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  1. Article ; Online: Editor Profile: Andrey Abramov.

    Abramov, Andrey Y

    The FEBS journal

    2024  Volume 291, Issue 10, Page(s) 2027–2029

    Abstract: In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Professor Andrey Abramov is a cell biologist and biophysicist at ...

    Abstract In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Professor Andrey Abramov is a cell biologist and biophysicist at University College London's Queen Square Institute of Neurology. He has served as an Editorial Board Member of The FEBS Journal since 2015.
    MeSH term(s) History, 21st Century ; History, 20th Century ; Humans ; Biophysics/history ; Cell Biology/history ; Periodicals as Topic/history
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Biography ; Historical Article ; Interview ; Portrait ; Editorial ; Journal Article
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.17131
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  2. Article ; Online: The brain-from neurodevelopment to neurodegeneration.

    Abramov, Andrey Y

    The FEBS journal

    2022  Volume 289, Issue 8, Page(s) 2010–2012

    Abstract: The brain is the organ that orchestrates the whole body. To do so, neurons and glia in different brain regions have evolved to be highly specialized and are regulated by diverse receptors and neuro- and gliotransmitters. Some of the features of the brain, ...

    Abstract The brain is the organ that orchestrates the whole body. To do so, neurons and glia in different brain regions have evolved to be highly specialized and are regulated by diverse receptors and neuro- and gliotransmitters. Some of the features of the brain, including a protective brain-blood barrier, high-energy demand, and electrical activity, mean that neurons and astrocytes are uniquely diverse components of tissue that vary greatly even across brain regions. This Special Issue features 19 review articles that cover different aspects of the broad field of neuroscience-from neurodevelopment, physiology and memory formation to the mechanisms underlying the development of neurodegenerative diseases.
    MeSH term(s) Astrocytes/physiology ; Brain ; Humans ; Neurodegenerative Diseases ; Neurons/physiology
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16436
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  3. Article ; Online: Redox biology in neurodegenerative disorders.

    Abramov, Andrey Y

    Free radical biology & medicine

    2022  Volume 188, Page(s) 24–25

    Abstract: Oxidative stress and alteration of redox signaling is shown to be involved in the mechanism of neuronal loss in the most of neurodegenerative diseases. This Special Issue features seven review articles that cover major aspects of the changes of redox ... ...

    Abstract Oxidative stress and alteration of redox signaling is shown to be involved in the mechanism of neuronal loss in the most of neurodegenerative diseases. This Special Issue features seven review articles that cover major aspects of the changes of redox biology in the mechanism of pathology of neurodegenerative diseases and discusses possible ways for prevention.
    MeSH term(s) Biology ; Humans ; Neurodegenerative Diseases/pathology ; Oxidation-Reduction ; Oxidative Stress/physiology ; Reactive Oxygen Species ; Signal Transduction
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.06.229
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  4. Article: The brain—from neurodevelopment to neurodegeneration

    Abramov, Andrey Y.

    FEBS journal. 2022 Apr., v. 289, no. 8

    2022  

    Abstract: The brain is the organ that orchestrates the whole body. To do so, neurons and glia in different brain regions have evolved to be highly specialized and are regulated by diverse receptors and neuro‐ and gliotransmitters. Some of the features of the brain, ...

    Abstract The brain is the organ that orchestrates the whole body. To do so, neurons and glia in different brain regions have evolved to be highly specialized and are regulated by diverse receptors and neuro‐ and gliotransmitters. Some of the features of the brain, including a protective brain–blood barrier, high‐energy demand, and electrical activity, mean that neurons and astrocytes are uniquely diverse components of tissue that vary greatly even across brain regions. This Special Issue features 19 review articles that cover different aspects of the broad field of neuroscience—from neurodevelopment, physiology and memory formation to the mechanisms underlying the development of neurodegenerative diseases.
    Keywords astrocytes ; blood-brain barrier ; brain ; memory ; neurodegenerative diseases ; neurodevelopment
    Language English
    Dates of publication 2022-04
    Size p. 2010-2012.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note EDITORIAL
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16436
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  5. Article: Inorganic Polyphosphate and F

    Baev, Artyom Y / Abramov, Andrey Y

    Progress in molecular and subcellular biology

    2022  Volume 61, Page(s) 1–13

    Abstract: Inorganic polyphosphate is a polymer which plays multiple important roles in yeast and bacteria. In higher organisms the role of polyP has been intensively studied in last decades and involvements of this polymer in signal transduction, cell death ... ...

