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Article ; Online: TFEB is a central regulator of the aging process and age-related diseases.

Abokyi, Samuel / Ghartey-Kwansah, George / Tse, Dennis Yan-Yin

2023 Volume 89, Page(s) 101985

Abstract: Old age is associated with a greater burden of disease, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic diseases. Coincidentally, popular lifestyle interventions, such as caloric ... ...

Abstract	Old age is associated with a greater burden of disease, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic diseases. Coincidentally, popular lifestyle interventions, such as caloric restriction, intermittent fasting, and regular exercise, in addition to pharmacological interventions intended to protect against age-related diseases, induce transcription factor EB (TFEB) and autophagy. In this review, we summarize emerging discoveries that point to TFEB activity affecting the hallmarks of aging, including inhibiting DNA damage and epigenetic modifications, inducing autophagy and cell clearance to promote proteostasis, regulating mitochondrial quality control, linking nutrient-sensing to energy metabolism, regulating pro- and anti-inflammatory pathways, inhibiting senescence and promoting cell regenerative capacity. Furthermore, the therapeutic impact of TFEB activation on normal aging and tissue-specific disease development is assessed in the contexts of neurodegeneration and neuroplasticity, stem cell differentiation, immune responses, muscle energy adaptation, adipose tissue browning, hepatic functions, bone remodeling, and cancer. Safe and effective strategies of activating TFEB hold promise as a therapeutic strategy for multiple age-associated diseases and for extending lifespan.
MeSH term(s)	Humans ; Autophagy/physiology ; Parkinson Disease/genetics ; Alzheimer Disease ; Aging ; Lysosomes ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Chemical Substances	TFEB protein, human ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2023.101985
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Article ; Online: Maximal incremental exercise improves macular photostress recovery time and lowers intraocular pressure in healthy athletes.

Abokyi, Samuel / Sekyere, Nyamaah Mensah / Ocansey, Stephen

Journal of science and medicine in sport

2023 Volume 26, Issue 12, Page(s) 646–649

Abstract: Objectives: Better visual performance in athletes compared to non-athletes could suggest improved macular function through physical exertion. The study aimed to investigate the effect of maximal incremental treadmill (MIT) exercise on macular function.!# ...

Abstract	Objectives: Better visual performance in athletes compared to non-athletes could suggest improved macular function through physical exertion. The study aimed to investigate the effect of maximal incremental treadmill (MIT) exercise on macular function. Design: An interventional study comparing the effect of maximal incremental treadmill (MIT) exercise until volitional exhaustion between athletes (n = 26) and non-athletes (n = 26). Methods: Participants underwent an ophthalmological assessment involving repeated measurements of the photostress recovery time (PSRT) at baseline and post-exercise. PSRT was recorded after a 10-second exposure of the macular to an intense light source from an ophthalmoscope positioned 2 cm in front of the eye. Secondary outcome measures also recorded included the best-corrected visual acuity (BCVA) and the intraocular pressure (IOP). Results: Compared to the baseline, MIT exercise markedly improved the PSRT of athletes from 42.7 ± 1.6 s to 39.6 ± 1.4 s (P < 0.001), while having no significant changes in the PSRT of non-athletes. After adjusting for exercise duration, the exercise intervention showed significant effects on the PSRT improvement in the athletes compared to non-athletes after exercise [F(1,49) = 16.941, P < 0.001], with estimated marginal means of 3.00 s and 0.47 s, respectively. Also, the exercise intervention resulted in significant improvements in IOP (P < 0.001) and BCVA (P < 0.01) of both groups. Conclusions: MIT exercise improves macular function, BCVA, and reduced IOP in healthy athletes. Maximal incremental exercise may be recommended for competitive sports athletes seeking optimal visual performance, as long as it does not adversely impact other relevant non-visual factors.
MeSH term(s)	Humans ; Intraocular Pressure ; Exercise ; Physical Exertion ; Athletes
Language	English
Publishing date	2023-09-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1437829-2
ISSN	1878-1861 ; 1440-2440
ISSN (online)	1878-1861
ISSN	1440-2440
DOI	10.1016/j.jsams.2023.09.017
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Zs.A 4926: Show issues

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Article ; Online: Associations between personality traits and adherence to treatment in patients with primary open-angle glaucoma in an African population.

