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  1. Article: Is systematic Gadolinium injection relevant during MRI follow-up for non-functioning pituitary macroadenomas?

    Villemaire, Axel / Adam, Gilles / Fayolle, Hélio / Roques, Margaux / Darcourt, Jean / Caron, Philippe / Bonneville, Fabrice

    Journal of neuroradiology = Journal de neuroradiologie

    2022  Volume 50, Issue 1, Page(s) 3–8

    Abstract: Objective: To compare the performance of coronal contrast-enhanced T1-weighted (ceT1-w) and T2-weighted (T2-w) sequences for diagnosing progression during the MRI follow-up of Non-Functioning Pituitary MacroAdenomas (NFPMAs).: Patients and methods: ... ...

    Abstract Objective: To compare the performance of coronal contrast-enhanced T1-weighted (ceT1-w) and T2-weighted (T2-w) sequences for diagnosing progression during the MRI follow-up of Non-Functioning Pituitary MacroAdenomas (NFPMAs).
    Patients and methods: 106 patients, who had at least two MRIs for the follow-up of NFPMA, were enrolled retrospectively. The largest adenoma diameter was measured on coronal ceT1-w sequences and separately on T2-w sequences for all follow-up MRIs. Interobserver variability was also assessed by 2 independent neuroradiologists in a sample series of 100 examinations. Progression was defined by an increase ≥ 2 mm in diameter between 2 MRIs. Progression thresholds of 3 and 4 mm were also tested. The results of ceT1-w and T2-w sequences were analysed for concordance.
    Results: 93.1% concordance was achieved between ceT1-w and T2-w coronal sequences in 580 follow-up MRIs. In the case of progression detected on at least one sequence, 64.4% concordance was documented for a 2-mm threshold, 87.7% for 3-mm and 97.1% for 4-mm. Discordance was mainly observed on the first postoperative MRI and in case of NFPMAs with multiple recurrences. Kappa was better for diagnosing progression on T2-w than on ceT1-w sequences (0.67 vs. 0.54). It should be noted that 100% agreement was observed between the 2 sequences in the 82 follow-up MRIs of patients with complete surgical resection.
    Conclusion: 93.1% concordance was achieved for coronal ceT1-w and T2-w sequences during the MRI follow-up of NFPMAs, thus challenging systematic injection of gadolinium. If MRI without gadolinium injection is a first-line option, our results suggest that ceT1-w sequences should be reserved for the first postoperative MRI and for the follow-up of aggressive and recurrent NFPMAs.
    MeSH term(s) Humans ; Gadolinium ; Follow-Up Studies ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Observer Variation ; Contrast Media ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery
    Chemical Substances Gadolinium (AU0V1LM3JT) ; Contrast Media
    Language English
    Publishing date 2022-08-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 131763-5
    ISSN 1773-0406 ; 0150-9861
    ISSN (online) 1773-0406
    ISSN 0150-9861
    DOI 10.1016/j.neurad.2022.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potential of acetic acid to restore methane production in anaerobic reactors critically intoxicated by ammonia as evidenced by metabolic and microbial monitoring.

    Lemaigre, Sébastien / Gerin, Patrick A / Adam, Gilles / Klimek, Dominika / Goux, Xavier / Herold, Malte / Frkova, Zuzana / Calusinska, Magdalena / Delfosse, Philippe

    Biotechnology for biofuels and bioproducts

    2023  Volume 16, Issue 1, Page(s) 188

    Abstract: Background: Biogas and biomethane production from the on-farm anaerobic digestion (AD) of animal manure and agri-food wastes could play a key role in transforming Europe's energy system by mitigating its dependence on fossil fuels and tackling the ... ...

    Abstract Background: Biogas and biomethane production from the on-farm anaerobic digestion (AD) of animal manure and agri-food wastes could play a key role in transforming Europe's energy system by mitigating its dependence on fossil fuels and tackling the climate crisis. Although ammonia is essential for microbial growth, it inhibits the AD process if present in high concentrations, especially under its free form, thus leading to economic losses. In this study, which includes both metabolic and microbial monitoring, we tested a strategy to restore substrate conversion to methane in AD reactors facing critical free ammonia intoxication.
    Results: The AD process of three mesophilic semi-continuous 100L reactors critically intoxicated by free ammonia (> 3.5 g_N L
    Conclusions: Despite an extreme free ammonia intoxication, the proposed process recovery strategy allowed CH
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article
    ISSN 2731-3654
    ISSN (online) 2731-3654
    DOI 10.1186/s13068-023-02438-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Microvascular ischemic isolated oculomotor nerve palsy revealed by contrast-enhanced 3D-CISS imaging.

