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Article ; Online: Letter to the AJT Editor re: Puttarajappa et al (doi:10.1111/ajt.16150).

Grewal, Abhijit S / Friedewald, John J / Abecassis, Michael M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 21, Issue 3, Page(s) 1346–1347

MeSH term(s)	Biomarkers ; Biopsy ; Kidney Transplantation ; Mass Screening
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16308
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Article ; Online: Targeted Quantification of Proteoforms in Complex Samples by Proteoform Reaction Monitoring.

Huang, Che-Fan / Kline, Jake T / Negrão, Fernanda / Robey, Matthew T / Toby, Timothy K / Durbin, Kenneth R / Fellers, Ryan T / Friedewald, John J / Levitsky, Josh / Abecassis, Michael M I / Melani, Rafael D / Kelleher, Neil L / Fornelli, Luca

Analytical chemistry

2024 Volume 96, Issue 8, Page(s) 3578–3586

Abstract: Existing mass spectrometric assays used for sensitive and specific measurements of target proteins across multiple samples, such as selected/multiple reaction monitoring (SRM/MRM) or parallel reaction monitoring (PRM), are peptide-based methods for ... ...

Abstract	Existing mass spectrometric assays used for sensitive and specific measurements of target proteins across multiple samples, such as selected/multiple reaction monitoring (SRM/MRM) or parallel reaction monitoring (PRM), are peptide-based methods for bottom-up proteomics. Here, we describe an approach based on the principle of PRM for the measurement of intact proteoforms by targeted top-down proteomics, termed proteoform reaction monitoring (PfRM). We explore the ability of our method to circumvent traditional limitations of top-down proteomics, such as sensitivity and reproducibility. We also introduce a new software program, Proteoform Finder (part of ProSight Native), specifically designed for the easy analysis of PfRM data. PfRM was initially benchmarked by quantifying three standard proteins. The linearity of the assay was shown over almost 3 orders of magnitude in the femtomole range, with limits of detection and quantification in the low femtomolar range. We later applied our multiplexed PfRM assay to complex samples to quantify biomarker candidates in peripheral blood mononuclear cells (PBMCs) from liver-transplanted patients, suggesting their possible translational applications. These results demonstrate that PfRM has the potential to contribute to the accurate quantification of protein biomarkers for diagnostic purposes and to improve our understanding of disease etiology at the proteoform level.
MeSH term(s)	Humans ; Leukocytes, Mononuclear/chemistry ; Reproducibility of Results ; Mass Spectrometry ; Proteins ; Proteomics/methods ; Protein Processing, Post-Translational ; Proteome/analysis
Chemical Substances	Proteins ; Proteome
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c05578
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Zs.A 4033: Show issues

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Article ; Online: Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.

Yu, Shuangjin / Dangi, Anil / Burnette, Melanie / Abecassis, Michael M / Thorp, Edward B / Luo, Xunrong

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 21, Issue 2, Page(s) 515–524

Abstract: We have previously shown that acute cytomegalovirus (CMV) infection disrupts the induction of transplantation tolerance. However, what impact acute CMV infection would have on the maintenance of established tolerance and on subsequent recipient allo- ... ...

Abstract	We have previously shown that acute cytomegalovirus (CMV) infection disrupts the induction of transplantation tolerance. However, what impact acute CMV infection would have on the maintenance of established tolerance and on subsequent recipient allo-sensitization is a clinically important unanswered question. Here we used an allogeneic murine islet transplantation tolerance model to examine the impact of acute CMV infection on: (a) disruption of established transplantation tolerance during tolerance maintenance; and (b) the possibility of recipient allo-sensitization by CMV-mediated disruption of stable tolerance. We demonstrated that acute CMV infection abrogated transplantation tolerance during the maintenance stage in 50%-60% recipients. We further demonstrated that acute CMV infection-mediated tolerance disruption led to recipient allo-sensitization by reverting the tolerant state of allo-specific T cells and promoting their differentiation to allo-specific memory cells. Consequently, a second same-donor islet allograft was rejected in an accelerated fashion by these recipients. Our study therefore supports close monitoring for allo-sensitization in previously tolerant transplant recipients in whom tolerance maintenance is disrupted by an episode of acute CMV infection.
MeSH term(s)	Animals ; Cytomegalovirus ; Cytomegalovirus Infections ; Mice ; Muromegalovirus ; Transplantation Tolerance ; Transplantation, Homologous
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16197
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Article ; Online: Kidney Graft Surveillance Biopsy Utilization and Trends: Results From a Survey of High-Volume Transplant Centers.

Lee, Darren M / Abecassis, Michael M / Friedewald, John J / Rose, Stanley / First, M Roy

Transplantation proceedings

2020 Volume 52, Issue 10, Page(s) 3085–3089

Abstract: An e-mail-based market research survey focused on high-volume US adult transplant centers was developed and implemented to assess surveillance based on United Network for Organ Sharing/Scientific Registry of Transplant Recipients data: 51 to 100 ... ...

