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  1. Article ; Online: Cimetidine for recurrent respiratory papillomatosis in pregnancy as an alternative adjuvant treatment.

    Tan, Sien Hui / Ghauth, Sakina / Liew, Yew Toong / Abu Bakar, Zulkiflee

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 281, Issue 2, Page(s) 1053–1055

    Abstract: Background: We report the first case of cimetidine as an alternative adjuvant therapy in a pregnant woman with recurrent respiratory papillomatosis (RRP). A 40 year old woman at 19 week gestation presented with progressive hoarseness and shortness of ... ...

    Abstract Background: We report the first case of cimetidine as an alternative adjuvant therapy in a pregnant woman with recurrent respiratory papillomatosis (RRP). A 40 year old woman at 19 week gestation presented with progressive hoarseness and shortness of breath for 1 month. Flexible nasopharyngolaryngoscopy revealed multiple papillomatous lesions over both vocal cords and subglottic area obstructing 60% of her airway. She had previously been diagnosed with juvenile onset RRP at the age of 5 and underwent endoscopic clearance regularly every 6 months.
    Method: The patient was started on a trial of oral cimetidine at a dose of 30 mg/kg and responded well, eventually requiring endoscopic excision only after 2 years. Subsequently, she underwent in vitro fertilisation treatment and stopped taking her cimetidine. After undergoing endoscopic clearance of her papillomata under general anaesthesia, she restarted on cimetidine during her 2nd and 3rd trimester.
    Results: Ensuing follow-up demonstrated stable minimal papillomata lesions on her right inferior surface of her vocal cord with no recurrence on her left vocal cord and subglottic area.
    Conclusion: Cimetidine is generally safe and not known to be associated with any major teratogenic risks during pregnancy. RRP is postulated to worsen in pregnant women due to the increase in oestrogen levels during pregnancy. Hence, adjuvant therapy was imperative for our patient to reduce recurrent papillomata formation during her pregnancy. Larger scale studies are warranted to assess the use of long-term high-dose cimetidine in terms of efficacy and safety in pregnancy.
    MeSH term(s) Adult ; Female ; Humans ; Pregnancy ; Adjuvants, Immunologic/therapeutic use ; Cimetidine/therapeutic use ; Papillomavirus Infections/diagnosis ; Respiratory Tract Infections/diagnosis
    Chemical Substances Adjuvants, Immunologic ; Cimetidine (80061L1WGD)
    Language English
    Publishing date 2023-12-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08364-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.50: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: A Single Institution Cadaveric Study on Anatomical Variation of the Sublingual Gland Duct.

    Ab Rahim, Nurul Asma Che / Liew, Yew Toong / Ghauth, Sakina / Narayanan, Prepageran / Abu Bakar, Zulkiflee

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2022  Volume 75, Issue 2, Page(s) 347–351

    Abstract: The purpose of this study was to conduct a cadaveric dissection study on the anatomical variation of the sublingual (SLG) excretory ducts and dictate an improved understanding of the anatomical communication between the SLG duct and submandibular (SMG) ... ...

    Abstract The purpose of this study was to conduct a cadaveric dissection study on the anatomical variation of the sublingual (SLG) excretory ducts and dictate an improved understanding of the anatomical communication between the SLG duct and submandibular (SMG) ducts. This study is carried out by standardized dissection of anterior floor of mouth in 6 formalin-fixed adult cadavers in Silent Mentor Workshop University Malaya in August 2020. The cadavers had no trace of scars, adhesions, signs of trauma or operation. SMG duct opening was identified lateral to the lingual frenulum through a papilla in the floor of mouth behind the lower incisor tooth. A horizontal incision line was done over floor of mouth just lateral to the opening. SMG duct and SLG was traced and skeletonized. Any presence of major duct arising from the SLG and its communication with SMG duct were investigated. We found there are 3 patterns of SLG excretory duct variants; (1) One major (Bartholin's) duct which open independently at its own orifice adjacent to the orifice of the Wharton's duct of SMG. (2) One major (Bartholin's) duct which joined into the Wharton's duct of SMG. (3) Absent of a major duct arising from SLG. The overall mean diameter of SLG ducts were 1.3 ± 0.41 and the mean length of SLG ducts were 18.5 ± 6.55. The overall mean diameter of SMG ducts was 2.6 ± 0.74 and the mean length of SMG ducts were 46.5 ± 6.57. Excretory ductal system of SLG showed great variations, not only between the different cadavers but also within the different sides of the same cadaver. Awareness of potential anatomical variations can aid in the accurate diagnosis and treatment of patients with salivary gland pathology as well as help surgeons reveal potential risk factor and avoid complications during surgical procedures in the floor of mouth.
    Language English
    Publishing date 2022-11-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-022-03261-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5300: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Neck stiffness in a post-irradiated nasopharyngeal carcinoma adult: An unusual diagnosis.

