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  1. Article ; Online: The Effectiveness of Ultraviolet Smart D60 in Reducing Contamination of Flexible Fiberoptic Laryngoscopes.

    Ezeh, Uche C / Achlatis, Efstratios / Crosby, Tyler / Kwak, Paul E / Phillips, Michael S / Amin, Milan R

    The Laryngoscope

    2023  Volume 133, Issue 12, Page(s) 3512–3519

    Abstract: Objective: To compare the effectiveness of disinfection protocols utilizing a ultraviolet (UV) Smart D60 light system with Impelux™ technology with a standard Cidex ortho-phthalaldehyde (OPA) disinfection protocol for cleaning flexible fiberoptic ... ...

    Abstract Objective: To compare the effectiveness of disinfection protocols utilizing a ultraviolet (UV) Smart D60 light system with Impelux™ technology with a standard Cidex ortho-phthalaldehyde (OPA) disinfection protocol for cleaning flexible fiberoptic laryngoscopes (FFLs).
    Methods: Two hundred FFLs were tested for bacterial contamination after routine use, and another 200 FFLs were tested after disinfection with one of four methods: enzymatic detergent plus Cidex OPA (standard), enzymatic detergent plus UV Smart D60, microfiber cloth plus UV Smart D60, and nonsterile wipe plus UV Smart D60. Pre- and post-disinfection microbial burden levels and positive culture rates were compared using Kruskal-Wallis ANOVA and Fisher's two-sided exact, respectively.
    Results: After routine use, approximately 56% (112/200) of FFLs were contaminated, with an average contamination level of 9,973.7 ± 70,136.3 CFU/mL. The standard reprocessing method showed no positive cultures. The enzymatic plus UV, microfiber plus UV, and nonsterile wipe plus UV methods yielded contamination rates of 4% (2/50), 6% (3/50), and 12% (6/50), respectively, with no significant differences among the treatment groups (p > 0.05). The pre-disinfection microbial burden levels decreased significantly after each disinfection technique (p < 0.001). The average microbial burden recovered after enzymatic plus UV, microfiber plus UV, and nonsterile wipe plus UV were 0.40 CFU/mL ± 2, 0.60 CFU/mL ± 2.4, and 12.2 CFU/mL ± 69.5, respectively, with no significant difference among the treatment groups (p > 0.05). Micrococcus species (53.8%) were most frequently isolated, and no high-concern organisms were recovered.
    Conclusion: Disinfection protocols utilizing UV Smart D60 were as effective as the standard chemical disinfection protocol using Cidex OPA.
    Level of evidence: NA Laryngoscope, 133:3512-3519, 2023.
    MeSH term(s) Humans ; Laryngoscopes/microbiology ; Glutaral ; Detergents ; Disinfection/methods ; o-Phthalaldehyde ; Equipment Contamination/prevention & control
    Chemical Substances Glutaral (T3C89M417N) ; Detergents ; o-Phthalaldehyde (643-79-8)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30869
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  2. Article ; Online: Presumptive Diagnosis in Tele-Health Laryngology: A Multi-Center Observational Study.

    Montalbaron, Michael B / Achlatis, Efstratios / Johnson, Aaron M / Ma, Yue / Young, VyVy N / Rosen, Clark A / Amin, Milan R / Kwak, Paul E

    The Annals of otology, rhinology, and laryngology

    2023  Volume 132, Issue 12, Page(s) 1511–1519

    Abstract: Objectives: Early in the COVID-19 pandemic, outpatient visits were adapted for the virtual setting, forcing laryngologists to presume certain diagnoses without the aid of laryngoscopy, solely based on history and the limited physical exam available via ... ...