Abstract	An e-mail-based market research survey focused on high-volume US adult transplant centers was developed and implemented to assess surveillance based on United Network for Organ Sharing/Scientific Registry of Transplant Recipients data: 51 to 100 transplants, 101 to 200 transplants, and more than 200 transplants. Eighty-three centers responded to the survey. Respondent centers represented 13,837/21,167 (65%) of the total kidney transplants in 2018. In total, 38/83 (46%) centers reported the use of surveillance biopsies-20 centers in all patients and 18 in select patients. Surveillance biopsies were performed in 37% (7/19) of centers performing 51 to 100 transplants annually, in 44% (15/34) doing 101 to 200 transplants, and in 53% (16/30) of centers doing more than 200 transplants. Of the 20 centers doing surveillance biopsies in all patients, 17/20 (85%) perform more than 100 annual transplants, and 3/20 (15%) perform less than 100 annual transplants. Of the 45 centers not currently doing surveillance biopsies, 13 (29%) used surveillance biopsies in the past; discontinuation was primarily due to patient inconvenience, adverse events, and cost. Using survey percentages, it is estimated that surveillance biopsies are performed in approximately 34% of kidney transplant recipients and that 74% of all surveillance biopsies occur in centers performing more than 100 kidney transplants per year.
MeSH term(s)	Adult ; Biopsy ; Humans ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Transplantation ; Practice Patterns, Physicians' ; Surveys and Questionnaires ; Transplants/pathology ; United States
Language	English
Publishing date	2020-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2020.04.1816
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Zs.A 835: Show issues

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Article ; Online: Emerging Ethical Considerations of Donation After Circulatory Death: Getting to the Heart of the Matter.

Gallagher, Thomas K / Skaro, Anton I / Abecassis, Michael M

Annals of surgery

2016 Volume 263, Issue 2, Page(s) 217–218

MeSH term(s)	Death ; Female ; Humans ; Male ; Tissue Donors/statistics & numerical data ; Tissue and Organ Procurement/methods
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000001585
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Article ; Online: A Practical Guide to the Clinical Implementation of Biomarkers for Subclinical Rejection Following Kidney Transplantation.

Naesens, Maarten / Friedewald, John / Mas, Valeria / Kaplan, Bruce / Abecassis, Michael M

Transplantation

2019 Volume 104, Issue 4, Page(s) 700–707

Abstract: Noninvasive biomarkers are needed to monitor stable patients following kidney transplantation (KT), as subclinical rejection, currently detectable only with invasive surveillance biopsies, can lead to chronic rejection and graft loss. Several biomarkers ... ...

Abstract	Noninvasive biomarkers are needed to monitor stable patients following kidney transplantation (KT), as subclinical rejection, currently detectable only with invasive surveillance biopsies, can lead to chronic rejection and graft loss. Several biomarkers have recently been developed to detect rejection in KT recipients, using different technologies as well as varying clinical monitoring strategies defined as "context of use (COU)." The various metrics utilized to evaluate the performance of each biomarker can also vary, depending on their intended COU. As the use of molecular biomarkers in transplantation represents a new era in patient management, it is important for clinicians to better understand the process by which the incremental value of each biomarkers is evaluated to determine its potential role in clinical practice. This process includes but is not limited to an assessment of clinical validity and utility, but to define these, the clinician must first appreciate the trajectory of a biomarker from bench to bedside as well as the regulatory and other requirements needed to navigate this course successfully. This overview summarizes this process, providing a framework that can be used by clinicians as a practical guide in general, and more specifically in the context of subclinical rejection following KT. In addition, we have reviewed available as well as promising biomarkers for this purpose in terms of the clinical need, COU, assessment of biomarker performance relevant to both the need and COU, assessment of biomarker benefits and risks relevant to the COU, and the evidentiary criteria of the biomarker relevant to the COU compared with the current standard of care. We also provide an insight into the path required to make biomarkers commercially available once they have been developed and validated so that they used by clinicians outside the research context in every day clinical practice.
MeSH term(s)	Asymptomatic Diseases ; Biomarkers/metabolism ; Clinical Decision-Making ; Graft Rejection/diagnosis ; Graft Rejection/metabolism ; Graft Rejection/therapy ; Humans ; Kidney Transplantation/adverse effects ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Treatment Outcome
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003064
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Trends and predictors of multidimensional health-related quality of life after living donor kidney transplantation.

Peipert, John D / Caicedo, Juan Carlos / Friedewald, John J / Abecassis, Michael M I / Cella, David / Ladner, Daniela P / Butt, Zeeshan

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2020 Volume 29, Issue 9, Page(s) 2355–2374

Abstract: Purpose: Living donor kidney transplant (LDKT) imparts the best graft and patient survival for most end-stage kidney disease (ESKD) patients. Yet, there remains variation in post-LDKT health-related quality of life (HRQOL). Improved understanding of ... ...

