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  1. Article ; Online: Non-resectional cordal repair for Barlow mitral valve disease.

    Florissi, Isabella S / Acton, Matthew / Kolesnik, Irina / Pasrija, Chetan / Patel, Ishani / Etchill, Eric / Holmes, Sari D / Quinn, Rachael / Gammie, James S

    The Journal of cardiovascular surgery

    2024  

    Abstract: Background: The redundant leaflet tissue and annular pathology of Barlow disease can make surgical repair challenging. We examined perioperative and late outcomes of a large cohort of patients with Barlow disease undergoing surgical repair.: Methods: ...

    Abstract Background: The redundant leaflet tissue and annular pathology of Barlow disease can make surgical repair challenging. We examined perioperative and late outcomes of a large cohort of patients with Barlow disease undergoing surgical repair.
    Methods: Patients included in this analysis underwent mitral valve repair from 01/2004-11/2021 by a single surgeon.
    Results: Of 2798 patients undergoing mitral valve operations, 46% (N.=1292) had degenerative pathology and 7% (N.=184) had Barlow disease. Of the 179 Barlow patients, median age at surgery was 62 (51-70) years; 64% were male (115/179). Rates of non-resectional cordal repair and resectional repair were 86% (154/179) and 14% (25/179). Among patients undergoing non-resectional repair, the median number of cordal pairs inserted on the anterior and posterior leaflets was 2 (2-3) and 4 (3-4). Incidence of return to bypass for systolic anterior motion of the mitral valve, perioperative death, stroke, and renal failure was 2% (4/179), 1% (2/179), 0% (0/179), and 0% (0/179). Rates of clinical and echocardiographic follow-up were 93% (165/177) and 89% (157/177). Median time to latest postoperative clinical and echocardiographic follow-up was 2.4 (0.8-6.1) and 2.1 (0.6-4.7) years. Mitral regurgitation grade at latest follow-up or time of repair failure was none/trace, mild, mild to moderate, and severe in 63% (98/157), 26% (41/157), 8% (12/157), and 4% (6/157); five of six patients with severe MR underwent reoperation. Since 2011 97% (139/144) of patients underwent cordal repair without resection.
    Conclusions: Non-resectional artificial cordal repair is safe and feasible in almost all patients with Barlow valves and is associated with excellent mid-term results.
    Language English
    Publishing date 2024-03-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    DOI 10.23736/S0021-9509.24.12899-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 469: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: One-stage surgical management of an esophagopericardial fistula presenting with tamponade.

    Vardas, Panos N / Acton, Matthew D / Rosati, Carlo Maria / Kesler, Kenneth A

    The Journal of thoracic and cardiovascular surgery

    2019  Volume 158, Issue 4, Page(s) e143–e145

    MeSH term(s) Adult ; Cardiac Tamponade/diagnostic imaging ; Cardiac Tamponade/etiology ; Cardiac Tamponade/surgery ; Chemoradiotherapy/adverse effects ; Esophageal Fistula/diagnostic imaging ; Esophageal Fistula/etiology ; Esophageal Fistula/surgery ; Esophageal Neoplasms/therapy ; Esophagectomy ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Diseases/surgery ; Humans ; Male ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/etiology ; Pericardial Effusion/surgery ; Pericardiocentesis ; Treatment Outcome
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2019.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Use of Bedside Portable Low-field Brain Magnetic Resonance Imaging in Patients on ECMO: The Results from Multicenter SAFE MRI ECMO Study.

    Cho, Sung-Min / Khanduja, Shivalika / Wilcox, Christopher / Dinh, Kha / Kim, Jiah / Kang, Jin Kook / Chinedozi, Ifeanyi David / Darby, Zachary / Acton, Matthew / Rando, Hannah / Briscoe, Jessica / Bush, Errol / Sair, Haris I / Pitts, John / Arlinghaus, Lori R / Wandji, Audrey-Carelle N / Moreno, Elena / Torres, Glenda / Akkanti, Bindu /
    Gavito-Higuera, Jose / Keller, Steven / Choi, HuiMahn A / Kim, Bo Soo / Gusdon, Aaron / Whitman, Glenn Jr

    Research square

    2024  

    Abstract: Purpose: Early detection of acute brain injury (ABI) is critical for improving survival for patients with extracorporeal membrane oxygenation (ECMO) support. We aimed to evaluate the safety of ultra-low-field portable MRI (ULF-pMRI) and the frequency ... ...

