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Article ; Online: Voltametric Sensor Based on Magnetic Chitosan Acetylindole-Based Nanocomposite for the Determination of Sulfamethazine.

Abd-Elsabour, Mohamed / Abou-Krisha, Mortaga M / Alhamzani, Abdulrahman G / Alotaibi, Abdullah N / Yousef, Tarek A

ACS omega

2024 Volume 9, Issue 15, Page(s) 17323–17333

Abstract: Sulfamethazine (SMZ), a persistent antibiotic, is frequently detected in drinking water and milk. For this reason, our research aimed to develop a novel electrochemical sensor based on a magnetic nanocomposite supported on chitosan modified by 3- ... ...

Abstract	Sulfamethazine (SMZ), a persistent antibiotic, is frequently detected in drinking water and milk. For this reason, our research aimed to develop a novel electrochemical sensor based on a magnetic nanocomposite supported on chitosan modified by 3-acetylindole through the formation of chitosan acetylindole Schiff base (Chs-Aci). The objective was to detect extremely low concentrations of SMZ in milk. The synthesized nanocomposites were characterized by various techniques, including FT-IR, XRD, EDX, SEM, and TEM. To enhance the electrocatalytic efficiency for sensitive SMZ detection in food samples, a magnetic chitosan acetylindole nanocomposite (M-Chs-Aci) was employed as a modifier for a carbon paste electrode (CPE). The electrochemical measurements revealed that the M-Chs-Aci/CPE exhibits good electrocatalytic performance compared to a bare CPE. Moreover, low detection limit, repeatability, and stability were achieved at 0.021 μM, 3.83%, and 94.87%, respectively. Finally, the proposed M-Chs-Aci/CPE proved to be highly effective in detecting SMZ in milk samples. The obtained findings paved the way for the effective usability of M-Chs-Aci/CPE as a sensor for detecting SMZ in real samples, with acceptable recoveries of 95%-98.87%.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c10390
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Novel Electrochemical Sensor Based on an Environmentally Friendly Synthesis of Magnetic Chitosan Nanocomposite Carbon Paste Electrode for the Determination of Diclofenac to Control Inflammation.

Abd-Elsabour, Mohamed / Abou-Krisha, Mortaga M / Kenawy, Sayed H / Yousef, Tarek A

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, ... ...

Abstract	A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, surface area, and morphology. The produced electrode showed a high electrocatalytic activity to use the DIC in 0.1 M of the BR buffer (pH 3.0). The effect of scanning speed and pH on the DIC oxidation peak suggests that the DIC electrode process has a typical diffusion characteristic with two electrons and two protons. Furthermore, the peak current linearly proportional to the DIC concentration ranged from 0.025 M to 4.0 M with the correlation coefficient (r2). The sensitivity, limit of detection (LOD; 3σ), and the limit of quantification (LOQ; 10σ) were 0.993, 9.6 µA/µM cm
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13061079
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Article ; Online: An effective, novel, and cheap carbon paste electrode for naproxen estimation

Abd-Elsabour Mohamed / Abou-Krisha Mortaga M. / Alhamzani Abdulrahman G. / Yousef Tarek A.

Reviews in Analytical Chemistry, Vol 41, Iss 1, Pp 168-

2022 Volume 179

Abstract: Herein, a carbon paste electrode (CPE) modified with poly(reduced-o-nitrobenzoic acid [r-o-NBA]) supported in graphene quantum dots (GQDs) was fabricated for the first time. The fabricated electrode’s surface morphology and composition were characterised ...

Abstract	Herein, a carbon paste electrode (CPE) modified with poly(reduced-o-nitrobenzoic acid [r-o-NBA]) supported in graphene quantum dots (GQDs) was fabricated for the first time. The fabricated electrode’s surface morphology and composition were characterised by scanning electron microscope and transmission electron microscope. The poly(r-o-NBA)/GQDs/CPE showed high electrocatalytic activity towards the oxidation of naproxen (NPX) using cyclic and differential pulse voltammetric methods. The effect of scan rate on the oxidation peak of NPX suggests that the electrode process was typically diffusion-controlled. In addition, the effect of pH reflects the participation of protons in the oxidation process of NPX. The peak current is linearly proportional to the concentration of NPX ranging from 1.0 to 100.0 µM, with the correlation coefficient (R 2), sensitivity, limit of detection (3σ), and limit of quantification (10σ) being 0.9995, 0.419 µA·µM−1·cm−2, 0.672, and 2.241 µM, respectively. Using chronoamperometry, the diffusion coefficient of NPX at the poly(r-o-NBA)/GQDs/CPE was estimated to be 5.36 × 10−6 cm2·s−1. The proposed electrode has good reproducibility, stability, and high selectivity for NPX oxidation. The obtained recovery range (96.7–102.0%) means that the proposed sensor performed satisfactorily when applied for the detection of NPX in its pharmaceutical formulations.
Keywords	naproxen ; modified carbon paste electrode ; graphene quantum dots ; cyclic voltammetry ; differential pulse voltammetry ; chronoamperometry ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Synthesis and in Silico Investigation of Organoselenium-Clubbed Schiff Bases as Potential M

Shaaban, Saad / Abdou, Aly / Alhamzani, Abdulrahman G / Abou-Krisha, Mortaga M / Al-Qudah, Mahmoud A / Alaasar, Mohamed / Youssef, Ibrahim / Yousef, Tarek A

Life (Basel, Switzerland)

2023 Volume 13, Issue 4

Abstract: Since the first report of the organoselenium compound, ebselen, as a potent inhibitor of the SARS-CoV-2 ... ...

