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  1. Book: Molecular probes for biomedical applications / 2

    Achilefu, Samuel

    (Proceedings of SPIE ; 6867 ; Progress in biomedical optics and imaging ; 9,26)

    2008  

    Author's details SPIE
    Series title Proceedings of SPIE ; 6867
    Progress in biomedical optics and imaging ; 9,26
    Molecular probes for biomedical applications
    Collection Molecular probes for biomedical applications
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publisher SPIE
    Publishing place Bellingham, Wash
    Publishing country United States
    Document type Book
    HBZ-ID HT015698321
    ISBN 978-0-8194-7042-3 ; 0-8194-7042-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 5906 order for loan Magazin

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  2. Book: Optical molecular probes for biomedical applications

    Achilefu, Samuel

    22 - 24 January 2006, San Jose, California, USA

    (SPIE ; 6097 ; Progress in biomedical optics and imaging ; 7,20)

    2006  

    Author's details SPIE, the International Society for Optical Engineering. Samuel I. Achilefu ..., chairs/ed
    Series title SPIE ; 6097
    Progress in biomedical optics and imaging ; 7,20
    Proceedings / SPIE, The International Society for Optical Engineering
    Collection Proceedings / SPIE, The International Society for Optical Engineering
    Keywords Molecular Probe Techniques ; Diagnostic Imaging ; Spectrometry, Fluorescence ; Nanostructures ; Biosensing Techniques
    Language English
    Size Getr. Zählung : ill., graph. Darst.
    Publisher SPIE
    Publishing place Bellingham, Wash
    Publishing country United States
    Document type Book
    HBZ-ID HT015307554
    ISBN 0-8194-6139-3 ; 978-0-8194-6139-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 6109 order for loan Magazin

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  3. Book: Optical, ultrasound, X-Ray and radiopharmaceutical imaging

    Achilefu, Samuel / Krause, Werner

    (Contrast agents ; 2 ; Topics in current chemistry ; 222)

    2002  

    Author's details with contributions by S. Achilefu ... Vol. ed.: Werner Krause
    Series title Contrast agents ; 2
    Topics in current chemistry ; 222
    Collection
    Language English
    Size VIII, 291 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013419676
    ISBN 3-540-43451-8 ; 978-3-540-43451-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2002 A 3693 order for loan Magazin

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  4. Article: Low-cost augmented reality goggles enable precision fluorescence-guided cancer surgery.

    Shmuylovich, Leonid / O'Brien, Christine M / Nwosu, Karen / Achilefu, Samuel

    Research square

    2023  

    Abstract: Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative ...

    Abstract Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlight tumors in real-time without using ionizing radiation. However, like many medical innovations, technical, economic, and logistic challenges have hindered widespread adoption of FGS beyond high-resource centers. To overcome these impediments, we developed the fully-wearable and battery-powered fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Novel device design ensures distance-independent coalignment between real and augmented FAR-Pi views and offers higher spatial resolution, depth of focus, and fluorescence detection sensitivity than existing bulkier, pricier, and wall-powered technologies. When paired with pan-tumor targeting fluorescent agents such as LS301, FAR-Pi objectively identifies tumors in vivo. As an open-source, affordable, and adaptable system, FAR-Pi is poised to democratize access to FGS and improve health outcomes worldwide.
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3084024/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid response activatable molecular probes for intraoperative optical image-guided tumor resection.

    Achilefu, Samuel

    Hepatology (Baltimore, Md.)

    2012  Volume 56, Issue 3, Page(s) 1170–1173

    Keywords covid19
    Language English
    Publishing date 2012-09
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.25807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: The insatiable quest for near-infrared fluorescent probes for molecular imaging.

    Achilefu, Samuel

    Angewandte Chemie (International ed. in English)

    2011  Volume 49, Issue 51, Page(s) 9816–9818

    MeSH term(s) Fluorescence Resonance Energy Transfer ; Fluorescent Dyes ; Humans ; Infrared Rays ; Luminescence ; Molecular Imaging/methods
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2011-01-25
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201005684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Early Expression of MMP-9 Predicts Recovery of Tibialis Anterior after Sciatic Nerve Crush Injury.

    Brogan, David M / Dy, Christopher J / Wever, Jason / Lee, Tony / Achilefu, Samuel

    Plastic and reconstructive surgery. Global open

    2022  Volume 10, Issue 4, Page(s) e4260

    Abstract: Background: The purpose of this study was to assess the expression of molecular markers and epineural blood flow after differing degrees of nerve injury to identify potential tools to predict nerve recovery in a rat sciatic nerve model.: Methods: A ... ...

