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Article: When dyspnea is a Hickam's Dictum.

Abraham, Annette / Moore, Nicholas / Sansom, Sarah E

2023 Volume 32, Page(s) e01786

Abstract: Synchronous opportunistic infections are luckily rare in people living with HIV (PLWH) in the era of highly effective antiretroviral medications. We describe the case of a middle-aged man who presented with diarrhea and shortness of breath and was found ... ...

Abstract	Synchronous opportunistic infections are luckily rare in people living with HIV (PLWH) in the era of highly effective antiretroviral medications. We describe the case of a middle-aged man who presented with diarrhea and shortness of breath and was found to have pneumocystis pneumonia, disseminated histoplasmosis and disseminated mycobacterium avium complex infection along with a new diagnosis of human immunodeficiency virus (HIV) infection. This case highlights that individuals who remain undiagnosed with HIV infection for a long time can still present with concurrent infections and clinicians should remain aware of this.
Language	English
Publishing date	2023-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01786
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Rare Case of Locally Contracted Cutaneous Corynebacterium diphtheriae.

Trubin, Marc / Eichinger, Sarah E / Abraham, Annette / Shankaran, Shivanjali

Cureus

2023 Volume 15, Issue 6, Page(s) e40854

Abstract: A 32-year-old man with a history of intravenous heroin use and housing instability presented with three years of worsening left forearm and wrist "infection," which had progressed over the past few months with worsening purulence, pain, and deformity. In ...

Abstract	A 32-year-old man with a history of intravenous heroin use and housing instability presented with three years of worsening left forearm and wrist "infection," which had progressed over the past few months with worsening purulence, pain, and deformity. In the emergency department, he was afebrile with stable vitals. Superficial cultures drawn demonstrated polymicrobial growth, including heavy growth of Corynebacterium diphtheriae. He was treated with vancomycin and then IV penicillin to complete 10 days of therapy. Given the uncharacteristic appearance of the lesion, a biopsy was recommended, but the patient left against medical advice. Later, the diphtheria isolate was identified as C. diphtheriae var. mitis by the Centers for Disease Control and Prevention (CDC). This describes an atypical case of cutaneous diphtheria, a disease that is infrequently seen in the United States due to the high prevalence of routine vaccination.
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Taenia solium neurocysticercosis

Abraham, Annette [Verfasser] / Winkler, Andrea Sylvia [Akademischer Betreuer]

evidence-based treatment recommendations and its surveillance in Europe

2023

Author's details	Annette Abraham ; Betreuer: Andrea Sylvia Winkler
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Animal-Assisted Interventions Improve Mental, But Not Cognitive or Physiological Health Outcomes of Higher Education Students: a Systematic Review and Meta-analysis.

Huber, Annalena / Klug, Stefanie J / Abraham, Annette / Westenberg, Erica / Schmidt, Veronika / Winkler, Andrea S

International journal of mental health and addiction

2022 , Page(s) 1–32

Abstract: Due to the high burden of mental health issues among students at higher education institutions world-wide, animal-assisted interventions (AAIs) are being used to relieve student stress. The objective of this study was to systematically review of the ... ...

Abstract	Due to the high burden of mental health issues among students at higher education institutions world-wide, animal-assisted interventions (AAIs) are being used to relieve student stress. The objective of this study was to systematically review of the effects of AAIs on the mental, physiological, and cognitive outcomes of higher education students. Randomized controlled trials using any unfamiliar animal as the sole intervention tool were included in this review. Study quality was assessed using the Cochrane Risk-of-Bias tool. Where possible, effect sizes (Hedges' Supplementary information: The online version contains supplementary material available at 10.1007/s11469-022-00945-4.
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2235886-9
ISSN	1557-1882 ; 1557-1874
ISSN (online)	1557-1882
ISSN	1557-1874
DOI	10.1007/s11469-022-00945-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The global cost of epilepsy: A systematic review and extrapolation.

