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  1. Article: Case report: Successful treatment of a patient undergoing haemodialysis with multifocal hepatocellular carcinoma using atezolizumab and bevacizumab.

    Abraham, Shalin / Samson, Adel

    Frontiers in oncology

    2024  Volume 13, Page(s) 1279501

    Abstract: In the last five years, the advent of combination immune checkpoint inhibitor atezolizumab and anti-angiogenic agent bevacizumab has transformed treatment of unresectable hepatocellular carcinoma. As patient outcomes improve, healthcare professionals ... ...

    Abstract In the last five years, the advent of combination immune checkpoint inhibitor atezolizumab and anti-angiogenic agent bevacizumab has transformed treatment of unresectable hepatocellular carcinoma. As patient outcomes improve, healthcare professionals will more frequently encounter patients with concomitant hepatocellular cancer and end stage kidney disease on haemodialysis. We present the first case in the literature of a 58-year-old male with multifocal hepatocellular carcinoma undertaking regular haemodialysis who was successfully treated with atezolizumab and bevacizumab with a partial response and stable disease for two years, who suffered grade 1 fatigue, grade 2 hypertension and eventually grade 3 wound infection leading to cessation of bevacizumab. After disease progression on atezolizumab monotherapy, all chemotherapy was stopped. We embed this case in a review of the current literature of atezolizumab and bevacizumab use in patients undertaking haemodialysis and conclude that both targeted therapies may be safely used in these patients. We recommend joint close management of these patients between oncology and nephrology teams, with initial cardiovascular risk stratification before commencing atezolizumab and bevacizumab therapy. During therapy, there should be regular monitoring of blood pressure, or proteinuria if the patient is oliguric under guidance of the dialysis team if preservation of residual renal function is required.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1279501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: PcvCO

    Abraham, Shilpa

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2021  Volume 25, Issue 12, Page(s) 1337–1338

    Abstract: How to cite this article: ...

    Abstract How to cite this article:
    Language English
    Publishing date 2021-01-23
    Publishing country India
    Document type Editorial
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Eating disorders

    Abraham, Suzanne

    (The facts)

    2008  

    Author's details Suzanne Abraham
    Series title The facts
    Keywords Eating disorders
    Subject code 616.8526
    Language English
    Size IX, 255 S. : Ill., graph. Darst.
    Edition 6. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015676958
    ISBN 978-0-19-955101-9 ; 0-19-955101-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    088/1378 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Fall Prevention Conceptual Framework.

    Abraham, Sam

    The health care manager

    2020  Volume 39, Issue 4, Page(s) 144–149

    Abstract: Falls can have lasting psychological and physical consequences, particularly fractures and slow- healing processes, and patients may also lose confidence in walking. Injuries from falls lead to functional decline, institutionalization, higher health care ...

    Abstract Falls can have lasting psychological and physical consequences, particularly fractures and slow- healing processes, and patients may also lose confidence in walking. Injuries from falls lead to functional decline, institutionalization, higher health care costs, and decreased quality of life. The process related to the problem of patient falls in the hospital, using the nursing model developed by the theorist, Ida Jean Orlando, is explained in this article. The useful tool that provides guidance to marketers in this endeavor is Maslow's hierarchy of needs. During acute illness, individuals are greatly in need of satisfying their physiological needs. If these needs are not met, patients leave the hospital lacking a positive experience. Initial fall risk assessment is critical to plan intervention and individualize care plan. Interventions depend on the severity of fall risk factors.
    MeSH term(s) Accidental Falls/prevention & control ; Humans ; Models, Psychological ; Nursing Theory ; Patient Safety ; Quality of Life/psychology ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2000690-1
    ISSN 1550-512X ; 1525-5794
    ISSN (online) 1550-512X
    ISSN 1525-5794
    DOI 10.1097/HCM.0000000000000300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3161: Show issues Location:
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  5. Article ; Online: A Review of Factor VIII and Factor IX Assay Methods for Monitoring Extended Half-Life Products in Hemophilia A and B.

