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  1. Article: Bio-Fabrication of Bio-Inspired Silica Nanomaterials from Orange Peels in Combating Oxidative Stress.

    Abomughaid, Mosleh Mohammad

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 18

    Abstract: Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed ... ...

    Abstract Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed with UV-visible spectroscopy and Fourier transform infrared spectroscopy. Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis and X-ray diffraction analysis were employed to confirm the shape, size and elemental purities of the silica nanoparticles. The thermal stability and mass loss of the silica nanoparticles was examined using thermogravimetric analysis and zeta potential analysis. The surface plasmon resonance band of the silica nanoparticle was obtained in the wavelength of 292 nm. Silica nanoparticles with a spherical and amorphous nature and an average size of 20 nm were produced and confirmed by X-ray diffraction and Scanning Electron Microscopy. The zeta potential of the silica nanoparticles was -25.00 mV. The strong and broad bands were located at 457, 642 and 796 cm
    Language English
    Publishing date 2022-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12183236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Long-Term Survival and Cancer Risk in the Hepatitis C Virus-Infected Patients After Antiviral Treatment: A Nationwide Cohort Study.

    Chen, Yi-Ju / Huang, Jing-Yang / Baskaran, Rathinasamy / Abomughaid, Mosleh Mohammad / Hsieh, Chang-Chi / Lin, Wan-Teng

    Journal of Cancer

    2024  Volume 15, Issue 1, Page(s) 113–125

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.87259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potato protein hydrolysate inhibits RANKL-induced osteoclast development by inhibiting osteoclastogenic genes via the NF-κB/MAPKs signaling pathways.

    Chen, Yi-Ju / He, Yen-Hua / Lo, Yun-Hsin / Yang, Hong-Siang / Abomughaid, Mosleh Mohammad / Kumar, K J Senthil / Lin, Wan-Teng

    Environmental toxicology

    2024  

    Abstract: In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti-osteoclast properties of potato protein ... ...

    Abstract In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti-osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor-κB ligand (RANKL), and PP902 was examined for its inhibitory effect. Initially, treatment with PP902 was found to significantly prevent RANKL-induced morphological changes in macrophage cells, as determined by tartrate-resistant acid phosphatase (TRAP) staining analysis. This notion was further supported by F-actin analysis using a confocal microscope. Furthermore, PP902 treatment effectively and dose-dependently down-regulated the expression of RANKL-induced osteoclastogenic marker genes, including TRAP, CTR, RANK, NFATc1, OC-STAMP, and c-Fos. These inhibitory effects were associated with suppressing NF-κB transcriptional activation and subsequent reduced nuclear translocation. The decrease in NF-κB activity resulted from reduced activation of its upstream kinases, including I-κBα and IKKα. Moreover, PP902 significantly inhibited RANKL-induced p38MAPK and ERK1/2 activities. Nevertheless, PP902 treatment prevents RANKL-induced intracellular reactive oxygen species generation via increased HO-1 activity. The combined antioxidant and anti-inflammatory effects of PP902 resulted in significant suppression of osteoclastogenesis, suggesting its potential as an adjuvant therapy for osteoclast-related diseases.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bio-fabrication of Bio-inspired Silica Nanomaterials from Bryophyllum pinnatum Leaf for Agricultural Applications

    Sankareswaran, M. / Periakaruppan, Rajiv / Sasivarnam, M. / Danaraj, Jeyapragash / Dhanasekaran, Sugapriya / Abomughaid, Mosleh Mohammad

    Applied biochemistry and biotechnology. 2022 Sept., v. 194, no. 9

    2022  

    Abstract: A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An ... ...

