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  1. Book: Cholesterol Crystals in Atherosclerosis and Other Related Diseases

    Nidorf, Stefan Mark / Abela, George S.

    (Contemporary Cardiology)

    2023  

    Author's details ¿George S. Abela, M.D., M.Sc., M.B.A. Michigan State University§ Department of Medicine, Cardiology B208 Clinical Center, East Lansing, MI 48824 Phone: 517-353-1754; Fax: 517-353-4978; email: abela@msu.edu § Stefan Mark Nidorf, M.B.B.S., F.R.A.C.P., M.D. Cardiologist Sir Charles Gairdner Hospital§ The Heart and Vascular Research Institute 3/140 Mount Bay Rd Perth, Western Australia 6000 (61+) 4803000 smnidorf@gmaiol.com § George S. Abela is a physician scientist and chief of cardiology at Michigan State University. He has conducted and authored the seminal research describing for the first time the critical role of cholesterol crystals in tissue injury. This was accomplished by demonstrating that cholesterol expands in volume when transformed from a liquid to solid state generating the hypothesis that this expansion in the confined environment of an atherosclerotic plaque can lead to rupture and erosion. Support data comes from demonstration of extensive crystals perforating ruptu
    Series title Contemporary Cardiology
    Keywords CholesterolCrystals ; CholesterolCrystalFormation ; CrystalFormation ; VascularInflammation ; Plaquerupture ; myocardialinfarction ; CholesterolCrystalsinCancer ; CholesterolCrystalsinRetinopathy ; CholesterolCrystalsinAlzeheimer's ; CrystalloidDiseases ; Cholesterol Crystals ; Cholesterol Crystal Formation ; Crystal Formation ; Atherosclerosis ; Vascular Inflammation ; Plaque Rupture ; Myocardial Infarction ; Cholesterol Crystals in Cancer ; Cholesterol Crystals in Retinopathy ; Cholesterol Crystals in Alzeheimer's ; Crystalloid Diseases
    Language English
    Size 520 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_24
    Format 160 x 241 x 32
    ISBN 9783031411915 ; 3031411919
    Database PDA

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  2. Book: Peripheral vascular disease

    Abela, George S.

    basic diagnostic and therapeutic approaches

    2004  

    Author's details ed. George S. Abela
    Keywords Peripheral Vascular Diseases / diagnosis ; Peripheral Vascular Diseases / therapy
    Language English
    Size XIX, 527 S., [2 Bl.] : Ill., graph. Darst.
    Publisher Lippincott, Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014097384
    ISBN 0-7817-4383-4 ; 978-0-7817-4383-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 3563 order for loan Magazin

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  3. Book ; Online: Peripheral vascular disease

    Abela, George S.

    basic diagnostic and therapeutic approaches

    2004  

    Author's details editor, George S. Abela
    Keywords Peripheral vascular diseases - diagnosis ; Peripheral vascular diseases - therapy
    Language English
    Size 1 Online-Ressource (xiv, 527 Seiten), Illustrationen
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-4383-9 ; 0-7817-4383-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: Diagnostic imaging of coronary artery disease

    Aziz, Kusai S. / Abela, George S.

    2009  

    Author's details Kusai S. Aziz ; George S. Abela
    Keywords Coronary Artery Disease / diagnosis ; Diagnostic Imaging / methods ; Coronary heart disease/Imaging
    Subject code 616.1230754
    Language English
    Size XII, 188 S. : Ill., graph. Darst.
    Publisher Wolters Kluwer, Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Zugang zu Internetausgabe über Code
    HBZ-ID HT015723322
    ISBN 978-0-7817-6602-9 ; 0-7817-6602-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 382 order for loan Magazin
    Zugang zu Internetausgabe aus lizenzrechtlichen Gründen nicht verfügbar

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  5. Book: Myocardial revascularization

    Abela, George S.

    novel percutaneous approaches

    2002  

    Author's details ed. by George S. Abela
    Keywords Myocardial Revascularization / methods ; Heart Catheterization ; Laser Surgery
    Language English
    Size XVII, 278 S. : Ill., graph. Darst.
    Publisher Wiley-Liss
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT013326835
    ISBN 0-471-36166-6 ; 978-0-471-36166-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 1710 order for loan Magazin

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  6. Book ; Online: Diagnostic imaging of coronary artery disease

    Aziz, Kusai S. / Abela, George S.

    2009  

    Author's details Kusai S. Aziz, George S. Abela
    Keywords Coronary artery disease - diagnosis ; Diagnostic imaging - methods
    Language English
    Size 1 Online-Ressource (xii, 188 Seiten), Illustrationen
    Publisher Wolters Kluwer Health/Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-6602-9 ; 0-7817-6602-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  7. Article: The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosis.

    Abideen, Zain Ul / Pathak, Dorothy R / Sabanci, Rand / Manu, Megan / Abela, George S

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1345521

    Abstract: Background: Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Thus, ... ...

