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  1. Article ; Online: Surgery Versus Ablation for Small Hepatocellular Carcinoma Treatment and Role of Personalized Medicine.

    Sadigh, Gelareh / Abi-Jaoudeh, Nadine

    Journal of the American College of Radiology : JACR

    2022  Volume 19, Issue 11, Page(s) 1224–1225

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Precision Medicine ; Catheter Ablation ; Microwaves ; Treatment Outcome
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2022.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Latest Technologies GI Interventions: Imaging, Techniques, Materials

    Abi-Jaoudeh, Nadine

    Digestive Disease Interventions

    (Latest Technologies GI Interventions: Imaging, Techniques, Materials)

    2022  Volume 06, Issue 01, Page(s) 1–2

    Series title Latest Technologies GI Interventions: Imaging, Techniques, Materials
    Language English
    Publishing date 2022-03-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2472-873X ; 2472-8721
    ISSN (online) 2472-873X
    ISSN 2472-8721
    DOI 10.1055/s-0041-1742094
    Database Thieme publisher's database

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  3. Article: Non-Thermal Liver Ablation: Existing and New Technology.

    Nakla, Tiffany / Chow, Jacqueline J / Pham, Kathleen / Abi-Jaoudeh, Nadine

    Seminars in interventional radiology

    2024  Volume 40, Issue 6, Page(s) 497–504

    Abstract: Cancer has and continues to be a complex health crisis plaguing millions around the world. Alcohol ablation was one of the initial methods used for the treatment of liver lesions. It was surpassed by thermal ablation which has played a big role in the ... ...

    Abstract Cancer has and continues to be a complex health crisis plaguing millions around the world. Alcohol ablation was one of the initial methods used for the treatment of liver lesions. It was surpassed by thermal ablation which has played a big role in the therapeutic arsenal for primary and metastatic liver tumors. However, thermal ablation has several shortcomings and limitations that prompted the development of alternative technologies including electroporation and histotripsy. Percutaneous alcohol injection in the liver lesion leads to dehydration and coagulative necrosis. This technology is limited to the lesion with relative sparing of the surrounding tissue, making it safe to use adjacent to sensitive structures. Electroporation utilizes short high-voltage pulses to permeabilize the cell membrane and can result in cell death dependent on the threshold reached. It can effectively target the tumor margins and has lower damage rates to surrounding structures due to the short pulse duration. Histotripsy is a novel technology, and although the first human trial was just completed, its results are encouraging, given the sharp demarcation of the targeted tissue, lack of thermal damage, and potential for immunomodulation of the tumor microenvironment. Herein, we discuss these techniques, their uses, and overall clinical benefit.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0043-1777844
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  4. Article ; Online: MRI radiomics to monitor therapeutic outcome of sorafenib plus IHA transcatheter NK cell combination therapy in hepatocellular carcinoma.

    Yu, Guangbo / Zhang, Zigeng / Eresen, Aydin / Hou, Qiaoming / Garcia, Emilie Elizabeth / Yu, Zeyang / Abi-Jaoudeh, Nadine / Yaghmai, Vahid / Zhang, Zhuoli