    Abraham, Sunil / Duncan, Elizabeth M

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 569–588

    Abstract: Clinical trials have used a variety of coagulation factor assay methods to assess treatment with recombinant Factor VIII (rFVIII) and recombinant Factor IX (rFIX) extended half-life (EHL) products. However, diagnostic laboratories may use different ... ...

    Abstract Clinical trials have used a variety of coagulation factor assay methods to assess treatment with recombinant Factor VIII (rFVIII) and recombinant Factor IX (rFIX) extended half-life (EHL) products. However, diagnostic laboratories may use different reagent combinations for routine use or for field trials of EHL products. The focus of this review is on the choice of one-stage clotting and chromogenic Factor VIII and Factor IX methods and the influence that assay principle and components may have on results, including the effects of different activated partial thromboplastin time reagents and factor-deficient plasma. Our aim is to tabulate the findings for each method and reagent group to give laboratories practical guidance as to how the reagent combinations used in their local laboratory compare to others, for the various EHLs available.
    MeSH term(s) Humans ; Factor VIII ; Factor IX ; Hemophilia A/diagnosis ; Hemophilia A/drug therapy ; Half-Life ; Blood Coagulation Tests/methods ; Indicators and Reagents ; Hemostatics
    Chemical Substances Factor VIII (9001-27-8) ; Factor IX (9001-28-9) ; Indicators and Reagents ; Hemostatics
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_37
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Metastasiertes Plattenepithelkarzinom auf einem Ulkus bei Graft-versus-Host-Disease nach allogener Stammzelltransplantation.

    Hobelsberger, S / Meier, F / Beissert, S / Abraham, S

    Dermatologie (Heidelberg, Germany)

    2022  Volume 73, Issue 9, Page(s) 722–726

    Abstract: We report the case of a 48-year-old multimorbid man who received allogeneic bone marrow transplantation 26 years ago for chronic myeloid leukemia. For 24 years, the patient suffered from sclerodermiform chronic graft-versus-host disease (GVHD) of the ... ...

    Title translation Metastatic squamous cell carcinoma on an ulcer in graft-versus-host disease after allogeneic stem cell transplantation.
    Abstract We report the case of a 48-year-old multimorbid man who received allogeneic bone marrow transplantation 26 years ago for chronic myeloid leukemia. For 24 years, the patient suffered from sclerodermiform chronic graft-versus-host disease (GVHD) of the skin and lung with partial lung resection and immunosuppressive therapy. Recurrent ulcerations developed on the lower legs at the sites affected by cutaneous GVHD. The patient presented to our clinic with an ulcer progressive in size with resistance to previous therapy. Histologically, squamous cell carcinoma was found. Magnetic resonance imaging showed bone involvement and cutaneous in-transit metastasis, and computed tomography revealed a metastasis in the sacrum. Before therapy was initiated, the patient died suddenly as a result of his previous illnesses. The development of cutaneous GVHD is common in patients with allogeneic stem cell transplantation. The risk for the development of squamous cell carcinoma is increased. Patients should be under close dermatologic surveillance. If squamous cell carcinoma is suspected in pre-existing GVHD, biopsy should be performed promptly to reduce the risk of metastasis.
    MeSH term(s) Bone Marrow Transplantation/adverse effects ; Carcinoma, Squamous Cell/etiology ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Middle Aged ; Skin Diseases/etiology ; Ulcer/etiology
    Language German
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ISSN 2731-7013
    ISSN (online) 2731-7013
    DOI 10.1007/s00105-021-04932-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Delusional.

