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Book: 3D histology evaluation of dermatologic surgery

Breuninger, Helmut / Adam, Patrick

2013

Title variant	Three-D histology evaluation of dermatologic surgery ; three-dimensional
Author's details	Helmut Breuninger ; Patrick Adam
Keywords	Dermatologic Surgical Procedures ; Imaging, Three-Dimensional ; Skin / anatomy & histology
Language	English
Size	XIII, 133 S. : zahlr. Ill., graph. Darst.
Publisher	Springer
Publishing place	London u.a.
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT017904901
ISBN	978-1-4471-4437-3 ; 1-4471-4437-6 ; 9781447144380 ; 1447144384
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2013 A 3681	available for loan (reading room)	Lesesaal EG

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Article ; Online: Building digital solutions to support brain health prescribing in primary care: Where to begin?

Siette, Joyce / Adam, Patrick J

Alzheimer's & dementia (New York, N. Y.)

2024 Volume 10, Issue 1, Page(s) e12447

Abstract: National and international policy goals on healthy ageing and dementia risk reduction are yet to be fully realised in community healthcare settings. Disease modification strategies through lifestyle and social interventions are viable, evidence-based ... ...

Abstract	National and international policy goals on healthy ageing and dementia risk reduction are yet to be fully realised in community healthcare settings. Disease modification strategies through lifestyle and social interventions are viable, evidence-based solutions to reduce age-related disease burden. However, prescribing lifestyle interventions targeting dementia risk in primary care remains deficient. Using digital technologies to support older individuals and healthcare professionals through formal health checks and lifestyle management is likely to enable shared understanding and consequences of personalized care and treatment options. These tailored solutions may bridge the translation gap and support healthy ageing.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12447
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Der Einfluß körperlicher Aktivität auf die Resorption eines oral zugeführten Arzneimittels am Beispiel von Pentoxifyllin

Adam, Patrick

1999

Author's details	vorgelegt von Patrick Adam
Language	German
Size	51, [18] S. : zahlr. graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 1999
HBZ-ID	HT012811477
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2000 D 2449	order for loan	Magazin

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Article ; Online: Exploring the usability of the virtual reality module LEAF CAFÉ: a qualitative think-aloud study.

Siette, Joyce / Campbell, Christopher / Adam, Patrick J / Harris, Celia B

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 162

Abstract: Background: The global healthcare system faces increasing strain from our ageing population, primarily due to the growing prevalence of age-related health conditions such as dementia. While modern healthcare technology offers potential solutions, it ... ...

Abstract	Background: The global healthcare system faces increasing strain from our ageing population, primarily due to the growing prevalence of age-related health conditions such as dementia. While modern healthcare technology offers potential solutions, it frequently lacks user-friendliness for older adults. Virtual Reality (VR) has emerged as a promising tool for diagnosing cognitive impairment, offering innovative solutions where traditional methods may fall short. This study explores older adults' perspectives on the usability of a newly designed VR module for cognitive assessment. Methods: During a 100-min session, participants were asked to engage and complete recall and recognition tasks within the VR module (think-aloud approach) and provide feedback upon completion (semi-structured interviews). Audio materials were transcribed for analysis and recordings of the users' interactions with the module were annotated to provide additional context. These combined textual data were analysed using content coding and thematic analysis to identify themes that reflect how participants used the module's features and what features are desirable to support that process better. Results: Participants (N = 10; Mean age = 73.3, SD = 7.53, range = 65-83 years) perceived the VR module as user-friendly and endorsed its potential as a cognitive screener due to its engaging and immersive nature. Older adults highlighted three key aspects of the module: the usefulness of the platform's ability to offer a comprehensive and reliable evaluation of an individual's cognitive abilities; the need to present concise and relevant content to optimise engagement and use; and the importance of overcoming barriers to support implementation. Suggested game improvements centred on food recognition and adjusting difficulty levels. Barriers to implementation included technology challenges for older adults and concerns about the game's suitability for everyday scenarios. Participants stressed the need for reliable implementation strategies, proposing locations such as libraries and advocating for home-based screening. Conclusion: Continued improvements in accessibility suggest that VR tools could help with diagnosing cognitive impairment in older adults. Using a simulated environment to assess cognitive status might fill the gap between current diagnostic methods, aiding treatment planning and early intervention. However, these findings should be approached cautiously, as more research is needed to fully grasp the potential impact of VR tools in this context.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Virtual Reality ; Cognition ; Aging ; Cognitive Dysfunction ; Data Collection
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04767-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Passive monitoring of avian habitat on working lands.

Dixon, Adam Patrick / Baker, Matthew E / Ellis, Erle C

Ecological applications : a publication of the Ecological Society of America

2023 Volume 33, Issue 5, Page(s) e2860

Abstract: Intensive agricultural landscapes pose a challenge to wildlife managers, policymakers, and landowners hoping to increase the diversity of desired wildlife species, such as grassland birds, which require urgent conservation action. In intensive ... ...