Abu, Emmanuel K / Antiri, Ebenezer O / Ocansey, Stephen / Ntodie, Michael / Abokyi, Samuel / Abraham, Carl Halladay

Clinical & experimental optometry

2022 Volume 106, Issue 5, Page(s) 509–515

Abstract: Clinical relevance: Inclusion of personality profile assessment and appropriate psychotherapeutic regimen in glaucoma diagnosis and management protocols could prove useful for enhanced medication adherence in patients living with glaucoma.: Background! ...

Abstract	Clinical relevance: Inclusion of personality profile assessment and appropriate psychotherapeutic regimen in glaucoma diagnosis and management protocols could prove useful for enhanced medication adherence in patients living with glaucoma. Background: There is poor adherence to medication among patients with glaucoma, especially in people of African ancestry. The present study assessed the influence of personality traits on adherence to glaucoma medication among patients living with primary open-angle glaucoma (POAG) from an African population. Methods: A clinic-based cross-sectional study was conducted among patients with POAG attending a specialist eye-care facility. Adapted and validated questionnaires for personality trait (The Big Five Inventory) and medication adherence (Medication Adherence Report Scale 5) were used. Results: Self-reported adherence to glaucoma medication was 60.8%. The personality traits conscientiousness and agreeableness significantly predicted medication adherence but accounted for only 30.3% and 13.3% of the variance, respectively. Non-adherence to glaucoma medication was significantly predicted by the personality profiles neuroticism, extraversion and openness which, respectively, accounted for 61.7%, 20.3% and 13.3% of the variance in the personality trait assessment. Old age and longer use of glaucoma medications were also significantly associated with non-adherence to glaucoma medication. Conclusions: Personality trait dimensions were significantly associated with glaucoma medication adherence in this at-risk population.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Glaucoma, Open-Angle/drug therapy ; Personality ; Medication Adherence ; Personality Inventory
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	639275-1
ISSN	1444-0938 ; 0816-4622
ISSN (online)	1444-0938
ISSN	0816-4622
DOI	10.1080/08164622.2022.2075253
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Article: In vitro

Sánchez-Vidaña, Dalinda Isabel / Li, Jingjing / Abokyi, Samuel / Chan, Jackie Ngai-Man / Ngai, Shirley Pui-Ching / Lau, Benson Wui-Man

Frontiers in molecular neuroscience

2023 Volume 16, Page(s) 1168948

Abstract: Background: Autophagy is a conserved physiological intracellular mechanism responsible for the degradation and recycling of cytoplasmic constituents (e.g., damaged organelles, and protein aggregates) to maintain cell homeostasis. Aberrant autophagy has ... ...

Abstract	Background: Autophagy is a conserved physiological intracellular mechanism responsible for the degradation and recycling of cytoplasmic constituents (e.g., damaged organelles, and protein aggregates) to maintain cell homeostasis. Aberrant autophagy has been observed in neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Huntington's Disease (HD), and recently aberrant autophagy has been associated with mood disorders, such as depression. Several Methods: Pubmed and Google Scholar were used to retrieve relevant Results: A repertoire of traditional and novel approaches and techniques was compiled and discussed. The methods used in autophagy research focused on the mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy. The Conclusion: This is the first review to compile, discuss, and provide a catalog of traditional and novel
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2023.1168948
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Article ; Online: Controlled blood sugar improves the eye's accommodative ability in type-1 diabetes.

Abokyi, Samuel / Ayerakwah, Patience Ansomah / Abu, Sampson Listowell / Abu, Emmanuel Kwasi

Eye (London, England)

2020 Volume 35, Issue 4, Page(s) 1198–1204

Abstract: Purpose: To evaluate the impact of blood sugar level on ocular measures, including refractive error (RE), amplitude of accommodation (AoA), and lag of accommodation (LoA), in pre-presbyopes with type-1 diabetes.: Method: The fasting blood sugar (FBS) ...

