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  1. Article ; Online: Fabry disease: patients at risk in Brazil!

    Abensur, Hugo

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2021  Volume 43, Issue 1, Page(s) 5–6

    MeSH term(s) Brazil/epidemiology ; Fabry Disease/diagnosis ; Fabry Disease/epidemiology ; Humans ; alpha-Galactosidase
    Chemical Substances alpha-Galactosidase (EC 3.2.1.22)
    Language Portuguese
    Publishing date 2021-02-11
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2021-E002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Th17/IL-17 Axis and Kidney Diseases, With Focus on Lupus Nephritis.

    Paquissi, Feliciano Chanana / Abensur, Hugo

    Frontiers in medicine

    2021  Volume 8, Page(s) 654912

    Abstract: Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and hyperreactivity of the immune response at various levels, including hyperactivation of effector cell subtypes, autoantibodies production, immune complex formation, and ... ...

    Abstract Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and hyperreactivity of the immune response at various levels, including hyperactivation of effector cell subtypes, autoantibodies production, immune complex formation, and deposition in tissues. The consequences of hyperreactivity to the self are systemic and local inflammation and tissue damage in multiple organs. Lupus nephritis (LN) is one of the most worrying manifestations of SLE, and most patients have this involvement at some point in the course of the disease. Among the effector cells involved, the Th17, a subtype of T helper cells (CD4+), has shown significant hyperactivation and participates in kidney damage and many other organs. Th17 cells have IL-17A and IL-17F as main cytokines with receptors expressed in most renal cells, being involved in the activation of many proinflammatory and profibrotic pathways. The Th17/IL-17 axis promotes and maintains repetitive tissue damage and maladaptive repair; leading to fibrosis, loss of organ architecture and function. In the podocytes, the Th17/IL-17 axis effects include changes of the cytoskeleton with increased motility, decreased expression of health proteins, increased oxidative stress, and activation of the inflammasome and caspases resulting in podocytes apoptosis. In renal tubular epithelial cells, the Th17/IL-17 axis promotes the activation of profibrotic pathways such as increased TGF-β expression and epithelial-mesenchymal transition (EMT) with consequent increase of extracellular matrix proteins. In addition, the IL-17 promotes a proinflammatory environment by stimulating the synthesis of inflammatory cytokines by intrinsic renal cells and immune cells, and the synthesis of growth factors and chemokines, which together result in granulopoiesis/myelopoiesis, and further recruitment of immune cells to the kidney. The purpose of this work is to present the prognostic and immunopathologic role of the Th17/IL-17 axis in Kidney diseases, with a special focus on LN, including its exploration as a potential immunotherapeutic target in this complication.
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.654912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How to explain the low penetration of peritoneal dialysis in Brazil.

    Abensur, Hugo

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2014  Volume 36, Issue 3, Page(s) 269–270

    MeSH term(s) Brazil ; Humans ; Peritoneal Dialysis/statistics & numerical data
    Language Portuguese
    Publishing date 2014-10-10
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.5935/0101-2800.20140039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Blockage of the renin-angiotensin system in peritoneal dialysis.

    Abensur, Hugo

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2013  Volume 35, Issue 4, Page(s) 245–247

    MeSH term(s) Cardiovascular Diseases/prevention & control ; Humans ; Peritoneal Dialysis ; Renin-Angiotensin System/drug effects
    Language Portuguese
    Publishing date 2013-10
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.5935/0101-2800.20130040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter.

    Kassar, Liliana de Meira Lins / Senna, João Paulo / Wayla, Karoline / Araujo, Luiza Karla Rp / Pereira, Benedito J / Abensur, Hugo / Elias, Rosilene M

    The International journal of artificial organs

    2024  Volume 47, Issue 3, Page(s) 127–128

    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Letter
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988241228677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Renal involvement in Fabry disease.

    Abensur, Hugo / Reis, Marlene Antônia Dos

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2016  Volume 38, Issue 2, Page(s) 245–254

    Abstract: Every cell in the human body has globotriaosylceramide accumulation (Gb3) in Fabry disease due to the mutation in gene of the enzyme α-galactosidase A. It is a disease linked to sex. The main clinical features are: cutaneous angiokeratomas; ... ...

    Title translation Acometimento renal na doença de Fabry.
    Abstract Every cell in the human body has globotriaosylceramide accumulation (Gb3) in Fabry disease due to the mutation in gene of the enzyme α-galactosidase A. It is a disease linked to sex. The main clinical features are: cutaneous angiokeratomas; acroparestesias and early strokes; decreased sweating and heat intolerance; ocular changes; myocardial hypertrophy, arrhythmias; gastrointestinal disorders and renal involvement. Renal involvement occurs due to Gb3 accumulation in all types of renal cells. Therefore, patients may present glomerular and tubular function disorders. Podocytes are particularly affected, with pedicels effacement and development of proteinuria. The diagnosis is made by detection of reduced plasma or leukocyte α-galactosidase activity and genetic study for detecting the α-galactosidase gene mutation. Treatment with enzyme replacement contributes to delay the progression of kidney disease, especially if initiated early.
    Language Portuguese
    Publishing date 2016-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.5935/0101-2800.20160034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A feasibility study of avoiding positive calcium balance and parathyroid hormone increase in patients on peritoneal dialysis.

    Piraciaba, Maria Clara Teixeira / Cordeiro, Lilian / Guimarães, Erica Adelina / Abensur, Hugo / Pereira, Benedito Jorge / Jorgetti, Vanda / Moysés, Rosa Maria Affonso / Elias, Rosilene Motta

    Bone reports

    2022  Volume 17, Page(s) 101625

    Abstract: Background: The effect of the dialysate calcium concentration (D[Ca]) on mineral and bone metabolism in patients on peritoneal dialysis (PD) is overlooked. D[Ca] of 1.75 mmol/L is still prescribed to many patients on PD around the world. Previous ... ...

