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  1. AU="Adam Orłowski"
  2. AU="Tumanov A"
  3. AU="Hsu, Rafael M C S"
  4. AU=Perfect John R
  5. AU="Francini, Saverio"
  6. AU="Hurley, David"
  7. AU=Thomas L
  8. AU="French, M S"
  9. AU=Bonek Krzysztof
  10. AU="Noviello, Colleen M"
  11. AU="Jill A. Hollenbach"
  12. AU="Bansal, Ramesh C."
  13. AU="Huang, Xuhua"
  14. AU="Latorre, Víctor"
  15. AU="Simon J. Waddell"
  16. AU="Luo, Yueming"

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  1. Artikel ; Online: Intraoperative endoscopy of the anterior epitympanum recess through the posterior tympanotomy

    Emilia B. Karchier / Kazimierz Niemczyk / Krzysztof F. Morawski / Robert Bartoszewicz / Adam Orłowski

    Videosurgery and Other Miniinvasive Techniques, Vol 11, Iss 3, Pp 208-

    2016  Band 213

    Abstract: Introduction : The anterior epitympanum recess (AER) is a common place of the development of the cholesteatoma, which is why removal of the matrix from this area plays a key role in the surgical treatment of chronic otitis media. Aim : To evaluate the ... ...

    Abstract Introduction : The anterior epitympanum recess (AER) is a common place of the development of the cholesteatoma, which is why removal of the matrix from this area plays a key role in the surgical treatment of chronic otitis media. Aim : To evaluate the intraoperative visibility of AER in endoscopic optics in comparison to microscopic optics and to determine the prevalence of cholesteatoma in various types of construction of the AER. Study design: Retrospective analysis of intraoperative search. Material and methods : The study included 55 patients treated in the Department of Otolaryngology, Medical University of Warsaw within the years 2009–2011, who underwent endoscopy-assisted canal wall up tympanoplasty with posterior tympanotomy. The type of construction of the AER – cellular or dome-shaped – was determined. Results : Cellular type of recess was found intraoperatively in 32% of ears and dome-shaped in 68% of the study group. The population with chronic otitis media does not differ significantly compared to the general population in terms of the construction of the anterior epitympanum recess (p = 0.668108; χ 2 = 0.1838235, df = 1). Among the ears with cholesteatoma a cellular AER was found in 48.3% of cases and a dome-shaped AER was found in 51.7%. Conclusions : The cellular type of AER was significantly more frequent in ears with cholesteatoma (p < 0.01, χ 2 = 29.86492, df = 1). Level of evidence: 1b.
    Schlagwörter middle ear ; endoscopy ; cholesteatoma ; chronic otitis media ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2016-07-01T00:00:00Z
    Verlag Termedia Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters

    Tomasz Róg / Adam Orłowski / Alicia Llorente / Tore Skotland / Tuulia Sylvänne / Dimple Kauhanen / Kim Ekroos / Kirsten Sandvig / Ilpo Vattulainen

    Data in Brief, Vol 7, Iss , Pp 1171-

    2016  Band 1174

    Abstract: In this Data in Brief article we provide a data package of GROMACS input files for atomistic molecular dynamics simulations of multicomponent, asymmetric lipid bilayers using the OPLS-AA force field. These data include 14 model bilayers composed of 8 ... ...

    Abstract In this Data in Brief article we provide a data package of GROMACS input files for atomistic molecular dynamics simulations of multicomponent, asymmetric lipid bilayers using the OPLS-AA force field. These data include 14 model bilayers composed of 8 different lipid molecules. The lipids present in these models are: cholesterol (CHOL), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine (POPE), 1-stearoyl-2-oleoyl-sn-glycero-3-phosphatidyl-ethanolamine (SOPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylserine (POPS), 1-stearoyl-2-oleoyl-sn-glycero-3-phosphatidylserine (SOPS), N-palmitoyl-D-erythro-sphingosyl-phosphatidylcholine (SM16), and N-lignoceroyl-D-erythro-sphingosyl-phosphatidylcholine (SM24). The bilayers׳ compositions are based on lipidomic studies of PC-3 prostate cancer cells and exosomes discussed in Llorente et al. (2013) [1], showing an increase in the section of long-tail lipid species (SOPS, SOPE, and SM24) in the exosomes. Former knowledge about lipid asymmetry in cell membranes was accounted for in the models, meaning that the model of the inner leaflet is composed of a mixture of PC, PS, PE, and cholesterol, while the extracellular leaflet is composed of SM, PC and cholesterol discussed in Van Meer et al. (2008) [2]. The provided data include lipids׳ topologies, equilibrated structures of asymmetric bilayers, all force field parameters, and input files with parameters describing simulation conditions (md.mdp). The data is associated with the research article “Interdigitation of Long-Chain Sphingomyelin Induces Coupling of Membrane Leaflets in a Cholesterol Dependent Manner” (Róg et al., 2016) [3]. Keywords: Molecular dynamics simulations, Force field, Topology, Lipidomics, Lipid, GROMACS
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2016-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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