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  1. Article ; Online: Mutations of PHOX2B Gene in Patients of Obesity Hypoventilation Syndrome in Central India

    Ankita Tyagi / Abhishek Goyal / Prashant Chaware / Bertha A.D. Rathinam

    Journal of Laboratory Physicians, Vol 14, Iss 02, Pp 164-

    2022  Volume 168

    Abstract: Background Paired-like homeobox 2B (PHOX2B) gene on chromosome 4p12 codes for a transcription factor having a role in the formation of noradrenergic neuronal circuits. Its mutations have been linked to congenital central hypoventilation syndrome (CCHS). ... ...

    Abstract Background Paired-like homeobox 2B (PHOX2B) gene on chromosome 4p12 codes for a transcription factor having a role in the formation of noradrenergic neuronal circuits. Its mutations have been linked to congenital central hypoventilation syndrome (CCHS). The clinical presentation of both, obesity hypoventilation syndrome (OHS) and CCHS in adults (named late-onset central hypoventilation syndrome), is quite similar. Because of this symptomatic similarity, multifactorial causation of OHS, the mutation of PHOX2B gene was studied in patients with OHS in this study. Methods A hospital-based cross-sectional study was performed on patients diagnosed with OHS. The deoxyribonucleic acid was extracted from 2 mL of venous blood and was further amplified, specific to exon 3. The amplified products were cast and run in 2% agarose gel and then subjected to Sanger sequencing. Results Thirty patients of OHS (21 male; 9 female) were enrolled in the present study, average age being 51.7 years. The Sanger sequencing of the samples revealed no apparent areas of deletions and no apparent mutations. Conclusion Primers for exon 3 were used for amplification in thermocycler, as exon 3 is the most frequently mutated exon for PHOX2B gene, as per existing literature. The entire gene needs to be studied for mutations and the sample size needs to be increased.
    Keywords obesity hypoventilation syndrome ; phox2b gene ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Nanobiotechnology in Bone Tissue Engineering Applications

    Neelam Iqbal / Tejal Pant / Nanda Rohra / Abhishek Goyal / Merin Lawrence / Anomitra Dey / Payal Ganguly

    Applied Biosciences, Vol 2, Iss 4, Pp 617-

    Recent Advances and Future Perspectives

    2023  Volume 638

    Abstract: Bone regeneration and repair are complex processes with the potential of added complications, like delayed repair, fracture non-union, and post-surgical infections. These conditions remain a challenge globally, pressurizing the economy and patients ... ...

    Abstract Bone regeneration and repair are complex processes with the potential of added complications, like delayed repair, fracture non-union, and post-surgical infections. These conditions remain a challenge globally, pressurizing the economy and patients suffering from these conditions. Applications of nanotechnology (NBT) in the field of medicine have provided a medium for several approaches to support these global challenges. Tissue engineering is one such field that has been on the rise in the last three decades through the utilization of NBT for addressing the challenges related to bone regeneration. First, NBT enables the formation of scaffolds at the nanoscale needed for bone tissue engineering (BTE) using natural and synthetic polymers, as well as with minerals and metals. Then, it aids the development of the nano-formulation strategized to deliver antimicrobial drugs and/or growth factors through various ways to enhance bone repair through the scaffold. Third, NBT facilitates the use of specialized nanoparticles to image and track cellular events in vitro as well as in vivo. This review is an effort to bring together the current knowledge in the field of BTE and present the scope of ever-evolving NBT, a contribution towards precision medicine.
    Keywords bone repair ; tissue engineering ; bone regeneration ; nanomedicine ; nanobiotechnology (NBT) ; nanoparticle (NP) ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5 ; Biotechnology ; TP248.13-248.65
    Subject code 616
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pulmonary rehabilitation in COVID-19 pneumonia sequelae

    Aqeel Hussain / Alkesh Kumar Khurana / Abhishek Goyal / Raj Krishnan Soman

    ERJ Open Research, Vol 7, Iss

    so near yet so far

    2021  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods

    Nupur S. Munjal / Dikscha Sapra / K. T. Shreya Parthasarathi / Abhishek Goyal / Akhilesh Pandey / Manidipa Banerjee / Jyoti Sharma