    Abstract Objectives: Early in the COVID-19 pandemic, outpatient visits were adapted for the virtual setting, forcing laryngologists to presume certain diagnoses without the aid of laryngoscopy, solely based on history and the limited physical exam available via video visit. This study aims to examine the accuracy of presumptive diagnoses made via telemedicine, compared to subsequent in-person follow up, where endoscopic examination could confirm or refute suspected diagnoses.
    Methods: A retrospective chart review was conducted of 38 patients evaluated for voice-related issues at NYU Langone Health and the University of California-San Francisco. Presumptive diagnoses at the initial telemedicine encounter were noted, along with diagnostic cues used for clinical reasoning and recommended treatment plans. These presumptive diagnoses were compared to diagnoses and plans established following laryngoscopy at follow-up in-person visits.
    Results: After laryngoscopy at the first in-person visit, 38% of presumptive diagnoses changed, as did 37% of treatment plans. The accuracy varied among conditions. Muscle tension dysphonia and Reinke's edema were accurately diagnosed without laryngoscopy, but other conditions, including vocal fold paralysis and subglottic stenosis, were not initially suspected, relying on laryngoscopy for diagnosis.
    Conclusions: While some laryngologic conditions may be reasonably identified without in-person examination, laryngoscopy remains central to definitive diagnosis and treatment. Telemedicine can increase access to care, but it may provide more utility as a screening tool, triaging which patients should present more urgently for in-person laryngoscopy.
    Level of evidence: 4.
    MeSH term(s) Humans ; Retrospective Studies ; Pandemics ; COVID-19/diagnosis ; COVID-19/epidemiology ; Dysphonia/diagnosis ; Laryngoscopy ; Otolaryngology ; Telemedicine ; COVID-19 Testing
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Multicenter Study ; Observational Study ; Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894231165811
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  3. Article ; Online: Longitudinal Effects of Base of Tongue Concurrent Chemoradiation Therapy in a Pre-Clinical Model.

    Benedict, Peter A / Kravietz, Adam / Yang, Jackie / Achlatis, Efstratios / Doyle, Carina / Johnson, Aaron M / Dion, Gregory R / Amin, Milan R

    The Laryngoscope

    2022  Volume 133, Issue 6, Page(s) 1455–1461

    Abstract: Background/objectives: Base of tongue (BOT) dysfunction is common following oropharyngeal concurrent chemoradiation therapy (CCRT). We present a clinically relevant animal model quantifying the effects of CCRT on tongue strength and elasticity over time. ...

    Abstract Background/objectives: Base of tongue (BOT) dysfunction is common following oropharyngeal concurrent chemoradiation therapy (CCRT). We present a clinically relevant animal model quantifying the effects of CCRT on tongue strength and elasticity over time.
    Methods: Fifty-three male and 53 female Sprague-Dawley rats were randomized to control or experimental groups. Experimental animals received cisplatin, 5-fluorouracil, and 5 fractions of 7 Gy directed to the BOT. Controls received no intervention. At 2 weeks, 5 months, or 10 months after CCRT, animals underwent non-survival surgery to measure twitch and tetanic tongue strength, which were analyzed using multivariate linear mixed effects models. Tongue displacement, a surrogate for tongue elasticity, was also determined via stress-strain testing and analyzed via a multivariate linear mixed effects model.
    Results: Reporting the combined results of both sexes, the estimated experimental group mean peak twitch forces became more divergent over time compared to controls, being 8.3% lower than controls at 2 weeks post-CCRT, 15.7% lower at 5 months, and 31.6% lower at 10 months. Estimated experimental group mean peak tetanic forces followed a similar course and were 2.9% lower than controls at 2 weeks post CCRT, 20.7% lower at 5 months, and 27.0% lower at 10 months. Stress-strain testing did not find CCRT to have a significant effect on tongue displacement across experimental timepoints.
    Conclusions: This study demonstrates an increasing difference in tongue strength over time between controls and animals exposed to CCRT. Tongue elasticity was not significantly affected by CCRT, suggesting that changes in strength may not be caused by fibrosis.
    Level of evidence: NA Laryngoscope, 133:1455-1461, 2023.
    MeSH term(s) Animals ; Female ; Male ; Rats ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy/methods ; Cisplatin ; Fluorouracil ; Rats, Sprague-Dawley ; Tongue
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30393
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  4. Article ; Online: Prospective, Multi-Center Study of the Anatomic Distribution of Recurrent Respiratory Papillomatosis.