    Abstract Purpose: Early detection of acute brain injury (ABI) is critical for improving survival for patients with extracorporeal membrane oxygenation (ECMO) support. We aimed to evaluate the safety of ultra-low-field portable MRI (ULF-pMRI) and the frequency and types of ABI observed during ECMO support.
    Methods: We conducted a multicenter prospective observational study (NCT05469139) at two academic tertiary centers (August 2022-November 2023). Primary outcomes were safety and validation of ULF-pMRI in ECMO, defined as exam completion without adverse events (AEs); secondary outcomes were ABI frequency and type.
    Results: ULF-pMRI was performed in 50 patients with 34 (68%) on venoarterial (VA)-ECMO (11 central; 23 peripheral) and 16 (32%) with venovenous (VV)-ECMO (9 single lumen; 7 double lumen). All patients were imaged successfully with ULF-pMRI, demonstrating discernible intracranial pathologies with good quality. AEs occurred in 3 (6%) patients (2 minor; 1 serious) without causing significant clinical issues.ABI was observed in ULF-pMRI scans for 22 patients (44%): ischemic stroke (36%), intracranial hemorrhage (6%), and hypoxic-ischemic brain injury (4%). Of 18 patients with both ULF-pMRI and head CT (HCT) within 24 hours, ABI was observed in 9 patients with 10 events: 8 ischemic (8 observed on ULF-oMRI, 4 on HCT) and 2 hemorrhagic (1 observed on ULF-pMRI, 2 on HCT).
    Conclusions: ULF-pMRI was shown to be safe and valid in ECMO patients across different ECMO cannulation strategies. The incidence of ABI was high, and ULF-pMRI may more sensitive to ischemic ABI than HCT. ULF-pMRI may benefit both clinical care and future studies of ECMO-associated ABI.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3858221/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Safety of Bedside Portable Low-Field Brain MRI in ECMO Patients Supported on Intra-Aortic Balloon Pump.

    Wilcox, Christopher / Acton, Matthew / Rando, Hannah / Keller, Steven / Sair, Haris I / Chinedozi, Ifeanyi / Pitts, John / Kim, Bo Soo / Whitman, Glenn / Cho, Sung Min

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 11

    Abstract: 1) Background: Fifty percent of patients supported on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are concurrently supported with an intra-aortic balloon pump (IABP). Acute brain injury (ABI) is a devastating complication related to ECMO ...

    Abstract (1) Background: Fifty percent of patients supported on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are concurrently supported with an intra-aortic balloon pump (IABP). Acute brain injury (ABI) is a devastating complication related to ECMO and IABP use. The standard of care for ABI diagnosis requires transport to a head CT (HCT) scanner. Recent data suggest that point-of-care (POC) magnetic resonance imaging (MRI) is safe and may be effective in diagnosing ABI in ECMO patients; however, no data exist in patients supported on ECMO with an IABP. We report pre-clinical safety data and a case series to evaluate the safety and feasibility of POC brain MRI in ECMO patients supported with IABP. (2) Methods: Prior to patient use, ex vivo testing with an IABP catheter within the Swoop
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12112871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessing the SAfety and FEasibility of bedside portable low-field brain Magnetic Resonance Imaging in patients on ECMO (SAFE-MRI ECMO study): study protocol and first case series experience.

    Cho, Sung-Min / Wilcox, Christopher / Keller, Steven / Acton, Matthew / Rando, Hannah / Etchill, Eric / Giuliano, Katherine / Bush, Errol L / Sair, Haris I / Pitts, John / Kim, Bo Soo / Whitman, Glenn

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 119

    Abstract: Background: To assess the safety and feasibility of imaging of the brain with a point-of-care (POC) magnetic resonance imaging (MRI) system in patients on extracorporeal membrane oxygenation (ECMO). Early detection of acute brain injury (ABI) is ... ...

    Abstract Background: To assess the safety and feasibility of imaging of the brain with a point-of-care (POC) magnetic resonance imaging (MRI) system in patients on extracorporeal membrane oxygenation (ECMO). Early detection of acute brain injury (ABI) is critical in improving survival for patients with ECMO support.
    Methods: Patients from a single tertiary academic ECMO center who underwent head CT (HCT), followed by POC brain MRI examinations within 24 h following HCT while on ECMO. Primary outcomes were safety and feasibility, defined as completion of MRI examination without serious adverse events (SAEs). Secondary outcome was the quality of MR images in assessing ABIs.
    Results: We report 3 consecutive adult patients (median age 47 years; 67% male) with veno-arterial (n = 1) and veno-venous ECMO (n = 2) (VA- and VV-ECMO) support. All patients were imaged successfully without SAEs. Times to complete POC brain MRI examinations were 34, 40, and 43 min. Two patients had ECMO suction events, resolved with fluid and repositioning. Two patients were found to have an unsuspected acute stroke, well visualized with MRI.
    Conclusions: Adult patients with VA- or VV-ECMO support can be safely imaged with low-field POC brain MRI in the intensive care unit, allowing for the assessment of presence and timing of ABI.
    MeSH term(s) Adult ; Brain/diagnostic imaging ; Extracorporeal Membrane Oxygenation/methods ; Feasibility Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies
    Language English
    Publishing date 2022-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-03990-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Sustainable gel electrolyte containing Pb2+ as corrosion inhibitor and dendrite suppressor for the zinc anode in the rechargeable hybrid aqueous battery