    Abstract Inorganic polyphosphate is a polymer which plays multiple important roles in yeast and bacteria. In higher organisms the role of polyP has been intensively studied in last decades and involvements of this polymer in signal transduction, cell death mechanisms, energy production, and many other processes were demonstrated. In contrast to yeast and bacteria, where enzymes responsible for synthesis and hydrolysis of polyP were identified, in mammalian cells polyP clearly plays important role in physiology and pathology but enzymes responsible for synthesis of polyP or consumption of this polymer are still not identified. Here, we discuss the role of mitochondrial F
    MeSH term(s) Animals ; Mammals/genetics ; Mammals/metabolism ; Mitochondria/genetics ; Nitric Oxide Synthase/metabolism ; Polymers/metabolism ; Polyphosphates/metabolism ; Proton-Translocating ATPases/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Polymers ; Polyphosphates ; Nitric Oxide Synthase (EC 1.14.13.39) ; Proton-Translocating ATPases (EC 3.6.3.14)
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article
    ISSN 0079-6484
    ISSN 0079-6484
    DOI 10.1007/978-3-031-01237-2_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond.

    Esteras, Noemí / Abramov, Andrey Y

    Free radical biology & medicine

    2022  Volume 189, Page(s) 136–153

    Abstract: Mitochondria are unique and essential organelles that mediate many vital cellular processes including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45-related factor 2) has emerged in the last few years as an important modulator ...

    Abstract Mitochondria are unique and essential organelles that mediate many vital cellular processes including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45-related factor 2) has emerged in the last few years as an important modulator of multiple aspects of mitochondrial function. Well-known for controlling cellular redox homeostasis, the cytoprotective effects of Nrf2 extend beyond its ability to regulate a diverse network of antioxidant and detoxification enzymes. Here, we review the role of Nrf2 in the regulation of mitochondrial function and structure. We focus on Nrf2 involvement in promoting mitochondrial quality control and regulation of basic aspects of mitochondrial function, including energy production, reactive oxygen species generation, calcium signalling, and cell death induction. Given the importance of mitochondria in the development of multiple diseases, these findings reinforce the pharmacological activation of Nrf2 as an attractive strategy to counteract mitochondrial dysfunction.
    MeSH term(s) Antioxidants/pharmacology ; Energy Metabolism ; GA-Binding Protein Transcription Factor ; Mitochondria/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress
    Chemical Substances Antioxidants ; GA-Binding Protein Transcription Factor ; NF-E2-Related Factor 2
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.07.013
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  7. Article ; Online: Carbon monoxide neurotoxicity is triggered by oxidative stress induced by ROS production from three distinct cellular sources.

    Angelova, Plamena R / Myers, Isabella / Abramov, Andrey Y

    Redox biology

    2023  Volume 60, Page(s) 102598

    Abstract: Carbon monoxide (CO) poisoning is one of the leading causes of toxic mortality and morbidity. We have studied the generation of reactive oxygen species in cortical neurons in culture in response to toxic doses of CO exposure. Fluorescence microscopy was ... ...