    Roques, Margaux / Biotti, Damien / Darcourt, Jean / Adam, Gilles / Varenne, Fanny / Bonneville, Fabrice

    Journal of neuroradiology = Journal de neuroradiologie

    2021  Volume 48, Issue 6, Page(s) 466–467

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Oculomotor Nerve Diseases/diagnostic imaging
    Language English
    Publishing date 2021-01-17
    Publishing country France
    Document type Letter
    ZDB-ID 131763-5
    ISSN 1773-0406 ; 0150-9861
    ISSN (online) 1773-0406
    ISSN 0150-9861
    DOI 10.1016/j.neurad.2021.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: L'anguille européenne

    Adam, Gilles

    indicateurs d'abondance et de colonisation

    (Savoir faire,)

    2008  

    Author's details Gilles Adam ... [et al.], coordinateurs
    Series title Savoir faire,
    Keywords Anguilla anguilla. ; Anguilla anguilla/Colonization.
    Language French
    Size v, 393 p. :, ill. (some col.), col. maps ;, 24 cm.
    Publisher Quae
    Publishing place Versailles
    Document type Book
    ISBN 9782759200856 ; 275920085X
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Reproducibility of volume analysis of dynamic susceptibility contrast perfusion-weighted imaging in untreated glioblastomas.

    Roques, Margaux / Raveneau, Magali / Adam, Gilles / De Barros, Amaury / Catalaa, Isabelle / Patsoura, Sofia / Cognard, Christophe / Darcourt, Jean / Bonneville, Fabrice

    Neuroradiology

    2022  Volume 64, Issue 9, Page(s) 1763–1771

    Abstract: Purpose: Despite a high variability, the hotspot method is widely used to calculate the cerebral blood volume (CBV) of glioblastomas on DSC-MRI. Our aim was to investigate inter- and intra-observer reproducibility of parameters calculated with the ... ...

    Abstract Purpose: Despite a high variability, the hotspot method is widely used to calculate the cerebral blood volume (CBV) of glioblastomas on DSC-MRI. Our aim was to investigate inter- and intra-observer reproducibility of parameters calculated with the hotspot or a volume method and that of an original parameter assessing the fraction of pixels in the tumour volume displaying rCBV > 2: %rCBV > 2.
    Methods: Twenty-seven consecutive patients with untreated glioblastoma (age: 63, women: 11) were retrospectively included. Three observers calculated the maximum tumour CBV value (rCBVmax) normalized with a reference ROI in the contralateral white matter (CBVWM) with (i) the hotspot method and (ii) with a volume method following tumour segmentation on 3D contrast-enhanced T1-WI. From this volume method, %rCBV > 2 was also assessed. After 8-12 weeks, one observer repeated all delineations. Intraclass (ICC) and Lin's (LCC) correlation coefficients were used to determine reproducibility.
    Results: Inter-observer reproducibility of rCBVmax was fair with the hotspot and good with the volume method (ICC = 0.46 vs 0.65, p > 0.05). For CBVWM, it was fair with the hotspot and excellent with the volume method (0.53 vs 0.84, p < 0.05). Reproducibility of one pairwise combination of observers was significantly better for both rCBVmax and CBVWM (LCC = 0.33 vs 0.75; 0.52 vs 0.89, p < 0.05). %rCBV > 2 showed excellent inter- and intra-observer reproducibility (ICC = 0.94 and 0.91).
    Conclusion: Calculated in glioblastomas with a volume method, rCBVmax and CBVWM yielded good to excellent reproducibility but only fair with the hotspot method. Overall, the volume analysis offers a highly reproducible parameter, %rCBV > 2, that could be promising during the follow-up of such heterogeneous tumours.
    MeSH term(s) Brain Neoplasms/pathology ; Contrast Media ; Female ; Glioblastoma/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Perfusion ; Reproducibility of Results ; Retrospective Studies
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-022-02937-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnostic utility of T2*-weighted GRE in migraine with aura attack. The cortical veins sign.

