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  1. Book ; Thesis: Experimentelle Untersuchungen der humoralen Immunantwort gegen das Vesikuläre-Stomatitis-Virus in der Maus

    Abraham, Diana R.

    1992  

    Author's details vorgelegt von Diana Raphaela Abraham
    Size 88 Bl. : graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1992
    HBZ-ID HT004314649
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    92 E 3029 order for loan Magazin

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  2. Article ; Online: Self-assembling human skeletal organoids for disease modeling and drug testing.

    Abraham, Diana M / Herman, Calvin / Witek, Lukasz / Cronstein, Bruce N / Flores, Roberto L / Coelho, Paulo G

    Journal of biomedical materials research. Part B, Applied biomaterials

    2021  Volume 110, Issue 4, Page(s) 871–884

    Abstract: Skeletal conditions represent a considerable challenge to health systems globally. Barriers to effective therapeutic development include a lack of accurate preclinical tissue and disease models. Most recently, work was attempted to present a novel whole ... ...

    Abstract Skeletal conditions represent a considerable challenge to health systems globally. Barriers to effective therapeutic development include a lack of accurate preclinical tissue and disease models. Most recently, work was attempted to present a novel whole organ approach to modeling human bone and cartilage tissues. These self-assembling skeletal organoids mimic the cellular milieu and extracellular organization present in native tissues. Bone organoids demonstrated osteogenesis and micro vessel formation, and cartilage organoids showed evidence of cartilage development and maturation. Skeletal organoids derived from both bone and cartilage tissues yielded spontaneous polarization of their cartilaginous and bone components. Using these hybrid skeletal organoids, we successfully generated "mini joint" cultures, which we used to model inflammatory disease and test Adenosine (A
    MeSH term(s) Bone and Bones ; Cartilage ; Chondrogenesis ; Humans ; Organoids ; Osteogenesis
    Language English
    Publishing date 2021-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.34968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining.

    Mortlock, Ryland D / Wu, Chuanfeng / Potter, E Lake / Abraham, Diana M / Allan, David S J / Hong, So Gun / Roederer, Mario / Dunbar, Cynthia E

    Frontiers in immunology

    2022  Volume 12, Page(s) 772332

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; CD56 Antigen/immunology ; Killer Cells, Natural/immunology ; Kinetics ; Lymph Nodes/immunology ; Macaca mulatta/immunology ; Staining and Labeling
    Chemical Substances CD56 Antigen
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.772332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques.

    Lee, Byung-Chul / Gin, Ashley / Wu, Chuanfeng / Singh, Komudi / Grice, Max / Mortlock, Ryland / Abraham, Diana / Fan, Xing / Zhou, Yifan / AlJanahi, Aisha / Choi, Uimook / DeRavin, Suk See / Shin, Taehoon / Hong, Sogun / Dunbar, Cynthia E

    Cell stem cell

    2024  Volume 31, Issue 4, Page(s) 455–466.e4

    Abstract: For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe editing of long-term engrafting hematopoietic stem cells (LT-HSCs) is required. The impact of HDR on true LT-HSC clonal dynamics in a relevant large animal model has ...

    Abstract For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe editing of long-term engrafting hematopoietic stem cells (LT-HSCs) is required. The impact of HDR on true LT-HSC clonal dynamics in a relevant large animal model has not been studied. To track the output and clonality of HDR-edited cells and to provide a comparison to lentivirally transduced HSCs in vivo, we developed a competitive rhesus macaque (RM) autologous transplantation model, co-infusing HSCs transduced with a barcoded GFP-expressing lentiviral vector (LV) and HDR edited at the CD33 locus. CRISPR/HDR-edited cells showed a two-log decrease by 2 months following transplantation, with little improvement via p53 inhibition, in comparison to minimal loss of LV-transduced cells long term. HDR long-term clonality was oligoclonal in contrast to highly polyclonal LV-transduced HSCs. These results suggest marked clinically relevant differences in the impact of current genetic modification approaches on HSCs.
    MeSH term(s) Animals ; Macaca mulatta/genetics ; Hematopoietic Stem Cell Transplantation/methods ; Lentivirus/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; Hematopoietic Stem Cells ; Gene Editing/methods ; CRISPR-Cas Systems/genetics
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 75: Show issues

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  5. Article ; Online: Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques.

