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  1. Article ; Online: Mitochondrial Respiration and Exercise Performance in Patients With Heart Failure With Preserved Ejection Fraction.

    Abu-Own, Huda / Wendler, Olaf / Okonko, Darlington O

    JAMA cardiology

    2023  Volume 8, Issue 11, Page(s) 1100

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure/therapy ; Ventricular Function, Left ; Exercise ; Respiration
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.3571
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  2. Article ; Online: Intravenous iron repletion in heart failure: bridging the gap between symptom relief and hard clinical outcomes.

    Abu-Own, Huda / Webb, Ian / Okonko, Darlington O

    European heart journal

    2023  Volume 44, Issue 48, Page(s) 5092–5094

    MeSH term(s) Humans ; Iron/therapeutic use ; Iron Deficiencies ; Ferric Compounds/therapeutic use ; Heart Failure/complications ; Heart Failure/drug therapy
    Chemical Substances Iron (E1UOL152H7) ; ferric carboxymaltose (6897GXD6OE) ; Ferric Compounds
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad746
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  3. Article ; Online: Coronary thrombosis in a patient with COVID-19 and haemophagocytic lymphohistiocytosis.

    Dancy, Luke H / Abu-Own, Huda / Byrne, Jonathan / Pareek, Nilesh

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2021  Volume 16, Issue 18, Page(s) e1531–e1532

    MeSH term(s) COVID-19 ; Coronary Thrombosis/diagnostic imaging ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2021-04-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-20-00636
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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  4. Article: Extensive coronary artery thrombosis complicating COVID-19 infection and haemophagocytic lymphohistiocytosis

    Dancy, Luke H / Abu-Own, Huda / Byrne, Jonathan / Pareek, Nilesh

    EuroIntervention

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #688783
    Database COVID19

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  5. Article ; Online: The effect of ethnicity and socioeconomic status on outcomes after resuscitated out-of-hospital cardiac arrest - Findings from a tertiary centre in South London.

    Roy, Roman / Kanyal, Ritesh / Abd Razak, Muhamad / To-Dang, Brian / Chotai, Shayna / Abu-Own, Huda / Cannata, Antonio / Dworakowski, Rafal / Webb, Ian / Pareek, Manish / Shah, Ajay M / MacCarthy, Philip / Byrne, Jonathan / Melikian, Narbeh / Pareek, Nilesh

    Resuscitation plus

    2023  Volume 14, Page(s) 100388

    Abstract: Background: Out-of-hospital cardiac arrest is a common cause of morbidity and mortality, and ethnic variation in outcomes is recognised. We investigated ethnic and socioeconomic differences in arrest circumstances, rates of coronary artery disease, ... ...

    Abstract Background: Out-of-hospital cardiac arrest is a common cause of morbidity and mortality, and ethnic variation in outcomes is recognised. We investigated ethnic and socioeconomic differences in arrest circumstances, rates of coronary artery disease, treatment, and outcomes in resuscitated OOHCA.
    Methods: Patients with resuscitated OOHCA of suspected cardiac aetiology were included in the King's Out-of-Hospital Cardiac Arrest Registry between 1-May-2012 and 31-December-2020.
    Results: Of 526 patients (median age 62.0 years, IQR 21.1, 74.1% male), 414 patients (78.7%) were White, 35 (6.7%) were Asian, and 77 (14.6%) were Black. Black patients had more co-existent hypertension (
    Conclusion: In this single-centre study, Black patients had higher mortality after resuscitated OOHCA than White/Asian patients. This may be in part due to differing underlying aetiology rather than differences in arrest circumstances or social deprivation.
    Language English
    Publishing date 2023-04-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2023.100388
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  6. Article ; Online: Effect of ferric carboxymaltose on calculated plasma volume status and clinical congestion: a FAIR-HF substudy.

    Okonko, Darlington O / Jouhra, Fadi / Abu-Own, Huda / Filippatos, Gerasimos / Colet, Josep Comin / Suki, Chainey / Mori, Claudio / Ponikowski, Piotr / Anker, Stefan D

    ESC heart failure

    2019  Volume 6, Issue 4, Page(s) 621–628

    Abstract: Aims: Iron deficiency worsens symptoms, quality of life, and exercise capacity in chronic heart failure (CHF) and might do so by promoting fluid retention. We assessed whether iron repletion improved congestion in CHF and appraised the prognostic ... ...

