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  1. Article ; Online: Overexpression of T3SS translocation signals in

    Abele, Taylor J / Billman, Zachary P / Harvest, Carissa K / Bryan, Alexia K / Larson, Heather N / Coers, Jörn / Miao, Edward A

    Infection and immunity

    2023  Volume 92, Issue 1, Page(s) e0032923

    Abstract: Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously ... ...

    Abstract Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously engineered
    MeSH term(s) Animals ; Mice ; Salmonella typhimurium ; Virulence ; Type III Secretion Systems/genetics ; Virulence Factors/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Type III Secretion Systems ; Virulence Factors ; Bacterial Proteins
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00329-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Apoptotic signaling clears engineered

    Abele, Taylor J / Billman, Zachary P / Li, Lupeng / Harvest, Carissa K / Bryan, Alexia K / Magalski, Gabrielle R / Lopez, Joseph P / Larson, Heather N / Yin, Xiao-Ming / Miao, Edward A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. Although pyroptosis and apoptosis have distinct signaling pathways, when a cell fails to complete pyroptosis, backup pathways will initiate ... ...

    Abstract Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. Although pyroptosis and apoptosis have distinct signaling pathways, when a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.06.539681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Apoptotic signaling clears engineered

    Abele, Taylor J / Billman, Zachary P / Li, Lupeng / Harvest, Carissa K / Bryan, Alexia K / Magalski, Gabrielle R / Lopez, Joseph P / Larson, Heather N / Yin, Xiao-Ming / Miao, Edward A

    eLife

    2023  Volume 12

    Abstract: Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to ... ...

    Abstract Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered
    MeSH term(s) Animals ; Mice ; Flagellin ; Apoptosis ; Cell Death ; Caspase 1/metabolism ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Pyroptosis ; Inflammasomes/metabolism
    Chemical Substances Flagellin (12777-81-0) ; Caspase 1 (EC 3.4.22.36) ; Inflammasomes
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2.

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Souza, Fernando W / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6686

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also ... ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also clears, the infection. The infected lesion can arise from a single bacterium that replicates despite the presence of a neutrophil swarm. Bacterial replication ceases when macrophages organize around the infection and form a granuloma. This granuloma response is accomplished independently of adaptive immunity that is typically required to organize granulomas. The C. violaceum-induced granuloma requires at least two separate defense pathways, gasdermin D and iNOS, to maintain the integrity of the granuloma architecture. This innate granuloma successfully eradicates C. violaceum infection. Therefore, this C. violaceum-induced granuloma model demonstrates that innate immune cells successfully organize a granuloma and thereby resolve infection by an environmental pathogen.
    MeSH term(s) Animals ; Mice ; Granuloma ; Macrophages/metabolism ; Neutrophils ; Nitric Oxide Synthase Type II/metabolism
    Chemical Substances Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Gsdmd protein, mouse
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42218-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An innate granuloma eradicates an environmental pathogen using

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice. ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.07.531568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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