    Abstract A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An analysis of the physicochemical properties of formed nanoparticles was successfully completed through sophisticated characterization methods, such as UV–Visible absorbance spectroscopy, Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, zeta potential analysis, and thermo-gravimetric analysis. All the characterization results indicated their spherical morphology and amorphous nature with an average size of 24 nm. FT-IR results highlighted the key bioactive compounds that could be responsible for capping and reducing the formation of SiNPs. Synthesized SiNPs show excellent stability with a negative zeta potential value of − 32 mV. The biomolecules from B. pinnatum were successfully working for the formation of Si NPs with spherical shapes. Moreover, to assess the agricultural application, green-synthesized SiNPs were carried out by seed germination assay on Vigna radiata. The seed germination assay confirms that a low concentration of SiNPs enhances seed germination. Meanwhile, a higher concentration of the SiNPs inhibits seed germination and shoot, and root formation. SiNPs at optimum concentration could be used in the agriculture field as nano growth promoters.
    Keywords Fourier transform infrared spectroscopy ; Kalanchoe pinnata ; Vigna radiata ; X-ray diffraction ; absorbance ; biochemical compounds ; biofabrication ; energy-dispersive X-ray analysis ; green chemistry ; leaves ; nanoparticles ; seed germination ; silica ; thermogravimetry ; zeta potential
    Language English
    Dates of publication 2022-09
    Size p. 4266-4277.
    Publishing place Springer US
    Document type Article
    ZDB-ID 392344-7
    ISSN 0273-2289
    ISSN 0273-2289
    DOI 10.1007/s12010-022-03996-4
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Bio-fabrication of Bio-inspired Silica Nanomaterials from Bryophyllum pinnatum Leaf for Agricultural Applications.

    Sankareswaran, M / Periakaruppan, Rajiv / Sasivarnam, M / Danaraj, Jeyapragash / Dhanasekaran, Sugapriya / Abomughaid, Mosleh Mohammad

    Applied biochemistry and biotechnology

    2022  Volume 194, Issue 9, Page(s) 4266–4277

    Abstract: A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An ... ...

    Abstract A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An analysis of the physicochemical properties of formed nanoparticles was successfully completed through sophisticated characterization methods, such as UV-Visible absorbance spectroscopy, Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, zeta potential analysis, and thermo-gravimetric analysis. All the characterization results indicated their spherical morphology and amorphous nature with an average size of 24 nm. FT-IR results highlighted the key bioactive compounds that could be responsible for capping and reducing the formation of SiNPs. Synthesized SiNPs show excellent stability with a negative zeta potential value of - 32 mV. The biomolecules from B. pinnatum were successfully working for the formation of Si NPs with spherical shapes. Moreover, to assess the agricultural application, green-synthesized SiNPs were carried out by seed germination assay on Vigna radiata. The seed germination assay confirms that a low concentration of SiNPs enhances seed germination. Meanwhile, a higher concentration of the SiNPs inhibits seed germination and shoot, and root formation. SiNPs at optimum concentration could be used in the agriculture field as nano growth promoters.
    MeSH term(s) Agriculture ; Green Chemistry Technology ; Kalanchoe ; Metal Nanoparticles/chemistry ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Silicon Dioxide ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
    Chemical Substances Plant Extracts ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-022-03996-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling.

    Hsieh, Ming-Ju / Ho, Hsin-Yu / Lo, Yu-Sheng / Lin, Chia-Chieh / Chuang, Yi-Ching / Abomughaid, Mosleh Mohammad / Hsieh, Ming-Chang / Chen, Mu-Kuan

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Despite advancement in treatment, advanced-stage OSCC is associated with poor prognosis and high mortality. The present study aimed to investigate the anticancer ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Despite advancement in treatment, advanced-stage OSCC is associated with poor prognosis and high mortality. The present study aimed to investigate the anticancer activities of semilicoisoflavone B (SFB), which is a natural phenolic compound isolated from
    MeSH term(s) Humans ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Mitogen-Activated Protein Kinase Kinases ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/metabolism ; Reactive Oxygen Species/metabolism ; Mitogen-Activated Protein Kinases/drug effects ; Mitogen-Activated Protein Kinases/metabolism ; ras Proteins/drug effects ; ras Proteins/metabolism ; Proto-Oncogene Proteins c-raf/drug effects ; Proto-Oncogene Proteins c-raf/metabolism
    Chemical Substances Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Reactive Oxygen Species ; semilicoisoflavone B (T9TP371NFX) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; ras Proteins (EC 3.6.5.2) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1)
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from

