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  1. Book ; Online ; E-Book: Proktologie in Praxis und Notaufnahme

    Gingert, Christian / Frei-Lanter, Cornelia / Adamina, Michel

    für Ärzte aller Fachrichtungen

    2018  

    Author's details Christian Gingert, Cornelia Frei-Lanter, Michel Adamina
    Keywords Endocrinology ; Internal medicine ; Surgery ; Dermatology ; Family medicine ; Gynecology
    Language German
    Size 1 Online-Ressource (VII, 134 Seiten), Illustrationen
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019809312
    ISBN 978-3-662-56814-9 ; 9783662568132 ; 3-662-56814-4 ; 3662568136
    DOI 10.1007/978-3-662-56814-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Authors' Reply: Nationwide Study on Stress Perception Among Surgical Residents.

    Adamina, Michel / Saillant, Stéphane

    World journal of surgery

    2022  Volume 46, Issue 12, Page(s) 3123–3124

    MeSH term(s) Humans ; Internship and Residency ; Perception
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Letter
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06775-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: At the Crossroads of Caution and Intervention: Anti-TNF Therapy Prior to Elective CD Surgery.

    Adamina, Michel / Fiorino, Gionata

    Journal of Crohn's & colitis

    2021  Volume 15, Issue 10, Page(s) 1778–1779

    MeSH term(s) Adalimumab/adverse effects ; Crohn Disease ; Humans ; Infliximab ; Postoperative Complications ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjab092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6634: Show issues Location:
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  4. Article ; Online: Abstracts presented at the 14th European Colorectal Congress (#ECCStGallen), 29.11.2020-2.12.2020, St.Gallen, Switzerland.

    Adamina, Michel / Pozza, Gioia

    Techniques in coloproctology

    2021  , Page(s) 607–656

    Language English
    Publishing date 2021-02-22
    Publishing country Italy
    Document type News
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-021-02408-9
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    Zs.A 5842: Show issues Location:
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  5. Article: Surgical Outcomes, Long-Term Recurrence Rate, and Resource Utilization in a Prospective Cohort of 165 Patients Treated by Transanal Total Mesorectal Excision for Distal Rectal Cancer.

    Gloor, Severin / Pozza, Gioia / Troller, Rebekka / Wehrli, Markus / Adamina, Michel

    Cancers

    2023  Volume 15, Issue 4

    Abstract: A transanal total mesorectal excision (taTME) is a smart alternative to a conventional TME. However, worrisome reports of a high recurrence and complications triggered a moratorium in a few countries. This study assessed the outcomes and resource ... ...

    Abstract A transanal total mesorectal excision (taTME) is a smart alternative to a conventional TME. However, worrisome reports of a high recurrence and complications triggered a moratorium in a few countries. This study assessed the outcomes and resource utilization of a taTME. Consecutive patients with distal rectal cancer treated by a taTME were prospectively included. Outcomes were reported as the median and interquartile range (IQR). One hundred sixty-five patients (67% male and 33% female) with a tumor 7 cm (IQR 5-10) from the anal verge were followed for 50 months (IQR 32-79). The resection margins were threatened in 25% of the patients, while 75% of the patients received neoadjuvant radiochemotherapy. A good mesorectal dissection and clear margins were achieved in 96% of the specimens, and 27 lymph nodes (IQR 20-38) were harvested. Ninety-day major morbidity affected 36 patients (21.8%), including 12 with anastomotic leakages (7.2%). A recurrence occurred locally in 9 patients (5.4%), and 44 patients had a distant metastasis (26.7%). The five-year disease-free survival and overall survival were 67% and 90%, respectively. A multivariate analysis found a long operation and frailty predicted an anastomotic leak, while a positive distal margin and lymph nodes predicted a local recurrence and distant metastasis. A two-team taTME saved 102 min of operative time and EUR 1385 when compared to a one-team approach. Transanal total mesorectal excision produced sound surgical quality and excellent oncologic outcomes.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Postoperative mortality after surgery for inflammatory bowel disease: The myth of Apollo and Artemis.

    Katsanos, Konstantinos H / Adamina, Michel

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 53, Issue 1, Page(s) 52–53

    MeSH term(s) Colitis ; Humans ; Inflammatory Bowel Diseases/surgery ; Postoperative Period
    Language English
    Publishing date 2020-11-11
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.10.019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.

    Schnoz, Christina / Schmid, Katrin / Ortega Sanchez, Guacimara / Schacher-Kaufmann, Sabina / Adamina, Michel / Peros, Georgios / Erdin, Dieter / Bode, Peter Karl

    Clinical & experimental metastasis

    2024  Volume 41, Issue 1, Page(s) 45–53

    Abstract: Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, ... ...

    Abstract Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, including the TNM staging system and European Society for Medical Oncology (ESMO) guidelines, recommend examination of at least 12 lymph nodes. However, identification of an adequate number of lymph nodes can be challenging, especially in the setting of neoadjuvant treatment, which may reduce nodal size. In this study, we investigated 384 colorectal cancer resections that were processed at our department of pathology between January 2012 and December 2022, in which the number of detected lymph nodes was less than 12 subsequent to conventional preparation of mesocolic fat tissue. By means of acetone compression, lymph node harvest increased significantly (p < 0.0001), and the intended number of ≥ 12 lymph nodes was achieved in 98% of resection specimens. The number of nodal positive cases increased significantly from n = 95 (24.7%) before versus n = 131 (34.1%) after acetone compression due to additionally identified lymph node metastases (p < 0.001). In 36 patients (9.4%) initially considered as nodal negative, acetone compression led to a staging adjustment to a nodal positive category and thereby drove a recommendation to offer post-operative therapy. In conclusion, acetone compression is a reliable and useful method implementable in routine surgical pathology for the retrieval of lymph nodes in colorectal cancer specimen, allowing for an adequate lymph node sampling and an increase in nodal staging reliability.
    MeSH term(s) Humans ; Lymphatic Metastasis/pathology ; Acetone ; Reproducibility of Results ; Colorectal Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neoplasm Staging ; Lymph Node Excision
    Chemical Substances Acetone (1364PS73AF)
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604952-7
    ISSN 1573-7276 ; 0262-0898
    ISSN (online) 1573-7276
    ISSN 0262-0898
    DOI 10.1007/s10585-023-10259-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1855: Show issues Location:
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  8. Article ; Online: Nationwide Study on Stress Perception Among Surgical Residents.

