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  1. Article ; Online: High-risk biochemical recurrence of locally treated prostate cancer after EMBARK. An end to decades of conventional wisdom?

    Achard, Vérane / Tombal, Bertrand

    Prostate cancer and prostatic diseases

    2023  

    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-023-00767-y
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    Zs.A 5277: Show issues Location:
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  2. Article ; Online: Prostate cancer intensity-modulated radiotherapy and long term genitourinary toxicity: an evolving therapeutic landscape.

    Achard, Vérane / Zilli, Thomas

    Prostate cancer and prostatic diseases

    2022  Volume 26, Issue 1, Page(s) 1–2

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/drug therapy ; Radiotherapy, Intensity-Modulated/adverse effects ; Dose Fractionation, Radiation ; Radiotherapy Dosage ; Treatment Outcome
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-022-00535-4
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: How To Manage T3b Prostate Cancer in the Contemporary Era: Is Radiotherapy the Standard of Care?

    Achard, Vérane / Peyrottes, Arthur / Sargos, Paul

    European urology open science

    2023  Volume 53, Page(s) 60–62

    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2023.05.009
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  4. Article ; Online: How To Manage T3b Prostate Cancer in the Contemporary Era: The Benefits of Surgery.

    Peyrottes, Arthur / Achard, Verane / Dariane, Charles

    European urology open science

    2023  Volume 53, Page(s) 55–57

    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2023.05.004
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  5. Article ; Online: Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction: Impact on urinary morbidity and mitigation strategies.

    Huck, Constance / Achard, Vérane / Maitre, Priyamvada / Murthy, Vedang / Zilli, Thomas

    Clinical and translational radiation oncology

    2023  Volume 45, Page(s) 100709

    Abstract: In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the ... ...

    Abstract In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the toxicity profile of SBRT for prostate cancer patients with a history of surgical treatment of benign prostate hyperplasia is still underreported. Here we present an overview of the available data on urinary morbidity for prostate cancer patients treated with SBRT after prior surgical treatments for benign prostate hyperplasia. Technical improvements useful to minimize toxicity and possible treatments for radiation-induced urethritis are discussed.
    Language English
    Publishing date 2023-12-10
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2023.100709
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  6. Article ; Online: Intraprostatic Urethra: The New Kid on the Block for Prostate Cancer Radiation Therapy?

    Zilli, Thomas / Achard, Vérane / Guevelou, Jennifer Le

    International journal of radiation oncology, biology, physics

    2022  Volume 113, Issue 1, Page(s) 92–95

    MeSH term(s) Brachytherapy ; Humans ; Male ; Prostate ; Prostatic Neoplasms/radiotherapy ; Urethra
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.01.022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Five fractions of SBRT for prostate cancer.

    Achard, Vérane / Bosetti, Davide / Pesce, Gianfranco / Zilli, Thomas

    The Lancet. Oncology

    2022  Volume 23, Issue 12, Page(s) e530

    MeSH term(s) Male ; Humans ; Radiosurgery/adverse effects ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00615-5
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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  8. Article ; Online: In Regard to Qi et al.

    Achard, Vérane / Zilli, Thomas

    International journal of radiation oncology, biology, physics

    2020  Volume 106, Issue 4, Page(s) 887–888

    MeSH term(s) Drugs, Chinese Herbal ; Humans ; Male ; Postoperative Period ; Prostatic Neoplasms
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2019.11.407
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Radiotherapy Combined with a Radiosensitizer for Bacillus Calmette-Guérin-unresponsive Non-muscle-invasive Carcinoma In Situ Bladder Cancer: An Open-label, Single-arm, Multicenter, Phase 2 European Organisation for Research and Treatment of Cancer Trial.

    Achard, Vérane / Fournier, Béatrice / D'Haese, David / Krzystyniak, Joanna / Tombal, Bertrand / Roupret, Morgan / Sargos, Paul / Dirix, Piet

    European urology oncology

    2024  

    Abstract: Radical cystectomy with pelvic lymph node dissection and urinary diversion is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC). However, many patients are unwilling or unable to ...