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 76

    Abstract: Background: Hepatocellular carcinoma (HCC) is a common liver malignancy with limited treatment options. Previous studies expressed the potential synergy of sorafenib and NK cell immunotherapy as a promising approach against HCC. MRI is commonly used to ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is a common liver malignancy with limited treatment options. Previous studies expressed the potential synergy of sorafenib and NK cell immunotherapy as a promising approach against HCC. MRI is commonly used to assess response of HCC to therapy. However, traditional MRI-based metrics for treatment efficacy are inadequate for capturing complex changes in the tumor microenvironment, especially with immunotherapy. In this study, we investigated potent MRI radiomics analysis to non-invasively assess early responses to combined sorafenib and NK cell therapy in a HCC rat model, aiming to predict multiple treatment outcomes and optimize HCC treatment evaluations.
    Methods: Sprague Dawley (SD) rats underwent tumor implantation with the N1-S1 cell line. Tumor progression and treatment efficacy were assessed using MRI following NK cell immunotherapy and sorafenib administration. Radiomics features were extracted, processed, and selected from both T1w and T2w MRI images. The quantitative models were developed to predict treatment outcomes and their performances were evaluated with area under the receiver operating characteristic (AUROC) curve. Additionally, multivariable linear regression models were constructed to determine the correlation between MRI radiomics and histology, aiming for a noninvasive evaluation of tumor biomarkers. These models were evaluated using root-mean-squared-error (RMSE) and the Spearman correlation coefficient.
    Results: A total of 743 radiomics features were extracted from T1w and T2w MRI data separately. Subsequently, a feature selection process was conducted to identify a subset of five features for modeling. For therapeutic prediction, four classification models were developed. Support vector machine (SVM) model, utilizing combined T1w + T2w MRI data, achieved 96% accuracy and an AUROC of 1.00 in differentiating the control and treatment groups. For multi-class treatment outcome prediction, Linear regression model attained 85% accuracy and an AUC of 0.93. Histological analysis showed that combination therapy of NK cell and sorafenib had the lowest tumor cell viability and the highest NK cell activity. Correlation analyses between MRI features and histological biomarkers indicated robust relationships (r = 0.94).
    Conclusions: Our study underscored the significant potential of texture-based MRI imaging features in the early assessment of multiple HCC treatment outcomes.
    MeSH term(s) Rats ; Animals ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Radiomics ; Rats, Sprague-Dawley ; Treatment Outcome ; Biomarkers, Tumor ; Magnetic Resonance Imaging/methods ; Killer Cells, Natural ; Retrospective Studies ; Tumor Microenvironment
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; Biomarkers, Tumor
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04873-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Subspecialty Training in IR.

    Josephs, Shellie / Keller, Eric J / Vadlamudi, Venu / Annam, Aparna / Abi-Jaoudeh, Nadine

    Journal of vascular and interventional radiology : JVIR

    2023  Volume 34, Issue 12, Page(s) 2074–2075

    MeSH term(s) Humans ; Education, Medical, Graduate ; Education, Medical ; Internship and Residency
    Language English
    Publishing date 2023-11-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2023.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3720: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Non-Thermal Liver Ablation: Existing and New Technology

    Nakla, Tiffany / Chow, Jacqueline J. / Pham, Kathleen / Abi-Jaoudeh, Nadine

    Seminars in Interventional Radiology

    (Liver Cancer (Part 1))

    2023  Volume 40, Issue 06, Page(s) 497–504

    Abstract: Cancer has and continues to be a complex health crisis plaguing millions around the world. Alcohol ablation was one of the initial methods used for the treatment of liver lesions. It was surpassed by thermal ablation which has played a big role in the ... ...

    Series title Liver Cancer (Part 1)
    Abstract Cancer has and continues to be a complex health crisis plaguing millions around the world. Alcohol ablation was one of the initial methods used for the treatment of liver lesions. It was surpassed by thermal ablation which has played a big role in the therapeutic arsenal for primary and metastatic liver tumors. However, thermal ablation has several shortcomings and limitations that prompted the development of alternative technologies including electroporation and histotripsy. Percutaneous alcohol injection in the liver lesion leads to dehydration and coagulative necrosis. This technology is limited to the lesion with relative sparing of the surrounding tissue, making it safe to use adjacent to sensitive structures. Electroporation utilizes short high-voltage pulses to permeabilize the cell membrane and can result in cell death dependent on the threshold reached. It can effectively target the tumor margins and has lower damage rates to surrounding structures due to the short pulse duration. Histotripsy is a novel technology, and although the first human trial was just completed, its results are encouraging, given the sharp demarcation of the targeted tissue, lack of thermal damage, and potential for immunomodulation of the tumor microenvironment. Herein, we discuss these techniques, their uses, and overall clinical benefit.
    Keywords liver cancer ; ablation ; electroporation ; histotripsy ; interventional radiology ; percutaneous alcohol ablation
    Language English
    Publishing date 2023-12-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0043-1777844
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Resin versus Glass Microspheres.

    Abi-Jaoudeh, Nadine

    Journal of vascular and interventional radiology : JVIR

    2016  Volume 27, Issue 6, Page(s) 822–823

    MeSH term(s) Glass ; Humans ; Liver Neoplasms ; Materials Testing ; Microspheres ; Yttrium Radioisotopes
    Chemical Substances Yttrium Radioisotopes
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2016.02.027
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Case of Brown Sequard syndrome with ipsilateral peripheral vasodilation.

    Nelson, Kari / Chu, Eleanor / Abi-Jaoudeh, Nadine

    Radiology case reports

    2020  Volume 15, Issue 8, Page(s) 1366–1368

    Abstract: Brown-Sequard Syndrome is a neurologic disorder caused by partial spinal cord injury and disruption of the corticospinal tract, dorsal columns, and spinothalamic tract. We present a 32-year-old male with partial T11-12 cord transection due to a ... ...