    Ho, Hsin-Yu / Lin, Chia-Chieh / Lo, Yu-Sheng / Chuang, Yi-Ching / Abomughaid, Mosleh Mohammad / Hsieh, Ming-Ju

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to investigate the anticancer effects of picrasidine J, a dimeric β-carboline-type alkaloid isolated from the southern Asian plant
    MeSH term(s) Picrasma ; Squamous Cell Carcinoma of Head and Neck ; Alkaloids/pharmacology ; Carbolines ; Antineoplastic Agents/pharmacology ; Polymers ; Head and Neck Neoplasms/drug therapy
    Chemical Substances Alkaloids ; Carbolines ; Antineoplastic Agents ; Polymers
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α.

    Baskaran, Rathinasamy / Balasubramanian, Balamuralikrishnan / Ho, Jou-Hsuan / Wang, Ming-Fu / Abomughaid, Mosleh Mohammad / Yang, Hong-Siang / Lin, Wan-Teng

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 22

    Abstract: Hypertension is a chronic disease related to age, which affects tens of millions of people around the world. It is an important risk factor that causes myocardial infarction, heart failure, stroke, and kidney damage. Bioactive peptide VHVV (VH-4) from ... ...

    Abstract Hypertension is a chronic disease related to age, which affects tens of millions of people around the world. It is an important risk factor that causes myocardial infarction, heart failure, stroke, and kidney damage. Bioactive peptide VHVV (VH-4) from soybean has shown several biological activities. Physical exercise is a cornerstone of non-pharmacologic treatment for hypertension and has established itself as an effective and complementary strategy for managing hypertension. The present study evaluates the efficacy of VH-4 supplement and swimming exercise training in preventing hypertension in spontaneously hypertensive rats (SHR). SHR animals were treated with VH-4 (25 mg/kg by intraperitoneal administration) and swimming exercise (1 h daily) for eight weeks, and the hemodynamic parameters, histology, and cell survival pathway protein expression were examined. In SHR rats, increased heart weight, blood pressure, and histological aberrations were observed. Cell survival protein p-PI3K and p-AKT and antiapoptosis proteins Bcl2 and Bcl-XL expression decreased in SHR animals. SIRT1 and FOXO3 were decreased in hypertensive rats. Both bioactive peptide VH-4 treatment and swimming exercise training in hypertensive rats increased the cell survival proteins p-PI3K and p-AKT and AMPKα1, Sirt1, PGC1α, and FoX3α proteins. Soy peptide VH-4, along with exercise, acts synergistically and prevents hypertension by activating cell survival and AMPKα1, Sirt1, PGC1α, and FoX3α proteins.
    MeSH term(s) Rats ; Animals ; Sirtuin 1/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Glycine max/metabolism ; Cell Survival ; Proto-Oncogene Proteins c-akt/metabolism ; Physical Conditioning, Animal ; Hypertension ; Rats, Inbred SHR ; Peptides/pharmacology ; Peptides/metabolism ; Fabaceae/metabolism ; Phosphatidylinositol 3-Kinases/metabolism
    Chemical Substances Sirtuin 1 (EC 3.5.1.-) ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Peptides ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Sirt1 protein, rat (EC 3.5.1.-)
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27227705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer's disease.

    Albadrani, Hind Muteb / Chauhan, Payal / Ashique, Sumel / Babu, M Arockia / Iqbal, Danish / Almutary, Abdulmajeed G / Abomughaid, Mosleh Mohammad / Kamal, Mehnaz / Paiva-Santos, Ana Cláudia / Alsaweed, Mohammed / Hamed, Munerah / Sachdeva, Punya / Dewanjee, Saikat / Jha, Saurabh Kumar / Ojha, Shreesh / Slama, Petr / Jha, Niraj Kumar

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 174, Page(s) 116376

    Abstract: Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta ... ...