    Abstract Radical cystectomy with pelvic lymph node dissection and urinary diversion is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC). However, many patients are unwilling or unable to undergo such major surgery associated with high morbidity and a negative impact on quality of life. Chemoradiotherapy is an established treatment option for muscle-invasive bladder cancer. However, it has not been investigated adequately in NMIBC until now. The European Organisation for Research and Treatment of Cancer (EORTC) 2235 study (NCT06310369) is designed as a multicenter, prospective, international, phase 2 trial of moderate hypofractionated radiotherapy combined with a radiosensitizer in BCG-unresponsive NMIBC patients with carcinoma in situ (CIS) who are not eligible for or declined to undergo radical cystectomy. Patients who have received nadofaragene firadenovec or TAR-200 are eligible. The primary endpoint is the 6-mo complete response (CR) rate defined by the absence of CIS proven by a control biopsy of the bladder. The secondary endpoints include overall survival, progression-free survival, durability of CR, grade 3-4 adverse events rate, patients' quality of life, and organ preservation rate. PATIENT SUMMARY: Intravesical instillation of bacillus Calmette-Guérin is the standard treatment of non-muscle-invasive, also coined as superficial, bladder cancer. In case the cancer recurs, even superficially, there is no other proven treatment than a radical cystectomy-the surgical removal of the bladder. Although the surgical technique has improved dramatically over the past few years, it remains contraindicated in patients with severe comorbidities. In addition, because it affects the quality of life, patients may reject this option. This study will assess the efficacy of external beam radiotherapy, a robust alternative to surgery in muscle-invasive bladder cancer. Radiotherapy will be administered 5 d a week for 4 wk. It will be associated with a "radiosensitizer," an intravenous or oral drug, during the radiotherapy treatment. The study will measure the proportion of patients remaining recurrence free at 6 mo and thereafter. It will also evaluate the safety of the treatment and its impact on quality of life.
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2024.03.008
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  10. Article ; Online: The diagnosis and treatment of castrate-sensitive oligometastatic prostate cancer: A review.

    Vanden Berg, Rand N Wilcox / Zilli, Thomas / Achard, Vérane / Dorff, Tanya / Abern, Michael

    Prostate cancer and prostatic diseases

    2023  Volume 26, Issue 4, Page(s) 702–711

    Abstract: Background: Oligometastatic prostate cancer (OMPCa) is emerging as a transitional disease state between localized and polymetastatic disease. This review will assess the current knowledge of castrate-sensitive OMPCa.: Methods: A review of the current ...

    Abstract Background: Oligometastatic prostate cancer (OMPCa) is emerging as a transitional disease state between localized and polymetastatic disease. This review will assess the current knowledge of castrate-sensitive OMPCa.
    Methods: A review of the current literature was performed to summarize the definition and classification of OMPCa, assess the diagnostic methods and imaging modalities utilized, and to review the treatment options and outcomes. We further identify gaps in knowledge and areas for future research.
    Results: Currently there is no unified definition of OMPCa. National guidelines mostly recommend systemic therapies without distinguishing oligometastatic and polymetastatic disease. Next generation imaging is more sensitive than conventional imaging and has led to early detection of metastases at initial diagnosis or recurrence. While mostly retrospective in nature, recent studies suggest that treatment (surgical or radiation) of the primary tumor and/or metastatic sites might delay initiation of androgen deprivation therapy while increasing survival in selected patients.
    Conclusions: Prospective data are required to better assess the incremental improvement in survival and quality of life achieved with various treatment strategies in patients with OMPCa.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/therapy ; Prostatic Neoplasms/pathology ; Prospective Studies ; Quality of Life ; Androgen Antagonists/therapeutic use ; Retrospective Studies
    Chemical Substances Androgen Antagonists
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-023-00688-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5277: Show issues Location:
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