Article ; Online: Heterogeneity in patterns of progression of chronic kidney disease.
2020 Volume 51, Issue 2, Page(s) 220–228
Abstract: Background: Progression of kidney disease is a deceptively simple word for a complex bio-clinical process, evidenced by the number of definitions in the literature. This has led to confusion and differences in interpretation of studies.: Methods: We ... ...
Abstract | Background: Progression of kidney disease is a deceptively simple word for a complex bio-clinical process, evidenced by the number of definitions in the literature. This has led to confusion and differences in interpretation of studies. Methods: We describe different patterns of progression, the performance of different definitions of progression and factors associated with chronic kidney disease (CKD) progression in a public renal service in Australia, in a study of patients enrolled in the CKD.QLD Registry with a minimum of 2 years' follow up. Results: Nine patterns of changing estimated glomerular filtration rate (eGFR) over two consecutive 12-month periods were identified. Most common was a stable eGFR over 2 years (30%), and the least was a sustainable improvement of eGFR over both periods (2.1%). There was a lack of congruence between the several definitions of progression of CKD evaluated. More people progressed using the definition of decline of eGFR of >5 mL/min/1.73 m Conclusions: This is one of the first demonstrations of the great variations among and within individuals in the progression of CKD over even a period as short as 2 years. Findings suggest considerable potential for renal function recovery and stability while demonstrating the importance of using identical definitions for comparisons across datasets from different sources. |
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MeSH term(s) | Australia/epidemiology ; Child, Preschool ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Kidney Failure, Chronic ; Proteinuria/epidemiology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors |
Language | English |
Publishing date | 2020-02-06 |
Publishing country | Australia |
Document type | Journal Article |
ZDB-ID | 2045436-3 |
ISSN | 1445-5994 ; 1444-0903 |
ISSN (online) | 1445-5994 |
ISSN | 1444-0903 |
DOI | 10.1111/imj.14770 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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