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Article ; Online: Evaluation on induction of driver fatigue in driving different traffic condition: An EEG study

Adachi, Masataka / Inagaki, Keiichiro

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–4

Abstract: Fatigue is the one of major causes of traffic accidents. Causes of driver fatigue can be divided into physical factors such as lack of sleep, long duration of driving, and a large amount of driving maneuvers, and mental factors such as recognition of ... ...

Abstract	Fatigue is the one of major causes of traffic accidents. Causes of driver fatigue can be divided into physical factors such as lack of sleep, long duration of driving, and a large amount of driving maneuvers, and mental factors such as recognition of traffic scenes to need to drive. Among those factors, a lot of studies on fatigue of drivers focused on the lack of sleep, and long duration of driving and induction of fatigue. However, little attention has been paid to the amount of driving maneuvers and recognition of traffic scenes on the induction of fatigue of drivers even both mental and physical factor related to driving. In this study, we created different traffic scenarios in terms of tuning traffic density and/or driving area to control the amount of driving maneuvers and recognition of traffic environment, and we evaluate the theta and alpha band EEG responses which are known to the one of biological index reflecting fatigue to investigate drivers' fatigue by driving in such different traffic condition.
MeSH term(s)	Humans ; Accidents, Traffic ; Attention ; Sleep ; Fatigue ; Electroencephalography ; Automobile Driving
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mineralocorticoid receptor blockers for moderate kidney dysfunction: more merit than ever?

Mukoyama, Masashi / Kuwabara, Takashige / Adachi, Masataka

Hypertension research : official journal of the Japanese Society of Hypertension

2021 Volume 44, Issue 10, Page(s) 1352–1354

MeSH term(s)	Humans ; Kidney ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Receptors, Mineralocorticoid ; Renal Insufficiency/drug therapy
Chemical Substances	Mineralocorticoid Receptor Antagonists ; Receptors, Mineralocorticoid
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Editorial
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-021-00690-6
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Article: [Kidney and hypertension].

Mukoyama, Masashi / Adachi, Masataka

Nihon Jinzo Gakkai shi

2016 Volume 58, Issue 1, Page(s) 26–32

MeSH term(s)	Angiotensins/metabolism ; Female ; Humans ; Hypertension/physiopathology ; Hypertension/therapy ; Kidney/innervation ; Kidney/physiopathology ; Kidney Diseases/complications ; Pregnancy ; Receptors, Angiotensin/immunology ; Receptors, Angiotensin/metabolism ; Sodium Channels/metabolism
Chemical Substances	Angiotensins ; Receptors, Angiotensin ; Sodium Channels
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1195538-7
ISSN	0385-2385
ISSN	0385-2385
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Zs.A 1383: Show issues

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Article ; Online: A case of chyluria with nephrotic-range proteinuria caused by lymphatic malformation, leading to a diagnosis of Klippel-Trenaunay syndrome.

Izumi, Yuichiro / Date, Ryosuke / Mizumoto, Teruhiko / Nakagawa, Terumasa / Kakizoe, Yutaka / Adachi, Masataka / Kuwabara, Takashige / Mukoyama, Masashi

CEN case reports

2022 Volume 12, Issue 2, Page(s) 205–209

Abstract: Klippel-Trenaunay syndrome (KTS) is a rare syndrome, which is clinically diagnosed by the presence of unilateral limb hypertrophy with vascular malformation including cutaneous capillaries, veins and lymphatic vessels. Most cases typically exhibit ... ...