    Pathogens, Vol 11, Iss 259, p

    2022  Volume 259

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accountable for the protracted COVID-19 pandemic. Its high transmission rate and pathogenicity led to health emergencies and economic crisis. Recent studies pertaining to the understanding ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accountable for the protracted COVID-19 pandemic. Its high transmission rate and pathogenicity led to health emergencies and economic crisis. Recent studies pertaining to the understanding of the molecular pathogenesis of SARS-CoV-2 infection exhibited the indispensable role of ion channels in viral infection inside the host. Moreover, machine learning (ML)-based algorithms are providing a higher accuracy for host-SARS-CoV-2 protein–protein interactions (PPIs). In this study, PPIs of SARS-CoV-2 proteins with human ion channels (HICs) were trained on the PPI-MetaGO algorithm. PPI networks (PPINs) and a signaling pathway map of HICs with SARS-CoV-2 proteins were generated. Additionally, various U.S. food and drug administration (FDA)-approved drugs interacting with the potential HICs were identified. The PPIs were predicted with 82.71% accuracy, 84.09% precision, 84.09% sensitivity, 0.89 AUC-ROC, 65.17% Matthews correlation coefficient score (MCC) and 84.09% F1 score. Several host pathways were found to be altered, including calcium signaling and taste transduction pathway. Potential HICs could serve as an initial set to the experimentalists for further validation. The study also reinforces the drug repurposing approach for the development of host directed antiviral drugs that may provide a better therapeutic management strategy for infection caused by SARS-CoV-2.
    Keywords virus and host ; protein interaction networks ; cellular pathways ; antiviral compounds ; Medicine ; R
    Subject code 572
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Recurrent episodes of pneumonia in a toddler

    Alkesh Kumar Khurana / Abhishek Goyal / Ujjawal Khurana / Bhavna Dhingra

    Journal of Family Medicine and Primary Care, Vol 8, Iss 3, Pp 1260-

    Don't forget chronic granulomatous disease

    2019  Volume 1262

    Abstract: A 4-year-old boy presented with community acquired pneumonia, hepatosplenomegaly and bilateral cervical lymphadenopathy. The peripheral blood film showed significant monocytosis and bone marrow examination revealed multiple histiocytic granulomas. ... ...

    Abstract A 4-year-old boy presented with community acquired pneumonia, hepatosplenomegaly and bilateral cervical lymphadenopathy. The peripheral blood film showed significant monocytosis and bone marrow examination revealed multiple histiocytic granulomas. Presence of CD 68 positive granulomas supported by cytological findings enabled us to make a diagnosis of chronic granulomatous disease.
    Keywords Chronic granulomatous disease ; granulomas ; pneumonia ; Medicine ; R
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Pulmonary Alveolar Microlithiasis

    Alkesh Khurana / Rajesh Malik / Jitendra Sharma / Ujjawal Khurana / Abhishek Goyal

    Sultan Qaboos University Medical Journal, Vol 18, Iss 2, Pp 236-

    A commonly misdiagnosed rare entity

    2018  Volume 238

    Abstract: Pulmonary alveolar microlithiasis (PAM) is an uncommon entity which can pose a diagnostic challenge. We report a 45-year-old female who was referred to the All India Institute of Medical Sciences, Bhopal, India, in 2017 with a two-year history of ... ...