    Lorna Ting, Kang Ni / Liew, Yew Toong / Abu Bakar, Zulkiflee / Narayanan, Prepageran

    Auris, nasus, larynx

    2018  Volume 46, Issue 3, Page(s) 469–473

    Abstract: Nasopharyngeal carcinoma is a neoplasm commonly found in population of South East Asia. The mainstay of treatment is high dose irradiation. Complications from radiotherapy are not uncommon especially to those nearby structures such as vertebrae and ... ...

    Abstract Nasopharyngeal carcinoma is a neoplasm commonly found in population of South East Asia. The mainstay of treatment is high dose irradiation. Complications from radiotherapy are not uncommon especially to those nearby structures such as vertebrae and spinal cord. A 57 year-old gentleman with nasopharyngeal carcinoma (NPC) who was treated with chemo-radiation (total of 35 fractions,70Gy) presented to us 6 months post therapy with bilateral nasal discharge and progressive neck stiffness. Nasoendoscopy showed inflamed nasophayngeal mucosa and Computed Tomography (CT) brain and cervical spine showed retropharyngeal and anterior epidural collection with extension into atlantoaxial bone and spinal cord compression. Histopathological specimen revealed features of chronic inflammations with multiple actinomycetes colonies. Our patient suffered severe neck stiffness and loss of sensations on both upper limbs. He was treated conservatively with Halo vest and intravenous antibiotics for 8 weeks and recovered fully. Irradiation in NPC is known to cause devastating complications to cervical spine such as osteoradionecrosis, osteomyelitis. It also renders tissues hypoxic and risk of getting rare infection like actinomycosis. This report can represent a great diagnostic and therapeutic challenge with differentials of tumor recurrence, osteoradionecrosis or osteomyelitis. Patients must be regularly followed up to look for possible cervical complications as a result from irradiation, to prevent devastating outcome or prognosis.
    MeSH term(s) Actinomycosis/diagnostic imaging ; Actinomycosis/etiology ; Cervical Vertebrae/diagnostic imaging ; Chemoradiotherapy ; Conservative Treatment ; Epidural Space/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nasopharyngeal Carcinoma/therapy ; Nasopharyngeal Neoplasms/therapy ; Radiotherapy, Conformal/adverse effects ; Spinal Cord Compression/diagnostic imaging ; Spinal Cord Compression/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-07-23
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2018.07.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Determining the Accuracy of the Mandibular Canal Region in 3D Biomodels Fabricated from CBCT Scanned Data: A Cadaveric Study.

    Abd Fattah, Syed Yusoff Alzawawi Syed / Hariri, Firdaus / Nambiar, Phrabhakaran / Abu Bakar, Zulkiflee / Abdul Rahman, Zainal Ariff

    Current medical imaging reviews

    2019  Volume 15, Issue 7, Page(s) 645–653

    Abstract: Objective: To validate the accuracy of the mandibular canal region in 3D biomodel produced by using data obtained from Cone-Beam Computed Tomography (CBCT) of cadaveric mandibles.: Methods: Six hemi-mandible samples were scanned using the i-CAT CBCT ... ...

