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  1. Article ; Online: Activating KIRs on Educated NK Cells Support Downregulation of CD226 and Inefficient Tumor Immunosurveillance.

    Guillamón, Concepción F / Martínez-Sánchez, María V / Gimeno, Lourdes / Campillo, José A / Server-Pastor, Gerardo / Martínez-García, Jerónimo / Martínez-Escribano, Jorge / Torroba, Amparo / Ferri, Belén / Abellán, Daniel J / Legaz, Isabel / López-Álvarez, María R / Moya-Quiles, María R / Muro, Manuel / Minguela, Alfredo

    Cancer immunology research

    2019  Volume 7, Issue 8, Page(s) 1307–1317

    Abstract: Therapies using NK cells (NKc) expanded/ ... ...

    Abstract Therapies using NK cells (NKc) expanded/activated
    MeSH term(s) Antigens, Differentiation, T-Lymphocyte/genetics ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Biomarkers ; Cell Line, Tumor ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Genotype ; HLA Antigens/genetics ; HLA Antigens/immunology ; Humans ; Immunologic Surveillance ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Ligands ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Prognosis ; Protein Binding ; Receptors, KIR/genetics ; Receptors, KIR/metabolism
    Chemical Substances Antigens, Differentiation, T-Lymphocyte ; Biomarkers ; CD226 antigen ; HLA Antigens ; Ligands ; Receptors, KIR
    Language English
    Publishing date 2019-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-18-0847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7022: Show issues Location:
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  2. Article ; Online: NK Cell Education in Tumor Immune Surveillance: DNAM-1/KIR Receptor Ratios as Predictive Biomarkers for Solid Tumor Outcome.

    Guillamón, Concepción F / Martínez-Sánchez, María V / Gimeno, Lourdes / Mrowiec, Anna / Martínez-García, Jerónimo / Server-Pastor, Gerardo / Martínez-Escribano, Jorge / Torroba, Amparo / Ferri, Belén / Abellán, Daniel / Campillo, José A / Legaz, Isabel / López-Álvarez, María R / Moya-Quiles, María Rosa / Muro, Manuel / Minguela, Alfredo

    Cancer immunology research

    2018  Volume 6, Issue 12, Page(s) 1537–1547

    Abstract: Natural killer cell (NKc)-based therapies offer promising outcomes in patients with tumors, but they could improve with appropriate selection of donors and optimization of methods to expand ... ...

    Abstract Natural killer cell (NKc)-based therapies offer promising outcomes in patients with tumors, but they could improve with appropriate selection of donors and optimization of methods to expand NKcs
    MeSH term(s) Aged ; Antigens, Differentiation, T-Lymphocyte/immunology ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Biomarkers, Tumor/immunology ; Case-Control Studies ; Female ; HLA-C Antigens/genetics ; Humans ; Immunologic Surveillance ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Male ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/mortality ; Middle Aged ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/immunology ; Ovarian Neoplasms/mortality ; Prospective Studies ; Receptors, KIR/genetics ; Receptors, KIR/immunology ; Receptors, KIR/metabolism ; Survival Analysis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/mortality
    Chemical Substances Antigens, Differentiation, T-Lymphocyte ; Biomarkers, Tumor ; CD226 antigen ; HLA-C Antigens ; Receptors, KIR
    Language English
    Publishing date 2018-09-21
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-18-0022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Immunological Risk Stratification of Bladder Cancer Based on Peripheral Blood Natural Killer Cell Biomarkers.

    Guillamón, Concepción F / Gimeno, Lourdes / Server, Gerardo / Martínez-Sánchez, María V / Escudero, José F / López-Cubillana, Pedro / Cabezas-Herrera, Juan / Campillo, José A / Abellan, Daniel J / Martínez-García, Jerónimo / Martínez-Escribano, Jorge / Ferri, Belén / López-Álvarez, María R / Moreno-Alarcón, Cristóbal / Moya-Quiles, María R / Muro, Manuel / Minguela, Alfredo

    European urology oncology

    2019  Volume 4, Issue 2, Page(s) 246–255

    Abstract: Background: Bladder cancer (BC) is highly immunogenic. Bacillus Calmette-Guérin (BCG) immunotherapy offers the best results in non-muscle-invasive BC (NMIBC). Natural killer cells (NKcs) play decisive roles in BCG-mediated immune response and in general ...

    Abstract Background: Bladder cancer (BC) is highly immunogenic. Bacillus Calmette-Guérin (BCG) immunotherapy offers the best results in non-muscle-invasive BC (NMIBC). Natural killer cells (NKcs) play decisive roles in BCG-mediated immune response and in general cancer immune-surveillance.
    Objective: To analyze killer-cell immunoglobulin-like receptors (KIRs), their human leukocyte antigen class-I (HLA-I) ligands, and the expression of DNAX Accessory Molecule-1 (DNAM-1/CD226) on peripheral blood (PB) NKcs, to identify useful predictive biomarkers in BC.
    Design, setting, and participants: KIR/HLA-ligand genotypes were compared between 132 BC, 201 other solid cancers, 164 plasma cell disorders, and 615 healthy Caucasoid controls. CD226 expression was evaluated by flow cytometry.
    Outcome measurements and statistical analysis: KIR/HLA-I interactions and CD226 expression on NKcs (CD226
    Results and limitations: Three immunological risk groups were identified: low risk (KIR2DL1
    Conclusions: Immunological risk stratification will complement BC histopathology to improve risk stratification and guide the selection of personalized treatments. Understanding of the molecular mechanisms of NKc tumor immune surveillance will enable the development of future NKc-based therapies.
    Patient summary: This work describes a peripheral blood test that aids in our understanding of the immune defense mechanisms against bladder cancer, is useful for classifying patient risk, and will guide personalized treatments.
    MeSH term(s) Biomarkers ; Humans ; Killer Cells, Natural ; Prognosis ; Risk Assessment ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-05-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2019.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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