy was started, but the patient developed bowel obstruction owing to cancer with ... ...

Abstract	Prosthetic valve endocarditis (PVE) is rare but devastating. A 69-year old man admitted for active endocarditis caused by Streptococcus pasteurianus. Antibiotic therapy was started, but the patient developed bowel obstruction owing to cancer with multiple liver metastases, and underwent transverse colectomy. Following colectomy, antibiotic agent was given continued for 4 weeks after and mitral valve replacement( MVR) using a bioprosthesis was performed. Oral antibiotic therapy was continued for six months after MVR to avoid infection recurrence. One year after MVR, the size of multiple liver metastases increased despite oral anticancer drugs administration. A totally implantable central venous access port( CV port) was placed and intravenous chemotherapy was started for progressive metastatic colorectal cancer. But the CV port was removed due to device infection caused by multiple drug resistant Staphyrococcus lugdunensis one month later, but the patient developed prosthetic valve endocarditits( PVE) due to the same bacterium, that caused valve stenosis. Redo MVR was indicated because of progressive dyspnea and uncontrollable fever. The patient was discharged one month after redo MVR, but suffered carcinomatous peritonitis, and eventually died eight months post-discharge. Chemotherapy needs caution because of potential risk of PVE in patients with prosthetic valves, especially for those with a history of infectious endocarditis.
MeSH term(s)	Humans ; Male ; Aged ; Mitral Valve/surgery ; Colonic Neoplasms/surgery ; Colonic Neoplasms/complications ; Heart Valve Prosthesis/adverse effects ; Fatal Outcome ; Reoperation ; Prosthesis-Related Infections/surgery ; Prosthesis-Related Infections/etiology ; Heart Valve Prosthesis Implantation ; Endocarditis, Bacterial/surgery
Language	Japanese
Publishing date	2024-05-13
Publishing country	Japan
Document type	Case Reports ; Journal Article ; English Abstract
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Article ; Online: B

Abe, Takayuki

Acta radiologica (Stockholm, Sweden : 1987)

2016 Volume 57, Issue 11, Page(s) 1289–1296

Abstract: Background Magnetic resonance imaging (MRI) using a 3-T MRI scanner is now widely used for clinical examinations. However, ... ...

Abstract	Background Magnetic resonance imaging (MRI) using a 3-T MRI scanner is now widely used for clinical examinations. However, B
MeSH term(s)	Adult ; Artifacts ; Breast/anatomy & histology ; Breast/diagnostic imaging ; Breast/surgery ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Mastectomy ; Middle Aged ; Patient Simulation ; Reference Values ; Reproducibility of Results ; Sensitivity and Specificity ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185115585616
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Article: [Anomalous Origin of Right Coronary Artery with Intramural Course, Aortic Valve Stenosis and Coronary Artery Stenosis:Report of a Case].

Kawasaki, Kyohei / Kondo, Taichi / Wakatabe, Makoto / Abe, Takayuki / Orii, Kouan

Kyobu geka. The Japanese journal of thoracic surgery

2023 Volume 76, Issue 11, Page(s) 945–948

Abstract: Anomalous origin of the coronary artery is a rare congenital malformation that can cause myocardial ischemia and arrhythmia in patients with or without atherosclerotic lesions. We present a case of aortic stenosis (AS) and coronary artery stenosis ... ...

Abstract	Anomalous origin of the coronary artery is a rare congenital malformation that can cause myocardial ischemia and arrhythmia in patients with or without atherosclerotic lesions. We present a case of aortic stenosis (AS) and coronary artery stenosis complicated by anomalous origin of the right coronary artery (RCA) from the aortic valve sinus and its intramural course. The patient was a 66-year-old woman who was diagnosed with AS 4 years prior, and scheduled for surgery owing to gradual progression of stenosis. Preoperative coronary angiography revealed an abnormal origin of the RCA, and during the surgery, the RCA was found located within the aortic wall close to the aortotomy. Thus, bypass surgery was performed using a great saphenous vein, to prevent ischemia of the RCA territory. The patient had good intraoperative and postoperative course, and a coronary computed tomography scan clearly showed the reconstructed RCA.
MeSH term(s)	Aged ; Female ; Humans ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Coronary Angiography/adverse effects ; Coronary Stenosis ; Coronary Vessel Anomalies/complications ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/surgery ; Coronary Vessels/surgery ; Myocardial Ischemia/etiology ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2023-12-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Article ; Online: Modified ESR-based photosafety test (ESR-PT) detecting singlet oxygen and free radical formation.