    Abstract Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, a class of naturally occurring compounds, are immensely beneficial for the treatment or management of various disorders and illnesses. Naturally occurring sources of polyphenols include plants and plant-based foods, such as fruits, herbs, tea, vegetables, coffee, red wine, and dark chocolate. Polyphenols have unique properties, such as being the major source of anti-oxidants and possessing anti-aging and anti-cancerous properties. Currently, dietary polyphenols have become a potential therapeutic approach for the management of AD, depending on various research findings. Dietary polyphenols can be an effective strategy to tackle multifactorial events that occur with AD. For instance, naturally occurring polyphenols have been reported to exhibit neuroprotection by modulating the Aβ biogenesis pathway in AD. Many nanoformulations have been established to enhance the bioavailability of polyphenols, with nanonization being the most promising. This review comprehensively provides mechanistic insights into the neuroprotective potential of dietary polyphenols in treating AD. It also reviews the usability of dietary polyphenol as nanoformulation for AD treatment.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/diet therapy ; Alzheimer Disease/metabolism ; Polyphenols/pharmacology ; Humans ; Animals ; Neuroprotective Agents/therapeutic use ; Neuroprotective Agents/pharmacology ; Nanoparticles/chemistry ; Diet ; Amyloid beta-Peptides/metabolism ; Biological Availability
    Chemical Substances Polyphenols ; Neuroprotective Agents ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-03-19
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways.

    Sinha, Jitendra Kumar / Trisal, Anchal / Ghosh, Shampa / Gupta, Saurabh / Singh, Krishna Kumar / Han, Sung Soo / Mahapatra, Madhumita / Abomughaid, Mosleh Mohammad / Abomughayedh, Ali M / Almutary, Abdulmajeed G / Iqbal, Danish / Bhaskar, Rakesh / Mishra, Prabhu Chandra / Jha, Saurabh Kumar / Jha, Niraj Kumar / Singh, Abhishek Kumar

    Ageing research reviews

    2024  Volume 96, Page(s) 102211

    Abstract: Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, ... ...

    Abstract Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, have been recognized for their ability to enhance neural plasticity through the activation of the serotoninergic and glutamatergic systems. However, the implications of these findings for the treatment of neurodegenerative disorders, particularly dementia, have not been fully explored. In recent years, studies have revealed the modulatory and beneficial effects of psychedelics in the context of dementia, specifically Alzheimer's disease (AD)-related dementia, which lacks a definitive cure. Psychedelics such as N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and Psilocybin have shown potential in mitigating the effects of this debilitating disease. These compounds not only target neurotransmitter imbalances but also act at the molecular level to modulate signalling pathways in AD, including the brain-derived neurotrophic factor signalling pathway and the subsequent activation of mammalian target of rapamycin and other autophagy regulators. Therefore, the controlled and dose-dependent administration of psychedelics represents a novel therapeutic intervention worth exploring and considering for the development of drugs for the treatment of AD-related dementia. In this article, we critically examined the literature that sheds light on the therapeutic possibilities and pathways of psychedelics for AD-related dementia. While this emerging field of research holds great promise, further studies are necessary to elucidate the long-term safety, efficacy, and optimal treatment protocols. Ultimately, the integration of psychedelics into the current treatment paradigm may provide a transformative approach for addressing the unmet needs of individuals living with AD-related dementia and their caregivers.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Alzheimer Disease/drug therapy ; Lysergic Acid Diethylamide/pharmacology ; Lysergic Acid Diethylamide/therapeutic use ; Psilocybin/pharmacology ; Psilocybin/therapeutic use ; N,N-Dimethyltryptamine
    Chemical Substances Hallucinogens ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Psilocybin (2RV7212BP0) ; N,N-Dimethyltryptamine (WUB601BHAA)
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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