Abstract	Klippel-Trenaunay syndrome (KTS) is a rare syndrome, which is clinically diagnosed by the presence of unilateral limb hypertrophy with vascular malformation including cutaneous capillaries, veins and lymphatic vessels. Most cases typically exhibit cutaneous manifestations such as port-wine stains and limb hypertrophy from infancy, but cases with mild manifestations may remain undiagnosed. We here report a case of KTS who was diagnosed by chance chyluria. A 15-year-old girl who exhibited hematochyluria with nephrotic-range proteinuria was referred to our hospital. She had been diagnosed as idiopathic scoliosis accompanied by left lower limb hypertrophy in the past. She noticed her milky urine for the first time two months before. Immediately thereafter, she noticed edema of her left leg. Hematochyluria with nephrotic-range proteinuria was found by our initial urine examination. Magnetic resonance imaging suggested venous or lymphatic malformation along the left common iliac vein at the retroperitoneal side. Lymphoscintigraphy showed congestion of radioisotope around backside of the pancreas to the left renal hilus, suggesting an existence of lymphostasis. Based on the findings, we diagnosed the patient as KTS. After admission, hematochyluria and proteinuria were decreased and became insignificant by three days with bed rest. Her left leg edema was reduced. After taking a guidance to avoid intensive exercise, she was discharged in two weeks. Because the present case exhibited mild manifestations, diagnosis was made by urine abnormalities for the first time. The case suggests that we should be aware of the presence of undiagnosed patients of KTS due to relatively mild manifestations.
MeSH term(s)	Female ; Humans ; Adolescent ; Klippel-Trenaunay-Weber Syndrome/complications ; Klippel-Trenaunay-Weber Syndrome/diagnosis ; Klippel-Trenaunay-Weber Syndrome/pathology ; Lower Extremity/pathology ; Hypertrophy ; Edema ; Proteinuria/complications
Language	English
Publishing date	2022-11-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-022-00747-6
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Article ; Online: Early mid-season drainage can mitigate greenhouse gas emission from organic rice farming with green manure application

Toma, Yo / Takechi, Yuuki / Inoue, Ayano / Nakaya, Natsuko / Hosoya, Kazuhiro / Yamashita, Youichi / Adachi, Masataka / Kono, Takayuki / Hideto, Ueno

Soil Science and Plant Nutrition. 2021 July 04, v. 67, no. 4 p.482-492

2021

Abstract: Organic rice farming is acknowledged as a safe and environmentally friendly rice production method. However, the application of fresh organic matter as fertilizer can increase methane (CH₄) emissions during the rice-growing period because it is a carbon ( ...

Abstract	Organic rice farming is acknowledged as a safe and environmentally friendly rice production method. However, the application of fresh organic matter as fertilizer can increase methane (CH₄) emissions during the rice-growing period because it is a carbon (C) source for CH₄ under anaerobic conditions. In this study, we evaluated the CH₄ emissions and net greenhouse gas emissions (NGHGE) from rice paddy fields managed by long-term organic farming. We also assessed the effect of early incorporation of green manure and mid-season drainage (to reduce CH₄ emission and NGHGE) on the rice grain yield. In the first year, we measured CH₄ and nitrous oxide (N₂O) emissions, C budget, and yield in conventionally managed (CF) and organically managed (GM) rice paddy fields, in which white clover was grown in the fallow period. In the second year, we set up four treatments with dried hairy vetch (Vicia villosa) as green manure, incorporated in the conventional season (G), one week (GE1), and three weeks (GE3) earlier, and early mid-season drainage (GED), in which green manure was incorporated in the same way as in G. In the second year, we measured the same factors as in the first year. In the first year, C was accumulated in GM due to the application of C from green manure, despite C being lost in CF. On the other hand, the large amount of CH₄ emission induced in GM contributed to global warming due to high NGHGE compared to CF. Early incorporation of green manure in rice paddy fields did not increase CO₂ or decrease CH₄ emissions before rice transplanting in the second year. A significant reduction in grain yield in GE3 suggested that three weeks earlier incorporation of green manure is not appropriate in terms of stable agricultural management. Meanwhile, early mid-season drainage reduced CH₄ emissions, which contributed to both soil C sequestration and NGHGE reduction. These results indicate that mid-season drainage a week earlier than conventional practice could be a workable way of maintaining the brown rice yield and soil C sequestration and mitigating global warming in rice paddy fields receiving green manure.
Keywords	Trifolium repens ; Vicia villosa ; brown rice ; carbon ; carbon dioxide ; carbon sequestration ; drainage ; fertilizers ; grain yield ; green manures ; greenhouse gas emissions ; greenhouse gases ; manure spreading ; methane ; nitrous oxide ; organic matter ; paddies ; plant nutrition ; Greenhouse gas emission ; green manure ; early incorporation ; mid-season drainage
Language	English
Dates of publication	2021-0704
Size	p. 482-492.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	406719-8
ISSN	1747-0765 ; 0038-0768
ISSN (online)	1747-0765
ISSN	0038-0768
DOI	10.1080/00380768.2021.1927832
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Article ; Online: A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats.

