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  1. Article: Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation (HD-ACI).

    Guillén-García, Pedro / Guillén-Vicente, Isabel / Rodríguez-Iñigo, Elena / Guillén-Vicente, Marta / Fernández-Jaén, Tomás Fernando / Navarro, Ramón / Aboli, Lucía / Torres, Raúl / Abelow, Steve / López-Alcorocho, Juan Manuel

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: Hyaline cartilage's inability to self-repair can lead to osteoarthritis and joint replacement. Various treatments, including cell therapy, have been developed for cartilage damage. Autologous chondrocyte implantation (ACI) is considered the best option ... ...

    Abstract Hyaline cartilage's inability to self-repair can lead to osteoarthritis and joint replacement. Various treatments, including cell therapy, have been developed for cartilage damage. Autologous chondrocyte implantation (ACI) is considered the best option for focal chondral lesions. In this article, we aimed to create a narrative review that highlights the evolution and enhancement of our chondrocyte implantation technique: High-Density-ACI (HD-ACI) Membrane-assisted Autologous Chondrocyte Implantation (MACI) improved ACI using a collagen membrane as a carrier. However, low cell density in MACI resulted in softer regenerated tissue. HD-ACI was developed to improve MACI, implanting 5 million chondrocytes per cm
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10091083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation: Two-Year Follow-up.

    Lopez-Alcorocho, Juan Manuel / Aboli, Lucia / Guillen-Vicente, Isabel / Rodriguez-Iñigo, Elena / Guillen-Vicente, Marta / Fernández-Jaén, Tomás F / Arauz, Santiago / Abelow, Steve / Guillen-García, Pedro

    Cartilage

    2017  Volume 9, Issue 4, Page(s) 363–369

    Abstract: Objective: The aim of this work was to study the short- and mid-term effectiveness and safety of high-density autologous chondrocyte implantation (HD-ACI) in the first 50 patients with knee cartilage damage treated in our unit.: Design: Fifty ... ...

    Abstract Objective: The aim of this work was to study the short- and mid-term effectiveness and safety of high-density autologous chondrocyte implantation (HD-ACI) in the first 50 patients with knee cartilage damage treated in our unit.
    Design: Fifty consecutive patients with cartilage lesions (Outerbridge grade III-IV) in the knee treated with HD-ACI were included in this study. Chondrocytes were isolated from a nonbearing cartilage area biopsy and were cultured until 40 to 50 million cells were obtained. Five million chondrocytes per cm
    Results: The percentage of patients with pain and swelling decreased progressively in the following visits, with differences being statistically significant ( P < 0.001 and P = 0.040, respectively). IKDC scores improved progressively throughout the 24-month follow-up ( P < 0.001). Thus, the mean IKDC score improvement was 26.3 points (95% confidence interval [CI] = 18.2-34.4 points) at 12 months and 31.0 points (95% CI = 22.9-39 points) at 24 months. No significant differences were found when performing extension ( P = 0.112). Flexion significantly improved by 25.1° at 24-month follow-up ( P = 0.013).
    Conclusions: HD-ACI is a safe and effective technique for the treatment of cartilage defects, improving clinical and subjective perception of knee functionality. These preliminary results encourage future studies comparing this technique with traditional ACI.
    MeSH term(s) Adolescent ; Adult ; Animals ; Arthroplasty, Subchondral/methods ; Cartilage Diseases/surgery ; Cartilage, Articular/surgery ; Chondrocytes/transplantation ; Female ; Follow-Up Studies ; Humans ; Knee Joint/surgery ; Male ; Middle Aged ; Prospective Studies ; Swine ; Transplantation, Autologous ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515870-3
    ISSN 1947-6043 ; 1947-6035
    ISSN (online) 1947-6043
    ISSN 1947-6035
    DOI 10.1177/1947603517693045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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