    Lee, Byung-Chul / Gin, Ashley / Wu, Chuanfeng / Singh, Komudi / Grice, Max / Mortlock, Ryland / Abraham, Diana / Fan, Xing / Zhou, Yifan / AlJanahi, Aisha / Choi, Uimook / DeRavin, Suk See / Shin, Taehoon / Hong, Sogun / Dunbar, Cynthia E

    Cell stem cell

    2024  Volume 31, Issue 5, Page(s) 788

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2024.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids.

    Tallapragada, Naren P / Cambra, Hailey M / Wald, Tomas / Keough Jalbert, Samantha / Abraham, Diana M / Klein, Ophir D / Klein, Allon M

    Cell stem cell

    2021  Volume 28, Issue 9, Page(s) 1516–1532.e14

    Abstract: How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal organoids offer a model of self-organization as they generate stem cell zones (SCZs) of typical size even without a spatially structured environment. Here we ... ...

    Abstract How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal organoids offer a model of self-organization as they generate stem cell zones (SCZs) of typical size even without a spatially structured environment. Here we examine processes governing the size of SCZs. We improve the viability and homogeneity of intestinal organoid cultures to enable long-term time-lapse imaging of multiple organoids in parallel. We find that SCZs are shaped by fission events under strong control of ion channel-mediated inflation and mechanosensitive Piezo-family channels. Fission occurs through stereotyped modes of dynamic behavior that differ in their coordination of budding and differentiation. Imaging and single-cell transcriptomics show that inflation drives acute stem cell differentiation and induces a stretch-responsive cell state characterized by large transcriptional changes, including upregulation of Piezo1. Our results reveal an intrinsic capacity of the intestinal epithelium to self-organize by modulating and then responding to its mechanical state.
    MeSH term(s) Cell Differentiation ; Intestinal Mucosa ; Intestines ; Morphogenesis ; Organoids ; Stem Cells
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2021.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques.

    Lee, Byung-Chul / Gin, Ashley / Wu, Chuanfeng / Singh, Komudi / Grice, Max / Mortlock, Ryland / Abraham, Diana / Fan, Xing / Zhou, Yifan / AlJanahi, Aisha / Choi, Uimook / de Ravin, Suk See / Shin, Taehoon / Hong, Sogun / Dunbar, Cynthia E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe editing of long-term engrafting hematopoietic stem cells (LT-HSCs) requires both sufficient HDR efficiency and protection of LT-HSC function and number. The impact ... ...

    Abstract For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe editing of long-term engrafting hematopoietic stem cells (LT-HSCs) requires both sufficient HDR efficiency and protection of LT-HSC function and number. The impact of HDR on true LT-HSCs clonal dynamics in a relevant large animal model has not previously been studied. To track the HDR-edited cells, autologous rhesus macaque (RM) CD34
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.13.571396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings ; Online: The Critical Link 2

    Roberts, Roda P / Abraham, Diana / Carr, Silvana E / Dufour, Aideen

    Interpreters in the Community. Selected papers from the Second International Conference on Interpreting in legal, health and social service settings, Vancouver, BC, Canada, 19-23 May 1998

    2000  

    Abstract: This volume of selected papers from the second Critical Link conference (Vancouver, 1998) shows a marked evolution in Community Interpreting (CI) since the first Critical Link conference of 1995. In the intervening three years the field has advanced from ...

    Abstract This volume of selected papers from the second Critical Link conference (Vancouver, 1998) shows a marked evolution in Community Interpreting (CI) since the first Critical Link conference of 1995. In the intervening three years the field has advanced from pioneering to professionalization in response to new social needs created by the influx of immigrants into the developed countries, or by an awakened sensitivity to the rights of those countries' aboriginal peoples. Most of the papers discuss professionalization in terms of standards, tests and examinations; training; accreditation; and profes
    Language English
    Size Online-Ressource (324 p)
    Publisher John Benjamins Publishing Company
    Publishing place Amsterdam/Philadelphia
    Document type Book ; Conference proceedings ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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