Hinoshita, Masumi / Abe, Takayuki / Sato, Asako / Maeda, Yosuke / Takeyoshi, Masahiro

Journal of applied toxicology : JAT

2023 Volume 44, Issue 4, Page(s) 651–662

Abstract: The electron spin resonance-based photosafety test (ESR-PT) was modified using a new parameter, photoreactivity index (PRI), to detect singlet oxygen and free radical photoproducts simultaneously. With this modification, the modified ESR-PT is expected ... ...

Abstract	The electron spin resonance-based photosafety test (ESR-PT) was modified using a new parameter, photoreactivity index (PRI), to detect singlet oxygen and free radical photoproducts simultaneously. With this modification, the modified ESR-PT is expected to reduce the number of false negative results due to chemicals producing free radical photoproducts other than singlet oxygen. The assay performance of the modified ESR-PT was evaluated using 56 chemicals, including hydrophobic chemicals. When using the PRI cutoff value of 2.0 in the modified ESR-PT, the accuracy relative to photosafety reference data was 91.1%, and the applicability (100%) was better than the other non-animal photosafety test. Among the chemicals producing positive results, bithionol, fenticlor, and doxycycline HCl were considered positive based on the detection of free radical photoproducts, suggesting that these three chemicals may have phototoxic or photoallergic potential via radical reactions. Additionally, this finding demonstrated the fundamental advantage of the modified ESR-PT using ESR spectroscopy, which can detect radicals selectively and quantitatively. Accordingly, the new parameter PRI is effective for photosafety evaluations based on not only singlet oxygen but also free radical photoproducts generated from chemicals. Therefore, the modified ESR-PT has a great potential for a photosafety test method applicable to various chemicals.
MeSH term(s)	Humans ; Singlet Oxygen/chemistry ; Reactive Oxygen Species ; Dermatitis, Phototoxic ; Free Radicals/toxicity ; Electron Spin Resonance Spectroscopy ; Oxygen
Chemical Substances	Singlet Oxygen (17778-80-2) ; Reactive Oxygen Species ; Free Radicals ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4569
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Article: [Innate immune DNA sensing pathways].

Abe, Takayuki

Uirusu

2014 Volume 64, Issue 1, Page(s) 83–94

Abstract: How the cells triggers the induction of innate immune genes in response to nucleic acids derived from microbes, such as DNA viruses, intracellular bacteria, and parasites, or self DNA, has not been elucidated fully. We have previously shown that an ... ...

Abstract	How the cells triggers the induction of innate immune genes in response to nucleic acids derived from microbes, such as DNA viruses, intracellular bacteria, and parasites, or self DNA, has not been elucidated fully. We have previously shown that an endoplasmic reticulum (ER)-associated multiple transmembrane protein, so-called STING (stimulator of interferon genes), functions as an essential molecules for triggering DNA-mediated gene induction. STING may directly associate with stimulatory ligands, which include DNA, as well as with cyclic dinucleotides (CDNs), which are secreted by intracellular bacteria. After DNA or CDN stimulation, STING traffics with kinase TBK1 in an autophagic signaling complex, from ER to perinuclear endosomal compartments harboring IRF3 and NF-κB. STING may involve in autoinflammatory disease manifested by aberrant self-DNA. Understanding of STING function may conceivably lead to the development of potent adjuvants for vaccine development or conversely therapeutics that could control inflammation aggravated disease.
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Autophagy ; DNA/genetics ; DNA/immunology ; Drug Discovery ; Endoplasmic Reticulum/metabolism ; Endosomes/metabolism ; Humans ; Immunity, Innate/genetics ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/therapy ; Interferon Regulatory Factor-3/metabolism ; Interferons/genetics ; Membrane Proteins/physiology ; Mice ; NF-kappa B/metabolism ; Nucleotides, Cyclic ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Transcriptional Activation/genetics
Chemical Substances	IRF3 protein, human ; Interferon Regulatory Factor-3 ; Membrane Proteins ; NF-kappa B ; Nucleotides, Cyclic ; DNA (9007-49-2) ; Interferons (9008-11-1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1)
Language	Japanese
Publishing date	2014
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	603272-2
ISSN	0042-6857
ISSN	0042-6857
DOI	10.2222/jsv.64.83
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Article ; Online: False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine.

Hinoshita, Masumi / Abe, Takayuki / Sato, Asako / Maeda, Yosuke / Takeyoshi, Masahiro

The Journal of toxicological sciences

2022 Volume 47, Issue 12, Page(s) 503–506

Abstract: The electron spin resonance (ESR)-based photosafety test (ESR-PT) is a non-animal prediction test for photosafety evaluations that can be used even for hydrophobic chemicals; the method is based on the detection of singlet oxygen generation using ESR ... ...