Abstract	Purpose: To evaluate the impact of blood sugar level on ocular measures, including refractive error (RE), amplitude of accommodation (AoA), and lag of accommodation (LoA), in pre-presbyopes with type-1 diabetes. Method: The fasting blood sugar (FBS) and ocular measures of type-1 diabetes patients (age: 14-39 years; n = 30) on insulin treatment was recorded while they fasted on two separate visits, at baseline and 3 months later. The AoA and LoA was measured with the appropriate spectacle correction worn. The Welch's t-test was used for comparison of the baseline measures between the normal FBS ≤ 7 (n = 10) and higher FBS > 7 (n = 20) patients, and the paired t-test used to investigate for differences between the baseline and follow-up data in patients with changes in FBS. Results: On average, the spectacle correction for the normal FBS group was marginally more myopic (RE: -0.30 ± 0.67 D vs. +0.18 ± 1.00 D, p = 0.032), and they showed greater AoA (5.38 ± 1.08 D vs. 3.68 ± 1.43 D, p < 0.001) and lower LoA (1.00 ± 0.30 D vs. 1.30 ± 0.38 D, p = 0.004) compared with the higher FBS group at baseline. On the follow-up visit attended by 25 patients, the FBS of 15 patients was reduced by an average of 7.0 mmol/L, 8 patients had an average increase of 5.2 mmol/L, while 2 patients recorded no changes relative to the baseline. The patients whose FBS was reduced showed improvement in the mean AoA from 3.78 ± 1.58 D to 4.88 ± 1.61 D (p < 0.001) and a reduction in the mean LoA from 1.37 ± 0.40D to 0.87 ± 0.19D (p < 0.001), whereas those with deteriorated control of the FBS showed an opposite trend. Conclusions: Controlling hyperglycemia improves ocular accommodation in type-1 diabetes.
MeSH term(s)	Accommodation, Ocular ; Adolescent ; Adult ; Blood Glucose ; Diabetes Mellitus, Type 1/drug therapy ; Eyeglasses ; Humans ; Myopia ; Refraction, Ocular ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-1058-y
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Article ; Online: Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models.

Abokyi, Samuel / To, Chi-Ho / Lam, Tim T / Tse, Dennis Y

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 7901270

Abstract: Age-related macular degeneration (AMD) is a common cause of visual impairment in the elderly. There are very limited therapeutic options for AMD with the predominant therapies targeting vascular endothelial growth factor (VEGF) in the retina of patients ... ...

Abstract	Age-related macular degeneration (AMD) is a common cause of visual impairment in the elderly. There are very limited therapeutic options for AMD with the predominant therapies targeting vascular endothelial growth factor (VEGF) in the retina of patients afflicted with wet AMD. Hence, it is important to remind readers, especially those interested in AMD, about current studies that may help to develop novel therapies for other stages of AMD. This study, therefore, provides a comprehensive review of studies on human specimens as well as rodent models of the disease, to identify and analyze the molecular mechanisms behind AMD development and progression. The evaluation of this information highlights the central role that oxidative damage in the retina plays in contributing to major pathways, including inflammation and angiogenesis, found in the AMD phenotype. Following on the debate of oxidative stress as the earliest injury in the AMD pathogenesis, we demonstrated how the targeting of oxidative stress-associated pathways, such as autophagy and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, might be the futuristic direction to explore in the search of an effective treatment for AMD, as the dysregulation of these mechanisms is crucial to oxidative injury in the retina. In addition, animal models of AMD have been discussed in great detail, with their strengths and pitfalls included, to assist inform in the selection of suitable models for investigating any of the molecular mechanisms.
MeSH term(s)	Animals ; Disease Models, Animal ; Humans ; Macular Degeneration/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/physiology ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	NF-E2-Related Factor 2 ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-02-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/7901270
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Article ; Online: Differential effect of maximal incremental treadmill exercise on tear secretion and tear film stability in athletes and non-athletes.