    Abstract Background: Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Thus, agents that affect CC formation, expansion, and morphology may reduce cardiovascular (CV) risk independent of lipid-lowering and anti-inflammatory therapy.
    Objective: Because colchicine is highly concentrated in leukocytes that can enter the atherosclerotic plaque core, we tested its effect on the formation and growth of CCs in bench experiments to determine whether it may have direct effects on CCs, independent of its known anti-inflammatory actions.
    Method: Different dosages of colchicine mixed with cholesterol (0.05-5 mg/ml/g of cholesterol) were used to influence the formation CCs and volume expansion
    Results: The addition of colchicine to cholesterol caused a substantial dose-dependent reduction in volume (
    Conclusions: Colchicine can reduce CC formation and expansion and alter CC morphology. These previously unappreciated effects of colchicine may contribute to its clinical benefit in patients with CV disease independent of its anti-inflammatory effects.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1345521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical outcomes between direct oral anticoagulants versus vitamin K antagonists in chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis.

    Salazar, Adolfo Martinez / Panama, Gabriel / Kim, Andrew Geunwon / Rayamajhi, Supratik / Abela, George S

    Current problems in cardiology

    2024  Volume 49, Issue 3, Page(s) 102377

    Abstract: Pulmonary hypertension (PH) is a known chronic condition that can lead to increased morbidity and mortality. Patients who develop PH due to thromboembolic disease are catalogued as chronic thromboembolic pulmonary hypertension (CTEPH). Anticoagulation ... ...

    Abstract Pulmonary hypertension (PH) is a known chronic condition that can lead to increased morbidity and mortality. Patients who develop PH due to thromboembolic disease are catalogued as chronic thromboembolic pulmonary hypertension (CTEPH). Anticoagulation remains a topic of interest in these patients. PUBMED, EMBASE and COCHRANE databases were searched by two investigators until December 2023. Information was analyzed for all-cause mortality, venous thromboembolism and major bleeding. We included a total of 10 studies in this meta-analysis. Our pooled analysis demonstrated that DOACs were non-inferior in all-cause mortality [OR 0.88, 95 % CI (0.48, 1.61)], venous thromboembolism [OR 1.00, 95 % CI (0.50, 1.98)] and major bleeding [OR 0.78, 95 % CI (0.43, 1.40)] when compared to VKAs. In conclusion, our meta-analysis supports the use of DOACs in patients with CTEPH. Further randomized trials are still needed to confirm our results in terms of safety and mortality.
    MeSH term(s) Humans ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Fibrinolytic Agents/therapeutic use ; Vitamin K ; Administration, Oral
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2024.102377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Book: Lasers in cardiovascular medicine and surgery

    Abela, George S.

    fundamentals and techniques

    (Developments in cardiovascular medicine ; 103)

    1990  

    Author's details ed. by George S. Abela
    Series title Developments in cardiovascular medicine ; 103
    Collection
    Keywords Cardiovascular Diseases / therapy ; Laser Surgery ; Lasers / therapeutic use ; Vascular Surgery ; Laserangioplastie ; Kardiovaskuläre Krankheit ; Laser
    Subject Laserrevaskularisation ; Light amplification by stimulated emission of radiation ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten
    Size XIV, 480 S. : Ill., graph. Darst.
    Publisher Kluwer
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003583890
    ISBN 0-7923-0440-3 ; 978-0-7923-0440-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 4642 order for loan Magazin

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  10. Article: Viewing atherosclerosis through a crystal lens: How the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability.

    Nidorf, Stefan Mark / Fiolet, Aernoud / Abela, George S

    Journal of clinical lipidology

    2020  Volume 14, Issue 5, Page(s) 619–630

    Abstract: Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis continues to be a challenge. Thus, understanding how cholesterol spontaneously self assembles into metastable structures that evolve into flat plate cholesterol ... ...

    Abstract Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis continues to be a challenge. Thus, understanding how cholesterol spontaneously self assembles into metastable structures that evolve into flat plate cholesterol crystals (CCs) in atherosclerotic plaque, and why they fundamentally change the nature of the disease provides a paradigm for the development of additional therapies. Specifically, flat plate CCs that form within lysosomes of macrophages may become large enough to disrupt lysosomal membranes leading to the release of cathepsin B and CCs fragments directly into the cytosol. In the cytosol, the surface of flat plate CCs can be recognized by complosome that together with cathepsin B may trigger pyrin domain-containing inflammasome. In addition, flat plate CCs in the cytosol may trigger caspase 8 initiating apoptosis. In the interstitial space, the surface of flat plate CCs can be recognized by complement and receptors on proinflammatory cells, and larger fragments can induce "frustrated phagocytosis" that together perpetuate inflammatory injury. In addition, rapid transition of metastable CCs into large flat plate CCs within lipid rich plaques can lead to traumatic injury by expansion of the plaque's necrotic core causing plaque disruption or rupture that may precipitate further inflammation. Other crystalloids in plaque including monosodium urate and calcium phosphate crystals can augment these processes. Thus, therapies that further limit the deposition of cholesterol in the vascular bed, slow the formation of flat plate CCs and inhibit crystal-induced inflammation may lead to further reduce CV risk in patients with established CV disease.
    MeSH term(s) Animals ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cholesterol/chemistry ; Cholesterol/metabolism ; Humans ; Plaque, Atherosclerotic/chemistry ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2020.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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