Iwata, Yasunobu / Deng, Qinyuan / Kakizoe, Yutaka / Nakagawa, Terumasa / Miyasato, Yoshikazu / Nakagawa, Miyuki / Nishiguchi, Kayo / Nagayoshi, Yu / Narita, Yuki / Izumi, Yuichiro / Kuwabara, Takashige / Adachi, Masataka / Mukoyama, Masashi

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: In proteinuric renal diseases, the serine protease (SP) plasmin activates the epithelial sodium channel (ENaC) by cleaving its γ subunit. We previously demonstrated that a high-salt (HS) diet provoked hypertension and proteinuria in Dahl salt-sensitive ( ... ...

Abstract	In proteinuric renal diseases, the serine protease (SP) plasmin activates the epithelial sodium channel (ENaC) by cleaving its γ subunit. We previously demonstrated that a high-salt (HS) diet provoked hypertension and proteinuria in Dahl salt-sensitive (DS) rats, accompanied by γENaC activation, which were attenuated by camostat mesilate (CM), an SP inhibitor. However, the effects of CM on plasmin activity in DS rats remain unclear. In this study, we investigated the effects of CM on plasmin activity, ENaC activation, and podocyte injury in DS rats. The DS rats were divided into the control diet, HS diet (8.0% NaCl), and HS+CM diet (0.1% CM) groups. After weekly blood pressure measurement and 24-h urine collection, the rats were sacrificed at 5 weeks. The HS group exhibited hypertension, massive proteinuria, increased urinary plasmin, and γENaC activation; CM treatment suppressed these changes. CM prevented plasmin(ogen) attachment to podocytes and mitigated podocyte injury by reducing the number of apoptotic glomerular cells, inhibiting protease-activated receptor-1 activation, and suppressing inflammatory and fibrotic cytokine expression. Our findings highlight the detrimental role of urinary plasmin in the pathogenesis of salt-sensitive hypertension and glomerular injury. Targeting plasmin with SP inhibitors, such as CM, may be a promising therapeutic approach for these conditions.
MeSH term(s)	Rats ; Animals ; Serine Proteinase Inhibitors/pharmacology ; Serine Proteinase Inhibitors/therapeutic use ; Fibrinolysin ; Podocytes/metabolism ; Rats, Inbred Dahl ; Hypertension ; Serpins/pharmacology ; Sodium Chloride, Dietary/pharmacology ; Proteinuria/pathology ; Blood Pressure ; Kidney/metabolism
Chemical Substances	Serine Proteinase Inhibitors ; camostat (0FD207WKDU) ; Fibrinolysin (EC 3.4.21.7) ; Serpins ; Sodium Chloride, Dietary
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115743
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Article ; Online: Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice.

Ono, Makoto / Izumi, Yuichiro / Maruyama, Kosuke / Yasuoka, Yukiko / Hiramatsu, Akiko / Aramburu, Jose / López-Rodríguez, Cristina / Nonoguchi, Hiroshi / Kakizoe, Yutaka / Adachi, Masataka / Kuwabara, Takashige / Mukoyama, Masashi

American journal of physiology. Renal physiology

2023 Volume 326, Issue 3, Page(s) F394–F410

Abstract: Nuclear factor of activated T cells 5 (NFAT5; also called TonEBP/OREBP) is a transcription factor that is activated by hypertonicity and induces osmoprotective genes to protect cells against hypertonic conditions. In the kidney, renal tubular NFAT5 is ... ...