    Benedict, Peter A / Kravietz, Adam / Achlatis, Efstratios / Wang, Binhuan / Zhang, Yan / Kidane, Joseph / Harrison, Tina / Miller, Jonas / Drake, Virginia E / Best, Simon R / McWhorter, Andrew J / Lin, R Jun / Rosen, Clark A / Smith, Libby J / Amin, Milan R

    The Laryngoscope

    2022  Volume 132, Issue 12, Page(s) 2403–2411

    Abstract: Objectives/hypothesis: To create a model of the anatomic distribution, recurrence, and growth patterns of recurrent respiratory papillomatosis (RRP).: Study design: Prospective, multi-institutional cohort study.: Methods: Adult patients with a ... ...

    Abstract Objectives/hypothesis: To create a model of the anatomic distribution, recurrence, and growth patterns of recurrent respiratory papillomatosis (RRP).
    Study design: Prospective, multi-institutional cohort study.
    Methods: Adult patients with a diagnosis of RRP evaluated between August 1, 2018 and February 1, 2021 at six participating centers were invited to enroll. At each office or operating room encounter, laryngologists recorded the location and size of RRP lesions using a 22-region schematic. A generalized linear mixed effects model was used to compare region variations in lesion prevalence and recurrence.
    Results: The cohort comprised 121 patients: 74% were male, 81% had been diagnosed with adult-onset RRP, and a plurality (34%) had undergone 0 to 3 RRP interventions prior to enrollment. Across the study period, the odds of a lesion occurring in the glottis was significantly higher (odds ratio [OR]: 26.51; 95% confidence interval [CI]: 11.76-59.75, P < .001) compared with all other areas of the larynx and trachea. Within the true vocal folds, the membranous vocal folds had significantly higher odds (OR: 6.16; 95% CI: 2.66-14.30, P < .001) of lesion occurrence compared to the cartilaginous vocal folds. Despite these strong trends in lesion distribution, there were no differences in the odds of lesion recurrence, growth, or in the time to recurrence, between anatomic subsites.
    Conclusions: RRP lesions are most likely to occur in the glottis, particularly the membranous vocal folds, compared with other regions of the larynx or trachea. However, all lesions demonstrate similar behavior with respect to recurrence, growth, and time to recurrence regardless of anatomic location.
    Level of evidence: 3 Laryngoscope, 132:2403-2411, 2022.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Prospective Studies ; Cohort Studies ; Retrospective Studies ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/pathology ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/pathology
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30036
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  5. Article ; Online: Treatment of Neurogenic Cough with Tramadol: A Pilot Study.

    Dion, Gregory R / Teng, Stephanie E / Achlatis, Efstratios / Fang, Yixin / Amin, Milan R

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2017  Volume 157, Issue 1, Page(s) 77–79

    Abstract: This study employs validated cough assessment tools to prospectively determine the impact of tramadol on cough severity and quality of life in subjects with neurogenic cough. The study was a prospective case series with planned data collection at a ... ...