Abstract	Since the first report of the organoselenium compound, ebselen, as a potent inhibitor of the SARS-CoV-2 M
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13040912
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Article: Cellulose Sulfate Nanofibers for Enhanced Ammonium Removal.

Johnson, Ken I / Borges, William / Sharma, Priyanka R / Sharma, Sunil K / Chang, Hao-Yen / Abou-Krisha, Mortaga M / Alhamzani, Abdulrahman G / Hsiao, Benjamin S

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 6

Abstract: In this study, a sulfonation approach using chlorosulfonic acid (CSA) to prepare cellulose sulfate nanofibers (CSNFs) from raw jute fibers is demonstrated. Both elemental sulfur content and zeta potential in the CSNFs are found to increase with ... ...

Abstract	In this study, a sulfonation approach using chlorosulfonic acid (CSA) to prepare cellulose sulfate nanofibers (CSNFs) from raw jute fibers is demonstrated. Both elemental sulfur content and zeta potential in the CSNFs are found to increase with increasing CSA content used. However, the corresponding crystallinity in the CSNFs decreases with the increasing amount of CSA used due to degradation of cellulose chains under harsh acidic conditions. The ammonium adsorption results from the CSNFs with varying degrees of sulfonation were analyzed using the Langmuir isotherm model, and the analysis showed a very high maximum ammonium adsorption capacity (41.1 mg/g) under neutral pH, comparable to the best value from a synthetic hydrogel in the literature. The high ammonium adsorption capacity of the CSNFs was found to be maintained in a broad acidic range (pH = 2.5 to 6.5).
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14060507
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Article ; Online: Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors

Yousef, Tarek A. / Alhamzani, Abdulrahman G. / Abou-Krisha, Mortaga M. / Kanthimathi, G. / Raghu, M.S. / Kumar, K. Yogesh / Prashanth, M.K. / Jeon, Byong-Hun

Heliyon. 2023 Feb. 08, p.e13460-

2023

Abstract: The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the ... ...

Abstract	The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the conventional medicine colchicine, compounds 8e and 8f demonstrated stronger sensitivity and improved IC₅₀ values in the range of 3.19-8.21 μM against breast MCF-7, colorectal HCT116, and liver HepG2 cancer cell lines. The target compounds were tested for enzymatic activity against the tubulin enzyme. Compounds 8e and 8f were shown to have the most effective inhibitory action among the new compounds, with IC₅₀ values of 7.95 and 9.81 nM, respectively. As compared to the reference drug, molecular docking investigations of the developed compounds revealed the crucial hydrogen bonding in addition to the hydrophobic interaction at the binding site, assisting in the prediction of the structural requirements for the found anticancer activity. These findings indicate that the 1,3,4-oxadizole scaffold has the potential for future research into new anticancer medicines.
Keywords	antineoplastic activity ; breasts ; colchicine ; drugs ; enzyme activity ; enzymes ; hydrogen ; hydrophobic bonding ; liver ; medicine ; neoplasm cells ; oxadiazoles ; polymerization ; prediction ; tubulin ; 1,3,4-Oxadiazole ; Anticancer ; Tubulin inhibitors ; Molecular docking
Language	English
Dates of publication	2023-0208
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13460
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis, Identification, Computer-Aided Docking Studies, and ADMET Prediction of Novel Benzimidazo-1,2,3-triazole Based Molecules as Potential Antimicrobial Agents.

Rashdan, Huda R M / Abdelmonsef, Aboubakr H / Abou-Krisha, Mortaga M / Yousef, Tarek A

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 23

Abstract: ... 2-azido- ... ...

Abstract	2-azido-1
MeSH term(s)	Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Aspergillus niger/drug effects ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Candida albicans/drug effects ; Candida albicans/pathogenicity ; DNA Gyrase/drug effects ; DNA Gyrase/genetics ; Escherichia coli/drug effects ; Escherichia coli/pathogenicity ; Humans ; Molecular Docking Simulation ; Pharmacokinetics ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/pathogenicity ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology
Chemical Substances	Anti-Infective Agents ; Topoisomerase II Inhibitors ; Triazoles ; DNA Gyrase (EC 5.99.1.3)
Language	English
Publishing date	2021-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26237119
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Article: A Novel Electrochemical Sensor for Detection of Nicotine in Tobacco Products Based on Graphene Oxide Nanosheets Conjugated with (1,2-Naphthoquinone-4-Sulphonic Acid) Modified Glassy Carbon Electrode.