Abokyi, Samuel / Mensah, Sekyere Nyamaah / Otchere, Heinz / Akoto, Yaw Osei / Ntodie, Michael

Experimental eye research

2021 Volume 214, Page(s) 108865

Abstract: The study investigated the differential response to a single bout of maximal incremental treadmill exercise between athletes and non-athletes without dry eyes regarding tear secretion, tear film stability, visual acuity (VA), and stereoacuity. ... ...

Abstract	The study investigated the differential response to a single bout of maximal incremental treadmill exercise between athletes and non-athletes without dry eyes regarding tear secretion, tear film stability, visual acuity (VA), and stereoacuity. Additionally, the study examined the effect of gender and the duration of exercise on exercise-induced changes. Study participants included young university students aged 18-25 years who were athletes (male/female: 13/13) or non-athletes (male/female: 17/9). Participants underwent an aerobic exercise session using a treadmill and following the laid down Bruce treadmill test protocol till exhaustion. Measurements were taken in the order of distance VA, stereopsis, non-invasive tear break-up time (TBUT), and phenol red thread test, at baseline and after the exercise regimen. Within- and between-subject analyses using multiple t-tests with correction for multiple comparisons were performed to determine differences before and after exercise in athletes and non-athletes. Subsequently, ANCOVA was used to assess the influence of gender and the duration of exercise. The mean age (SD) of the athletes and the non-athletes was 22.4 ± 2.1 years and 21.8 ± 2.1 years, respectively (p = 0.357). Before exercise, the athletes had higher TBUT than non-athletes (14.6 ± 2.9 s vs. 11.9 ± 3.8 s; p = 0.021), but no difference was observed in any other ocular measurements. After exercise, the athletes showed significant improvement in tear secretion with the basal tear secretion increasing from 22.3 ± 2.5 mm to 25.8 ± 1.7 mm (p < 0.001). The non-athletes on the other hand had a borderline increase in tear secretion from 21.42 ± 2.85 mm to 23.73 ± 2.68 mm (p = 0.08). Also, the TBUT was much improved in the athletes after exercise compared to the non-athletes (17.7 ± 2.7 s vs. 14.8 ± 2.9 s, p = 0.004). Additionally, exercise improved the VA indifferently between the groups, while stereoacuity was unchanged after exercise in either group. Gender had no influence on the differences in the tear function measures between athletes and non-athletes after exercise. The duration of exercise, however, showed a borderline effect on the tear film stability (p = 0.068) after exercise. Our findings support the differential effect of maximal incremental treadmill exercise on tear secretion and tear film stability between athletes and non-athletes. Thus, increased physical fitness and the duration of exercise might be crucial in the improvement of tear function through aerobic exercise.
MeSH term(s)	Adolescent ; Adult ; Athletes ; Depth Perception/physiology ; Dry Eye Syndromes/physiopathology ; Exercise/physiology ; Exercise Test ; Female ; Humans ; Male ; Sex Factors ; Tears/physiology ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2021-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2021.108865
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Article ; Online: Application and repeatability of ocular biometric measures for gaze position calibration in children.

Ntodie, Michael / Enimah, Eugene B / Akoto, Yaw O / Yennu, Joseph N / Abokyi, Samuel / Abu, Emmanuel K

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2021 Volume 41, Issue 5, Page(s) 1144–1151

Abstract: Purpose: The purpose of this study was to investigate the utility of two ocular biometric measurements to obtain Hirschberg ratios (HRs) in a binocularly normal paediatric population, and to assess the repeatability of this approach.: Methods: Ocular ...