    Abstract This study employs validated cough assessment tools to prospectively determine the impact of tramadol on cough severity and quality of life in subjects with neurogenic cough. The study was a prospective case series with planned data collection at a tertiary care academic medical center laryngology practice. Sixteen consecutive collected subjects with neurogenic cough prospectively completed pre- and posttreatment validated cough assessment tools, the cough severity index (CSI) and Leicester Cough Questionnaire (LCQ). All subjects in the study reported at least some improvement in their cough symptoms. In a Wilcoxon signed rank test that compared paired results, CSI scores improved from 23 to 14 and LCQ scores improved from 74 to 103 ( P = .003 and P = .005, respectively). This small preliminary assessment suggests that tramadol warrants additional evaluation as a treatment for neurogenic cough.
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesics, Opioid/therapeutic use ; Chronic Disease ; Cough/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Surveys and Questionnaires ; Tramadol/therapeutic use ; Treatment Outcome
    Chemical Substances Analgesics, Opioid ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599817703949
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  6. Article ; Online: Changes in Peak Airflow Measurement During Maximal Cough After Vocal Fold Augmentation in Patients With Glottic Insufficiency.

    Dion, Gregory R / Achlatis, Efstratios / Teng, Stephanie / Fang, Yixin / Persky, Michael / Branski, Ryan C / Amin, Milan R

    JAMA otolaryngology-- head & neck surgery

    2017  Volume 143, Issue 11, Page(s) 1141–1145

    Abstract: Importance: Compromised cough effectiveness is correlated with dysphagia and aspiration. Glottic insufficiency likely yields decreased cough strength and effectiveness. Although vocal fold augmentation favorably affects voice and likely improves cough ... ...

    Abstract Importance: Compromised cough effectiveness is correlated with dysphagia and aspiration. Glottic insufficiency likely yields decreased cough strength and effectiveness. Although vocal fold augmentation favorably affects voice and likely improves cough strength, few data exist to support this hypothesis.
    Objective: To assess whether vocal fold augmentation improves peak airflow measurements during maximal-effort cough following augmentation.
    Design, setting, and participants: This case series study was conducted in a tertiary, academic laryngology clinic. Participants included 14 consecutive individuals with glottic insufficiency due to vocal fold paralysis, which was diagnosed via videostrobolaryngoscopy as a component of routine clinical examination. All participants who chose to proceed with augmentation were considered for the study whether office-based or operative augmentation was planned. Postaugmentation data were collected only at the first follow-up visit, which was targeted for 14 days after augmentation but varied on the basis of participant availability. Data were collected from June 5, 2014, to October 1, 2015. Data analysis took place between October 2, 2015, and March 3, 2017.
    Main outcomes and measures: Peak airflow during maximal volitional cough was quantified before and after vocal fold augmentation. Participants performed maximal coughs, and peak expiratory flow during the maximal cough was captured according to American Thoracic Society guidelines.
    Results: Among the 14 participants (7 men and 7 women), the mean (SD) age was 62 (18) years. Three types of injectable material were used for vocal fold augmentation: carboxymethylcellulose in 5 patients, hyaluronic acid in 5, and calcium hydroxylapatite in 4. Following augmentation, cough strength increased in 11 participants and decreased cough strength was observed in 3. Peak airflow measurements during maximal cough varied from a decrease of 40 L/min to an increase of 150 L/min following augmentation. When preaugmentation and postaugmentation peak airflow measurements were compared, the median improvement was 50 L/min (95% CI, 10-75 L/min; P = .01). Immediate peak airflow measurements during cough collected within 30 minutes of augmentation varied when compared with measurements collected at follow-up (103-380 vs 160-390 L/min).
    Conclusions and relevance: Peak airflow during maximal cough may improve with vocal fold augmentation. Additional assessment and measurements are needed to further delineate which patients will benefit most regarding their cough from vocal fold augmentation.
    MeSH term(s) Carboxymethylcellulose Sodium/administration & dosage ; Cough ; Durapatite/administration & dosage ; Female ; Glottis/physiopathology ; Humans ; Hyaluronic Acid/administration & dosage ; Injections ; Laryngoscopy ; Male ; Middle Aged ; Treatment Outcome ; Vocal Cord Paralysis/drug therapy ; Vocal Cord Paralysis/physiopathology
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Durapatite (91D9GV0Z28) ; Carboxymethylcellulose Sodium (K679OBS311)
    Language English
    Publishing date 2017-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2017.0976
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