Abstract	The electron spin resonance (ESR)-based photosafety test (ESR-PT) is a non-animal prediction test for photosafety evaluations that can be used even for hydrophobic chemicals; the method is based on the detection of singlet oxygen generation using ESR spectroscopy and showing high accuracy for compounds with known photosafety information. During the process of extending the application data for ESR-PT, we found three false-negative chemicals: bithionol, fenticlor and cilnidipine. These chemicals did not show the characteristic triplet signal of 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl (4-hydroxy-TEMPO), which is used as a classifier for positive or negative chemicals; instead, bithionol and fenticlor induced an apparent single peak signal with a g-value of 2.0048, while cilnidipine produced a small, fragmented signal. Bithionol and fenticlor reportedly induce free radicals, and positive phototoxic or photoallergic evidence have been reported. Although the small, fragmented signal observed for cilnidipine was confirmed to be identical to that of a phenylnitroxy radical by the computer simulation, the significance of this chemical for photosafety considerations may be low because cilnidipine has quite a low incidence of phototoxic or photoallergic reactions in humans. Accordingly, the current ESR-PT protocol should be improved to detect free radical photoproducts generated from chemicals such as bithionol and fenticlor, thereby helping to reduce false negatives in ESR-PT.
MeSH term(s)	Humans ; Bithionol ; Computer Simulation ; Chlorophenols ; Dermatitis, Photoallergic ; Dermatitis, Phototoxic
Chemical Substances	cilnidipine (97T5AZ1JIP) ; Bithionol (AMT77LS62O) ; fentichlor (97-24-5) ; Chlorophenols
Language	English
Publishing date	2022-11-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	770623-6
ISSN	1880-3989 ; 0388-1350
ISSN (online)	1880-3989
ISSN	0388-1350
DOI	10.2131/jts.47.503
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Article: Frequency-Selective Fat Suppression Radiofrequency Pulse Train to Remove Olefinic Fats.

Abe, Takayuki

Applied magnetic resonance

2013 Volume 44, Page(s) 1213–1221

Abstract: CHESS pulse can suppress the signal originating from aliphatic fat protons but cannot suppress the signal from olefinic fat protons, which is near the resonance frequency of water protons. Adipose tissue contains various fat species; aliphatic fat ... ...

Abstract	CHESS pulse can suppress the signal originating from aliphatic fat protons but cannot suppress the signal from olefinic fat protons, which is near the resonance frequency of water protons. Adipose tissue contains various fat species; aliphatic fat comprises about 90 % and olefinic fat about 10 % of adipose tissue. Thus, CHESS pulse cannot be used to suppress the signal from adipose tissue completely. The purpose of this study was to find a method to suppress the signal from adipose tissue completely. The Fatsat train pulse, created with an arbitrary flip angle and insensitive to B1 inhomogeneity, was used. Because B1 inhomogeneity is larger on higher field magnetic resonance imaging, the fat suppression radiofrequency pulse needs to be B1-insensitive. To investigate a percentage of olefinic fat in adipose tissues, the excitation frequency of the Fatsat train pulse was varied from -240 to +400 Hz and the images and fat-suppressed images were obtained. The presence of olefinic fat comprising about 10 % of abdominal adipose tissue was identified. The result agreed with some previous papers. Complete fat suppression could be achieved by partial (10 %) inversion of longitudinal aliphatic fat magnetization and by canceling out the two fat magnetizations. The flip angle was identified to about 95°. In conclusion, the cause that the signal from adipose tissues cannot be suppressed completely has been found. Improved images that signals from adipose tissues were suppressed completely have been demonstrated. This technique can also be applied to several pulse sequences.
Language	English
Publishing date	2013-07-19
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1480644-7
ISSN	1613-7507 ; 0937-9347
ISSN (online)	1613-7507
ISSN	0937-9347
DOI	10.1007/s00723-013-0474-6
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Article ; Online: Half radiofrequency pulse excitation with a dedicated prescan to correct eddy current effect and gradient delay.

Abe, Takayuki

Medical physics

2013 Volume 40, Issue 3, Page(s) 32304

Abstract: Purpose: To improve the slice profile of the half radiofrequency (RF) pulse excitation and image quality of ultrashort echo time (UTE) imaging by compensating for an eddy current effect.: Methods: The dedicated prescan has been developed to measure ... ...