Abstract	Purpose: The purpose of this study was to investigate the utility of two ocular biometric measurements to obtain Hirschberg ratios (HRs) in a binocularly normal paediatric population, and to assess the repeatability of this approach. Methods: Ocular biometry data from 80 participants (aged 5 to 14 years) was obtained using the KM-1 LED manual keratometer and the Tomey Biometer AL-100 A-scan. HRs were calculated from corneal curvature and anterior chamber depth measurements in the horizontal and vertical meridians of each eye using a regression equation based on a geometric optics model. To assess intrasubject variability in the HRs obtained from biometry, measurements were repeated approximately 1 h later. Results: At the initial measurement, mean (SD, range) HRs were 10.77 (0.79, 9.14-12.73) and 11.02 (0.82, 9.48-13.32) °/mm for the horizontal and vertical meridians, respectively. There was a significant difference between the horizontal and vertical HRs (p < 0.0001). Mean intrasubject variability of HR was 0.06 °/mm (95% Limit of Agreement [LOA]: -0.82 to 0.94 °/mm), and 0.05 °/mm (95% LOA: -1.05 to 1.15 °/mm) for the horizontal and vertical meridians, respectively. Conclusion: The results indicated that HRs obtained through ocular biometry in a binocularly normal paediatric population are consistent with previous studies in both strabismic children and adult cohorts. The HRs obtained with this technique were highly repeatable in this study population. This approach to gaze position calibration could be used in lieu of other empirical techniques in children.
MeSH term(s)	Adult ; Anterior Chamber ; Biometry ; Calibration ; Child ; Cornea ; Humans ; Optics and Photonics ; Reproducibility of Results
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.12866
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Article ; Online: Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.

Abokyi, Samuel / Shan, Sze Wan / To, Chi-Ho / Chan, Henry Ho-Lung / Tse, Dennis Yan-Yin

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 5296341

Abstract: Trehalose is a natural dietary molecule that has shown antiaging and neuroprotective effects in several animal models of neurodegenerative diseases. The role of trehalose in the management of age-related macular degeneration (AMD) is yet to be ... ...

Abstract	Trehalose is a natural dietary molecule that has shown antiaging and neuroprotective effects in several animal models of neurodegenerative diseases. The role of trehalose in the management of age-related macular degeneration (AMD) is yet to be investigated and whether trehalose could be a remedy for the treatment of diseases linked to oxidative stress and NRF2 dysregulation. Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes
MeSH term(s)	Animals ; Autophagy ; Disease Models, Animal ; Humans ; NF-E2-Related Factor 2/antagonists & inhibitors ; Oxidative Stress/drug effects ; Retinal Pigment Epithelium/metabolism ; Trehalose/pharmacology ; Trehalose/therapeutic use ; Up-Regulation
Chemical Substances	NF-E2-Related Factor 2 ; Trehalose (B8WCK70T7I)
Language	English
Publishing date	2020-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/5296341
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Article ; Online: Knowledge, usage and barriers associated with contact lens wear in Ghana.

Abokyi, Samuel / Manuh, George / Otchere, Heinz / Ilechie, Alex

Contact lens & anterior eye : the journal of the British Contact Lens Association

2017 Volume 40, Issue 5, Page(s) 329–334

Abstract: Background: Despite findings that contact lens wear for vision correction provides better quality of life than spectacles, contact lens use in developing countries is low. This study evaluated knowledge, usage and barriers associated with contact lens ... ...

Abstract	Background: Despite findings that contact lens wear for vision correction provides better quality of life than spectacles, contact lens use in developing countries is low. This study evaluated knowledge, usage and barriers associated with contact lens wear among spectacle wearers in Cape Coast, Ghana. Method: A cross-sectional survey using a structured questionnaire was conducted on an adult population of spectacle wearers to assess their knowledge of contact lens wear for vision correction. The participants were proportionately sampled from three eye clinics in the Cape Coast Metropolis, Ghana. Questionnaires were either self-administered or completed with the help of a research assistant. Results: Of the 422 participants, only 147 (34.8%) knew of contact lens wear for vision correction. The proportion of spectacle wearers reporting history of contact lens wear was 14 (3.3%). Barriers to contact lens wear reported were satisfaction with vision through spectacles 102 (25.0%), lack of adequate information 111 (27.2%), fear of side effects 94 (23.0%) and cost 78 (19.1%). The younger adults and those with higher number of changes of spectacles were more likely to know of contact lenses. Conclusion: Knowledge and usage of contact lenses among spectacle wearers was low. Contact lens education and demonstration of visual performance through fitting of trial contact lenses on potential candidates may help overcome barriers to contact lens wear.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2004847-6
ISSN	1476-5411 ; 1367-0484
ISSN (online)	1476-5411
ISSN	1367-0484
DOI	10.1016/j.clae.2017.05.006
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