Abstract	Intensive agricultural landscapes pose a challenge to wildlife managers, policymakers, and landowners hoping to increase the diversity of desired wildlife species, such as grassland birds, which require urgent conservation action. In intensive agricultural landscapes, like those of the Midwestern United States, most land area is privately owned and operated and managed primarily for production. Thus, conducting ecological research in intensive agricultural landscapes requires collaborative approaches aimed at farm owners and operators. Recent advances in acoustic data collection and high-resolution habitat mapping, including low-cost acoustic recorders and satellite remote sensing, may be well positioned to address this challenge by enabling expanded assessments and monitoring of wildlife populations and habitats across regions. This study examined fine-grained habitat characteristics and their relationship with avian biodiversity in intensive agricultural landscapes at 44 agricultural sites across the state of Iowa. Passive acoustic monitoring and manual identification of bird species allowed for measurement of vocalizing bird richness. High-resolution mapping of noncrop vegetation provided detailed information on small noncrop vegetation habitat complexes within row-crop agriculture. Measures of image texture provided characterizations of compositional heterogeneity within noncrop vegetation. General linear Poisson modeling demonstrated robust associations between noncrop vegetation and vocalizing bird richness, yet variation in grassland bird richness was not well predicted by noncrop vegetation. Noncrop vegetation texture demonstrated potential as a predictor of vocalizing bird richness, though not better than or when combined with noncrop vegetated area, indicating it may not be an independent measure of habitat quality. Passive acoustic monitoring resulted in useful data at 44 out of 60 originally selected sites, with some lost to failed recorders and/or collaboration issues. Challenges remain in detecting habitat characteristics that promote grassland birds in row crop landscapes. Working toward probabilistic research design across privately owned working landscapes and incorporating more detailed management practice information would improve the transferability of this approach to farmland management and policy.
MeSH term(s)	Animals ; Ecosystem ; Biodiversity ; Agriculture ; Animals, Wild ; Birds
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2860
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Passive monitoring of avian habitat on working lands

Dixon, Adam Patrick / Baker, Matthew E. / Ellis, Erle C.

Ecological Applications. 2023 July, v. 33, no. 5 p.e2860-

2023

Abstract	Intensive agricultural landscapes pose a challenge to wildlife managers, policymakers, and landowners hoping to increase the diversity of desired wildlife species, such as grassland birds, which require urgent conservation action. In intensive agricultural landscapes, like those of the Midwestern United States, most land area is privately owned and operated and managed primarily for production. Thus, conducting ecological research in intensive agricultural landscapes requires collaborative approaches aimed at farm owners and operators. Recent advances in acoustic data collection and high‐resolution habitat mapping, including low‐cost acoustic recorders and satellite remote sensing, may be well positioned to address this challenge by enabling expanded assessments and monitoring of wildlife populations and habitats across regions. This study examined fine‐grained habitat characteristics and their relationship with avian biodiversity in intensive agricultural landscapes at 44 agricultural sites across the state of Iowa. Passive acoustic monitoring and manual identification of bird species allowed for measurement of vocalizing bird richness. High‐resolution mapping of noncrop vegetation provided detailed information on small noncrop vegetation habitat complexes within row‐crop agriculture. Measures of image texture provided characterizations of compositional heterogeneity within noncrop vegetation. General linear Poisson modeling demonstrated robust associations between noncrop vegetation and vocalizing bird richness, yet variation in grassland bird richness was not well predicted by noncrop vegetation. Noncrop vegetation texture demonstrated potential as a predictor of vocalizing bird richness, though not better than or when combined with noncrop vegetated area, indicating it may not be an independent measure of habitat quality. Passive acoustic monitoring resulted in useful data at 44 out of 60 originally selected sites, with some lost to failed recorders and/or collaboration issues. Challenges remain in detecting habitat characteristics that promote grassland birds in row crop landscapes. Working toward probabilistic research design across privately owned working landscapes and incorporating more detailed management practice information would improve the transferability of this approach to farmland management and policy.
Keywords	acoustics ; agricultural land ; biodiversity ; birds ; data collection ; farms ; grasslands ; habitats ; issues and policy ; rowcrops ; satellites ; texture ; wildlife ; Iowa
Language	English
Dates of publication	2023-07
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2860
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones.

Kosmidis, Perikles / Mankel, Barbara / Fend, Falko / Adam, Patrick

Diagnostic pathology

2018 Volume 13, Issue 1, Page(s) 25

Abstract: Background: The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85-90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be observed in ... ...

