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  1. Article ; Online: Impact of therapeutic education on the choice of renal replacement therapy. Moroccan monocentric experience

    Abouzid, Zineb / Sebti, Kaoutar / Ouzeddoun, Naima / Bayahia, Rabia / Benamar, Loubna

    Nephrologie & therapeutique

    2023  Volume 19, Issue 7, Page(s) 555–567

    Abstract: Introduction: Therapeutic patient education (TPE) is gaining importance in the management of patients with chronic kidney disease (CKD). The objective of this study is to assess the interest of TPE in the acquisition of knowledge concerning CKD and ... ...

    Title translation Impact de l’éducation thérapeutique sur le choix du traitement de suppléance. Expérience monocentrique marocaine
    Abstract Introduction: Therapeutic patient education (TPE) is gaining importance in the management of patients with chronic kidney disease (CKD). The objective of this study is to assess the interest of TPE in the acquisition of knowledge concerning CKD and renal replacement therapy, as well as the orientation of the patients towards a personalized choice of treatment.
    Materials and methods: Patients with a minimum stage 4 CKD were prospectively included between November 2016 and February 2020. We proposed TPE sessions on CKD and its treatment to all patients. We explained the theoretical part through a slideshow about the definition of end-stage renal disease, its symptoms and the various methods of renal replacement therapy. A “basket” of essential material to illustrate a session of hemodialysis (HD) or peritoneal dialysis (PD) was used to achieve the practical part of the study. Data was collected using two questionnaires: the first one, at the start of the session, included the socio-demographic and clinical characteristics of the patients and evaluated their level of basic knowledge, and the second one, at the end of the session, assessed the evolution of knowledge after TPE, leading to a therapeutic choice.
    Results: The mean age of the 211 included patients was 55.59 years old (SD = 15.47). Male to female ratio was 0.73. The level of education was low in 69% of the cases of whom 23.7% were employees. The glomerular filtration rate (GFR) was between 15 and 30 mL/min in 56.8% of the cases. Initial nephropathy was known in 60% of patients while the stage of CKD was unknown in 66.4%. Before TPE, patients with a good level of overall knowledge were around 29%, rising to 73% after TPE. A significant correlation was found between the level of education of the patients and their knowledge score before and after TPE. The choice of renal replacement therapy was taken for PD, TR and HD respectively in 36%, 19% and 11.8% of the cases, while 33.2% asked for time to think. Elderly and/or low educated patients most often remained undecided; moreover those who are young and/or educated prefer TR. During the follow-up period, 46% of patients started renal replacement therapy (36.5% started HD, 8.1% PD and 1.4% KT). The choice made by our patients was respected in 42% of the cases: in all the patients who chose HD; in 36% of those who chose PD, and 19% of those who chose kidney transplantation (KT). The final therapeutic modality was strongly linked to the following parameters: age, GFR and level of education.
    Conclusion: This study highlighted the insufficient level of patients’ information about CKD and its treatment and allowed the patients to express their choice of their replacement therapy, which is a complicated process that must ­integrate the opinion of the nephrologist and the patient’s preference to lead to an ­optimal organization of the therapeutic modality.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Middle Aged ; Renal Replacement Therapy ; Renal Dialysis/methods ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic ; Educational Status
    Language French
    Publishing date 2023-12-07
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1684/ndt.2023.50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: La thymoglobuline en traitement d’induction chez les transplantés rénaux à faible risque immunologique: une expérience marocaine.

    Abouzid, Zineb / Amar, Mohamed Anass / Abdessater, Maher / Alioubane, Meryem / Benjaafar, Anissa / Ouzeddoun, Naima / Benamar, Loubna / Bayahia, Rabia / Bouattar, Tarik

    The Pan African medical journal

    2022  Volume 41, Page(s) 138

    Abstract: Introduction: Thymoglobulin® is a polyclonal antibody indicated for induction treatment in kidney transplantation. The purpose of this study is to estimate the effectiveness of Thymoglobulin® as induction treatment in kidney transplant patients with low ...

    Title translation Thymoglobulin as induction treatment in kidney transplantants with low immunological risk: a Moroccan experience.
    Abstract Introduction: Thymoglobulin® is a polyclonal antibody indicated for induction treatment in kidney transplantation. The purpose of this study is to estimate the effectiveness of Thymoglobulin® as induction treatment in kidney transplant patients with low immune risk.
    Methods: we conducted a retrospective study between January 2012 and September 2017. Patients with low immunological risk, defined as the absence of previous transplantation and donor-specific antibodies (DSA), were included and received Thymoglobulin® induction therapy. Demographic and clinical characteristics, biological parameters and post-renal transplant complications were studied.
    Results: we enrolled 55 kidney transplant patients with an average follow-up period of 38 ± 16 months. The average age of patients was 39,1 ± 12,1 years with a male predominance (58.2%). No patient had DSA prior to transplant. Cumulative dose of Thymoglobulin® was 4,26 ± 0,87 mg/kg, with an average duration of 5 ± 0,82 days. Lymphocyte depletion was maximal on the first day of infusion. Three patients had delayed graft function, at least one episode of bacterial infection in 56,4% of patients, 7 cases of CMV infections (12,7%) and 2 cases of CMV disease (3,6%). Graft survival rate was calculated for all patients with an average serum creatinine of 11,7 ± 3,6 mg/l during the last visit.
    Conclusion: although it is not indicated for first line treatment in patients with low immunological risk, Thymoglobulin® can nevertheless be prescribed at a lower dose, with similar efficacy and without exposure to a higher risk of rejection.
    MeSH term(s) Antilymphocyte Serum ; Cytomegalovirus Infections/drug therapy ; Female ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Infant, Newborn ; Kidney ; Male ; Retrospective Studies
    Chemical Substances Antilymphocyte Serum ; Immunosuppressive Agents ; thymoglobulin (D7RD81HE4W)
    Language French
    Publishing date 2022-02-17
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2022.41.138.23091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Polyangéite microscopique induite par un inhibiteur de la recapture de la sérotonine. À propos d’un cas.

    Sebti, Kaoutar / Benjaafar, Anissa / Bouattar, Tarik / Abouzid, Zineb / Chattahi, Manal / Rouass, Lamia / Benamar, Loubna / Bayahia, Rabia / Ouzeddoun, Naima

    Nephrologie & therapeutique

    2021  Volume 18, Issue 1, Page(s) 66–69

    Abstract: Microscopic polyangiitis is an ANCA-associated vasculitis and affects small sized vessels. We report a case of microscopic polyangiitis, in a 31 year old patient with renal, skin and neurologic manifestations, which was probably triggered by a selective ... ...

    Title translation Microscopic polyangiitis induced by a serotonin reuptake inhibitor. Case report.
    Abstract Microscopic polyangiitis is an ANCA-associated vasculitis and affects small sized vessels. We report a case of microscopic polyangiitis, in a 31 year old patient with renal, skin and neurologic manifestations, which was probably triggered by a selective serotonin reuptake inhibitor. Under induction therapy with corticosteroids and cyclophosphamide, the kidney recovery is complete, neurological is slow but satisfactory.
    MeSH term(s) Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Antibodies, Antineutrophil Cytoplasmic ; Cyclophosphamide ; Humans ; Kidney ; Microscopic Polyangiitis/diagnosis ; Microscopic Polyangiitis/drug therapy ; Serotonin Uptake Inhibitors/adverse effects
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Serotonin Uptake Inhibitors ; Cyclophosphamide (8N3DW7272P)
    Language French
    Publishing date 2021-06-02
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2021.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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