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  1. Article: Anti-Inflammatory Properties of Plants from Serbian Traditional Medicine.

    Radovanović, Katarina / Gavarić, Neda / Aćimović, Milica

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Inflammation is a natural protective response of the human body to a variety of hostile agents and noxious stimuli. Standard anti-inflammatory therapy includes drugs whose usage is associated with a number of side effects. Since ancient times, natural ... ...

    Abstract Inflammation is a natural protective response of the human body to a variety of hostile agents and noxious stimuli. Standard anti-inflammatory therapy includes drugs whose usage is associated with a number of side effects. Since ancient times, natural compounds have been used for the treatment of inflammation. Traditionally, the use of medicinal plants is considered safe, inexpensive, and widely acceptable. In Serbia, traditional medicine, based on the strong belief in the power of medicinal herbs, is the widespread form of treatment. This is supported by the fact that Serbia is classified as one of 158 world centers of biodiversity, which confirms that this country is a treasure of medicinal herbs. Some of the most used herbs for the treatment of inflammations of various causes in Serbian tradition are yarrow, common agrimony, couch grass, onion, garlic, marshmallow, common birch, calendula, liquorice, walnut, St. John's wort, chamomile, peppermint, white willow, sage, and many others. The biological activity and anti-inflammatory effect of selected plants are attributed to different groups of secondary biomolecules such as flavonoids, phenolic acids, sterols, terpenoids, sesquiterpenes, and tannins. This paper provides an overview of plants with traditional anti-inflammatory use in Serbia with reference to available studies that examined this effect. Plants used in traditional medicine could be a powerful source for the development of new remedies. Therefore intensive research on the bioactive potential of medicinal plants in each region should be the focus of scientists around the world.
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New esters from the essential oil of dry flowers of elder (Sambucus nigra L.).

    Raičević, Vidak / Mladenović, Marko / Aćimović, Milica / Radulović, Niko

    Journal of the science of food and agriculture

    2023  Volume 104, Issue 3, Page(s) 1308–1321

    Abstract: Background: Elder (Sambucus nigra L.) has relevance for the food, fragrance and pharmaceutical industries. Flowers of this species emit a very pleasant scent; for processing purposes, inflorescences are either collected from the wild or harvested from a ...

    Abstract Background: Elder (Sambucus nigra L.) has relevance for the food, fragrance and pharmaceutical industries. Flowers of this species emit a very pleasant scent; for processing purposes, inflorescences are either collected from the wild or harvested from a cultivated crop. The study of elderflower-derived volatiles bears both phytochemical and commercial importance.
    Results: Three samples of dry elderflower essential oil obtained from laboratory-scale hydrodistillations were analyzed. By use of gas chromatography-mass spectrometry, synthesis and NMR studies of chromatographic fractions of a distillation water extract prepared in a semi-industrial scale steam distillation, 252 constituents of the oil were identified; 115 compounds were not previously reported as elderflower volatiles, seven of which were new natural esters. Particularly interesting were those of isosenecioic (3-methylbut-3-enoic) acid because these were never before found in the plant kingdom.
    Conclusion: With these identifications, the known essential oil constituents accounted for 89.0-93.0% of the analyzed samples. Although the number of known S. nigra flower-derived volatiles is now quite high, further research (both analytical and olfactory) is needed to unveil all of the relevant contributions to the unique odor of elderflowers. © 2023 Society of Chemical Industry.
    MeSH term(s) Sambucus nigra/chemistry ; Oils, Volatile/analysis ; Flowers/chemistry ; Inflorescence/chemistry ; Gas Chromatography-Mass Spectrometry/methods
    Chemical Substances Oils, Volatile
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparison of the Properties of Pullulan-Based Active Edible Coatings Implemented for Improving Sliced Cheese Shelf Life.

    Erceg, Tamara / Šovljanski, Olja / Tomić, Ana / Aćimović, Milica / Stupar, Alena / Baloš, Sebastian

    Polymers

    2024  Volume 16, Issue 2

    Abstract: The development of active edible coatings with improved mechanical and barrier properties is a huge challenge. In this study, active edible coatings for sliced cheese have been developed using pullulan (Pull) in combination with two different biopolymers, ...

    Abstract The development of active edible coatings with improved mechanical and barrier properties is a huge challenge. In this study, active edible coatings for sliced cheese have been developed using pullulan (Pull) in combination with two different biopolymers, chitosan (CS) and gelatine (Gel), and a combination of hydrolats as a source of active compounds with antimicrobial effects. In comparison to the monolayer coating, the bilayer coating system demonstrates improved barrier and mechanical properties. A preliminary assessment of the antimicrobial effect of lemongrass and curry plant hydrolats has revealed that both hydrolats exhibited antimicrobial activity against the targeted bacterium
    Language English
    Publishing date 2024-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16020178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (

    Aćimović, Milica / Stanković Jeremić, Jovana / Miljković, Ana / Rat, Milica / Lončar, Biljana

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 12

    Abstract: Ironwort ( ...

    Abstract Ironwort (
    MeSH term(s) Lamiaceae/chemistry ; Plants, Medicinal/chemistry ; Serbia ; Phytotherapy ; Oils, Volatile/chemistry ; Teucrium/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Sideritis ; Diterpenes
    Chemical Substances caryophyllene (BHW853AU9H) ; germacrene D (V2I9ATG34E) ; Oils, Volatile ; Plant Extracts ; Diterpenes
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28124611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Biological and Chemical Diversity of Angelica archangelica L.—Case Study of Essential Oil and Its Biological Activity

    Aćimović, Milica / Rat, Milica / Pezo, Lato / Lončar, Biljana / Pezo, Milada / Miljković, Ana / Lazarević, Jovan

    Agronomy. 2022 June 29, v. 12, no. 7

    2022  

    Abstract: Garden angelica (Angelica archangelica L.), native to the northern temperate region, is widespread in Europe and Asia. Since the middle ages, it has been used for healing and as a vegetable in traditional dishes. In the modern era, it has been proven ... ...

