Article: Oxidative stress in hepatitis C virus-human immunodeficiency virus co-infected patients.
2019 Volume 19, Issue 1, Page(s) 92–98
Abstract: Introduction and objectives: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection generates sustained inflammation with increased reactive oxygen species production. The pathogenic impact of systemic oxidative stress is known to ... ...
Abstract | Introduction and objectives: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection generates sustained inflammation with increased reactive oxygen species production. The pathogenic impact of systemic oxidative stress is known to influence drug treatment and follow-up. The aim of this case-control study was to compare the redox status in HCV-HIV co-infected with respect to HIV-infected individuals and to explore the relation between redox and HIV follow-up variables. Patients or materials and methods: Blood samples were drawn from 330 individuals divided into three groups: HIV, HCV-HIV and presumable healthy subjects. Redox, hematological, hemochemical, immunologic and virological indexes were determined. Results: Both HIV groups had significant differences in global indexes of damage and antioxidant status (p<0.05) with respect to the supposedly healthy individual group. HCV-HIV group showed a significantly higher damage (total hydroperoxide and advanced oxidation protein products) compared to the control and HIV groups (p<0.05). The overall modification of the redox indexes showed that 72% of individuals with simultaneous detrimental differences were related to HCV-HIV condition. Conclusions: These results corroborate that oxidative stress occurs in the HIV condition and also during HCV-HIV co-infection, with different molecular changes of follow-up indexes. Redox indexes diagnosis should be considered in early diagnosis and treatment of HCV-HIV co-infection. |
---|---|
MeSH term(s) | Adult ; Advanced Oxidation Protein Products/metabolism ; Anti-Retroviral Agents/therapeutic use ; Antioxidants/metabolism ; Antiviral Agents/therapeutic use ; Case-Control Studies ; Catalase/metabolism ; Coinfection ; Female ; Glutathione/metabolism ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/metabolism ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation ; Male ; Malondialdehyde/metabolism ; Middle Aged ; Oxidants/metabolism ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Viral Load |
Chemical Substances | Advanced Oxidation Protein Products ; Anti-Retroviral Agents ; Antioxidants ; Antiviral Agents ; Oxidants ; Malondialdehyde (4Y8F71G49Q) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O) |
Language | English |
Publishing date | 2019-09-12 |
Publishing country | Mexico |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2188733-0 |
ISSN | 1665-2681 |
ISSN | 1665-2681 |
DOI | 10.1016/j.aohep.2019.05.009 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 6221: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.