    Abraham, Sajit

    Schizophrenia bulletin

    2019  Volume 46, Issue 6, Page(s) 1339–1340

    MeSH term(s) Adult ; Antipsychotic Agents/therapeutic use ; Delusions/drug therapy ; Delusions/etiology ; Delusions/physiopathology ; Hallucinations/drug therapy ; Hallucinations/etiology ; Hallucinations/physiopathology ; Humans ; Male ; Olanzapine/therapeutic use ; Psychotic Disorders/complications ; Psychotic Disorders/drug therapy ; Psychotic Disorders/physiopathology
    Chemical Substances Antipsychotic Agents ; Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbz083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1323: Show issues Location:
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  8. Article: Kutane Mastozytose im Kindesalter

    Nemat, K. / Abraham, S.

    Allergologie

    2022  Volume 45, Issue 1, Page(s) 29

    Language German
    Document type Article
    ZDB-ID 547065-1
    ISSN 0344-5062
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1398: Show issues Location:
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  9. Article ; Online: Cutaneous mastocytosis in childhood.

    Nemat, Katja / Abraham, Susanne

    Allergologie select

    2022  Volume 6, Page(s) 1–10

    Abstract: Mastocytoses are characterized by clonal proliferation of mast cells in various tissues. In childhood, cutaneous mastocytosis (CM) occurs almost exclusively. It is confined to the skin, and has a good prognosis. The most common form is the maculopapular ... ...

    Abstract Mastocytoses are characterized by clonal proliferation of mast cells in various tissues. In childhood, cutaneous mastocytosis (CM) occurs almost exclusively. It is confined to the skin, and has a good prognosis. The most common form is the maculopapular cutaneous mastocytosis (MPCM), formerly called urticaria pigmentosa. A distinction is made between a monomorphic variant of MPCM with multiple small, roundish maculopapular skin lesions and the - more common - polymorphic variant with larger lesions of variable size. One quarter of CM diagnosed in childhood are mastocytomas, which often occur solitary or at multiple sites. The diffuse variant of CM (DCM), which affects 5% of children with CM, should be distinguished from these forms. Systemic mastocytoses (SM) with mast cell infiltrates in the bone marrow or other extracutaneous tissues, such as the gastrointestinal tract, occur predominantly in adults. The diagnosis of CM is usually made clinically: Manifestation in infancy, typical morphology and distribution, pathognomonic Darier sign. Basal serum tryptase is determined if DCM or systemic mastocytosis are to be diagnosed. Children with mastocytosis should be managed in a specialized outpatient clinic. For affected families, detailed information about the clinical picture including prognosis assessment is essential. Mast cell mediated symptoms are controlled by oral non-sedating antihistamines if needed.
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02304E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Postcopulatory Behavior of Tephritid Flies.

    Pérez-Staples, Diana / Abraham, Solana

    Annual review of entomology

    2022  Volume 68, Page(s) 89–108

    Abstract: Mating produces profound changes in the behavior of female flies, such as an increase in oviposition, reduction in sexual receptivity, increase in feeding, and even excretion. Many of these changes are produced by copulation, sperm, and accessory gland ... ...

    Abstract Mating produces profound changes in the behavior of female flies, such as an increase in oviposition, reduction in sexual receptivity, increase in feeding, and even excretion. Many of these changes are produced by copulation, sperm, and accessory gland products that males transfer to females during mating. Our knowledge on the function of the male ejaculate and its effect on female insects is still incipient. In this article, we review peri- and postcopulatory behaviors in tephritid flies. We address the effects of male copulatory behavior; copula duration; and the male ejaculate, sperm, and accessory gland products on female remating behavior. Many species from these families are pests of economic importance; thus, understanding male mating effects on female behavior contributes to both developing more effective environmentally friendly control methods and furthering our understanding of evolutionary implications of intersexual competition and sexual conflict.
    MeSH term(s) Male ; Female ; Animals ; Diptera ; Semen ; Spermatozoa ; Copulation ; Sexual Behavior, Animal
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207927-6
    ISSN 1545-4487 ; 0066-4170
    ISSN (online) 1545-4487
    ISSN 0066-4170
    DOI 10.1146/annurev-ento-120220-113618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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