Abd-Elsabour, M / Alsoghier, Hesham M / Alhamzani, Abdulrahman G / Abou-Krisha, Mortaga M / Yousef, Tarek A / Assaf, Hytham F

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 14

Abstract: A simple electrochemical sensor for nicotine (NIC) detection was performed. The sensor based on a glassy carbon electrode (GCE) was modified by (1,2-naphthoquinone-4-sulphonic acid)(Nq) decorated by graphene oxide (GO) nanocomposite. The synthesized (GO) ...

Abstract	A simple electrochemical sensor for nicotine (NIC) detection was performed. The sensor based on a glassy carbon electrode (GCE) was modified by (1,2-naphthoquinone-4-sulphonic acid)(Nq) decorated by graphene oxide (GO) nanocomposite. The synthesized (GO) nanosheets were characterized using X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscope (SEM), transmission electron microscope (TEM), FT-IR, and UV-Visible Spectroscopy. The insertion of Nq with GO nanosheets on the surface of GCE displayed high electrocatalytic activity towards NIC compared to the bare GCE. NIC determination was performed under the optimum conditions using 0.10 M of Na
Language	English
Publishing date	2022-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12142354
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Article ; Online: Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.

Alhamzani, Abdulrahman G / Yousef, Tarek A / Abou-Krisha, Mortaga M / Raghu, M S / Yogesh Kumar, K / Prashanth, M K / Jeon, Byong-Hun

Bioorganic & medicinal chemistry letters

2022 Volume 77, Page(s) 129042

Abstract: Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant anticonvulsant activity in both maximum electroshock seizure (MES) and ... ...

Abstract	Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant anticonvulsant activity in both maximum electroshock seizure (MES) and pentylenetetrazole (PTZ) induced seizure during the preliminary screening. The phase II anticonvulsant activity statistics revealed that compounds 4e, 4f, 4g, 4i, and 4j demonstrated excellent activity as compared to the conventional drugs methaqualone and valproate, supporting the potential of these triazine-linked triazole analogues as novel anticonvulsant agents. To take use of the findings, computational parameters including docking analysis and drug-likeness prediction were carried out. Molecular modelling studies supported the essential pharmacophoric information that the structure activity relationship offered. The triazine-linked triazole analogues that were investigated might be viewed as helpful models for future research and derivatization.
MeSH term(s)	Humans ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Anticonvulsants/chemistry ; Molecular Docking Simulation ; Triazines/pharmacology ; Pentylenetetrazole ; Seizures/chemically induced ; Seizures/drug therapy ; Electroshock ; Triazoles ; Structure-Activity Relationship ; Molecular Structure
Chemical Substances	Anticonvulsants ; Triazines ; Pentylenetetrazole (WM5Z385K7T) ; Triazoles
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2022.129042
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Article ; Online: DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6'-Diamino-1,1',3,3'-tetramethyl-5,5'-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione].

El-Shamy, Nesreen T / Alkaoud, Ahmed M / Hussein, Rageh K / Ibrahim, Moez A / Alhamzani, Abdulrahman G / Abou-Krisha, Mortaga M

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 3

Abstract: Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are ... ...

Abstract	Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are investigated. Computational techniques such as the density functional theory, ADMET evaluation, and molecular docking were applied to elucidate the chemical nature, drug likeness and antibacterial function of molecule. The viewpoint of quantum chemical computations revealed that the molecule was relatively stable and has a high electrophilic nature. The contour maps of HOMO-LUMO and molecular electrostatic potential were analyzed to illustrate the charge density distributions that could be associated with the biological activity. Natural bond orbital (NBO) analysis revealed details about the interaction between donor and acceptor within the bond. Drug likeness and ADMET analysis showed that the molecule possesses the agents of safety and the effective combination therapy as pharmaceutical drug. The antimicrobial activity was investigated using molecular docking. The investigated molecule demonstrated a high affinity for binding within the active sites of antibacterial and antimalarial proteins. The high affinity of the antibacterial protein was proved by its low binding energy (-7.97 kcal/mol) and a low inhibition constant value (1.43 µM). The formation of four conventional hydrogen bonds in ligand-protein interactions confirmed the high stability of the resulting complexes. When compared to known standard drugs, the studied molecule displayed a remarkable antimalarial activity, as indicated by higher binding affinity (B.E. -5.86 kcal/mol & Ki = 50.23 M). The pre-selected molecule could be presented as a promising drug candidate for the development of novel antimicrobial agents.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Antimalarials/pharmacology ; Bacteria/drug effects ; Density Functional Theory ; Ligands ; Models, Molecular ; Molecular Docking Simulation ; Pyrimidines/chemistry ; Quantum Theory
Chemical Substances	Anti-Bacterial Agents ; Antimalarials ; Ligands ; Pyrimidines
Language	English
Publishing date	2022-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27030620
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