Abstract	Background: The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85-90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be observed in other cell types of the microenvironment remains debated. Of interest, cases of associated histiocytic and dendritic cell sarcomas arising in the background of FL have been shown to be clonally related and carry the t(14;18), suggesting a "transdifferentiation" of the malignant FL clone into a neoplasm of a different hematopoietic lineage. Methods: We analyzed the presence of the t(14;18)(q32;q21) as a surrogate marker of the malignant clone in cells of the FL microenvironment using combined fluorescence immunophenotyping and interphase cytogenetics targeting the BCL2 gene locus. In addition to non-lymphoid cells in FL, we analysed FL with preserved IgD+ mantle zones and cases of in situ follicular neoplasia (ISFN) to investigate whether cells of non-germinal center B-cell phenotype are part of the malignant clone. Results: Six (40%) of 15 manifest FL cases with preserved IgD+ mantle zones did not harbour the t(14;18)(q32;q21) translocation. In all t(14;18) + FL cases, follicular dendritic cells and endothelial cells lacked the t(14;18) translocation. 2/9 FL revealed t(14;18)- IgD+ mantle zone B-cells. In the seven ISFN cases, the t(14;18) translocation was strictly confined to germinal center cells. Conclusions: The t(14;18) translocation in follicular lymphoma is limited to B-cells. The origin of IgD+ mantle cells is heterogeneous, in the majority of cases belonging to the neoplastic clone, whereas a minority of cases of manifest FL show nonneoplastic mantle zones, similar to ISFN.
MeSH term(s)	Chromosomes, Human, Pair 14/genetics ; Chromosomes, Human, Pair 18/genetics ; Dendritic Cells, Follicular/pathology ; Endothelial Cells/pathology ; Germinal Center/pathology ; Humans ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/pathology ; Translocation, Genetic/genetics
Language	English
Publishing date	2018-05-02
Publishing country	England
Document type	Journal Article
ISSN	1746-1596
ISSN (online)	1746-1596
DOI	10.1186/s13000-018-0703-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: 3D histology evaluation of dermatologic surgery

Breuninger, Helmut / Adam, Patrick

2013

Title variant	Three-dimensional histology evaluation of dermatologic surgery
Author's details	Helmut Breuninger, Patrick Adam
MeSH term(s)	Dermatologic Surgical Procedures ; Imaging, Three-Dimensional ; Skin/anatomy & histology
Language	English
Size	xiii, 133 pages :, illustrations
Document type	Book
ISBN	9781447144373 ; 9781447144380 ; 1447144376 ; 1447144384
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Online: 3D Histology Evaluation of Dermatologic Surgery

Breuninger, Helmut / Adam, Patrick

2013

Abstract: Both surgical skill and histological preparation and evaluation are important for successful treatment of various malignant skin tumors. In addition, good knowledge of local patterns of infiltration is required to achieve complete excision. All tumors ... ...

Author's details	by Helmut Breuninger, Patrick Adam
Abstract	Both surgical skill and histological preparation and evaluation are important for successful treatment of various malignant skin tumors. In addition, good knowledge of local patterns of infiltration is required to achieve complete excision. All tumors may show an irregular, often asymmetric, mainly horizontal subclinical infiltration with a wide extent. When deep infiltrations are present, they are also often asymmetric and hard to determine before excision. Until recently these tumor outgrowths have only been detectable using histologic evaluation, but 3D histology is highly sensitive and can detect even very small tumor infiltrations. Very narrow margins can thus be taken for excision, which helps spare healthy skin as only a subsequently targeted re-excision will be necessary to remove all of the asymmetric tumor infiltrations. Therefore the resulting defect will be as small as possible and as large as necessary, and can be adapted to the requirements for aesthetic surgical defect closure. 3D Histology Evaluation of Dermatologic Surgery compares the most commonly used methods in order to give the reader a graphical overview of the current state-of-the-art. The basic principles of various surgical methods and histological workups of the complete 3D tumor margins are described and extensively illustrated to allow better understanding. Furthermore, more complex treatments of larger tumors are also included. Therefore, this book will be vital for all involved in the management of these patients, including practicing and trainee dermatologists, ENT, plastic and facial-surgeons, pathologists and oncologists
Keywords	Cancer/Surgery ; Dermatology ; Medicine ; Pathology ; Surgery
Language	English
Size	Online-Ressource (XIII, 133 p. 64 illus. in color), digital
Publisher	Springer
Publishing place	London
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	9781447144373 ; 9781447144380 ; 1447144376 ; 1447144384
DOI	10.1007/978-1-4471-4438-0
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Stability of antibacterial Te(IV) compounds: A combined experimental and computational study.

D'Arcy, Kenneth / Doyle, Adam Patrick / Kavanagh, Kevin / Ronconi, Luca / Fresch, Barbara / Montagner, Diego

Journal of inorganic biochemistry

2019 Volume 198, Page(s) 110719

Abstract: Inorganic Te(IV) compounds are important cysteine protease inhibitors and antimicrobial agents; AS-101 [ammonium trichloro (dioxoethylene-O,O')tellurate] is the first compound of a family with formula ... ...

Abstract	Inorganic Te(IV) compounds are important cysteine protease inhibitors and antimicrobial agents; AS-101 [ammonium trichloro (dioxoethylene-O,O')tellurate] is the first compound of a family with formula NH
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Density Functional Theory ; Drug Stability ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Models, Chemical ; Molecular Structure ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Tellurium/chemistry
Chemical Substances	Anti-Bacterial Agents ; Coordination Complexes ; Cysteine Proteinase Inhibitors ; Prodrugs ; Tellurium (NQA0O090ZJ)
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2019.110719
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