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  1. Article ; Online: Prolonged and high dosage of tigecycline – successful treatment of spondylodiscitis caused by multidrug-resistant Acinetobacter baumannii

    Olga Tsachouridou / Adamantini Georgiou / Sideris Nanoudis / Theofilos Chrysanthidis / Georgia Loli / Petros Morfesis / Pantelis Zebekakis / Symeon Metallidis

    Journal of Medical Case Reports, Vol 11, Iss 1, Pp 1-

    a case report

    2017  Volume 4

    Abstract: Abstract Background The incidence of infectious spondylodiscitis has been increasing over the last few years. This reflects the expanding elderly and immunocompromised populations and the rising implementation of invasive spinal procedures. Infection may ...

    Abstract Abstract Background The incidence of infectious spondylodiscitis has been increasing over the last few years. This reflects the expanding elderly and immunocompromised populations and the rising implementation of invasive spinal procedures. Infection may be inoculated into the disc space directly during invasive spinal procedures. Osteomyelitis caused by Acinetobacter species is rare and mainly caused by multidrug-resistant strains. Case presentation We present the case of a 72-year-old Greek woman with postoperative spondylodiscitis caused by a multidrug-resistant Acinetobacter baumannii strain that was successfully treated, after she declined surgical treatment, with prolonged and high dosage of tigecycline. She received intravenously administered tigecycline 200 mg per day for 60 days and then 100 mg per day for a total of 102 days and was infection-free. Conclusions We reviewed the literature on the role of Acinetobacter baumannii as a cause of osteomyelitis, emphasizing the difficulty of treatment and the potential role of tigecycline in conservative treatment of the infection. We believe that 102 days in total is the longest time that any patient has received tigecycline in the literature, thus our patient is a unique case of successful treatment of spondylodiscitis.
    Keywords Spondylodiscitis ; Acinetobacter baumannii ; Multi-drug resistance ; Tigecycline ; Prolonged administration ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2017-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Predictors of humoral response to recommended vaccines in HIV-infected adults

    Tsachouridou, Olga / Adamantini Georgiou / Dimitra Vasdeki / Eirini Christaki / Evropi Forozidou / Georgia Kotoreni / Georgios Germanidis / Lemonia Skoura / Maria-Anna Ntziovara / Paraskevi Tsoukra / Sideris Nanoudis / Symeon Metallidis

    Comparative immunology, microbiology, and infectious diseases. 2017 Oct., v. 54

    2017  

    Abstract: Humoral response to vaccination has been found to be inadequate in individuals infected with the human immunodeficiency virus (HIV). We retrospectively assessed antibody responses to three routinely recommended vaccines, against hepatitis B, hepatitis A ... ...

    Abstract Humoral response to vaccination has been found to be inadequate in individuals infected with the human immunodeficiency virus (HIV). We retrospectively assessed antibody responses to three routinely recommended vaccines, against hepatitis B, hepatitis A and S. pneumoniae, in HIV-infected individuals. Data regarding age at HIV diagnosis, years of infection, sex, nationality, HIV mode of transmission, CD4 cell count, nadir CD4 count, plasma viral load, HIV stage, insurance status, educational level and treatment with Highly Active Antiretroviral Therapy (HAART) were collected. Univariate and multivariate analysis was performed in order to detect factors associated with response to vaccination. 437 patients were assessed for hepatitis B, 627 patients for hepatitis A and 66 patients for S. pneumoniae serologic vaccine responsiveness. Regarding hepatitis B and hepatitis A, education level and insurance status were the only predictors of response. As for S. pneumoniae vaccination HAART and control of viremia were correlated with better response to vaccination.
    Keywords adults ; antibodies ; antiretroviral agents ; CD4-positive T-lymphocytes ; educational status ; hepatitis A ; hepatitis B ; HIV infections ; Human immunodeficiency virus ; humoral immunity ; insurance ; lymphocyte count ; multivariate analysis ; nationalities and ethnic groups ; patients ; vaccination ; vaccines ; viral load ; viremia
    Language English
    Dates of publication 2017-10
    Size p. 27-33.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2017.07.006
    Database NAL-Catalogue (AGRICOLA)

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