Begley, Charles / Wagner, Ryan G / Abraham, Annette / Beghi, Ettore / Newton, Charles / Kwon, Churl-Su / Labiner, David / Winkler, Andrea S

Epilepsia

2022 Volume 63, Issue 4, Page(s) 892–903

Abstract: Objective: Global action for epilepsy requires information on the cost of epilepsy, which is currently unknown for most countries and regions of the world. To address this knowledge gap, the International League Against Epilepsy Commission on ... ...

Abstract	Objective: Global action for epilepsy requires information on the cost of epilepsy, which is currently unknown for most countries and regions of the world. To address this knowledge gap, the International League Against Epilepsy Commission on Epidemiology formed the Global Cost of Epilepsy Task Force. Methods: We completed a systematic search of the epilepsy cost-of-illness literature and identified studies that provided a comprehensive set of direct health care and/or indirect costs, followed standard methods of case identification and cost estimation, and used data on a representative population or subpopulation of people with epilepsy. Country-specific costs per person with epilepsy were extracted and adjusted to generate an average cost per person in 2019 US dollars. For countries with no cost data, estimates were imputed based on average costs per person of similar income countries with data. Per person costs for each country were then applied to data on the prevalence of epilepsy from the Global Burden of Disease collaboration adjusted for the treatment gap. Results: One hundred one cost-of-illness studies were included in the direct health care cost database, 74 from North America or Western Europe. Thirteen studies were used in the indirect cost database, eight from North America or Western Europe. The average annual cost per person with epilepsy in 2019 ranged from $204 in low-income countries to $11 432 in high-income countries based on this highly skewed database. The total cost of epilepsy, applying per person costs to the estimated 52.51 million people in the world with epilepsy and adjusting for the treatment gap, was $119.27 billion. Significance: Based on a summary and extrapolations of this limited database, the global cost of epilepsy is substantial and highly concentrated in countries with well-developed health care systems, higher wages and income, limited treatment gaps, and a relatively small percentage of the epilepsy population.
MeSH term(s)	Cost of Illness ; Epilepsy/epidemiology ; Epilepsy/therapy ; Health Care Costs ; Humans ; Income ; Poverty ; Prevalence
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17165
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Animal-assisted interventions improve mental, but not cognitive or physiological health outcomes of higher education students

Huber, Annalena / Klug, Stefanie J. / Abraham, Annette / Westenberg, Erica / Schmidt, Veronika / Winkler, Andrea S.

International Journal of Mental Health and Addiction

A systematic review and meta-analysis

2022 , Page(s) 1–32

Title translation	Tiergestützte Interventionen verbessern die psychischen, aber nicht die kognitiven oder physiologischen Gesundheitsleistungen von Hochschulstudenten: Eine systematische Überprüfung und Meta-Analyse
Abstract	Due to the high burden of mental health issues among students at higher education institutions world-wide, animal-assisted interventions (AAIs) are being used to relieve student stress. The objective of this study was to systematically review of the effects of AAIs on the mental, physiological, and cognitive outcomes of higher education students. Randomized controlled trials using any unfamiliar animal as the sole intervention tool were included in this review. Study quality was assessed using the Cochrane Risk-of-Bias tool. Where possible, effect sizes (Hedges' g) were pooled for individual outcomes using random-effects meta-analyses. Albatross plots were used to supplement the data synthesis. Of 2.494 identified studies, 35 were included. Almost all studies used dogs as the intervention animal. The quality of most included studies was rated as moderate. Studies showed an overall reduction of acute anxiety and stress. For other mental outcomes, studies showed smaller, but nonetheless beneficial effects. Studies showed no clear effect on physiological or cognitive outcomes. Strong methodological heterogeneity between studies limited the ability to draw clear conclusions.
Keywords	Angst ; Animal Assisted Therapy ; Anxiety ; Higher Education ; Hochschulausbildung ; Intervention ; Körperliche Gesundheit ; Mental Health ; Physical Health ; Psychische Gesundheit ; Stress ; Therapieergebnisse ; Tierunterstützte Therapie ; Treatment Outcomes
Language	English
Document type	Article
ZDB-ID	2235886-9
ISSN	1557-1882 ; 1557-1874
ISSN (online)	1557-1882
ISSN	1557-1874
DOI	10.1007/s11469-022-00945-4
Database	PSYNDEX

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Article ; Online: The data are inadequate to assess safety and efficacy of mass chemotherapy for Taenia solium taeniasis.