    Abstract Background: The purpose of this study was to assess the expression of molecular markers and epineural blood flow after differing degrees of nerve injury to identify potential tools to predict nerve recovery in a rat sciatic nerve model.
    Methods: A total of 72 rats were divided into nine groups. Each group was subjected to one of three crush injuries, created by applying one of three vascular clamps for 30 seconds. Vascularity was assessed with laser Doppler flowmetry before and after crush, and at nonsurvival surgery. Nonsurvival surgeries were performed 6 hours, 2 weeks, or 6 weeks later with nerve conduction studies and muscle strength testing. Expression of matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2) in each nerve was quantified using with enzyme linked immunosorbent analysis.
    Results: Persistent hyperemia was noted in the zone of injury compared with baseline at 2 weeks and 6 weeks in the groups that displayed incomplete recovery. Expression of MMP-9 at 6 hours increased with increasing severity of crush and was inversely related to tibialis anterior muscle force recovery. The ratio of MMP-9:MMP-2 expression correlated well with recovery of compound nerve action potential amplitude at 6 weeks.
    Conclusions: Resolution of nerve hyperemia may correlate with nerve recovery from trauma, but early measures of nerve blood flow after injury are not prognostic of recovery. Ratio of MMP-9:MMP-2 expression 6 hours after injury correlates with recovery of compound nerve action potential at 6 weeks, while MMP-9 expression alone predicts tibialis anterior recovery. These findings together suggest that increased MMP-9 expression is a potentially useful marker of more severe nerve injury.
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
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  8. Article ; Online: Introduction to concepts and strategies for molecular imaging.

    Achilefu, Samuel

    Chemical reviews

    2010  Volume 110, Issue 5, Page(s) 2575–2578

    MeSH term(s) Animals ; Humans ; Molecular Imaging/methods
    Language English
    Publishing date 2010-05-12
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/cr1001113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  9. Book ; Conference proceedings: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI

    Achilefu, Samuel / Raghavachari, Ramesh

    2-5 February 2014, San Francisco, California, United States

    (Progress in biomedical optics and imaging, ; vol. 15, no. 31 ; Proceedings of SPIE, ; volume 8956)

    2014  

    Title variant Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications 6 ; Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications Six
    Institution SPIE (Society),
    Event/congress Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (Conference) (6th, 2014, SanFranciscoCalif.) ; SPIE Photonics West (Conference) (2014, SanFranciscoCalif.)
    Author's details Samuel Achilefu, Ramesh Raghavachari, editors ; sponsored and published by SPIE
    Series title Progress in biomedical optics and imaging, ; vol. 15, no. 31
    Proceedings of SPIE, ; volume 8956
    MeSH term(s) Nanoparticles/therapeutic use ; Molecular Probe Techniques ; Molecular Probes ; Nanoparticles ; Spectroscopy, Near-Infrared
    Language English
    Size 1 volume (various pagings) :, illustrations.
    Document type Book ; Conference proceedings
    Note "SPIE Photonics West"--cover.
    ISBN 9780819498694 ; 0819498696
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases.

    Cui, Shaojie / Ghai, Anchal / Deng, Yaqin / Li, Shili / Zhang, Ruihui / Egbulefu, Christopher / Liang, Guosheng / Achilefu, Samuel / Ye, Jin

    Molecular cell

    2023  Volume 83, Issue 21, Page(s) 3931–3939.e5

    Abstract: Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid peroxides, has been challenging to identify in physiological conditions owing to the lack of a specific marker. Here, we identify hyperoxidized peroxiredoxin 3 (PRDX3) as ... ...

    Abstract Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid peroxides, has been challenging to identify in physiological conditions owing to the lack of a specific marker. Here, we identify hyperoxidized peroxiredoxin 3 (PRDX3) as a marker for ferroptosis both in vitro and in vivo. During ferroptosis, mitochondrial lipid peroxides trigger PRDX3 hyperoxidation, a posttranslational modification that converts a Cys thiol to sulfinic or sulfonic acid. Once hyperoxidized, PRDX3 translocates from mitochondria to plasma membranes, where it inhibits cystine uptake, thereby causing ferroptosis. Applying hyperoxidized PRDX3 as a marker, we determined that ferroptosis is responsible for death of hepatocytes in mouse models of both alcoholic and nonalcoholic fatty liver diseases, the most prevalent chronic liver disorders. Our study highlights the importance of ferroptosis in pathophysiological conditions and opens the possibility to treat these liver diseases with drugs that inhibit ferroptosis.
    MeSH term(s) Animals ; Mice ; Ferroptosis/genetics ; Non-alcoholic Fatty Liver Disease/genetics ; Peroxides ; Peroxiredoxin III/genetics ; Sulfhydryl Compounds
    Chemical Substances Peroxides ; Peroxiredoxin III (EC 1.11.1.15) ; Sulfhydryl Compounds ; Prdx3 protein, mouse
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.09.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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