Abstract	Nuclear factor of activated T cells 5 (NFAT5; also called TonEBP/OREBP) is a transcription factor that is activated by hypertonicity and induces osmoprotective genes to protect cells against hypertonic conditions. In the kidney, renal tubular NFAT5 is known to be involved in the urine concentration mechanism. Previous studies have suggested that NFAT5 modulates the immune system and exerts various effects on organ damage, depending on organ and disease states. Pathophysiological roles of NFAT5 in renal tubular cells, however, still remain obscure. We conducted comprehensive analysis by performing transcription start site (TSS) sequencing on the kidney of inducible and renal tubular cell-specific NFAT5 knockout (KO) mice. Mice were subjected to unilateral ureteral obstruction to examine the relevance of renal tubular NFAT5 in renal fibrosis. TSS sequencing analysis identified 722 downregulated TSSs and 1,360 upregulated TSSs, which were differentially regulated ≤-1.0 and ≥1.0 in log
MeSH term(s)	Animals ; Mice ; Fibrosis ; Gene Expression ; Kidney ; Mice, Knockout ; Ureteral Obstruction
Chemical Substances	Nfat5 protein, mouse
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00233.2023
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Article ; Online: Basic research on uterus transplantation in nonhuman primates in Japan.

Kisu, Iori / Banno, Kouji / Matoba, Yusuke / Adachi, Masataka / Aoki, Daisuke

The journal of obstetrics and gynaecology research

2018 Volume 44, Issue 10, Page(s) 1871–1881

Abstract: Uterus transplantation (UTx) is now a potential option for women with uterine factor infertility to have a child. However, UTx is still in an experimental stage and basic animal studies including in nonhuman primates are needed for accumulation of data ... ...

Abstract	Uterus transplantation (UTx) is now a potential option for women with uterine factor infertility to have a child. However, UTx is still in an experimental stage and basic animal studies including in nonhuman primates are needed for accumulation of data that will provide important information for establishment of UTx in humans. Herein, we summarized our experiences using cynomolgus macaques, with the goal of promoting further development of UTx studies in nonhuman primates. Our basic studies using cynomolgus macaques were summarized, including the results of other teams in nonhuman primates. Our team in Japan launched UTx research in 2009 using cynomolgus macaques and has accumulated a large archive of results in the UTx research field, including examination of uterine blood flow, surgical procedures of autologous and allogeneic UTx, organ perfusion methods in deceased donor models, immunological response and rejection and ischemia/reperfusion injury. We achieved the first delivery after autologous UTx in primates and the first periodic recovery of menstruation after allogeneic UTx in nonhuman primate models. Results from animal studies, including those in nonhuman primates, provide the basis for clinical application of UTx. Therefore, our accumulated data since 2009 and our basic experience in cynomolgus macaque are meaningful for future UTx trials in Japan. In addition, more validation in nonhuman primate models is needed for resolution of medical issues and further development of UTx in humans, despite clinical application of UTx in several countries.
MeSH term(s)	Animals ; Disease Models, Animal ; Female ; Infertility, Female/surgery ; Japan ; Macaca ; Uterus/transplantation
Language	English
Publishing date	2018-07-05
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.13724
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Article ; Online: Intracardiac metastasis from unknown uterine cervical cancer with severe thrombocytopenia.

Kasai, Mio / Osako, Motohiko / Yamada, Toshiyuki / Adachi, Masataka / Yamashita, Hiroshi / Hatano, Mami / Yorozu, Atsunori

Journal of cardiac surgery

2019 Volume 35, Issue 2, Page(s) 473–476

Abstract: Introduction: Cardiac metastasis is relatively common in malignant neoplasms, such as lung cancers, breast cancers, melanomas, lymphomas, and leukemias. In contrast, cardiac metastasis of uterine cervical cancer, solitary metastasis to the heart, and ... ...