    Abstract Brown-Sequard Syndrome is a neurologic disorder caused by partial spinal cord injury and disruption of the corticospinal tract, dorsal columns, and spinothalamic tract. We present a 32-year-old male with partial T11-12 cord transection due to a penetrating knife injury. In addition to the classical neurological symptoms of Brown-Sequard Syndrome, he also exhibited ipsilateral peripheral vasodilatation below the level of injury. This finding is attributed to the disruption of the intermediolateral columns of the spinal cord and impaired sympathetic tone on the peripheral vasculature. Awareness of this finding can raise the radiologist's suspicion for spinal cord injury in the setting of trauma and peripheral vasodilation.
    Language English
    Publishing date 2020-06-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2020.06.005
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  9. Article: Therapy in Advanced Hepatocellular Carcinoma.

    Javan, Hanna / Dayyani, Farshid / Abi-Jaoudeh, Nadine

    Seminars in interventional radiology

    2020  Volume 37, Issue 5, Page(s) 466–474

    Abstract: Treatment of advanced hepatocellular carcinoma (HCC) is challenging. Several randomized clinical trials are investigating the efficacy of systemic therapy, immunotherapy, and locoregional therapy as monotherapy or combined with other modalities in the ... ...

    Abstract Treatment of advanced hepatocellular carcinoma (HCC) is challenging. Several randomized clinical trials are investigating the efficacy of systemic therapy, immunotherapy, and locoregional therapy as monotherapy or combined with other modalities in the treatment of HCC. Systemic therapy is the preferred treatment in advanced disease. To date, multiple first-line and second-line agents received Food and Drug Administration approval. For over a decade, sorafenib was the only first-line agent. In May 2020, combination of atezolizumab and bevacizumab has been approved as a first-line systemic regimen. Lenvatinib is another first-line agent that has multikinase activity. Second-line agents include cabozantinib, regorafenib, ramucirumab, and nivolumab. Adoptive cell transfer therapy is a highly specific immunotherapy that has shown antitumor activity against HCC. Oncolytic viruses are genetically modified viruses that infect cancer cells and induce apoptosis. Locoregional therapies such as transarterial chemoembolization and radioembolization have shown a potential benefit in selected patients with advanced HCC. In this review, we aim to summarize the treatment options available for advanced HCC.
    Language English
    Publishing date 2020-12-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0040-1719187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Drug-Eluting Embolic Loaded with Tyrosine Kinase Inhibitor Targeted Therapies for Transarterial Chemoembolization in a VX2 Model.

    Abi-Jaoudeh, Nadine / Sadeghi, Ben / Javan, Hanna / Na, Jim / Beaton, Graham / Tucci, Fabio / Ravula, Satheesh / Imagawa, David K

    Cancers

    2023  Volume 15, Issue 12

    Abstract: Drug-eluting embolic transarterial chemoembolization (DEE-TACE) improves the overall survival of hepatocellular carcinoma (HCC), but the agents used are not tailored to HCC. Our patented liposomal formulation enables the loading and elution of targeted ... ...

    Abstract Drug-eluting embolic transarterial chemoembolization (DEE-TACE) improves the overall survival of hepatocellular carcinoma (HCC), but the agents used are not tailored to HCC. Our patented liposomal formulation enables the loading and elution of targeted therapies onto DEEs. This study aimed to establish the safety, feasibility, and pharmacokinetics of sorafenib or regorafenib DEE-TACE in a VX2 model. DEE-TACE was performed in VX2 hepatic tumors in a selective manner until stasis using liposomal sorafenib- or regorafenib-loaded DEEs. The animals were euthanized at 1, 24, and 72 h timepoints post embolization. Blood samples were taken for pharmacokinetics at 5 and 20 min and at 1, 24, and 72 h. Measurements of sorafenib or regorafenib were performed in all tissue samples on explanted hepatic tissue using the same mass spectrometry method. Histopathological examinations were carried out on tumor tissues and non-embolized hepatic specimens. DEE-TACE was performed on 23 rabbits. The plasma concentrations of sorafenib and regorafenib were statistically significantly several folds lower than the embolized liver at all examined timepoints. This study demonstrates the feasibility of loading sorafenib or regorafenib onto commercially available DEEs for use in TACE. The drugs eluted locally without release into systemic circulation.
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15123236
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