Abstract	Purpose: Living donor kidney transplant (LDKT) imparts the best graft and patient survival for most end-stage kidney disease (ESKD) patients. Yet, there remains variation in post-LDKT health-related quality of life (HRQOL). Improved understanding of post-LDKT HRQOL can help identify patients for interventions to maximize the benefit of LDKT. Methods: For 477 LDKT recipients transplanted between 11/2007 and 08/2016, we assessed physical, mental, social, and kidney-targeted HRQOL pre-LDKT, as well as 3 and 12 months post-operatively using the SF-36, Kidney Disease Quality of Life-Short Form (KDQOL-SF), and the Functional Assessment of Cancer Therapy-Kidney Symptom Index 19 item version (FKSI-19). We then examined trajectories of each HRQOL domain using latent growth curve models (LGCMs). We also examined associations between decline in HRQOL from 3 months to 12 months post-LDKT and death censored graft failure (DCGF) using Cox regression. Results: Large magnitude effects (d > 0.80) were observed from pre- to post-LDKT change on the SF-36 Vitality scale (d = 0.81) and the KDQOL-SF Burden of Kidney Disease (d = 1.05). Older age and smaller pre- to post-LDKT decreases in serum creatinine were associated with smaller improvements on many HRQOL scales across all domains in LGCMs. Higher DCGF rates were associated with worse physical [e.g., SF-36 PCS Conclusion: Clinical HRQOL monitoring may help identify patients who are most likely to have failing grafts and who would benefit from post-LDKT intervention.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Health Status ; Humans ; Kidney/surgery ; Kidney Failure, Chronic/therapy ; Kidney Transplantation/psychology ; Living Donors ; Male ; Middle Aged ; Postoperative Period ; Psychometrics ; Quality of Life/psychology ; Transplant Recipients/psychology ; Young Adult
Language	English
Publishing date	2020-04-13
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-020-02498-2
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Zs.A 3796: Show issues

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Article ; Online: Correction to: Trends and predictors of multidimensional health-related quality of life after living donor kidney transplantation.

Peipert, John D / Caicedo, Juan Carlos / Friedewald, John J / Abecassis, Michael M I / Cella, David / Ladner, Daniela P / Butt, Zeeshan

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2020 Volume 29, Issue 11, Page(s) 3179–3180

Abstract: In its original publication, an erroneous version of Fig. 2d was included in the manuscript. The corrected figure has now been added. ...

Abstract	In its original publication, an erroneous version of Fig. 2d was included in the manuscript. The corrected figure has now been added.
Language	English
Publishing date	2020-07-20
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-020-02574-7
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Article ; Online: New Insights Into the Molecular Mechanisms and Immune Control of Cytomegalovirus Reactivation.

Heald-Sargent, Taylor A / Forte, Eleonora / Liu, Xuefeng / Thorp, Edward B / Abecassis, Michael M / Zhang, Zheng Jenny / Hummel, Mary A

Transplantation

2020 Volume 104, Issue 5, Page(s) e118–e124

Abstract: Cytomegalovirus (CMV) is a β-herpesvirus that establishes lifelong latency in infected hosts. Following transplantation of a latently infected organ, reactivation can occur and consists of a spectrum of clinically apparent syndromes from mild symptoms to ...

Abstract	Cytomegalovirus (CMV) is a β-herpesvirus that establishes lifelong latency in infected hosts. Following transplantation of a latently infected organ, reactivation can occur and consists of a spectrum of clinically apparent syndromes from mild symptoms to tissue-invasive, resulting in both direct and indirect sequelae. Before the advent of effective antiviral agents, the primary treatment was reduction in immunosuppression (IS). While antiviral agents provide effective prophylaxis, there are several important caveats associated with their use, including drug toxicity and resistance. The traditional view attributes CMV reactivation and the ensuing clinical disease primarily to IS, either intrinsic to disease-related immune compromise or from the extrinsic administration of IS agents. However, previous data from both animal models and human subjects showed that inflammatory signals could induce upregulation of latent viral gene expression. New data demonstrate that ischemia/reperfusion is necessary and sufficient to induce CMV reactivation following murine transplantation of a latently infected graft. In this article, we review a growing body of evidence that suggests that reactivation of both human CMV and murine CMV is first triggered by molecular events that activate CMV gene expression and lytic infection and viral dissemination are then facilitated by IS. The initial activation of viral gene expression may be mediated by oxidative stress, DNA damage, or inflammatory cytokines, and these factors may act synergistically. New therapeutic approaches are needed to capture this complex array of targets.
MeSH term(s)	Animals ; Antibodies, Viral/immunology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Virus Activation/immunology ; Virus Latency/immunology
Chemical Substances	Antibodies, Viral ; Immunosuppressive Agents
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003138
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to "Shifting the conversation on outcomes reporting".

Peipert, John Devin / Abecassis, Michael M I / Butt, Zeeshan / Cella, David / Ladner, Daniela P

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2018 Volume 18, Issue 9, Page(s) 2368–2369

MeSH term(s)	Humans ; Tissue and Organ Procurement ; Transplants ; United States ; Volatilization
Language	English
Publishing date	2018-06-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14968
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