    Abstract Background: The effect of the dialysate calcium concentration (D[Ca]) on mineral and bone metabolism in patients on peritoneal dialysis (PD) is overlooked. D[Ca] of 1.75 mmol/L is still prescribed to many patients on PD around the world. Previous studies on the effects of reducing D[Ca] have been carried out before the incorporation of calcimimetics in clinical practice. We hypothesized that a reduction in D[Ca] is safe and without the risk of a rise in serum parathyroid hormone (PTH).
    Methods: In this non-randomized clinical trial, the D[Ca] was reduced from 1.75 mmol/L to 1.25 mmol/L for one year in prevalent patients on PD. Demographic, clinical, and CKD-MBD-related biomarkers were evaluated at baseline, 3, 6, and 12 months of follow-up.
    Results: 20 patients completed 1-year follow-up (56 ± 16 years, 50 % male, 25 % diabetic, 55 % with baseline parathyroid hormone - PTH >300 pg/mL). Over time, there was no significant change in calcium, phosphate, total alkaline phosphatase, 25(OH)-vitamin D or PTH, although adjustments in calcitriol and sevelamer prescription were required. After 1 year, absolute and percentual change in PTH levels were 36 (-58, 139) pg/mL, and 20 % (-28, 45) respectively. The proportion of patients with PTH > 300 pg/mL did not change during the follow-up (p = 0.173).
    Conclusion: Knowing the risk of a positive calcium balance in patients on PD, reducing the D[Ca] concentration is a safe and valuable option, although medication adjustments are needed to detain PTH rising.
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2821774-3
    ISSN 2352-1872
    ISSN 2352-1872
    DOI 10.1016/j.bonr.2022.101625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 3. Reposição de ferro no tratamento da anemia.

    Abensur, Hugo / Castro, Manuel Carlos Martins

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2014  Volume 36, Issue 1 Suppl 1, Page(s) 15–18

    Title translation Iron supplementation in anemia treatment.
    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/etiology ; Dietary Supplements ; Humans ; Iron/therapeutic use ; Practice Guidelines as Topic ; Renal Insufficiency, Chronic/complications
    Chemical Substances Iron (E1UOL152H7)
    Language Portuguese
    Publishing date 2014-04-25
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.5935/0101-2800.2014s005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fisiologia do transporte de fluidos e solutos atraves da membrana peritoneal.

    Aguirre, Anna Rita / Abensur, Hugo

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2013  Volume 36, Issue 1, Page(s) 74–79

    Abstract: In this review, phenomena involved in fluid and solute exchange through the peritoneal membrane, both in the physiologic and in the peritoneal dialysis settings, are explained. For that purpose, mathematical models developed for the study of molecule ... ...

    Title translation Physiology of fluid and solute transport across the peritoneal membrane.
    Abstract In this review, phenomena involved in fluid and solute exchange through the peritoneal membrane, both in the physiologic and in the peritoneal dialysis settings, are explained. For that purpose, mathematical models developed for the study of molecule transport through the membrane, such as the "Pore Model" and the "Distributive Model" are used. Scientific accomplishments in the field are described and areas that require additional research are also cited. Knowledge about the physiologic mechanisms involved in this renal replacement therapy modality, concerning events directly related to the peritoneal membrane itself, is synthesized in this manuscript.
    MeSH term(s) Biological Transport ; Dialysis Solutions/pharmacokinetics ; Models, Theoretical ; Peritoneal Dialysis ; Peritoneum/metabolism
    Chemical Substances Dialysis Solutions
    Language Portuguese
    Publishing date 2013-12-01
    Publishing country Brazil
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.5935/0101-2800.20140013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Wünderlich Syndrome in Renal Transplant Recipients: A Case Report and Literature Review.

    Lopes, Rolf Passos / Junior, João Egidio Romão / Taromaru, Eduardo / Campagnari, João Carlos / Araújo, Maria Regina Teixeira / Abensur, Hugo

    Transplantation proceedings

    2021  Volume 53, Issue 8, Page(s) 2517–2520

    Abstract: Background: Wünderlich syndrome, or spontaneous atraumatic renal hemorrhage, is a clinical entity rarely described in the native kidney of patients who have undergone renal transplant. Although its manifestation is quite similar in reported cases, it ... ...

    Abstract Background: Wünderlich syndrome, or spontaneous atraumatic renal hemorrhage, is a clinical entity rarely described in the native kidney of patients who have undergone renal transplant. Although its manifestation is quite similar in reported cases, it may present few symptoms, from bleeding of unidentified etiology to dramatic pictures associated with hypovolemic shock. There are few reports of spontaneous hemorrhage of a native kidney after kidney transplantation.
    Case report: We present a 38-year-old male patient who developed hemorrhage of a ruptured native kidney after a late renal transplantation. We analyze what has been reported in the literature and highlight the possibility of this complication after kidney transplantation. Imaging exams and surgical specimen demonstrated the presence of ruptured angiomyolipoma in the patient's native right kidney. The postoperative period was not complicated, with a benign clinical evolution.
    Conclusion: Although rare in patients who have undergone renal transplant, it is justified to suggest Wünderlich syndrome in the presence of acute flank pain, abdominal tenderness, and signs of internal bleeding (Lenk's triad), with unexplained hemoglobin drop.
    MeSH term(s) Adult ; Angiomyolipoma ; Hemorrhage/etiology ; Humans ; Kidney ; Kidney Neoplasms ; Kidney Transplantation/adverse effects ; Male
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.08.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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