White, A Clinton / O'Neal, Seth / Winkler, Andrea / Abraham, Annette / Carabin, Hélène

PLoS neglected tropical diseases

2020 Volume 14, Issue 7, Page(s) e0008294

Abstract: As members of the Pan American Health Organization (PAHO) and World Health Organization (WHO) guidelines development group on chemotherapy strategies for the control of Taenia solium taeniasis, we are very disappointed at the systematic review by Haby ... ...

Abstract	As members of the Pan American Health Organization (PAHO) and World Health Organization (WHO) guidelines development group on chemotherapy strategies for the control of Taenia solium taeniasis, we are very disappointed at the systematic review by Haby and colleagues. With respect to the analysis of efficacy, the authors did not account for differences in the methods used to ascertain the outcome in the studies analyzed. There are also major concerns regarding the safety analyses. Few of the included studies used carefully designed active surveillance protocols to detect epileptic seizures and/or chronic progressive headaches. These neurologic side effects, due the inadvertent killing of viable brain cysts, have been noted after mass therapy with praziquantel and albendazole. We wholeheartedly agree with the authors' statement in their discussion that control programs applying chemotherapy using mass drug administration "need to be informed by evidence of the best drug and dose in terms of efficacy and side-effects." Unfortunately, the flawed analysis that was published is contrary to that goal.
MeSH term(s)	Albendazole ; Animals ; Cysticercosis ; Praziquantel ; Taenia solium ; Taeniasis
Chemical Substances	Praziquantel (6490C9U457) ; Albendazole (F4216019LN)
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0008294
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute Rheumatic Fever Presenting as a Mimicker of Septic Arthritis.

Achebe, Ikechukwu / Hussain, Kifah / Abraham, Annette / Asotibe, Jennifer C / Shaka, Hafeez

Cureus

2020 Volume 12, Issue 7, Page(s) e9431

Abstract: Acute rheumatic fever (ARF) describes the non-suppurative and autoimmune inflammation of joint, muscle, and fibrous tissue that occurs after group A streptococcal (GAS) pharyngitis. This report describes a rare case of a 39-year-old male with migratory ... ...

Abstract	Acute rheumatic fever (ARF) describes the non-suppurative and autoimmune inflammation of joint, muscle, and fibrous tissue that occurs after group A streptococcal (GAS) pharyngitis. This report describes a rare case of a 39-year-old male with migratory arthralgias as a presenting sign of ARF. Through this case, we review the current literature on ARF and highlight clinical and objective findings that differentiate ARF from similar presenting arthralgias, specifically post-streptococcal reactive arthritis (PSRA). With this report, we hope to increase clinical suspicion for ARF in patients with acute joint pain, as differentiating ARF from other arthritides, PSRA specifically, determines management strategy and need for secondary prophylaxis against rheumatic heart disease.
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.9431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa.

Zulu, Gideon / Stelzle, Dominik / Mwape, Kabemba E / Welte, Tamara M / Strømme, Hilde / Mubanga, Chishimba / Mutale, Wilbroad / Abraham, Annette / Hachangu, Alex / Schmidt, Veronika / Sikasunge, Chummy S / Phiri, Isaac K / Winkler, Andrea S

PLoS neglected tropical diseases

2023 Volume 17, Issue 3, Page(s) e0011042

Abstract: Background: Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review ...