    Hirtz, Chloe / Adam, Gilles / Raposo, Nicolas / Fabre, Nelly / Ducros, Anne / Calviere, Lionel / Rousseau, Vanessa / Albucher, Jean François / Olivot, Jean-Marc / Bonneville, Fabrice / Viguier, Alain

    Cephalalgia : an international journal of headache

    2022  Volume 42, Issue 8, Page(s) 730–738

    Abstract: Objective: To evaluate the frequency, distribution, and clinical associations of the dilated appearance of cerebral cortical veins, termed cortical veins sign on T2*-weighted gradient recalled-echo (T2*-GRE) in the acute setting of migraine with aura ... ...

    Abstract Objective: To evaluate the frequency, distribution, and clinical associations of the dilated appearance of cerebral cortical veins, termed cortical veins sign on T2*-weighted gradient recalled-echo (T2*-GRE) in the acute setting of migraine with aura attack in adult patients.
    Methods: We conducted a retrospective analysis of 60 consecutive patients admitted for acute neurological symptoms with a final diagnosis of migraine with aura (42%) or probable migraine with aura (58%) who underwent emergency brain magnetic resonance imaging and 60 non-migrainous control adults. The cortical veins sign was defined as a marked hypo-intensity and/or an apparent increased diameter of at least one cortical vein. We examined the prevalence, the spatial distribution, and the associations of cortical veins sign with clinical characteristics of migraine with aura.
    Results: We detected the cortical veins sign in 25 patients (42%) with migraine with aura, compared to none in the control group (
    Conclusion: In the setting of acute neurological symptoms, the presence of cortical veins sign is frequent in patients with migraine with aura and can be detected with good reliability. This imaging marker may help clinicians identify underlying migraine with aura.
    MeSH term(s) Adult ; Epilepsy ; Humans ; Magnetic Resonance Imaging ; Migraine Disorders ; Migraine with Aura/diagnostic imaging ; Reproducibility of Results ; Retrospective Studies
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024221076484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Absence of susceptibility vessel sign is associated with aspiration-resistant fibrin/platelet-rich thrombi.

    Darcourt, Jean / Garcia, Cédric / Phuong, Do M / Michelozzi, Caterina / Bellanger, Guillaume / Adam, Gilles / Roques, Margaux / Januel, Anne C / Tall, Philippe / Albucher, Jean F / Olivot, Jean M / Bonneville, Fabrice / Payrastre, Bernard / Cognard, Christophe

    International journal of stroke : official journal of the International Stroke Society

    2021  Volume 16, Issue 8, Page(s) 972–980

    Abstract: Background: The composition of the thrombus influences its retrievability by mechanical thrombectomy.: Purpose: Our study aimed to report on thrombi resistant to aspiration, regarding susceptibility vessel sign and histologic composition.: Methods!# ...

    Abstract Background: The composition of the thrombus influences its retrievability by mechanical thrombectomy.
    Purpose: Our study aimed to report on thrombi resistant to aspiration, regarding susceptibility vessel sign and histologic composition.
    Methods: This observational study was based on a prospective database of acute anterior circulation ischemic strokes treated by mechanical thrombectomy. Endovascular first-line strategy was aspiration and in case of failure, combined therapy-rescue was performed. The positivity of susceptibility vessel sign (SVS+) or its negativity (SVS-) was assessed on T2* sequences. The thrombus composition was analyzed with hematoxylin eosin staining.
    Results: Histological analysis was performed on 102 clots. Thrombi with SVS- were significantly richer in fibrin/platelets, p = 0.04. Out of 210 mechanical thrombectomy, aspiration first pass strategy was performed in 131/210 (62%) patients. Combined therapy-rescue was needed in 37% of aspiration first pass strategy cases (
    Conclusions: Our results confirm that SVS- clots are rich in fibrin/platelets and suggest that these "white clots" are less likely to be retrieved by aspiration alone and more often require the use of combined therapy.
    MeSH term(s) Blood Platelets ; Fibrin ; Humans ; Stroke/therapy ; Thrombectomy ; Thrombosis/therapy ; Treatment Outcome
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493020986626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Magnetic resonance imaging of arterial stroke mimics: a pictorial review.