    Abstract Objective: To validate the accuracy of the mandibular canal region in 3D biomodel produced by using data obtained from Cone-Beam Computed Tomography (CBCT) of cadaveric mandibles.
    Methods: Six hemi-mandible samples were scanned using the i-CAT CBCT system. The scanned data was transferred to the OsiriX software for measurement protocol and subsequently into Mimics software to fabricate customized cutting jigs and 3D biomodels based on rapid prototyping technology. The hemi-mandibles were segmented into 5 dentoalveolar blocks using the customized jigs. Digital calliper was used to measure six distances surrounding the mandibular canal on each section. The same distances were measured on the corresponding cross-sectional OsiriX images and the 3D biomodels of each dentoalveolar block.
    Results: Statistically no significant difference was found when measurements from OsiriX images and 3D biomodels were compared to the "gold standard" -direct digital calliper measurement of the cadaveric dentoalveolar blocks. Moreover, the mean value difference of the various measurements between the different study components was also minimal.
    Conclusion: Various distances surrounding the mandibular canal from 3D biomodels produced from the CBCT scanned data was similar to that of direct digital calliper measurements of the cadaveric specimens.
    MeSH term(s) Cone-Beam Computed Tomography ; Humans ; Imaging, Three-Dimensional ; Mandible/diagnostic imaging ; Models, Anatomic ; Reproducibility of Results
    Language English
    Publishing date 2019-12-19
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    DOI 10.2174/1573405614666181012144745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An audiological evaluation of syndromic and non-syndromic craniosynostosis in pre-school going children.

    Goh, Liang Chye / Azman, Ali / Siti, Hufaidah Binti Konting / Khoo, Wee Vien / Muthukumarasamy, Premala A/P / Thong, Meow Keong / Abu Bakar, Zulkiflee / Manuel, Anura Michelle

    International journal of pediatric otorhinolaryngology

    2018  Volume 109, Page(s) 50–53

    Abstract: Objective: To study the audiological outcome and early screening of pre-school going children with craniosynostosis under follow-up at the University of Malaya Medical Center(UMMC), Kuala Lumpur, Malaysia over a 10 year period.: Methods: A ... ...

    Abstract Objective: To study the audiological outcome and early screening of pre-school going children with craniosynostosis under follow-up at the University of Malaya Medical Center(UMMC), Kuala Lumpur, Malaysia over a 10 year period.
    Methods: A retrospective descriptive cohort study on the audiological findings detected during the first hearing assessment done on a child with craniosynostosis using otoacoustic emissions, pure tone audiometry or auditory brainstem response examination. The main aim of this study was to evaluate the type and severity of hearing loss when compared between syndromic and non-sydromic craniosynostosis, and other associated contributory factors.
    Results: A total of 31 patients with 62 ears consisting of 14 male patients and 17 female patients were evaluated. Twenty two patients (71%) were syndromic and 9 (29%) were non-syndromic craniosynostosis. Amongst the syndromic craniosynostosis, 9 (41%) had Apert syndrome, 7 (32%) had Crouzon syndrome, 5 (23%) had Pfieffer syndrome and 1 (4%) had Shaethre Chotzen syndrome. Patients with syndromic craniosynostosis were more likely to present with all types and severity of hearing loss, including severe to profound sensorineural hearing loss while children with non-syndromic craniosynostosis were likely to present with normal hearing (p < 0.05). In addition, when the first hearing test was done at a later age, a hearing loss including sensorineural hearing loss is more likely to be present in a child with syndromic craniosynostosis (p < 0.05).
    Conclusion: Our study suggested that children who are born with syndromic craniosynostosis were more likely to suffer from a hearing loss, including that of a severe to profound degree compared to children with non-syndromic craniosynostosis. In addition to that, hearing loss is more likely to be detected when the first hearing test is done at a later age, and this can be an irreversible sensorineural hearing loss. We would like to advocate the need for early audiological screening and follow up in children with syndromic craniosynostosis.
    MeSH term(s) Acrocephalosyndactylia/complications ; Audiometry, Pure-Tone ; Child, Preschool ; Craniofacial Dysostosis/complications ; Craniosynostoses/complications ; Evoked Potentials, Auditory, Brain Stem ; Female ; Hearing Loss/diagnosis ; Hearing Loss/etiology ; Hearing Loss/physiopathology ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/etiology ; Hearing Loss, Sensorineural/physiopathology ; Humans ; Infant ; Male ; Otoacoustic Emissions, Spontaneous ; Retrospective Studies
    Language English
    Publishing date 2018-03-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2018.03.010
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    In stock of ZB MED Cologne/Königswinter

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