    Guglielmetti, Laura C / Gingert, Christian / Holtz, Anna / Westkämper, Reinhard / Lange, Jochen / Adamina, Michel

    World journal of surgery

    2022  Volume 46, Issue 7, Page(s) 1609–1622

    Abstract: Objective: Declining number of applicants and high attrition of residents are a dire reality. Surgeons in training are confronted to various stressors which interfere with their performance and may promote burnout. This study measures stress levels of ... ...

    Abstract Objective: Declining number of applicants and high attrition of residents are a dire reality. Surgeons in training are confronted to various stressors which interfere with their performance and may promote burnout. This study measures stress levels of Swiss surgical residents.
    Methods: Swiss surgery residents taking the Surgical Basic Exam from 2016 to 2020 completed the Perceived Stress Scale 10 (PSS). The PSS measures how unpredictable, uncontrollable, and overloaded the respondents evaluate their work life. Scores up to 13 are normal, and scores around 20 are highly pathologic. High subscores of helplessness (PH) and lower subscores of self-efficacy (PSE) indicate distress.
    Results: A total of 1694 questionnaires were evaluated (return rate 95.7%). Resident median (m) age was 29 years, 43.5% were female, and 72.7% of the residents were in their first 2 years of training. Residents reported a high PSS (m = 15), a high PH (m = 9), and an ordinary PSE (m = 5). Females reported worse PSS (p < 0.001), PH (p < 0.001), and PSE (p = 0.036). In multivariable analysis, male sex (p < 0.001), aiming at orthopedic (p = 0.017) or visceral surgery (p = 0.004), and French as mother tongue (p = 0.037) predicted lower stress levels, while graduating from a country not adjacent to Switzerland led to higher stress (p = 0.047).
    Conclusion: Perceived stress levels are high in this prospective and representative cohort study of Swiss surgical residents. Females endured significantly worse stress and helplessness levels than males. These figures are worrisome as they may directly contribute to the declining attractivity of surgical residencies. Detailed sex-specific analysis and correction of stressors are urgently needed to improve residency programs.
    MeSH term(s) Adult ; Burnout, Professional ; Cohort Studies ; Female ; Humans ; Internship and Residency ; Male ; Perception ; Prospective Studies ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06521-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: When gene therapy meets adoptive cell therapy: better days ahead for cancer immunotherapy?

    Adamina, Michel

    Expert review of vaccines

    2010  Volume 9, Issue 4, Page(s) 359–363

    Abstract: Evaluation of: Johnson LA, Morgan RA, Dudley ME et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 114(3), 535-546 (2009). Effective cancer immunotherapy ... ...

    Abstract Evaluation of: Johnson LA, Morgan RA, Dudley ME et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 114(3), 535-546 (2009). Effective cancer immunotherapy requires large numbers of antitumor lymphocytes with effective homing and effector functions over a prolonged time. Adoptive cell therapy (ACT) has proven a promising immunotherapy approach by achieving clinical responses in patients bearing metastatic melanoma. ACT expands a cancer patient's own cytotoxic lymphocytes in vitro and reinfuses them in vivo. Identifying cytotoxic T lymphocytes directed against cancer cells can, however, be a tedious endeavor. The paper under evaluation overcomes this hurdle and proposes a highly effective gene therapy approach to transduce a patient's lymphocytes with a high-avidity T-cell receptor, thus turning reinfused lymphocytes into strong effector cells directed against cancer. Furthermore, transgenic mice were used to broaden the repertoire of human transduced T-cell receptor to evasive tumor-associated antigens. Patients bearing metastatic melanoma were successfully treated with ACT using peripheral blood lymphocytes transduced with Mart-1 and gp100 tumor-associated epitopes. Objective clinical response rates of 30 and 19% were obtained in patients treated with the human and mouse T-cell receptors, respectively. Gene-engineered cells persisted in all patients at high level for 1 month after treatment. These findings have two major implications: first, transgenic mice can be used to obtain high-avidity T-cell receptors specific for elusive tumor-associated antigens, bypassing the need for frustrating immunizations attempts. Second, a gene therapy approach to ACT allows for an efficient transduction of patient's lymphocytes into highly avid tumor-specific cytotoxic cells, eliminating the requirement for identification and selection of tumor-specific lymphocytes in individual patients. Taken together, these results mark a step towards standardized immunotherapy protocols open to all patients and that will be able to deliver consistent clinical results.
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.10.24
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    Zs.A 6077: Show issues Location:
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  10. Article ; Online: Swiss consensus on the management of acute diverticulitis.

    Girardin, Timothée / Martin, David / Lázaro-Fontanet, Enrique / Clerc, Daniel / Hübner, Martin / Brügger, Lukas / Turina, Matthias / Brunner, Walter / Christoforidis, Dimitri / Ris, Frederic / Adamina, Michel / von Strauss, Marco / Hahnloser, Dieter

    BJS open

    2024  Volume 8, Issue 1

    MeSH term(s) Humans ; Consensus ; Switzerland ; Diverticulitis/surgery ; Acute Disease
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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