Abstract	Background: Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review aimed to describe the current information available and gaps in the epidemiology of human T. solium infections in ESA. Methods/principle findings: Scientific literature published between 1st January 2000 and 20th June 2022 in international databases [MEDLINE (Ovid), Embase (Ovid), Global Health (Ovid), Scopus (Elsevier), African Index Medicus (via WHO Global Index Medicus), and Open Grey] was systematically reviewed for ESA. The study area included 27 countries that make up the ESA region. Information on either taeniosis, cysticercosis or NCC was available for 16 of 27 countries within the region and a total of 113 reports were retained for the review. Most case reports for cysticercosis and NCC were from South Africa, while Tanzania had the most aggregated cysticercosis reports. Eleven countries reported on NCC with seven countries reporting data on NCC and epilepsy. Unconfirmed human T. solium taeniosis cases were reported in nine countries while two countries (Madagascar and Zambia) reported confirmed T. solium cases. The cysticercosis seroprevalence ranged between 0.7-40.8% on antigen (Ag) ELISA and between 13.1-45.3% on antibody (Ab) ELISA. Based on immunoblot tests the Ab seroprevalence was between 1.7-39.3%, while the proportion of NCC-suggestive lesions on brain CT scans was between 1.0-76% depending on the study population. The human taeniosis prevalence based on microscopy ranged between 0.1-14.7%. Based on Copro Ag-ELISA studies conducted in Kenya, Rwanda, Tanzania, and Zambia, the highest prevalence of 19.7% was reported in Kenya. Conclusions: Despite the public health and economic impact of T. solium in ESA, there are still large gaps in knowledge about the occurrence of the parasite, and the resulting One Health disease complex, and monitoring of T. solium taeniosis and cysticercosis is mostly not in place.
MeSH term(s)	Humans ; Swine ; Animals ; Seroepidemiologic Studies ; Taeniasis/epidemiology ; Taeniasis/parasitology ; Cysticercosis/epidemiology ; Cysticercosis/parasitology ; Taenia solium ; Africa, Southern/epidemiology ; Tanzania/epidemiology ; Prevalence ; Swine Diseases/parasitology
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vitamin E and its anticancer effects

Abraham, Annette / Kattoor, Ajoe John / Mehta, Jawahar L / Saldeen, Tom

Critical reviews in food science and nutrition. 2019 Sept. 25, v. 59, no. 17

2019

Abstract: Vitamin E is a lipid soluble vitamin comprising of eight natural isoforms, namely, α, β, δ, γ isoforms of tocopherol and α, β, δ, γ isoforms of tocotrienol. Many studies have been performed to elucidate its role in cancer. Until last decade, major focus ... ...

Abstract	Vitamin E is a lipid soluble vitamin comprising of eight natural isoforms, namely, α, β, δ, γ isoforms of tocopherol and α, β, δ, γ isoforms of tocotrienol. Many studies have been performed to elucidate its role in cancer. Until last decade, major focus was on alpha tocopherol and its anticancer effects. However, major clinical trials using alpha-tocopherol like SELECT trial and ATBC trial did not yield meaningful results. Hence there was a shift of focus to gamma-tocopherol, delta-tocopherol and tocotrienol. Unlike alpha-tocopherol, gamma-tocopherol and delta-tocopherol can scavenge reactive nitrogen species in addition to reactive oxygen species. Antiangiogenic effect, inhibition of HMG CoA reductase enzyme and inhibition of NF-κB pathway make the anti-cancer effects of tocotrienols unique compared to other vitamin E isoforms. Preclinical research on non-alpha tocopherol isoforms of vitamin E showed promising data on their anticancer effects. In this review, we deal with the current understanding on the potential mechanisms involved in the anticancer effects of vitamin E and the controversies in this field over last three decades. We also highlight the need to conduct further research on the anticancer effects of non-alpha-tocopherol isoforms in larger population and clinical setting.
Keywords	alpha-tocopherol ; antineoplastic activity ; clinical trials ; delta-tocopherol ; gamma-tocopherol ; hydroxymethylglutaryl-CoA reductases ; lipids ; neoplasms ; reactive nitrogen species ; reactive oxygen species ; tocotrienols ; transcription factor NF-kappa B
Language	English
Dates of publication	2019-0925
Size	p. 2831-2838.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2018.1474169
Database	NAL-Catalogue (AGRICOLA)

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