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  1. Article ; Online: Retraction Note: Rectal vs. sublingual misoprostol before cesarean section: double-blind, three-arm, randomized clinical trial.

    Sweed, Mohamed S / El-Saied, Mourad M / Abou-Gamrah, Amgad E / El-Sabaa, Haitham A / Abdel-Hamid, Mohamed M / Hemeda, Hossam / Mansour, Ahmed M / Shawky, Mohamed E / El-Sayed, Medhat A / Mohamed, Radwa M

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 5, Page(s) 2265

    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07428-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rectal vs. sublingual misoprostol before cesarean section: double-blind, three-arm, randomized clinical trial.

    Sweed, Mohamed S / El-Saied, Mourad M / Abou-Gamrah, Amgad E / El-Sabaa, Haitham A / Abdel-Hamid, Mohamed M / Hemeda, Hossam / Mansour, Ahmed M / Shawky, Mohamed E / El-Sayed, Medhat A / Mohamed, Radwa M

    publication RETRACTED

    Archives of gynecology and obstetrics

    2018  Volume 298, Issue 6, Page(s) 1115–1122

    Abstract: Purpose: The commonest surgical procedure for women is cesarean delivery. Postpartum hemorrhage and intra-operative blood during cesarean delivery is a major concern to all obstetricians. This study was conducted to assess the efficacy of the adjuvant ... ...

    Abstract Purpose: The commonest surgical procedure for women is cesarean delivery. Postpartum hemorrhage and intra-operative blood during cesarean delivery is a major concern to all obstetricians. This study was conducted to assess the efficacy of the adjuvant use of misoprostol and oxytocin in decreasing intra-operative blood loss in cesarean delivery.
    Methods: This was a double-blinded randomized clinical trial including 636 term pregnant woman scheduled for cesarean section at Ain Shams University Maternity Hospital, Cairo, Egypt, between February 2013 and February 2014. Participants received either 400-μg misoprostol rectally or sublingually or placebo before cesarean section together with 5-IU oxytocin IV. The main outcome measure was intra-operative blood loss. Difference between the three groups was analyzed using one-way ANOVA test (for numeric variables) and Chi-square test (for categorical variables). P < 0.05 was considered statistically significant.
    Results: Intra-operative blood loss was higher in patients who did not receive misoprostol (Placebo Group) (295-1075 ml, 641.7 ± 135.7) than those who received it, regardless the route of administration, rectal (135-830 ml, 457.5 ± 140.7; P < 0.001), and sublingual (135-680 ml, 357.8 ± 129.7; P < 0.001). In addition, sublingual route was associated with significantly lower estimated intra-operative blood loss compared to rectal administration (P < 0.001).
    Conclusions: Misoprostol with oxytocin is an effective drug-combination for decreasing intra-operative blood loss during cesarian section with clinical superiority to sublingual over rectal route.
    MeSH term(s) Administration, Rectal ; Administration, Sublingual ; Adult ; Cesarean Section/methods ; Double-Blind Method ; Female ; Humans ; Misoprostol/administration & dosage ; Misoprostol/pharmacology ; Misoprostol/therapeutic use ; Oxytocics/administration & dosage ; Oxytocics/pharmacology ; Oxytocics/therapeutic use ; Pregnancy ; Prospective Studies ; Young Adult
    Chemical Substances Oxytocics ; Misoprostol (0E43V0BB57)
    Language English
    Publishing date 2018-10-05
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-018-4894-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um I Zs.55: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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