    Hoang, Tuan K.A. / Acton, Matthew / Chen, Henry T.H. / Huang, Yan / Doan, The Nam Long / Chen, P.

    Materials Today Energy. 2017,

    2017  

    Abstract: Dendrite formation and corrosion are two major problems occurring on the zinc electrode of the rechargeable hybrid aqueous battery (ReHAB). In this work, we have designed a gel electrolyte containing fumed silica as the gelling agent and Pb2+ as the ... ...

    Abstract Dendrite formation and corrosion are two major problems occurring on the zinc electrode of the rechargeable hybrid aqueous battery (ReHAB). In this work, we have designed a gel electrolyte containing fumed silica as the gelling agent and Pb2+ as the dendrite suppressor and also the corrosion inhibitor in aqueous liquid media. Both Pb2+ and fumed silica can inhibit dendrite formation, evidenced by chronoamperometry results and ex-situ scanning electron microscopy images. Furthermore, linear polarization results reveal that corrosion current density on the Zn anode when in contact with the PbSO4 doped 5%FS gel electrolyte is 20% smaller than that of the Zn when in contact with the reference aqueous electrolyte. The ReHAB using the Pb2+ containing gel electrolyte exhibits higher cyclability (75% capacity retention after 300 cycles at 1 C rate) than the ReHAB using the reference aqueous electrolyte (60% capacity retention at the same condition). Self-discharge is massively reduced, represented by an 18% smaller loss of open-circuit voltage after monitoring for 24 h. Float charge current density is reduced significantly up to 35% after 24-h of constant charging the batteries at 2.1 V vs. Zn2+/Zn. The results suggest that battery performance improves when both corrosion current density and dendrite formation are suppressed.
    Keywords Zinc anode ; Aqueous electrolyte ; Gel electrolyte ; Dendrite ; Corrosion
    Language English
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ISSN 2468-6069
    DOI 10.1016/j.mtener.2017.03.003
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Examining the Influence of Phosphorylation on Peptide Ion Structure by Ion Mobility Spectrometry-Mass Spectrometry.

    Glover, Matthew S / Dilger, Jonathan M / Acton, Matthew D / Arnold, Randy J / Radivojac, Predrag / Clemmer, David E

    Journal of the American Society for Mass Spectrometry

    2016  Volume 27, Issue 5, Page(s) 786–794

    Abstract: Ion mobility spectrometry-mass spectrometry (IMS-MS) techniques are used to study the general effects of phosphorylation on peptide structure. Cross sections for a library of 66 singly phosphorylated peptide ions from 33 pairs of positional isomers, and ... ...

    Abstract Ion mobility spectrometry-mass spectrometry (IMS-MS) techniques are used to study the general effects of phosphorylation on peptide structure. Cross sections for a library of 66 singly phosphorylated peptide ions from 33 pairs of positional isomers, and unmodified analogues were measured. Intrinsic size parameters (ISPs) derived from these measurements yield calculated collision cross sections for 85% of these phosphopeptide sequences that are within ±2.5% of experimental values. The average ISP for the phosphoryl group (0.64 ± 0.05) suggests that in general this moiety forms intramolecular interactions with the neighboring residues and peptide backbone, resulting in relatively compact structures. We assess the capability of ion mobility to separate positional isomers (i.e., peptide sequences that differ only in the location of the modification) and find that more than half of the isomeric pairs have >1% difference in collision cross section. Phosphorylation is also found to influence populations of structures that differ in the cis/trans orientation of Xaa-Pro peptide bonds. Several sequences with phosphorylated Ser or Thr residues located N-terminally adjacent to Pro residues show fewer conformations compared to the unmodified sequences.
    MeSH term(s) Ions/chemistry ; Ions/metabolism ; Isomerism ; Mass Spectrometry/methods ; Phosphopeptides/chemistry ; Phosphopeptides/metabolism ; Phosphorylation ; Proline/chemistry ; Proline/metabolism
    Chemical Substances Ions ; Phosphopeptides ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1007/s13361-016-1343-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 241: Show issues

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