    Abstract Garden angelica (Angelica archangelica L.), native to the northern temperate region, is widespread in Europe and Asia. Since the middle ages, it has been used for healing and as a vegetable in traditional dishes. In the modern era, it has been proven that A. archangelica has a complex chemical composition. The main derivatives that contribute to the plant’s biological activities are essential oil and coumarins. In this review, the focus is on the cross-analysis of the taxonomy of A. archangelica, and its distribution in different regions, with the presentation of the richness of its biochemical composition, which overall contributes to the widespread use of the roots of this plant in folk medicine. It belongs to the plants that were introduced to the wider area of Central, Eastern, and Southern Europe; as a medicinal plant, it represents a significant part of the medical flora of many areas. Cluster analysis of pooled data indicates a clear differentiation of chemotypes.
    Keywords Angelica archangelica ; agronomy ; bioactive properties ; chemical composition ; chemotypes ; cluster analysis ; coumarins ; essential oils ; flora ; medicinal plants ; temperate zones ; traditional medicine ; vegetables ; Asia ; Europe ; Southern European region
    Language English
    Dates of publication 2022-0629
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy12071570
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Agricultural Parameters and Essential Oil Content Composition Prediction of Aniseed, Based on Growing Year, Locality and Fertilization Type-An Artificial Neural Network Approach.

    Pezo, Lato / Lončar, Biljana / Šovljanski, Olja / Tomić, Ana / Travičić, Vanja / Pezo, Milada / Aćimović, Milica

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 11

    Abstract: Predicting yield is essential for producers, stakeholders and international interchange demand. The majority of the divergence in yield and essential oil content is associated with environmental aspects, including weather conditions, soil variety and ... ...

    Abstract Predicting yield is essential for producers, stakeholders and international interchange demand. The majority of the divergence in yield and essential oil content is associated with environmental aspects, including weather conditions, soil variety and cultivation techniques. Therefore, aniseed production was examined in this study. The categorical input variables for artificial neural network modelling were growing year (two successive growing years), growing locality (three different locations in Vojvodina Province, Serbia) and fertilization type (six different treatments). The output variables were morphological and quality parameters, with agricultural importance such as plant height, umbel diameter, number of umbels, number of seeds per umbel, 1000-seed weight, seed yield per plant, plant weight, harvest index, yield per ha, essential oil (EO) yield, germination energy, total germination, EO content, as well as the share of EOs compounds, including limonene,
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12111722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phytochemical Variability of Essential Oils of Two Balkan Endemic Species:

    Zheljazkov, Valtcho D / Semerdjieva, Ivanka B / Cantrell, Charles L / Astatkie, Tess / Aćimović, Milica

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 10

    Abstract: ... Satureja ... ...

    Abstract Satureja pilosa
    MeSH term(s) Balkan Peninsula ; Lamiaceae/chemistry ; Oils, Volatile/chemistry ; Phytochemicals ; Satureja/chemistry
    Chemical Substances Oils, Volatile ; Phytochemicals
    Language English
    Publishing date 2022-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27103153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine

    Smiljanić, Katarina / Prodić, Ivana / Trifunovic, Sara / Krstić Ristivojević, Maja / Aćimović, Milica / Stanković Jeremić, Jovana / Lončar, Biljana / Tešević, Vele

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we ... ...

    Abstract As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10-30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12111988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives.

    Tomić, Ana / Šovljanski, Olja / Nikolić, Višnja / Pezo, Lato / Aćimović, Milica / Cvetković, Mirjana / Stanojev, Jovana / Kuzmanović, Nebojša / Markov, Siniša

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: The main challenge in controlling the microbiological contamination of historical paper is finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides whose effectiveness is maintained over time and without ... ...

    Abstract The main challenge in controlling the microbiological contamination of historical paper is finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides whose effectiveness is maintained over time and without adverse effects on cultural heritage and human health. Therefore, this study demonstrated the possibility of using a non-invasive method of historical paper conservation based on plant essential oils (EOs) application. Evaluation of antimicrobial effects of different EOs (lemongrass, oregano, rosemary, peppermint, and eucalyptus) was conducted against
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment.

    Jovanović, Darko / Aćimović, Miodrag / Pejčić, Tomislav / Milojević, Bogomir / Čegar, Bojan / Zeković, Milica / Lisičić, Nikola / Džamić, Zoran / Marić, Gorica

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 23

    Abstract: Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient' ... ...

    Abstract Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient's body integrity and self-image, sexual life and intimacy, voiding and mental health. The aim of our study was to comprehensively evaluate PC patients' post-treatment quality of life (QoL), sexual activity, self-esteem, fatigue and fear of disease recurrence. (2) Methods: A cross-sectional study was conducted at the Clinic of Urology, University Clinical Centre of Serbia, and included 31 PC patients. Data were collected by means of a questionnaire. (3) Results: The average score on the Global health status scale was 67.2 out of 100 (ranging from 16.7 to 100), and the SD was 22.5. Hierarchical linear regression analysis showed that demographic characteristics, Hospital Anxiety and Depression scale (HADS) anxiety and depression scores, total Multidimensional Fatigue Inventory, Fear of cancer recurrence and Rosenberg scores and erectile function score explained a total of 78.2% of the variance in the global health status/QoL scale of PC patients. (4) Conclusions: Efforts should be made not only to increase the survival of PC patients after surgical treatment but also to enable the best possible level of QoL in the post-operative period.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11233091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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