Abstract	Purpose: To improve the slice profile of the half radiofrequency (RF) pulse excitation and image quality of ultrashort echo time (UTE) imaging by compensating for an eddy current effect. Methods: The dedicated prescan has been developed to measure the phase accumulation due to eddy currents induced by the slice-selective gradient. The prescan measures two one-dimensional excitation k-space profiles, which can be acquired with a readout gradient in the slice-selection direction by changing the polarity of the slice-selective gradient. The time shifts due to the phase accumulation in the excitation k-space were calculated. The time shift compensated for the start time of the slice-selective gradient. The total prescan time was 6-15 s. The slice profile and the UTE image with the half RF pulse excitation were acquired to evaluate the slice selectivity and the image quality. Results: Improved slice selectivity was obtained. The simple method proposed in this paper can eliminate eddy current effect. Good UTE images were obtained. Conclusions: The slice profile of the half RF pulse excitation and the image quality of UTE images have been improved by using a dedicated prescan. This method has a possibility that can improve the image quality of a clinical UTE imaging.
MeSH term(s)	Artifacts ; Electric Conductivity ; Humans ; Knee ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Radio Waves ; Time Factors
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4792672
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Article ; Online: Transcription Factor JunB Suppresses Hepatitis C Virus Replication.

Ariffianto, Adi / Deng, Lin / Harada, Saki / Liang, Yujiao / Matsui, Chieko / Abe, Takayuki / Shoji, Ikuo

The Kobe journal of medical sciences

2023 Volume 69, Issue 3, Page(s) E86–E95

Abstract: We previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, ... ...

Abstract	We previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infection, we investigated the phosphorylation of JunB in HCV J6/JFH1-infected Huh-7.5 cells. Immunoblot analysis revealed that HCV-induced ROS/JNK activation promoted phosphorylation of JunB. The small interfering RNA (siRNA) knockdown of JunB significantly increased the amount of intracellular HCV RNA as well as the intracellular and extracellular HCV infectivity titers. Conversely, overexpression of JunB significantly reduced the amount of intracellular HCV RNA and the intracellular and extracellular HCV infectivity titers. These results suggest that JunB plays a role in inhibiting HCV propagation. Additionally, HCV-mediated JunB activation promoted hepcidin promoter activity and hepcidin mRNA levels, a key factor in modulating iron homeostasis, suggesting that JunB is involved in HCV-induced transcriptional upregulation of hepcidin. Taken together, we propose that the HCV-induced ROS/JNK/JunB signaling pathway plays roles in inhibiting HCV replication and contributing to HCV-mediated iron metabolism disorder.
MeSH term(s)	Humans ; Hepacivirus ; Hepcidins ; Reactive Oxygen Species ; Hepatitis C ; Transcription Factors ; RNA ; Liver Neoplasms ; Virus Replication
Chemical Substances	Hepcidins ; Reactive Oxygen Species ; Transcription Factors ; RNA (63231-63-0) ; JunB protein, human
Language	English
Publishing date	2023-08-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	840671-6
ISSN	1883-0498 ; 0023-2513
ISSN (online)	1883-0498
ISSN	0023-2513
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Article: [Analysis of the application of host innate immune response to control and prevent infection].

Abe, Takayuki

Uirusu

2012 Volume 62, Issue 1, Page(s) 103–112

Abstract: The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been widely used not only to achieve a high level of foreign gene expression in insect cells but also for efficient gene transduction into mammalian cells without any ...

Abstract	The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been widely used not only to achieve a high level of foreign gene expression in insect cells but also for efficient gene transduction into mammalian cells without any replication. In addition to the efficient gene delivery, baculovirus has been shown to induce host innate immune responses in various mammalian cells and in mice. The baculovirus has abundant CpG motifs in the viral genome and is capable of inducing pro-inflammatory cytokines and interferons (IFNs) through Toll-like receptor (TLR)-dependent and -independent signaling pathways in a cell-type-specific manner. The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma-differentiation-associated gene 5) have been identified as viral dsRNA detectors and the adaptor IPS-1 (IFN-beta promoter stimulator-1) interacts with RIG-I and MDA5 to facilitate type-I IFN production mediated interferon regulatory factor 3 (IRF3) and 7 (IRF7). These helicases and IPS-1, however, were not essential for the type-I IFN and inflammatory cytokine responses to baculovirus. The baculovirus also has a strong adjuvant activity, and recombinant baculoviruses encoding neutralization epitopes elicit protective immunity in mice. This review deals with the current status of our knowledge of the induction of host innate immune responses by baculovirus and discusses the future prospects for baculovirus vectors.
MeSH term(s)	Adjuvants, Immunologic ; Animals ; Baculoviridae/genetics ; Baculoviridae/immunology ; Cytokines/metabolism ; Genetic Vectors ; Genome, Viral ; Humans ; Immunity, Innate/immunology ; Interferon Type I/metabolism ; Mice ; Toll-Like Receptors/immunology ; Transduction, Genetic ; Vaccines
Chemical Substances	Adjuvants, Immunologic ; Cytokines ; Interferon Type I ; Toll-Like Receptors ; Vaccines
Language	Japanese
Publishing date	2012-11-28
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	603272-2
ISSN	0042-6857
ISSN	0042-6857
DOI	10.2222/jsv.62.103
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