    Abstract Carbon monoxide (CO) poisoning is one of the leading causes of toxic mortality and morbidity. We have studied the generation of reactive oxygen species in cortical neurons in culture in response to toxic doses of CO exposure. Fluorescence microscopy was used to measure the rate of free radical generation, lipid peroxidation, GSH level and also mitochondrial metabolism. We have found that toxic concentrations of CO released from CORM-401 induced mitochondrial depolarisation and inhibition of NADH dependent respiration to a lesser degree than when compared to ischaemia. Energy collapse was not observed within 40 min of CO exposure. We have found that CO induces the generation of reactive oxygen species resulting in lipid peroxidation and a decrease in GSH via three different mechanisms: from mitochondria during the first minutes of CO exposure, from xanthine oxidase at around 20 min exposure due to energy deprivation, and considerable ROS production from NADPH oxidase in the post CO exposure period (re-oxygenation). Inhibition of these different phases with mitochondrial antioxidants, inhibitors of xanthine oxidase, or NADPH oxidase, protected neurons and astrocytes against CO-induced oxidative stress and cell death. The most profound effect was seen during NADPH oxidase inhibition. Thus, oxidative stress has a remarkably significant role in CO-induced neuronal cell death and preventing its occurrence during reoxygenation is of great importance in the consideration of a positive, neurologically protective therapeutic outcome for CO exposed patients.
    MeSH term(s) Humans ; Reactive Oxygen Species/metabolism ; Carbon Monoxide/pharmacology ; Xanthine Oxidase/metabolism ; Cells, Cultured ; Oxidative Stress ; NADPH Oxidases/metabolism
    Chemical Substances Reactive Oxygen Species ; Carbon Monoxide (7U1EE4V452) ; Xanthine Oxidase (EC 1.17.3.2) ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2023-01-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2022.102598
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  8. Article ; Online: Different faces of neurodegeneration.

    Abramov, Andrey Y

    The FEBS journal

    2018  Volume 285, Issue 19, Page(s) 3544–3546

    Abstract: This Special Issue comprises nine reviews offering perspectives from the development of neurodegeneration in different pathologies to neuronal protection, providing new views on the mechanism of neurodegeneration and associated processes and a summary of ...

    Abstract This Special Issue comprises nine reviews offering perspectives from the development of neurodegeneration in different pathologies to neuronal protection, providing new views on the mechanism of neurodegeneration and associated processes and a summary of the progress in neuroscience. We hope you find these reviews interesting and informative and we thank the authors for these excellent contributions to The FEBS Journal.
    MeSH term(s) Humans ; Neurodegenerative Diseases/classification ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/prevention & control ; Neurosciences ; Prognosis
    Language English
    Publishing date 2018-10-28
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.14646
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  9. Article ; Online: Neurodegenerative disorders-Searching for targets and new ways of diseases treatment.

    Abramov, Andrey Y / Bachurin, Sergey O

    Medicinal research reviews

    2021  Volume 41, Issue 5, Page(s) 2603–2605

    MeSH term(s) Humans ; Neurodegenerative Diseases/drug therapy
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603210-2
    ISSN 1098-1128 ; 0198-6325
    ISSN (online) 1098-1128
    ISSN 0198-6325
    DOI 10.1002/med.21794
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  10. Article ; Online: Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology.

    Esteras, Noemi / Abramov, Andrey Y

    Cells

    2020  Volume 9, Issue 9

    Abstract: Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer's disease (AD) and other tauopathies including frontotemporal dementia (FTD). The interaction between ... ...

    Abstract Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer's disease (AD) and other tauopathies including frontotemporal dementia (FTD). The interaction between oxidative stress, mitochondrial dysfunction and the impairment of calcium ions (Ca
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Cell Death ; Cholinesterase Inhibitors/therapeutic use ; Frontotemporal Dementia/drug therapy ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Gene Expression Regulation ; Humans ; Memantine/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Permeability Transition Pore/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/therapeutic use ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Sodium-Calcium Exchanger/genetics ; Sodium-Calcium Exchanger/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; Calcium Channels ; Cholinesterase Inhibitors ; MAPT protein, human ; Mitochondrial Permeability Transition Pore ; Neuroprotective Agents ; Reactive Oxygen Species ; Sodium-Calcium Exchanger ; mitochondrial calcium uniporter ; tau Proteins ; Calcium (SY7Q814VUP) ; Memantine (W8O17SJF3T)
    Language English
    Publishing date 2020-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9092135
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