Abstract	Introduction: Cardiac metastasis is relatively common in malignant neoplasms, such as lung cancers, breast cancers, melanomas, lymphomas, and leukemias. In contrast, cardiac metastasis of uterine cervical cancer, solitary metastasis to the heart, and tumors inducing severe thrombocytopenia are rare. Case report: The present patient was a 52-year-old female who was diagnosed with a solitary cardiac tumor prior to uterine cervical cancer and presented with severe thrombocytopenia. Our case had two remarkable aspects: 1) successful treatment under the condition of severe thrombocytopenia in association with the presence of a cardiac tumor, and survival without recurrence of the carcinoma one year after surgery; and 2) a solitary cardiac metastatic tumor larger than the primary uterine cervix carcinoma. Comment: we report an extremely rare case of solitary cardiac metastasis of uterine cervical cancer, which wassuccessfully treated. One year after cardiac surgery, the patient is alive without recurrence of the carcinoma.
MeSH term(s)	Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/secondary ; Carcinoma, Squamous Cell/therapy ; Cardiac Surgical Procedures/methods ; Cisplatin/administration & dosage ; Combined Modality Therapy ; Female ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/secondary ; Heart Neoplasms/therapy ; Humans ; Platelet Transfusion ; Rare Diseases ; Severity of Illness Index ; Thrombocytopenia/etiology ; Thrombocytopenia/therapy ; Treatment Outcome ; Uterine Neoplasms/complications ; Uterine Neoplasms/diagnostic imaging ; Uterine Neoplasms/pathology ; Uterine Neoplasms/therapy
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2019-11-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.14362
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Article ; Online: Profiling of the Causative Bacteria in Infected Lymphocysts after Lymphadenectomy for Gynecologic Cancer by Pyrosequencing the 16S Ribosomal RNA Gene Using Next-Generation Sequencing Technology.

Nogami, Yuya / Banno, Kouji / Adachi, Masataka / Kunitomi, Haruko / Kobayashi, Yusuke / Tominaga, Eiichiro / Aoki, Daisuke

Infectious diseases in obstetrics and gynecology

2019 Volume 2019, Page(s) 9326285

Abstract: Background: Surgery for gynecologic cancer with lymphadenectomy and pelvic radiotherapy can produce lymphoceles that sometimes complicate with infection, resulting in abscesses. The true pathogenic bacteria of abscesses are not always found because of ... ...

Abstract	Background: Surgery for gynecologic cancer with lymphadenectomy and pelvic radiotherapy can produce lymphoceles that sometimes complicate with infection, resulting in abscesses. The true pathogenic bacteria of abscesses are not always found because of false-negative results due to administered antibiotics and difficulty with detection, including for anaerobic bacteria. Analyzing bacteria flora by next-generation sequencing (NGS) using 16S ribosomal DNA may reveal the true pathogenic bacteria in abscesses. This is the first report on causative pathogens for infectious lymphocele using this technology. Methods: The subjects were patients who developed infectious lymphocele after surgery for gynecologic cancer at our hospital from July 2015 to September 2016. NGS analyses of bacterial flora were performed using specimens preserved at -80°C. Two steps of PCR were performed for purified DNA samples to obtain sequence libraries. Processing of sequence data, including operational taxonomic unit (OTU) definition, taxonomy assignment, and an OTU BLAST search were performed. All patients gave written informed consent and the study was approved by the institutional research ethics committee. Results: Six patients underwent puncture and drainage. The result in most cases indicated a single causative pathogen, including
MeSH term(s)	DNA, Bacterial ; DNA, Ribosomal ; Female ; Genital Neoplasms, Female/complications ; Genital Neoplasms, Female/surgery ; High-Throughput Nucleotide Sequencing ; Humans ; Lymph Node Excision/adverse effects ; Lymphocele/etiology ; Lymphocele/microbiology
Chemical Substances	DNA, Bacterial ; DNA, Ribosomal
Language	English
Publishing date	2019-02-21
Publishing country	Egypt
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1176776-5
ISSN	1098-0997 ; 1064-7449
ISSN (online)	1098-0997
ISSN	1064-7449
DOI	10.1155/2019/9326285
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