    Abstract Pulmonary alveolar microlithiasis (PAM) is an uncommon entity which can pose a diagnostic challenge. We report a 45-year-old female who was referred to the All India Institute of Medical Sciences, Bhopal, India, in 2017 with a two-year history of progressively worsening dyspnoea and dry coughing. She had been previously diagnosed with pulmonary tuberculosis elsewhere and prescribed antitubercular therapy; however, there was little improvement in her symptoms. Following referral, the patient was diagnosed with PAM based on high-resolution computed tomography findings and the abundance of lamellar microliths in a bronchoalveolar lavage sample. She was subsequently managed symptomatically and enrolled in a rehabilitation programme. Keywords: Calcinosis; Pulmonary Alveolar Microlithiasis; Pulmonary Tuberculosis; Misdiagnosis; Case Report; India.
    Keywords Medicine ; R
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Sultan Qaboos University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correcting inhaler technique decreases severity of obstruction and improves quality of life among patients with obstructive airway disease

    Alkesh Kumar Khurana / Kapil Dubey / Abhishek Goyal / Kamendra Singh Pawar / Chaiti Phulwaria / Abhijit Pakhare

    Journal of Family Medicine and Primary Care, Vol 8, Iss 1, Pp 246-

    2019  Volume 250

    Abstract: Background: Asthma and chronic obstructive lung disease (COPD) together constitute a huge burden on healthcare all around the world. Treatment of these patients is largely dependent on the way the inhalation devices are used. This study aimed at ... ...

    Abstract Background: Asthma and chronic obstructive lung disease (COPD) together constitute a huge burden on healthcare all around the world. Treatment of these patients is largely dependent on the way the inhalation devices are used. This study aimed at measuring the impact of rectification of inhalation technique on quality of life and severity of obstruction in patients with asthma and COPD. Materials and Methods: A total of 45 asthma (partly controlled) and 38 patients with COPD (categories B and C) were enrolled after applying optimal exclusion criteria. These patients underwent Asthma Control Test (ACT)/COPD Assessment Test (CAT) questionnaire as a measure of quality of life and forced expiratory volume in one second (FEV1) as a measure of severity of obstruction at 0 and 4 weeks, respectively. Results: In asthmatics, the mean FEV1 improved from 2.0 to 2.15 L after 4 weeks of technique correction (P < 0.001). In addition, the mean ACT scores improved from 18.0 to 20.75 (P < 0.001). In patients with COPD, the mean FEV1 improved slightly from 1.54 to 1.56 L after 4 weeks of technique correction (P = 0.28). In addition, the mean CAT scores improved from 21.86 to 19.83 (P < 0.001). Conclusion: Demonstration of correct inhalation technique should be an indispensible part of the treatment prescription of patients with obstructive airway disease. This simple and important task can be undertaken at the level of primary care physicians in a community-based setting to improve patient compliance.
    Keywords Asthma ; chronic obstructive lung disease ; inhalation technique ; quality of life ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: An Optimized Machine Learning Model Accurately Predicts In-Hospital Outcomes at Admission to a Cardiac Unit

    Sandeep Chandra Bollepalli / Ashish Kumar Sahani / Naved Aslam / Bishav Mohan / Kanchan Kulkarni / Abhishek Goyal / Bhupinder Singh / Gurbhej Singh / Ankit Mittal / Rohit Tandon / Shibba Takkar Chhabra / Gurpreet S. Wander / Antonis A. Armoundas

    Diagnostics, Vol 12, Iss 241, p

    2022  Volume 241

    Abstract: Risk stratification at the time of hospital admission is of paramount significance in triaging the patients and providing timely care. In the present study, we aim at predicting multiple clinical outcomes using the data recorded during admission to a ... ...