    Abstract Aims: Iron deficiency worsens symptoms, quality of life, and exercise capacity in chronic heart failure (CHF) and might do so by promoting fluid retention. We assessed whether iron repletion improved congestion in CHF and appraised the prognostic utility of calculated plasma volume status (PVS), a novel index of congestion, in the FAIR-HF data set.
    Methods and results: In FAIR-HF, 459 iron deficient CHF patients were randomized to intravenous ferric carboxymaltose (FCM) or saline and assessed at 4, 12, and 24 weeks. Using weight and haematocrit, we calculated PVS in 436 patients. At baseline, PVS and weight were -5.5 ± 7.7% and 76.9 ± 14.3 kg, with peripheral oedema evident in 35% of subjects. Higher PVS values correlated to other congestion surrogates such as lower serum albumin. At 4 weeks, FCM was associated with greater reductions in weight (0.02) and PVS (P < 0.0001), and a trend for improved peripheral oedema at 24 weeks (0.07). Irrespective of treatment allocation, patients with a decrease in PVS from baseline to week 24 had higher increments in 6 min walking distance (61.4 m vs. 43.5 m, 0.02) and were more likely to improve their NYHA class (33.3% vs. 15.5%, 0.001). A PVS > -4% at baseline predicted worse outcomes even after adjustment for treatment assignment (hazard ratio 1.88, 95% confidence interval 1.01-3.51, 0.046).
    Conclusions: Intravenous iron therapy with FCM is associated with early reductions in PVS and weight, implying that decongestion might be one mechanism via which iron repletion aids CHF patients. Calculated PVS is of prognostic utility in this cohort.
    MeSH term(s) Aged ; Aged, 80 and over ; Chronic Disease ; Double-Blind Method ; Female ; Ferric Compounds/therapeutic use ; Heart Failure/complications ; Heart Failure/physiopathology ; Humans ; Iron/deficiency ; Iron Metabolism Disorders/complications ; Iron Metabolism Disorders/drug therapy ; Male ; Maltose/analogs & derivatives ; Maltose/therapeutic use ; Middle Aged ; Plasma Volume
    Chemical Substances Ferric Compounds ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-05-30
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.12462
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  7. Article ; Online: Calculated plasma volume status and outcomes in patients undergoing coronary bypass graft surgery.

    Maznyczka, Annette Marie / Barakat, Mohamad Fahed / Ussen, Bassey / Kaura, Amit / Abu-Own, Huda / Jouhra, Fadi / Jaumdally, Hannah / Amin-Youssef, George / Nicou, Niki / Baghai, Max / Deshpande, Ranjit / Wendler, Olaf / Kolvekar, Shyam / Okonko, Darlington O

    Heart (British Cardiac Society)

    2019  Volume 105, Issue 13, Page(s) 1020–1026

    Abstract: Objectives: Congestion is associated with worse outcomes in critically ill surgical patients but can be difficult to quantify noninvasively. We hypothesised that plasma volume status (PVS), estimated preoperatively using a validated formula that ... ...

    Abstract Objectives: Congestion is associated with worse outcomes in critically ill surgical patients but can be difficult to quantify noninvasively. We hypothesised that plasma volume status (PVS), estimated preoperatively using a validated formula that enumerates percentage change from ideal plasma volume (PV), would provide incremental prognostic utility after coronary artery bypass graft (CABG) surgery.
    Methods: In this retrospective cohort study, patients who underwent CABG surgery (1999-2010) were identified from a prospectively collected database. Actual ([1-haematocrit] x [a+(b x weight [kg])]) and ideal (c x weight [kg]) PV were obtained from equations where a, b and c are sex-dependent constants. Calculated PVS was then derived (100% x [(actual-ideal)/ideal]).
    Results: In 1887 patients (mean age 67±10 years; 79% male; median European System for Cardiac Operative Risk Evaluation [EuroSCORE] 4), mean PVS was -8.2±9%. While 8% of subjects had clinical evidence of congestion, a relatively increased PV (PVS >0%) was estimated in 17% and correlated with lower serum sodium, higher EuroSCORE and a diagnosis of diabetes mellitus. A PVS≥5.6% was optimally prognostic and associated with greater mortality (HR: 2.31, p=0.009), independently of, and incremental to, EuroSCORE, New York Heart Association class and serum sodium. A PVS≥5.6% also independently predicted longer intensive care (β: 0.65, p=0.007) and hospital (β: 2.01, p=0.006) stays, and greater postoperative renal (OR: 1.61, p=0.008) and arrhythmic (OR: 1.29, p=0.03) complications.
    Conclusions: Higher PVS values, calculated simply from weight and haematocrit, are associated with worse inpatient outcomes after CABG. PVS could help refine risk stratification and further investigations are warranted to evaluate the potential clinical utility of PVS-guided management in patients undergoing CABG.
    MeSH term(s) Aged ; Aged, 80 and over ; Cohort Studies ; Coronary Artery Bypass ; Female ; Humans ; Male ; Middle Aged ; Plasma Volume ; Preoperative Period ; Prognosis ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2019-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2018-314246
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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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