    Adam, Gilles / Ferrier, Marine / Patsoura, Sofia / Gramada, Raluca / Meluchova, Zuzana / Cazzola, Vanessa / Darcourt, Jean / Cognard, Christophe / Viguier, Alain / Bonneville, Fabrice

    Insights into imaging

    2018  Volume 9, Issue 5, Page(s) 815–831

    Abstract: Acute ischaemic stroke represents the most common cause of new sudden neurological deficit, but other diseases mimicking stroke happen in about one-third of the cases. Magnetic resonance imaging (MRI) is the best technique to identify those 'stroke ... ...

    Abstract Acute ischaemic stroke represents the most common cause of new sudden neurological deficit, but other diseases mimicking stroke happen in about one-third of the cases. Magnetic resonance imaging (MRI) is the best technique to identify those 'stroke mimics'. In this article, we propose a diagnostic approach of those stroke mimics on MRI according to an algorithm based on diffusion-weighted imaging (DWI), which can be abnormal or normal, followed by the results of other common additional MRI sequences, such as T2 with gradient recalled echo weighted imaging (T2-GRE) and fluid-attenuated inversion recovery (FLAIR). Analysis of the signal intensity of the parenchyma, the intracranial arteries and, overall, of the veins, is crucial on T2-GRE, while anatomic distribution of the parenchymal lesions is essential on FLAIR. Among stroke mimics with abnormal DWI, T2-GRE demonstrates obvious abnormalities in case of intracerebral haemorrhage or cerebral amyloid angiopathy, but this sequence also allows to propose alternative diagnoses when DWI is negative, such as in migraine aura or headaches with associated neurological deficits and lymphocytosis (HaNDL), in which cortical venous prominence is observed at the acute phase on T2-GRE. FLAIR is also of major interest when DWI is positive by better showing evocative distribution of cerebral lesions in case of seizure (involving the hippocampus, pulvinar and cortex), hypoglycaemia (bilateral lesions in the posterior limb of the internal capsules, corona radiata, striata or splenium of the corpus callosum) or in posterior reversible encephalopathy syndrome (PRES). Other real stroke mimics such as mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes (MELAS), Susac's syndrome, brain tumour, demyelinating diseases and herpes simplex encephalitis are also included in our detailed and practical algorithm. KEY POINTS: • About 30% of sudden neurological deficits are due to non-ischaemic causes. • MRI is the best technique to identify stroke mimics. • Our practical illustrated algorithm based on DWI helps to recognise stroke mimics.
    Language English
    Publishing date 2018-06-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1007/s13244-018-0637-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Upscaling of an electronic nose for completely stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant

    Adam, Gilles / Sébastien Lemaigre / Xavier Goux / Philippe Delfosse / Anne-Claude Romain

    Bioresource technology. 2015 Feb., v. 178

    2015  

    Abstract: This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, ... ...

    Abstract This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling’s T2 statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase.
    Keywords alkalinity ; anaerobic digestion ; biogas ; control methods ; electronic nose ; fatty acid composition ; gases ; monitoring ; pH ; principal component analysis ; process control ; volatile fatty acids
    Language English
    Dates of publication 2015-02
    Size p. 285-296.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2014.09.106
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Upscaling of an electronic nose for completely stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant.

    Adam, Gilles / Lemaigre, Sébastien / Goux, Xavier / Delfosse, Philippe / Romain, Anne-Claude

    Bioresource technology

    2015  Volume 178, Page(s) 285–296

    Abstract: This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, ... ...

    Abstract This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling's T(2) statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase.
    MeSH term(s) Agriculture ; Biofuels/analysis ; Bioreactors ; Biotechnology/instrumentation ; Biotechnology/methods ; Electronic Nose ; Hydrogen-Ion Concentration ; Organic Chemicals/analysis ; Pilot Projects ; Principal Component Analysis
    Chemical Substances Biofuels ; Organic Chemicals
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2014.09.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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