    Abstract Risk stratification at the time of hospital admission is of paramount significance in triaging the patients and providing timely care. In the present study, we aim at predicting multiple clinical outcomes using the data recorded during admission to a cardiac care unit via an optimized machine learning method. This study involves a total of 11,498 patients admitted to a cardiac care unit over two years. Patient demographics, admission type (emergency or outpatient), patient history, lab tests, and comorbidities were used to predict various outcomes. We employed a fully connected neural network architecture and optimized the models for various subsets of input features. Using 10-fold cross-validation, our optimized machine learning model predicted mortality with a mean area under the receiver operating characteristic curve (AUC) of 0.967 (95% confidence interval (CI): 0.963–0.972), heart failure AUC of 0.838 (CI: 0.825–0.851), ST-segment elevation myocardial infarction AUC of 0.832 (CI: 0.821–0.842), pulmonary embolism AUC of 0.802 (CI: 0.764–0.84), and estimated the duration of stay (DOS) with a mean absolute error of 2.543 days (CI: 2.499–2.586) of data with a mean and median DOS of 6.35 and 5.0 days, respectively. Further, we objectively quantified the importance of each feature and its correlation with the clinical assessment of the corresponding outcome. The proposed method accurately predicts various cardiac outcomes and can be used as a clinical decision support system to provide timely care and optimize hospital resources.
    Keywords machine learning ; mortality ; duration of stay ; heart failure ; STEMI ; pulmonary embolism ; Medicine (General) ; R5-920
    Subject code 610 ; 310
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Impact of a nurse-led teleconsultation strategy for cardiovascular disease management during COVID-19 pandemic in India

    Dorairaj Prabhakaran / Kavita Singh / Ambuj Roy / Bishav Mohan / Rohit Tandon / Abhishek Goyal / Bhupinder Singh / Shibba Takkar Chhabra / Naved Aslam / Gurpreet Singh Wander / Nitish Naik / Gurbhej SIngh / Shivaansh Aggarwal / Aftabh Saini

    BMJ Open, Vol 12, Iss

    a pyramid model feasibility study

    2022  Volume 7

    Abstract: Objective The COVID-19 pandemic necessitated the use of telemedicine to maintain continuity of care for patients with cardiovascular diseases (CVDs). This study aimed to demonstrate the feasibility of implementing a nurse-led teleconsultation strategy ... ...

    Abstract Objective The COVID-19 pandemic necessitated the use of telemedicine to maintain continuity of care for patients with cardiovascular diseases (CVDs). This study aimed to demonstrate the feasibility of implementing a nurse-led teleconsultation strategy for CVD management during the COVID-19 pandemic in India and evaluated the impact of nurse-led teleconsultations on patient treatment satisfaction.Design, setting and participants We developed a two-stage teleconsultation strategy and tested the feasibility of implementing a nurse-led teleconsultation strategy to manage CVD in a northern state (Punjab) in India. A multidisciplinary team of experts developed the treatment protocol used for teleconsultations to manage CVD. Nurses were trained to provide teleconsultation, triaging of patients and referrals to the physicians. Patients with CVD who had an outpatient visit or hospitalisation between September 2019 and March 2020 at the Dayanand Medical College Hospital, Ludhiana, India, were contacted by phone and offered teleconsultations. Telemedicine strategy comprised: stage 1 nurse-led teleconsultations and stage 2 physician-led teleconsultations. Descriptive analysis was performed to report the proportion of patients triaged by the two-stage telemedicine strategy, and patient’s clinical characteristics, and treatment satisfaction between the nurse-led versus physician-led teleconsultations.Results Overall, nurse-led stage 1 teleconsultations were provided to 12 042 patients with CVD. The mean (SD) age of the participants was 58.9 years (12.8), and men were 65.4%. A relatively small proportion of patients (6.3%) were referred for the stage-2 physician-led teleconsultations and of these only 8.4% required hospitalisations. During stage 1 nurse-led teleconsultations, patients were referred to the physicians due to uncontrolled diabetes (24.9%), uncontrolled hypertension (18.7%) and congestive heart failure (16.2%). The patient’s treatment satisfaction was similar between the nurse-led versus physician-led ...
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Six-Week Hospital-Based Pulmonary Rehabilitation in Covid Pneumonia ICU Survivors

    Alkesh Kumar Khurana / Aqeel Hussain / Abhishek Goyal / Sunaina Tejpal Karna / Saurabh Saigal / Raj Krishnan Soman / Mamta Verma / Sagar Khadanga / Gaurav Sahu / Brijendra Singh

    Turkish Thoracic Journal, Vol 23, Iss 2, Pp 89-

    Experience from a Tertiary Care Center in Central India

    2022  Volume 96

    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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